JP2004522706A5 - - Google Patents

Download PDF

Info

Publication number
JP2004522706A5
JP2004522706A5 JP2002539332A JP2002539332A JP2004522706A5 JP 2004522706 A5 JP2004522706 A5 JP 2004522706A5 JP 2002539332 A JP2002539332 A JP 2002539332A JP 2002539332 A JP2002539332 A JP 2002539332A JP 2004522706 A5 JP2004522706 A5 JP 2004522706A5
Authority
JP
Japan
Prior art keywords
group
hydrogen
alkyl
substituted
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002539332A
Other languages
English (en)
Japanese (ja)
Other versions
JP4340437B2 (ja
JP2004522706A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2001/045581 external-priority patent/WO2002036573A2/en
Publication of JP2004522706A publication Critical patent/JP2004522706A/ja
Publication of JP2004522706A5 publication Critical patent/JP2004522706A5/ja
Application granted granted Critical
Publication of JP4340437B2 publication Critical patent/JP4340437B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2002539332A 2000-10-31 2001-10-31 ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン Expired - Lifetime JP4340437B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24443800P 2000-10-31 2000-10-31
PCT/US2001/045581 WO2002036573A2 (en) 2000-10-31 2001-10-31 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2003422779A Division JP2004137288A (ja) 2000-10-31 2003-12-19 ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン

Publications (3)

Publication Number Publication Date
JP2004522706A JP2004522706A (ja) 2004-07-29
JP2004522706A5 true JP2004522706A5 (https=) 2005-02-24
JP4340437B2 JP4340437B2 (ja) 2009-10-07

Family

ID=22922766

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002539332A Expired - Lifetime JP4340437B2 (ja) 2000-10-31 2001-10-31 ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン
JP2003422779A Pending JP2004137288A (ja) 2000-10-31 2003-12-19 ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2003422779A Pending JP2004137288A (ja) 2000-10-31 2003-12-19 ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン

Country Status (9)

