NZ541703A - Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative for treating a proliferative disease - Google Patents
Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative for treating a proliferative diseaseInfo
- Publication number
- NZ541703A NZ541703A NZ541703A NZ54170302A NZ541703A NZ 541703 A NZ541703 A NZ 541703A NZ 541703 A NZ541703 A NZ 541703A NZ 54170302 A NZ54170302 A NZ 54170302A NZ 541703 A NZ541703 A NZ 541703A
- Authority
- NZ
- New Zealand
- Prior art keywords
- epothilone
- lower alkyl
- proliferative disease
- hydrogen
- administered
- Prior art date
Links
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- 229940125714 antidiarrheal agent Drugs 0.000 title claims abstract description 30
- 239000003793 antidiarrheal agent Substances 0.000 title claims abstract description 30
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 23
- 201000010099 disease Diseases 0.000 title claims abstract description 22
- 230000002062 proliferating effect Effects 0.000 title claims abstract description 22
- 229930013356 epothilone Natural products 0.000 title abstract description 7
- 150000003839 salts Chemical class 0.000 claims abstract description 21
- 239000003112 inhibitor Substances 0.000 claims abstract description 18
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- 239000004480 active ingredient Substances 0.000 claims abstract description 9
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 claims abstract 2
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims description 43
- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 239000001257 hydrogen Substances 0.000 claims description 23
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- QXRSDHAAWVKZLJ-OXZHEXMSSA-N Epothilone B Natural products O=C1[C@H](C)[C@H](O)[C@@H](C)CCC[C@@]2(C)O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C QXRSDHAAWVKZLJ-OXZHEXMSSA-N 0.000 claims description 21
- QXRSDHAAWVKZLJ-PVYNADRNSA-N epothilone B Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 QXRSDHAAWVKZLJ-PVYNADRNSA-N 0.000 claims description 21
- 238000002360 preparation method Methods 0.000 claims description 18
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 10
- 239000002552 dosage form Substances 0.000 claims description 8
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims description 6
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Classifications
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Landscapes
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- Neurosurgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US27715301P | 2001-03-19 | 2001-03-19 | |
| US27720701P | 2001-03-20 | 2001-03-20 |
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| NZ541703A true NZ541703A (en) | 2007-04-27 |
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| NZ541703A NZ541703A (en) | 2001-03-19 | 2002-03-18 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative for treating a proliferative disease |
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| US (1) | US7030147B2 (https=) |
| EP (1) | EP1372650B1 (https=) |
| JP (2) | JP2004519493A (https=) |
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| CY (1) | CY1108845T1 (https=) |
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| DK (1) | DK1372650T3 (https=) |
| ES (1) | ES2318001T3 (https=) |
| HU (1) | HUP0303621A3 (https=) |
| IL (1) | IL157333A0 (https=) |
| MX (1) | MXPA03008462A (https=) |
| NO (1) | NO333106B1 (https=) |
| NZ (1) | NZ541703A (https=) |
| PT (1) | PT1372650E (https=) |
| RU (1) | RU2330661C2 (https=) |
| SI (1) | SI1372650T1 (https=) |
| SK (1) | SK287334B6 (https=) |
| TW (1) | TWI331525B (https=) |
| WO (1) | WO2002074042A2 (https=) |
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Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| WO1999001124A1 (en) | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| EP1312612A4 (en) * | 2000-08-24 | 2004-09-22 | Chugai Pharmaceutical Co Ltd | CYCLIC PEPTIDE DERIVATIVE |
| WO2002072085A1 (en) | 2001-03-14 | 2002-09-19 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| US6727261B2 (en) | 2001-12-27 | 2004-04-27 | Hoffman-La Roche Inc. | Pyrido[2,1-A]Isoquinoline derivatives |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| DE60330407D1 (de) | 2002-08-23 | 2010-01-14 | Sloan Kettering Inst Cancer | Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7550590B2 (en) * | 2003-03-25 | 2009-06-23 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2004103993A1 (en) | 2003-05-14 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| KR20060041309A (ko) * | 2003-08-13 | 2006-05-11 | 다케다 야쿠힌 고교 가부시키가이샤 | ４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도 |
| US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2005030751A2 (en) * | 2003-09-08 | 2005-04-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7790734B2 (en) * | 2003-09-08 | 2010-09-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| CN102127057A (zh) | 2004-03-15 | 2011-07-20 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
| RU2253440C1 (ru) * | 2004-03-31 | 2005-06-10 | Открытое Акционерное Общество "Фаберлик" | Средство для устранения нарушений нейрогенной и эндокринной регуляции системы капиллярного кровотока |
| JP2008501714A (ja) * | 2004-06-04 | 2008-01-24 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
| WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
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| US6302838B1 (en) * | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
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