JP2004513608A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004513608A5 JP2004513608A5 JP2001565728A JP2001565728A JP2004513608A5 JP 2004513608 A5 JP2004513608 A5 JP 2004513608A5 JP 2001565728 A JP2001565728 A JP 2001565728A JP 2001565728 A JP2001565728 A JP 2001565728A JP 2004513608 A5 JP2004513608 A5 JP 2004513608A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- cells
- taste receptor
- cell
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 description 64
- 102000004196 processed proteins & peptides Human genes 0.000 description 64
- 108090000765 processed proteins & peptides Proteins 0.000 description 64
- 210000004027 cell Anatomy 0.000 description 62
- 108091005708 gustatory receptors Proteins 0.000 description 48
- 238000000034 method Methods 0.000 description 28
- 238000003556 assay Methods 0.000 description 26
- 108091028043 Nucleic acid sequence Proteins 0.000 description 22
- 150000007523 nucleic acids Chemical group 0.000 description 22
- 101100315287 Homo sapiens TAS1R3 gene Proteins 0.000 description 16
- 101000659774 Homo sapiens Taste receptor type 1 member 3 Proteins 0.000 description 16
- 102100035942 Taste receptor type 1 member 3 Human genes 0.000 description 16
- 150000001875 compounds Chemical class 0.000 description 15
- 230000000694 effects Effects 0.000 description 14
- 239000003446 ligand Substances 0.000 description 14
- 108091006027 G proteins Proteins 0.000 description 12
- 102000030782 GTP binding Human genes 0.000 description 12
- 108091000058 GTP-Binding Proteins 0.000 description 12
- 241000283984 Rodentia Species 0.000 description 11
- 210000004962 mammalian cell Anatomy 0.000 description 9
- 102000005962 receptors Human genes 0.000 description 7
- 108020003175 receptors Proteins 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 5
- 210000005253 yeast cell Anatomy 0.000 description 5
- 241000238631 Hexapoda Species 0.000 description 4
- 241000269370 Xenopus <genus> Species 0.000 description 4
- 230000027455 binding Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 230000003834 intracellular effect Effects 0.000 description 3
- 230000009870 specific binding Effects 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 101000659767 Homo sapiens Taste receptor type 1 member 1 Proteins 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 102100035941 Taste receptor type 1 member 1 Human genes 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 238000002875 fluorescence polarization Methods 0.000 description 1
- 239000003269 fluorescent indicator Substances 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 238000002825 functional assay Methods 0.000 description 1
- 238000012188 high-throughput screening assay Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- XOFLBQFBSOEHOG-UUOKFMHZSA-N γS-GTP Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=S)[C@@H](O)[C@H]1O XOFLBQFBSOEHOG-UUOKFMHZSA-N 0.000 description 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18754600P | 2000-03-07 | 2000-03-07 | |
| US60/187,546 | 2000-03-07 | ||
| US19553600P | 2000-04-07 | 2000-04-07 | |
| US60/195,536 | 2000-04-07 | ||
| US20984000P | 2000-06-06 | 2000-06-06 | |
| US60/209,840 | 2000-06-06 | ||
| US21421300P | 2000-06-23 | 2000-06-23 | |
| US60/214,213 | 2000-06-23 | ||
| US22644800P | 2000-08-17 | 2000-08-17 | |
| US60/226,448 | 2000-08-17 | ||
| US25922701P | 2001-01-03 | 2001-01-03 | |
| US60/259,227 | 2001-01-03 | ||
| PCT/US2001/007265 WO2001066563A2 (en) | 2000-03-07 | 2001-03-07 | T1r taste receptors and genes encoding same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013156284A Division JP5903078B2 (ja) | 2000-03-07 | 2013-07-29 | Ｔ１ｒ味覚受容体とこれをコードする遺伝子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004513608A JP2004513608A (ja) | 2004-05-13 |