Country Link
US (9) US6784187B2 (https=)
EP (3) EP1353909B1 (https=)
JP (2) JP4340437B2 (https=)
AT (2) ATE391712T1 (https=)
AU (2) AU2002227135B2 (https=)
CA (1) CA2426942C (https=)
DE (2) DE60109960T2 (https=)
ES (3) ES2572332T3 (https=)
WO (1) WO2002036573A2 (https=)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002227135B2 (en) * 2000-10-31 2008-01-03 Rensselaer Polytechnic Institute 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents
US6974824B2 (en) * 2001-01-08 2005-12-13 Research Triangle Institute Kappa opioid receptor ligands
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
EP2987788A1 (en) * 2002-05-17 2016-02-24 Taiwanj Pharmaceuticals Co., Ltd. Opioid and opioid-like compounds and uses thereof
EP1602374A4 (en) * 2003-03-07 2007-03-07 Toray Industries MEANS FOR TREATMENT OF MEDICAMENT / SUBSTANCE DEPENDENCE
US7381721B2 (en) 2003-03-17 2008-06-03 Adolor Corporation Substituted piperidine compounds
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US6992090B2 (en) 2003-06-16 2006-01-31 Adolor Corporation Substituted piperidine compounds and methods of their use
US7589103B2 (en) 2003-06-27 2009-09-15 Janssen Pharmaceutica N.V. Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators
EP1595541A1 (en) 2004-05-12 2005-11-16 Alcasynn Pharmaceuticals Gmbh Use of opioid receptor antagonist compounds for the prevention and/or treatment of diseases associated with the target calcineurin
AU2005245403B2 (en) * 2004-05-14 2012-04-19 Janssen Pharmaceutica N.V. Carboxamido opioid compounds
EP1910353A1 (en) 2004-08-05 2008-04-16 Janssen Pharmaceutica N.V. Tricyclic delta- opioid modulators
AR053098A1 (es) 2004-11-04 2007-04-25 Toray Industries Analgesico derivado de morfinano
ES2387737T3 (es) * 2004-11-05 2012-10-01 Rensselaer Polytechnic Institute 4-Hidroxibenzomorfanos
JP2008525483A (ja) 2004-12-22 2008-07-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式δ−オピオイド調節剤
ATE432279T1 (de) 2004-12-22 2009-06-15 Janssen Pharmaceutica Nv Tricyclische delta-opioid-modulatoren
KR20070104380A (ko) 2005-01-06 2007-10-25 얀센 파마슈티카 엔.브이. 트리사이클릭 δ-오피오이드 조절제
WO2006126529A1 (ja) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
ATE490251T1 (de) 2005-06-16 2010-12-15 Janssen Pharmaceutica Nv Tricyclische opioidmodulatoren
JP5266051B2 (ja) 2005-07-21 2013-08-21 レンセラール ポリテクニック インスティチュート 大きい置換基を有する非フェノール性オピオイド
US7538110B2 (en) 2005-10-27 2009-05-26 Adolor Corporation Opioid antagonists
TWI425945B (zh) * 2007-05-28 2014-02-11 Seldar Pharma Inc 四氫異喹啉－１－酮衍生物或其鹽
CN101827819B (zh) * 2007-08-09 2013-06-12 伦斯勒理工学院 阿片样物质酰胺季铵盐
JP5727374B2 (ja) * 2008-07-21 2015-06-03 レンセラール ポリテクニック インスティチュート 大型置換基を有する非フェノール性アミンオピオイド
EP3170395A1 (en) * 2009-03-19 2017-05-24 Alkermes Pharma Ireland Limited Morphinan derivatives with high oral bioavailability
US8624040B2 (en) 2009-06-22 2014-01-07 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US9096518B2 (en) 2009-06-22 2015-08-04 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
AU2010295464B2 (en) * 2009-09-18 2015-11-26 Merck Sharp & Dohme Corp. Use of opioid receptor antagonist for gastrointestinal tract disorders
TR201908514T4 (tr) * 2009-12-04 2019-07-22 Alkermes Pharma Ireland Ltd İlaç doz aşimi tedavi̇si̇ i̇çi̇n morfi̇nan türevleri̇
US8546588B2 (en) * 2010-02-26 2013-10-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2011106632A1 (en) * 2010-02-26 2011-09-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US8436175B2 (en) 2010-03-22 2013-05-07 Rensselaer Polytechnic Institute Carboxamide bioisosteres of opiates
WO2011130163A1 (en) 2010-04-12 2011-10-20 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
CA2804940C (en) 2010-07-08 2017-03-07 Alkermes Pharma Ireland Limited Process for the synthesis of substituted morphinans
WO2012008984A1 (en) 2010-07-16 2012-01-19 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
US8778960B2 (en) 2010-08-23 2014-07-15 Alkermes Pharma Ireland Limited Methods for treating antipsychotic-induced weight gain
US8471026B2 (en) 2010-08-26 2013-06-25 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2012054332A1 (en) 2010-10-18 2012-04-26 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2012088015A2 (en) * 2010-12-22 2012-06-28 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2012138888A1 (en) 2011-04-05 2012-10-11 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
WO2013003720A1 (en) 2011-06-29 2013-01-03 Alkermes, Inc. Peripherally acting opioid compounds
LT3153171T (lt) 2011-12-15 2018-12-10 Alkermes Pharma Ireland Limited Samidorfanas (alks 33) derinyje su buprenorfinu, skirtas depresinių sutrikimų gydymui
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
CA2890655A1 (en) * 2012-11-09 2014-05-15 Purdue Pharma L.P. Benzomorphan analogs and the use thereof
ES2770978T3 (es) 2013-05-24 2020-07-06 Alkermes Pharma Ireland Ltd Análogos de morfanos y morfinanos y métodos de uso
EP3003311A2 (en) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
US9688638B2 (en) 2013-11-27 2017-06-27 Nektar Therapeutics Opioid agonists and uses thereof
CA2948144A1 (en) * 2014-05-06 2015-11-12 Purdue Pharma L.P. Benzomorphan analogs and use thereof
SG11201708622UA (en) 2015-02-02 2017-11-29 Forma Therapeutics Inc 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors
WO2016126726A1 (en) 2015-02-02 2016-08-11 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors
EP3472131B1 (en) 2016-06-17 2020-02-19 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors
WO2018125716A1 (en) 2017-01-02 2018-07-05 Purdue Pharma L.P. Morphinan derivatives and use thereof
EP4243768A1 (en) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH581624A5 (https=) 1970-08-14 1976-11-15 Sumitomo Chemical Co
US3856795A (en) 1972-04-25 1974-12-24 American Home Prod Process for preparation of secondary amines from tertiary amines
US4032529A (en) * 1974-09-20 1977-06-28 Sterling Drug Inc. Aminomethanobenzazocine intermediates
US3957793A (en) 1974-09-20 1976-05-18 Sterling Drug Inc. Hydroxyiminobenzazocines
US4205171A (en) 1976-01-12 1980-05-27 Sterling Drug Inc. Aminomethanobenzazocines and nitromethanobenzazocines
US4373139A (en) 1979-04-30 1983-02-08 Motorola, Inc. Detectors
US4464378A (en) * 1981-04-28 1984-08-07 University Of Kentucky Research Foundation Method of administering narcotic antagonists and analgesics and novel dosage forms containing same
US4374139A (en) * 1981-11-09 1983-02-15 Hoffmann-La Roche Inc. Levorotatory N-substituted acylmorphinans useful as analgesic agents
US4649200A (en) * 1986-05-08 1987-03-10 Regents Of The University Of Minnesota Substituted pyrroles with opioid receptor activity
US4939264A (en) 1986-07-14 1990-07-03 Abbott Laboratories Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies
US5258386A (en) 1991-06-05 1993-11-02 The United States Of America As Represented By The Secretary Of The Army (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents
US5607941A (en) 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
SE9103745D0 (sv) * 1991-12-18 1991-12-18 Wikstroem Haakan Aryl-triflates and related compounds
AU3423493A (en) 1991-12-31 1993-07-28 Zymogenetics Inc. Methods and compositions for reducing blood loss
EP0632041A1 (en) * 1993-07-01 1995-01-04 Katholieke Universiteit Nijmegen New morphine derivatives having improved analgesic and narcotic properties
ATE229958T1 (de) * 1996-01-10 2003-01-15 Glaxosmithkline Spa Heterocyclische kondensierte morphin-derivate
GB9709972D0 (en) * 1997-05-19 1997-07-09 Pfizer Ltd Tetrazoles
GB9912411D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
AU2002227135B2 (en) 2000-10-31 2008-01-03 Rensselaer Polytechnic Institute 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents
US20050222204A1 (en) 2002-05-30 2005-10-06 Mitch Charles H Opioid receptor antagonists
ES2387737T3 (es) * 2004-11-05 2012-10-01 Rensselaer Polytechnic Institute 4-Hidroxibenzomorfanos
JP5266051B2 (ja) * 2005-07-21 2013-08-21 レンセラール ポリテクニック インスティチュート 大きい置換基を有する非フェノール性オピオイド

