JP2004518742A - 化学化合物 - Google Patents
化学化合物 Download PDFInfo
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- JP2004518742A JP2004518742A JP2002565975A JP2002565975A JP2004518742A JP 2004518742 A JP2004518742 A JP 2004518742A JP 2002565975 A JP2002565975 A JP 2002565975A JP 2002565975 A JP2002565975 A JP 2002565975A JP 2004518742 A JP2004518742 A JP 2004518742A
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- Prior art keywords
- alkyl
- alkoxy
- formula
- compound
- phenyl
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 4
- -1 methylenedioxy Chemical group 0.000 claims description 38
- 150000003839 salts Chemical class 0.000 claims description 36
- 239000012453 solvate Substances 0.000 claims description 35
- 229910052736 halogen Inorganic materials 0.000 claims description 29
- 125000000217 alkyl group Chemical group 0.000 claims description 26
- 150000002367 halogens Chemical class 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 26
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
- 239000001257 hydrogen Substances 0.000 claims description 24
- 229910052739 hydrogen Inorganic materials 0.000 claims description 24
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 18
- 125000003545 alkoxy group Chemical group 0.000 claims description 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
- 125000001072 heteroaryl group Chemical group 0.000 claims description 13
- 150000002431 hydrogen Chemical class 0.000 claims description 11
- 125000003118 aryl group Chemical group 0.000 claims description 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims description 8
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- 239000011593 sulfur Substances 0.000 claims description 5
- 125000004504 1,2,4-oxadiazolyl group Chemical group 0.000 claims description 4
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims description 4
- 125000001781 1,3,4-oxadiazolyl group Chemical group 0.000 claims description 4
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
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- 238000005160 1H NMR spectroscopy Methods 0.000 description 4
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 description 4
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 4
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
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- 238000006243 chemical reaction Methods 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 4
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- HSDUASDXEODUDE-UHFFFAOYSA-N n-[1-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]-4-hydrazinyl-4-oxobutanamide Chemical compound C1CC(NC(=O)CCC(=O)NN)CCN1CC1=CC=C(Cl)C(Cl)=C1 HSDUASDXEODUDE-UHFFFAOYSA-N 0.000 description 4
- 229920002223 polystyrene Polymers 0.000 description 4
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- MCGIQVVVGVAMEI-UHFFFAOYSA-N 1-[(3,4-dichlorophenyl)methyl]piperidin-4-amine Chemical compound C1CC(N)CCN1CC1=CC=C(Cl)C(Cl)=C1 MCGIQVVVGVAMEI-UHFFFAOYSA-N 0.000 description 3
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 3
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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Landscapes
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| PCT/SE2002/000269 WO2002066460A1 (en) | 2001-02-19 | 2002-02-18 | Chemical compounds |
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| JP2004518742A true JP2004518742A (ja) | 2004-06-24 |
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| EP (1) | EP1363902B1 (https=) |
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| DE (1) | DE60201259T2 (https=) |
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| FR2854158B1 (fr) | 2003-04-25 | 2006-11-17 | Sanofi Synthelabo | Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique |
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| US7652044B2 (en) * | 2003-06-03 | 2010-01-26 | Novartis A.G. | P-38 inhibitors |
