JP2004520325A - 5−ヒドロキシトリプトアミン−6−リガンドとしてのヘテロシクリルアルキルインドールまたは−アザインドール化合物 - Google Patents
5−ヒドロキシトリプトアミン−6−リガンドとしてのヘテロシクリルアルキルインドールまたは−アザインドール化合物 Download PDFInfo
- Publication number
- JP2004520325A JP2004520325A JP2002552927A JP2002552927A JP2004520325A JP 2004520325 A JP2004520325 A JP 2004520325A JP 2002552927 A JP2002552927 A JP 2002552927A JP 2002552927 A JP2002552927 A JP 2002552927A JP 2004520325 A JP2004520325 A JP 2004520325A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- formula
- fluoro
- indole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25768400P | 2000-12-22 | 2000-12-22 | |
PCT/US2001/047938 WO2002051832A2 (en) | 2000-12-22 | 2001-12-11 | Heterocyclylalkylindole or -azaindole compounds as 5-hydroxytryptamine-6 ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2004520325A true JP2004520325A (ja) | 2004-07-08 |
Family
ID=22977310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002552927A Pending JP2004520325A (ja) | 2000-12-22 | 2001-12-11 | 5−ヒドロキシトリプトアミン−6−リガンドとしてのヘテロシクリルアルキルインドールまたは−アザインドール化合物 |
Country Status (20)
Country | Link |
---|---|
US (1) | US6613781B2 (es) |
EP (1) | EP1355900B1 (es) |
JP (1) | JP2004520325A (es) |
KR (1) | KR20030062440A (es) |
CN (1) | CN1492863A (es) |
AR (1) | AR034284A1 (es) |
AT (1) | ATE327232T1 (es) |
BR (1) | BR0116481A (es) |
CA (1) | CA2432661A1 (es) |
DE (1) | DE60119982T2 (es) |
DK (1) | DK1355900T3 (es) |
EA (1) | EA200300716A1 (es) |
ES (1) | ES2264994T3 (es) |
HU (1) | HUP0400682A2 (es) |
IL (1) | IL156518A0 (es) |
MX (1) | MXPA03005433A (es) |
NO (1) | NO20032841L (es) |
PL (1) | PL363238A1 (es) |
WO (1) | WO2002051832A2 (es) |
ZA (1) | ZA200305625B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009504633A (ja) * | 2005-08-12 | 2009-02-05 | スヴェン・ライフ・サイエンシズ・リミテッド | 機能性5−ht6リガンドとしてのアミノアリールスルホンアミド誘導体 |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002098857A1 (en) * | 2001-06-07 | 2002-12-12 | F. Hoffmann-La Roche Ag | New indole derivatives with 5-ht6 receptor affinity |
US20030225121A1 (en) * | 2001-12-20 | 2003-12-04 | Wyeth | Heterocyclylalkylindole or-azaindole compounds as 5-hydroxytryptamine-6 ligands |
AU2003208711A1 (en) * | 2002-02-12 | 2003-09-04 | Akzo Nobel N.V. | 1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders |
TW200401641A (en) * | 2002-07-18 | 2004-02-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands |
AU2003237599B2 (en) * | 2002-11-28 | 2009-06-18 | Suven Life Sciences Limited | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
JP2007500253A (ja) * | 2003-01-22 | 2007-01-11 | イーライ リリー アンド カンパニー | ステロイドホルモン核内受容体のインドール誘導体モジュレーター |
NZ541699A (en) * | 2003-02-14 | 2009-01-31 | Wyeth Corp | Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands |
AU2004213375A1 (en) * | 2003-02-14 | 2004-09-02 | Wyeth | Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-Hydroxytryptamine-6 ligands |
ES2222828B1 (es) | 2003-07-30 | 2006-04-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos. |
CN100443487C (zh) * | 2003-07-31 | 2008-12-17 | 惠氏公司 | 作为5-羟色胺-6配位体的n-磺酰基杂环吡咯基烷基胺化合物 |
BRPI0614343A2 (pt) * | 2005-08-15 | 2011-03-22 | Wyeth Corp | derivados de 3-sulfonilindazol substituìdo como ligantes de 5-hidroxitriptamina-6 |
WO2007031838A1 (en) | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
EP1842541A1 (en) * | 2006-03-29 | 2007-10-10 | G.I.M.-Gesellschaft Für Innovative Medizin Gmbh Nfg Ohg | Plant components and extracts and uses thereof |
JP2009532471A (ja) * | 2006-04-05 | 2009-09-10 | ワイス | 5−ヒドロキシトリプタミン−6リガンドとしてのスルホニル−3−ヘテロシクリルインダゾール誘導体 |
WO2007120596A1 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS |
CA2680625C (en) | 2007-03-14 | 2016-02-23 | Ranbaxy Laboratories Limited | Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors |
CN101730680A (zh) * | 2007-05-24 | 2010-06-09 | 记忆医药公司 | 具有5-ht6受体亲和力的4’取代的化合物 |
US20100016297A1 (en) * | 2008-06-24 | 2010-01-21 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
US20100022581A1 (en) * | 2008-07-02 | 2010-01-28 | Memory Pharmaceuticals Corporation | Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity |
US20100029629A1 (en) * | 2008-07-25 | 2010-02-04 | Memory Pharmaceuticals Corporation | Acyclic compounds having 5-ht6 receptor affinity |
US20100056531A1 (en) * | 2008-08-22 | 2010-03-04 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
JP6454346B2 (ja) | 2013-12-20 | 2019-01-16 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. | 芳香族複素環式化合物及び医薬におけるその応用 |