Similar Documents

Publication Publication Date Title
JP2004522706A5 (https=)
CA2426942A1 (en) 8-carboxamido-2,6-methano-3-benzazocines
JP2015518892A5 (https=)
JP2004507519A5 (https=)
JP2004137288A5 (https=)
JP2001515084A5 (https=)
KR920701193A (ko) 신규 크로만 및 티오크로만 유도체
JP2011503096A5 (https=)
Fan et al. Direct Pd-catalyzed benzylation of highly electron-deficient perfluoroarenes
JP2016505053A5 (https=)
JP2013100367A (ja) ジヒドロイソキノリンからのヘキサヒドロイソキノリンの調製
JP2005504738A5 (https=)
JP2004522795A5 (https=)
JP2018515550A5 (https=)
CN103664816A (zh) Hiv逆转录酶抑制剂依法韦伦类化合物的一锅法不对称合成工艺
CN1662488A (zh) 制备芳基肼和取代的吲哚的方法
HUP0103428A2 (hu) Új eljárás optikailag aktív alfa-amino-nitrilek előállítására
CN102311352B (zh) 一种2-甲氧基-4-甲基苄胺的合成方法
JP2017513885A5 (https=)
JP2003524004A5 (https=)
JP2005508930A5 (https=)
CN115028641A (zh) 一种钴催化合成5,8-双官能团取代咪唑并[1,2-a]吡嗪类化合物的方法
CN1863752A (zh) 铜催化的芳基化
JP3975269B2 (ja) イミンまたはヒドラゾンの製造方法
RU2003112454A (ru) Феноксифенилалкансульфонаты