| JP2004513608A5 true JP2004513608A5 (enExample) | 2008-05-01 |
| JP5403842B2 JP5403842B2 (ja) | 2014-01-29 |
Family
ID=27558784
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001565728A Expired - Lifetime JP5403842B2 (ja) | 2000-03-07 | 2001-03-07 | Ｔ１ｒ味覚受容体とこれをコードする遺伝子 |
| JP2013156284A Expired - Lifetime JP5903078B2 (ja) | 2000-03-07 | 2013-07-29 | Ｔ１ｒ味覚受容体とこれをコードする遺伝子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013156284A Expired - Lifetime JP5903078B2 (ja) | 2000-03-07 | 2013-07-29 | Ｔ１ｒ味覚受容体とこれをコードする遺伝子 |
Country Status (15)
| Country | Link |
|---|---|
| US (25) | US7244835B2 (enExample) |
| EP (4) | EP2143732B1 (enExample) |
| JP (2) | JP5403842B2 (enExample) |
| CN (3) | CN1766108A (enExample) |
| AT (2) | ATE403669T1 (enExample) |
| AU (2) | AU2001240086B2 (enExample) |
| CA (1) | CA2402214C (enExample) |
| DE (3) | DE60141237D1 (enExample) |
| DK (3) | DK1309606T3 (enExample) |
| ES (3) | ES2338497T3 (enExample) |
| IL (1) | IL151578A0 (enExample) |
| MX (1) | MXPA02008724A (enExample) |
| NO (1) | NO20024276L (enExample) |
| TW (1) | TW201006846A (enExample) |
| WO (1) | WO2001066563A2 (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1100811B1 (en) | 1998-07-28 | 2007-07-04 | The Regents Of The University Of California | Nucleic acids encoding a g-protein coupled receptor involved in sensory transduction |
| US7402400B2 (en) | 2001-07-03 | 2008-07-22 | Regents Of The University Of California | Mammalian sweet taste receptors |
| TW201006846A (en) | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
| EP1280899A2 (en) * | 2000-04-28 | 2003-02-05 | Warner-Lambert Company | Gene and sequence variation associated with sensing carbohydrate compounds and other sweeteners |
| GB2364058A (en) * | 2000-05-05 | 2002-01-16 | Smithkline Beecham Corp | AXOR79, a G-protein coupled receptor |
| JP2004515215A (ja) * | 2000-05-22 | 2004-05-27 | インサイト・ゲノミックス・インコーポレイテッド | Ｇタンパク質結合受容体 |
| DE60138808D1 (de) * | 2000-06-16 | 2009-07-09 | Incyte Corp | G-protein gekoppelte rezeptoren |
| EP1322758A2 (en) * | 2000-09-25 | 2003-07-02 | Bayer Aktiengesellschaft | Regulation of human g protein-coupled receptor |
| TW201022287A (en) * | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
| US6955887B2 (en) | 2001-03-30 | 2005-10-18 | Senomyx, Inc. | Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling |
| US7763431B1 (en) | 2001-03-07 | 2010-07-27 | Senomyx, Inc. | Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste |
| US7309577B2 (en) * | 2001-03-07 | 2007-12-18 | Senomyx, Inc. | Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste |
| US7301009B2 (en) | 2001-06-26 | 2007-11-27 | Senomyx, Inc. | Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli |
| US20080244761A1 (en) | 2001-03-07 | 2008-10-02 | Senomyx, Inc. | T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
| US7368285B2 (en) | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
| US7803982B2 (en) | 2001-04-20 | 2010-09-28 | The Mount Sinai School Of Medicine Of New York University | T1R3 transgenic animals, cells and related methods |
| EP1572871A4 (en) * | 2001-04-20 | 2007-11-14 | Sinai School Medicine | T1R3, A NEW TASTE RECEPTOR |
| CN100489102C (zh) * | 2001-06-26 | 2009-05-20 | 塞诺米克斯公司 | T1r异源寡聚的味觉受体和表达所述受体的细胞系及其在鉴定味觉化合物中的用途 |
| DK2327985T3 (en) * | 2001-06-26 | 2016-09-05 | Senomyx Inc | H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds |
| EP1585954B1 (en) * | 2001-07-03 | 2014-03-26 | The Regents of The University of California | Mammalian sweet and amino acid heterodimeric taste receptors |
| US20040029789A1 (en) * | 2001-07-05 | 2004-02-12 | Anderson David W. | Novel proteins and nucleic acids encoding same |
