JP2004522748A5 - - Google Patents
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- Publication number
- JP2004522748A5 JP2004522748A5 JP2002560670A JP2002560670A JP2004522748A5 JP 2004522748 A5 JP2004522748 A5 JP 2004522748A5 JP 2002560670 A JP2002560670 A JP 2002560670A JP 2002560670 A JP2002560670 A JP 2002560670A JP 2004522748 A5 JP2004522748 A5 JP 2004522748A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- protein
- mutein
- binding protein
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003112 inhibitor Substances 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 102000044166 interleukin-18 binding protein Human genes 0.000 claims 6
- 108010070145 interleukin-18 binding protein Proteins 0.000 claims 6
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 102000003390 tumor necrosis factor Human genes 0.000 claims 4
- 108090000426 Caspase-1 Proteins 0.000 claims 3
- 102100035904 Caspase-1 Human genes 0.000 claims 3
- 102000001708 Protein Isoforms Human genes 0.000 claims 3
- 108010029485 Protein Isoforms Proteins 0.000 claims 3
- 239000005557 antagonist Substances 0.000 claims 3
- 230000004071 biological effect Effects 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 208000031225 myocardial ischemia Diseases 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- UOUBHJRCKHLGFB-DGJUNBOTSA-N (3s)-3-[[(2s)-2-[[(2s)-2-[[(2s)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-chloro-4-oxopentanoic acid Chemical group OC(=O)C[C@@H](C(=O)CCl)NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(C)=O)CC1=CC=C(O)C=C1 UOUBHJRCKHLGFB-DGJUNBOTSA-N 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 101000828805 Cowpox virus (strain Brighton Red) Serine proteinase inhibitor 2 Proteins 0.000 claims 1
- 101500028161 Homo sapiens Tumor necrosis factor-binding protein 1 Proteins 0.000 claims 1
- 101500028163 Homo sapiens Tumor necrosis factor-binding protein 2 Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- XVZUMQAMCYSUMS-SIUGBPQLSA-N OC(=O)C[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 Chemical compound OC(=O)C[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 XVZUMQAMCYSUMS-SIUGBPQLSA-N 0.000 claims 1
- 102400000089 Tumor necrosis factor-binding protein 1 Human genes 0.000 claims 1
- 102400000091 Tumor necrosis factor-binding protein 2 Human genes 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- PFBLRDXPNUJYJM-UHFFFAOYSA-N tert-butyl 2-methylpropaneperoxoate Chemical group CC(C)C(=O)OOC(C)(C)C PFBLRDXPNUJYJM-UHFFFAOYSA-N 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01101959 | 2001-01-29 | ||
| EP01101959.3 | 2001-01-29 | ||
| PCT/EP2002/000844 WO2002060479A1 (en) | 2001-01-29 | 2002-01-28 | Use of il-18 inhibitors for the treatment and/or prevention of heart disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008319532A Division JP2009102354A (ja) | 2001-01-29 | 2008-12-16 | 心疾患の治療および／または予防のためのｉｌ−１８阻害剤の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004522748A JP2004522748A (ja) | 2004-07-29 |
| JP2004522748A5 true JP2004522748A5 (cg-RX-API-DMAC10.html) | 2011-11-17 |
| JP4860897B2 JP4860897B2 (ja) | 2012-01-25 |
Family
ID=8176323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002560670A Expired - Lifetime JP4860897B2 (ja) | 2001-01-29 | 2002-01-28 | 心疾患の治療および／または予防のためのｉｌ−１８阻害剤の使用 |
| JP2008319532A Pending JP2009102354A (ja) | 2001-01-29 | 2008-12-16 | 心疾患の治療および／または予防のためのｉｌ−１８阻害剤の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008319532A Pending JP2009102354A (ja) | 2001-01-29 | 2008-12-16 | 心疾患の治療および／または予防のためのｉｌ−１８阻害剤の使用 |
Country Status (31)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK12942002A3 (sk) | 2000-02-10 | 2003-05-02 | Abbott Laboratories | Protilátky viažuce ľudský interleukín-18, spôsoby ich výroby a použitia |
| AU2002211744B8 (en) | 2000-10-11 | 2008-03-20 | Viron Therapeutics, Inc. | Nucleic acid molecules and polypeptides for immune modulation |
| US7718368B2 (en) | 2000-12-04 | 2010-05-18 | Viron Therapeutics Inc. | Immunomodulatory protein and useful embodiments thereof |
| AU2004238524B2 (en) | 2003-05-13 | 2011-06-23 | Merck Serono Sa | Active variants of the IL-18 binding protein and medical uses thereof |
| US7968684B2 (en) * | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| JP4961559B2 (ja) * | 2004-03-11 | 2012-06-27 | 友昭 星野 | インターロイキン１８阻害剤を有効成分とする疾患の予防又は治療剤 |
| CA2609060C (en) | 2005-06-03 | 2014-07-15 | Urs Weber | Production of recombinant il-18 binding protein |
| PT1891088E (pt) | 2005-06-10 | 2011-12-19 | Ares Trading Sa | Processo para a purificação da proteína de ligação il-18 |
| TW200927060A (en) | 2007-11-05 | 2009-07-01 | Kci Licensing Inc | Identification of tissue for debridement |
| US9376489B2 (en) | 2012-09-07 | 2016-06-28 | Novartis Ag | IL-18 binding molecules |
