JP2004519493A5 - - Google Patents

Info

Publication number

JP2004519493A5

JP2004519493A5 JP2002572770A JP2002572770A JP2004519493A5 JP 2004519493 A5 JP2004519493 A5 JP 2004519493A5 JP 2002572770 A JP2002572770 A JP 2002572770A JP 2002572770 A JP2002572770 A JP 2002572770A JP 2004519493 A5 JP2004519493 A5 JP 2004519493A5

Authority

JP

Japan

Prior art keywords

hydrogen

lower alkyl

combination

bond

combination according

Prior art date

2002-03-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 125000000217 alkyl group Chemical group 0.000 claims 9
• 229910052739 hydrogen Inorganic materials 0.000 claims 9
• 239000001257 hydrogen Substances 0.000 claims 9
• 229940125714 antidiarrheal agent Drugs 0.000 claims 6
• 239000003793 antidiarrheal agent Substances 0.000 claims 6
• 201000010099 disease Diseases 0.000 claims 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 150000003883 epothilone derivatives Chemical class 0.000 claims 5
• 230000002062 proliferating effect Effects 0.000 claims 5
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 3
• -1 bapreotide Chemical compound 0.000 claims 2
• 239000002552 dosage form Substances 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims 1
• PUDHBTGHUJUUFI-SCTWWAJVSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-n-[(2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2r)-2-amino-3-naphthalen-2-ylpropanoyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-p Chemical compound C([C@H]1C(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](N)CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)=O)C(C)C)C1=CC=C(O)C=C1 PUDHBTGHUJUUFI-SCTWWAJVSA-N 0.000 claims 1
• UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 1
• 239000005995 Aluminium silicate Substances 0.000 claims 1
• 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 claims 1
• 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 claims 1
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
• 229940116366 Motilin antagonist Drugs 0.000 claims 1
• 108010016076 Octreotide Proteins 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 235000012211 aluminium silicate Nutrition 0.000 claims 1
• YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 claims 1
• 229940093265 berberine Drugs 0.000 claims 1
• QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 claims 1
• ZREIPSZUJIFJNP-UHFFFAOYSA-K bismuth subsalicylate Chemical compound C1=CC=C2O[Bi](O)OC(=O)C2=C1 ZREIPSZUJIFJNP-UHFFFAOYSA-K 0.000 claims 1
• 229960000782 bismuth subsalicylate Drugs 0.000 claims 1
• 229940111134 coxibs Drugs 0.000 claims 1
• 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 1
• 229960002743 glutamine Drugs 0.000 claims 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
• 150000002431 hydrogen Chemical class 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• 229960000829 kaolin Drugs 0.000 claims 1
• NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims 1
• 229960002437 lanreotide Drugs 0.000 claims 1
• 108010021336 lanreotide Proteins 0.000 claims 1
• 229960002700 octreotide Drugs 0.000 claims 1
• 229960000292 pectin Drugs 0.000 claims 1
• 235000010987 pectin Nutrition 0.000 claims 1
• 229920001277 pectin Polymers 0.000 claims 1
• 239000001814 pectin Substances 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 229960003433 thalidomide Drugs 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1