| US7314725B2 (en) | 2001-07-20 | 2008-01-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Phenylthiocarbamide (PTC) taste receptor |
| WO2003025137A2 (en) * | 2001-09-18 | 2003-03-27 | Irm, Llc | Sweet taste receptors |
| CA2486423A1 (en) * | 2002-05-20 | 2003-12-11 | Tvd Taste Virtual Dimensions, Inc. | Antibodies and their use for the modulation of taste sensation |
| CA2534027A1 (en) | 2003-06-19 | 2005-01-27 | Dennis Drayna | Variants of human taste receptor genes |
| CN103275058B (zh) | 2003-08-06 | 2016-02-24 | 西诺米克斯公司 | 调味剂、味道调节剂、促味剂、味觉增强剂、鲜味剂或甜味剂和/或增强剂及其用途 |
| US20050244810A1 (en) * | 2003-09-29 | 2005-11-03 | Egan Josephine M | Taste signaling in gastrointestinal cells |
| US20050106571A1 (en) | 2003-10-02 | 2005-05-19 | The Regents Of The University Of California | Mammalian T1R3 sweet taste receptors |
| US20060045953A1 (en) * | 2004-08-06 | 2006-03-02 | Catherine Tachdjian | Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers |
| WO2006068745A1 (en) | 2004-12-22 | 2006-06-29 | Cargill, Incorporated | Methods for determining cellular response to stimuli |
| US20060257543A1 (en) * | 2005-02-04 | 2006-11-16 | Catherine Tachdjian | Molecules comprising linked organic moieties as flavor modifiers for comestible compositions |
| KR101340859B1 (ko) | 2005-02-04 | 2013-12-13 | 세노믹스, 인코포레이티드 | 연결형 헤테로 아릴 잔기를 포함한 화합물, 및 식용조성물을 위한 신규의 우마미 향미 개선제, 맛 촉진물질 및맛 향상제로서의 그의 용도 |
| US8796441B2 (en) | 2005-04-13 | 2014-08-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Human sweet and umami taste receptor variants |
| US7851006B2 (en) | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
| CA2604760C (en) | 2005-05-23 | 2012-06-26 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
| CN101179943B (zh) | 2005-05-23 | 2013-06-26 | 卡夫食品环球品牌有限责任公司 | 填充液体的咀嚼型胶基糖组合物 |
| US7851005B2 (en) | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
| TW200715993A (en) * | 2005-06-15 | 2007-05-01 | Senomyx Inc | Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers |
| US20110097741A1 (en) * | 2006-04-20 | 2011-04-28 | Jay Patrick Slack | Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays |
| EP3235811B1 (en) | 2006-04-21 | 2018-07-25 | Senomyx, Inc. | Process of preparing oxalamides |
| WO2007127479A2 (en) * | 2006-04-28 | 2007-11-08 | Redpoint Bio Corporation | Triaryl substituted imidazole derivatives and taste-inhibiting uses thereof |
| WO2008008224A2 (en) | 2006-07-10 | 2008-01-17 | Duke University | Sour taste receptor compositions and methods |
| WO2008060576A2 (en) * | 2006-11-15 | 2008-05-22 | Redpoint Bio Corporation | Spicematrix technology for taste compound identification |
| US9603848B2 (en) * | 2007-06-08 | 2017-03-28 | Senomyx, Inc. | Modulation of chemosensory receptors and ligands associated therewith |
| US8633186B2 (en) | 2007-06-08 | 2014-01-21 | Senomyx Inc. | Modulation of chemosensory receptors and ligands associated therewith |
| US7928111B2 (en) * | 2007-06-08 | 2011-04-19 | Senomyx, Inc. | Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors |
| GB0713297D0 (en) | 2007-07-10 | 2007-08-15 | Cadbury Schweppes Plc | Chocolate compositions having improved flavour characteristics |
| WO2009018467A2 (en) * | 2007-07-31 | 2009-02-05 | Massachusetts Institute Of Technology | Bio-sensing nanodevice |
| WO2010014903A1 (en) | 2008-07-31 | 2010-02-04 | Massachusetts Institute Of Technology | Multiplexed olfactory receptor-based microsurface plasmon polariton detector |
| UA117296C2 (uk) | 2008-07-31 | 2018-07-10 | Сіномікс, Інк. | Способи і проміжні сполуки для одержання підсилювачів солодкого смаку |
| DK2328426T3 (en) | 2008-07-31 | 2014-12-08 | Senomyx Inc | COMPOSITIONS INCLUDING SWEET AMPLIFIERS AND PROCEDURES FOR PRODUCING THEREOF |