| TW200538098A (en) * | 2004-03-22 | 2005-12-01 | Astrazeneca Ab | Therapeutic agents |
| CA2579207C (en) | 2004-09-08 | 2011-10-18 | Mitsubishi Pharma Corporation | Morpholine compound |
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| EP1996551A2 (en) * | 2006-03-07 | 2008-12-03 | AstraZeneca AB | Piperidine derivatives, their process for preparation, their use as therapeutic agents and pharmaceutical compositions containing them. |
| US20090197914A1 (en) * | 2006-03-07 | 2009-08-06 | Peter Cage | Piperidine Derivatives, Their Process for Preparation, Their Use as Therapeutic Agents and Pharmaceutical Compositions Containing Them |
| JP2009529038A (ja) * | 2006-03-07 | 2009-08-13 | アストラゼネカ・アクチエボラーグ | ピペリジン誘導体、それらの製造法、治療剤としてのそれらの使用およびそれらを含む医薬組成物 |
| WO2025147657A1 (en) * | 2024-01-05 | 2025-07-10 | Board Of Trustees Of Michigan State University | Methods for treating alopecia |
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| DE1220440B (de) | 1962-02-14 | 1966-07-07 | Sanol Arznei Schwarz Gmbh | Verfahren zur Herstellung von Derivaten des 1-(o-Bromphenoxy)-2-hydroxy-3-amino-propans und deren Saeureadditionssalzen |
| US3577432A (en) | 1968-12-23 | 1971-05-04 | Robins Co Inc A H | 1-substituted-3-phenoxypyrrolidines |
| US4029801A (en) | 1970-09-03 | 1977-06-14 | John Wyeth & Brother Limited | Pharmaceutical compositions and methods of treating hypertension |
| GB1404868A (en) | 1972-12-21 | 1975-09-03 | Wyeth John & Brother Ltd | Pyridine tetrahydropyridine and piperidine derivatives |
| JPS5511670B1 (https=) | 1971-07-13 | 1980-03-26 | ||
| US3755584A (en) | 1972-04-03 | 1973-08-28 | Abbott Lab | Tranquilizers |
| FR2190430A1 (en) | 1972-06-29 | 1974-02-01 | Ferlux | N-aminomethylhydroxamic acids - with antiinflammatory activity pre-pared by Mannich reaction |
| US3818017A (en) | 1973-01-04 | 1974-06-18 | Janssen Pharmaceutica Nv | 1-{8 1-(2-hydroxy-3-aryloxypropyl)-4-piperidyl{9 -2-benzimidazolinones and related compounds |
| US3894030A (en) | 1973-01-04 | 1975-07-08 | Janssen Pharmaceutica Nv | 1-{8 1-(2-Hydroxy-3-aryloxypropyl)-4-piperidyl{9 -2-benzimidazolinones and related compounds |
| GB1425354A (en) | 1973-10-10 | 1976-02-18 | Wyeth John & Brother Ltd | Indole derivatives |
| FR2361880A1 (fr) | 1976-04-29 | 1978-03-17 | Science Union & Cie | Nouvelles 4-amino piperidines, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant |
| GB1538543A (en) | 1976-06-23 | 1979-01-24 | Wyeth John & Brother Ltd | N-aminoalkyl piperidine derivatives |
| GB1532671A (en) | 1976-07-16 | 1978-11-15 | Wyeth John & Brother Ltd | Piperidine derivatives |
| GB1538542A (en) | 1977-06-23 | 1979-01-24 | Wyeth John & Brother Ltd | Oxime derivatives |
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| SE0103818D0 (sv) | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
| GB0127547D0 (en) | 2001-11-16 | 2002-01-09 | Astrazeneca Ab | Chemical compounds |
-
2001
- 2001-02-19 GB GBGB0104050.0A patent/GB0104050D0/en not_active Ceased
-
2002
- 2002-02-18 WO PCT/SE2002/000269 patent/WO2002066460A1/en not_active Ceased
- 2002-02-18 EP EP02711619A patent/EP1363902B1/en not_active Expired - Lifetime
- 2002-02-18 DE DE60201259T patent/DE60201259T2/de not_active Expired - Fee Related
- 2002-02-18 JP JP2002565975A patent/JP2004518742A/ja active Pending
- 2002-02-18 US US10/468,179 patent/US6958350B2/en not_active Expired - Fee Related
- 2002-02-18 AT AT02711619T patent/ATE276246T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60201259D1 (de) | 2004-10-21 |
| EP1363902A1 (en) | 2003-11-26 |
| GB0104050D0 (en) | 2001-04-04 |
| WO2002066460A1 (en) | 2002-08-29 |
| ATE276246T1 (de) | 2004-10-15 |
| DE60201259T2 (de) | 2005-09-29 |
| US6958350B2 (en) | 2005-10-25 |
| EP1363902B1 (en) | 2004-09-15 |
| US20040102483A1 (en) | 2004-05-27 |
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