| WO2015032932A1 (en) * | 2013-09-05 | 2015-03-12 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) in inflammatory diseases |
| CN107660150B (zh) * | 2015-03-05 | 2023-10-24 | Ab2生物股份有限公司 | Il-18结合蛋白(il-18bp)和抗体在炎性疾病中 |
| US11091795B2 (en) | 2016-07-11 | 2021-08-17 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for diagnosing and treating arrhythmias |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| US5605690A (en) * | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
| NZ322197A (en) * | 1995-11-21 | 1999-02-25 | Yamanouchi Pharma Co Ltd | Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof |
| ATE310528T1 (de) * | 1996-09-12 | 2005-12-15 | Idun Pharmaceuticals Inc | Hemmung der apoptose unter verwendung von inhibitoren der interleukin-1 beta converting enzym (ice)/ced-3 familie |
| JP4094066B2 (ja) * | 1996-12-06 | 2008-06-04 | バーテックス ファーマシューティカルズ インコーポレイテッド | インターロイキン−１β変換酵素のインヒビター |
| SK122199A3 (en) * | 1997-03-18 | 2000-12-11 | Basf Ag | Methods and compositions for modulating responsiveness to corticosteroids |
| IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| DE19743687C1 (de) * | 1997-10-06 | 1998-11-26 | Henkel Kgaa | Detergensgemische und deren Verwendung |
| AU4961499A (en) * | 1998-06-26 | 2000-01-17 | Eli Lilly And Company | 5-HT1f agonists |
| CA2340579A1 (en) * | 1998-09-01 | 2000-03-09 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin 18-binding protein |
| EP1022027A1 (en) * | 1999-01-22 | 2000-07-26 | Applied Research Systems ARS Holding N.V. | Tumor necrosis factor antagonists and their use in endometriosis |
| EP1165490B1 (en) * | 1999-03-16 | 2006-08-16 | Cytovia, Inc. | Substituted 2-aminobenzamide caspase inhibitors and the use thereof |
| CA2369619A1 (en) * | 1999-04-09 | 2000-10-19 | Cytovia, Inc. | Caspase inhibitors and the use thereof |
| AU6078500A (en) * | 1999-07-09 | 2001-01-30 | Amgen, Inc. | Combination therapy for conditions leading to bone loss |
| SK12942002A3 (sk) * | 2000-02-10 | 2003-05-02 | Abbott Laboratories | Protilátky viažuce ľudský interleukín-18, spôsoby ich výroby a použitia |
| CA2407895C (en) * | 2000-05-05 | 2012-12-18 | Applied Research Systems Ars Holding N.V. | Use of il-18 inhibitors for the treatment and/or prevention of atherosclerosis |
| WO2002032374A2 (en) * | 2000-10-18 | 2002-04-25 | Immunex Corporation | Methods for treating il-18 mediated disorders |
-
2002
- 2002-01-28 IL IL15702402A patent/IL157024A0/xx unknown
- 2002-01-28 HR HR20030609A patent/HRP20030609A2/xx not_active Application Discontinuation
- 2002-01-28 CZ CZ2003-2335A patent/CZ305653B6/cs not_active IP Right Cessation
- 2002-01-28 JP JP2002560670A patent/JP4860897B2/ja not_active Expired - Lifetime
- 2002-01-28 EA EA200300844A patent/EA006767B1/ru not_active IP Right Cessation
- 2002-01-28 PL PL366802A patent/PL213568B1/pl unknown
- 2002-01-28 RS YUP-578/03A patent/RS51125B/sr unknown
- 2002-01-28 EE EEP200300328A patent/EE05534B1/xx unknown
- 2002-01-28 MX MXPA03006776A patent/MXPA03006776A/es active IP Right Grant
- 2002-01-28 DE DE60224004T patent/DE60224004T2/de not_active Expired - Lifetime
- 2002-01-28 CN CNB02807503XA patent/CN1326562C/zh not_active Expired - Lifetime
- 2002-01-28 BR BR0206819-2A patent/BR0206819A/pt not_active Application Discontinuation
- 2002-01-28 WO PCT/EP2002/000844 patent/WO2002060479A1/en not_active Ceased
- 2002-01-28 SI SI200230667T patent/SI1355668T1/sl unknown
- 2002-01-28 HU HU0303306A patent/HU229164B1/hu unknown
- 2002-01-28 EP EP02718052A patent/EP1355668B1/en not_active Expired - Lifetime
- 2002-01-28 SK SK1089-2003A patent/SK287620B6/sk not_active IP Right Cessation
- 2002-01-28 EA EA200501549A patent/EA010180B1/ru not_active IP Right Cessation
- 2002-01-28 ES ES02718052T patent/ES2295332T3/es not_active Expired - Lifetime
- 2002-01-28 AT AT02718052T patent/ATE380558T1/de active
- 2002-01-28 DK DK02718052T patent/DK1355668T3/da active
- 2002-01-28 PT PT02718052T patent/PT1355668E/pt unknown
- 2002-01-28 UA UA2003088056A patent/UA80676C2/uk unknown
- 2002-01-28 ZA ZA200305439A patent/ZA200305439B/en unknown
- 2002-01-28 ME MEP-2008-681A patent/ME00549B/me unknown
- 2002-01-28 US US10/470,303 patent/US20040234523A1/en not_active Abandoned
- 2002-01-28 KR KR1020037009941A patent/KR100857376B1/ko not_active Expired - Lifetime
- 2002-01-28 CA CA2435466A patent/CA2435466C/en not_active Expired - Lifetime
- 2002-01-29 AR ARP020100315A patent/AR032422A1/es unknown
-
2003
- 2003-07-16 NO NO20033228A patent/NO331083B1/no not_active IP Right Cessation
- 2003-07-20 IL IL157024A patent/IL157024A/en active IP Right Grant
- 2003-08-25 BG BG108128A patent/BG66483B1/bg unknown
-
2008
- 2008-02-18 CY CY20081100195T patent/CY1107203T1/el unknown
- 2008-12-16 JP JP2008319532A patent/JP2009102354A/ja active Pending
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