| WO2011011292A2 (en) * | 2009-07-20 | 2011-01-27 | Verdezyne, Inc. | Combinatorial methods for optimizing engineered microorganism function |
| US8795977B2 (en) | 2009-12-02 | 2014-08-05 | Conopco, Inc. | Method for screening a potential modulator compound of a taste receptor |
| CN106107406B (zh) | 2010-08-12 | 2020-06-09 | 弗门尼舍公司 | 提高甜味增强剂的稳定性的方法和包含稳定的甜味增强剂的组合物 |
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| CN103635096B (zh) | 2011-04-29 | 2016-08-17 | 洲际大品牌有限责任公司 | 被包封的酸、其制备方法及包括所述被包封的酸的咀嚼型胶基糖 |
| US9128079B2 (en) | 2011-08-08 | 2015-09-08 | The Coca-Cola Company | Methods of using lung or bronchial epithelial cells to identify bitter taste modulators |
| US10314492B2 (en) | 2013-05-23 | 2019-06-11 | Medibotics Llc | Wearable spectroscopic sensor to measure food consumption based on interaction between light and the human body |
| US9536449B2 (en) | 2013-05-23 | 2017-01-03 | Medibotics Llc | Smart watch and food utensil for monitoring food consumption |
| US9254099B2 (en) | 2013-05-23 | 2016-02-09 | Medibotics Llc | Smart watch and food-imaging member for monitoring food consumption |
| US9456916B2 (en) | 2013-03-12 | 2016-10-04 | Medibotics Llc | Device for selectively reducing absorption of unhealthy food |
| US9042596B2 (en) | 2012-06-14 | 2015-05-26 | Medibotics Llc | Willpower watch (TM)—a wearable food consumption monitor |
| US9442100B2 (en) | 2013-12-18 | 2016-09-13 | Medibotics Llc | Caloric intake measuring system using spectroscopic and 3D imaging analysis |
| EP3593648B1 (en) | 2012-08-06 | 2021-07-14 | Firmenich Incorporated | Sweet flavor modifier |
| JO3155B1 (ar) | 2013-02-19 | 2017-09-20 | Senomyx Inc | معدِّل نكهة حلوة |
| US9011365B2 (en) | 2013-03-12 | 2015-04-21 | Medibotics Llc | Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food |
| US9067070B2 (en) | 2013-03-12 | 2015-06-30 | Medibotics Llc | Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type |
| US9804157B1 (en) | 2013-03-15 | 2017-10-31 | Senomyx, Inc. | Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives |
| US9529385B2 (en) | 2013-05-23 | 2016-12-27 | Medibotics Llc | Smart watch and human-to-computer interface for monitoring food consumption |
| US9826662B2 (en) | 2013-12-12 | 2017-11-21 | General Electric Company | Reusable phase-change thermal interface structures |
| US10660571B2 (en) * | 2013-12-19 | 2020-05-26 | Kent State University | Thermochromic fabrics utilizing cholesteric liquid crystal material |
| ES2802376T3 (es) | 2014-02-12 | 2021-01-19 | Firmenich Incorporated | Procedimiento mejorado para la síntesis de 1-bencil-3-(1-(isoxazol-4-ilmetil)-1h-pirazol-4-il)imidazolidin-2,4-dionas sustituidas |
| WO2015163905A1 (en) | 2014-04-25 | 2015-10-29 | General Mills, Inc. | Food products having sweetness enhancer |
| JP6383704B2 (ja) * | 2015-07-02 | 2018-08-29 | 日立オートモティブシステムズ株式会社 | 電池制御装置 |
| US11945813B2 (en) | 2018-08-07 | 2024-04-02 | Firmenich Incorporated | 5-substituted 4-amino-1H-benzo[c][1,2,6]thiadiazine 2,2-dioxides and formulations and uses thereof |
| US11783920B2 (en) | 2019-02-06 | 2023-10-10 | Tata Consultancy Services Limited | System and method for evaluation of at least one potential tastant from a plurality of tastants |
| WO2021150686A1 (en) | 2020-01-22 | 2021-07-29 | Firmenich Incorporated | High-sensitivity detection of gpcr activity and uses thereof |
| CN115715146A (zh) | 2020-06-25 | 2023-02-24 | 麦可科技有限公司 | 来自块菌的甜蛋白 |
| US20240345068A1 (en) | 2023-03-01 | 2024-10-17 | Alcheme Bio Inc. | Systems, methods, and compositions for production of cellular agriculture products |
| CN116554350B (zh) * | 2023-04-26 | 2024-01-09 | 之江实验室 | 基于人类甜味受体蛋白的生物传感器及其应用 |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US788470A (en) * | 1903-06-16 | 1905-04-25 | Edouard Jehn | Changing mechanism for picture-exhibitors. |