SG11201610407QA (en) | 2014-07-08 | 2017-01-27 | Sunshine Lake Pharma Co Ltd | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4208417A (en) | 1978-06-29 | 1980-06-17 | Pharmindustrie | Indole derivatives and their use as anxiolytics |
FR2701026B1 (fr) * | 1993-02-02 | 1995-03-31 | Adir | Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
IT1271352B (it) * | 1993-04-08 | 1997-05-27 | Boehringer Ingelheim Italia | Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale |
US6100291A (en) | 1998-03-16 | 2000-08-08 | Allelix Biopharmaceuticals Inc. | Pyrrolidine-indole compounds having 5-HT6 affinity |
US6133287A (en) * | 1998-03-24 | 2000-10-17 | Allelix Biopharmaceuticals Inc. | Piperidine-indole compounds having 5-HT6 affinity |
AR015035A1 (es) * | 1998-04-29 | 2001-04-11 | American Home Prod | Agentes serotonergicos, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamento |
US6251893B1 (en) | 1998-06-15 | 2001-06-26 | Nps Allelix Corp. | Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity |
US6066637A (en) | 1998-06-19 | 2000-05-23 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
US6191141B1 (en) | 1999-08-12 | 2001-02-20 | Nps Allelix Corp. | Azaindoles having serotonin receptor affinity |
WO2002032863A1 (en) * | 2000-10-20 | 2002-04-25 | Biovitrum Ab | 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy |
-
2001
- 2001-12-11 AT AT01993251T patent/ATE327232T1/de not_active IP Right Cessation
- 2001-12-11 KR KR10-2003-7008333A patent/KR20030062440A/ko not_active Application Discontinuation
- 2001-12-11 ES ES01993251T patent/ES2264994T3/es not_active Expired - Lifetime
- 2001-12-11 IL IL15651801A patent/IL156518A0/xx unknown
- 2001-12-11 EP EP01993251A patent/EP1355900B1/en not_active Expired - Lifetime
- 2001-12-11 HU HU0400682A patent/HUP0400682A2/hu unknown
- 2001-12-11 EA EA200300716A patent/EA200300716A1/ru unknown
- 2001-12-11 DE DE60119982T patent/DE60119982T2/de not_active Expired - Fee Related
- 2001-12-11 PL PL01363238A patent/PL363238A1/xx unknown
- 2001-12-11 MX MXPA03005433A patent/MXPA03005433A/es active IP Right Grant
- 2001-12-11 JP JP2002552927A patent/JP2004520325A/ja active Pending
- 2001-12-11 CA CA002432661A patent/CA2432661A1/en not_active Abandoned
- 2001-12-11 CN CNA018228232A patent/CN1492863A/zh active Pending
- 2001-12-11 WO PCT/US2001/047938 patent/WO2002051832A2/en active IP Right Grant
- 2001-12-11 BR BR0116481-3A patent/BR0116481A/pt not_active IP Right Cessation
- 2001-12-11 DK DK01993251T patent/DK1355900T3/da active
- 2001-12-20 US US10/028,487 patent/US6613781B2/en not_active Expired - Fee Related
- 2001-12-21 AR ARP010106003A patent/AR034284A1/es unknown
-
2003
- 2003-06-20 NO NO20032841A patent/NO20032841L/no not_active Application Discontinuation
- 2003-07-21 ZA ZA200305625A patent/ZA200305625B/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009504633A (ja) * | 2005-08-12 | 2009-02-05 | スヴェン・ライフ・サイエンシズ・リミテッド | 機能性5−ht6リガンドとしてのアミノアリールスルホンアミド誘導体 |
Also Published As
Publication number | Publication date |
---|---|
US20020128477A1 (en) | 2002-09-12 |
ATE327232T1 (de) | 2006-06-15 |
US6613781B2 (en) | 2003-09-02 |
EP1355900A2 (en) | 2003-10-29 |
WO2002051832A3 (en) | 2002-09-06 |
ZA200305625B (en) | 2004-10-21 |
AR034284A1 (es) | 2004-02-18 |
IL156518A0 (en) | 2004-01-04 |
DE60119982T2 (de) | 2006-12-21 |
EA200300716A1 (ru) | 2003-12-25 |
MXPA03005433A (es) | 2003-09-10 |
BR0116481A (pt) | 2004-01-06 |
KR20030062440A (ko) | 2003-07-25 |
ES2264994T3 (es) | 2007-02-01 |
PL363238A1 (en) | 2004-11-15 |
CN1492863A (zh) | 2004-04-28 |
WO2002051832A2 (en) | 2002-07-04 |
DE60119982D1 (de) | 2006-06-29 |
NO20032841L (no) | 2003-08-20 |
HUP0400682A2 (hu) | 2004-06-28 |
DK1355900T3 (da) | 2006-09-11 |
EP1355900B1 (en) | 2006-05-24 |
NO20032841D0 (no) | 2003-06-20 |
CA2432661A1 (en) | 2002-07-04 |
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Legal Events
Date | Code | Title | Description |
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A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20040622 |
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A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20080228 |
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A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080513 |
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A02 | Decision of refusal |
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