| US1733847A (en) * | 1927-03-11 | 1929-10-29 | Variety Fire Door Company | Door-latch retainer |
| JPS5825980B2 (ja) | 1976-02-12 | 1983-05-31 | ヤマサ醤油株式会社 | サイクリックヌクレオチドの定量法 |
| US4391904A (en) | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4517288A (en) | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
| US4661768A (en) * | 1983-09-14 | 1987-04-28 | Johnson Service Company | Capacitance transducing method and apparatus |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| CA1291031C (en) | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
| US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| HK1000547A1 (en) | 1989-12-22 | 1998-04-03 | Merck Serono Sa | Endogenous gene expression modification with regulatory element by way of homologous recombination |
| US5180940A (en) | 1990-02-09 | 1993-01-19 | Asulab S.A. | Radial field electrostatic micromotor produced using a photolithographic micromanufacturing technique and a process for producing said micromotor |
| IE66205B1 (en) | 1990-06-14 | 1995-12-13 | Paul A Bartlett | Polypeptide analogs |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
| WO1992017585A1 (en) | 1991-04-05 | 1992-10-15 | The Trustees Of Columbia University In The City Of New York | Odorant receptors ans uses thereof |
| US6270989B1 (en) | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| PT101031B (pt) | 1991-11-05 | 2002-07-31 | Transkaryotic Therapies Inc | Processo para o fornecimento de proteinas por terapia genetica |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US6664107B1 (en) | 1993-05-26 | 2003-12-16 | Ontario Cancer Institute, University Health Network | CD45 disrupted nucleic acid |
| US5426039A (en) | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
| EP0720650B1 (en) * | 1993-09-20 | 2004-12-01 | Novartis AG | Human metabotropic glutamate receptor subtype hmglur7 and related dna compounds |
| IL108205A0 (en) | 1993-12-28 | 1994-04-12 | Yeda Res & Dev | Olfactory genes and receptors |
| US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
| US5593853A (en) | 1994-02-09 | 1997-01-14 | Martek Corporation | Generation and screening of synthetic drug libraries |
| US5691188A (en) | 1994-02-14 | 1997-11-25 | American Cyanamid Company | Transformed yeast cells expressing heterologous G-protein coupled receptor |
| US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
| EP0831854A4 (en) | 1995-06-06 | 2001-01-24 | Isis Pharmaceuticals Inc | OLIGONUCLEOTIDS WITH PHOSPHOROTHIOATE BINDINGS OF HIGH CHIRAL PURITY |
| US5985662A (en) | 1995-07-13 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense inhibition of hepatitis B virus replication |
| AU1118197A (en) | 1995-11-09 | 1997-05-29 | Johns Hopkins University School Of Medicine, The | Novel sperm receptors |
| US5874243A (en) | 1997-03-28 | 1999-02-23 | Smithkline Beecham Corporation | OLRCC15 receptor |
| US5993778A (en) * | 1997-05-07 | 1999-11-30 | Firestein; Stuart J. | Functional expression of, and assay for, functional cellular receptors in vivo |
| US5940153A (en) * | 1998-04-03 | 1999-08-17 | Motorola, Inc. | Display assembly having LCD and seal captured between interlocking lens cover and lightpipe |
| FR2780405B1 (fr) | 1998-06-25 | 2001-12-28 | Centre Nat Rech Scient | Nouveaux recepteurs olfactifs et leurs utilisations |
| WO2000006692A1 (en) | 1998-07-28 | 2000-02-10 | Canadian Inovatech, Inc. | Methods and compositions for inhibiting microbial growth in wine |
| EP1100867B1 (en) | 1998-07-28 | 2004-12-01 | Victoria Ann Heslop | Digester |
| US7402400B2 (en) | 2001-07-03 | 2008-07-22 | Regents Of The University Of California | Mammalian sweet taste receptors |
| CN1198836C (zh) | 1998-07-28 | 2005-04-27 | 加利福尼亚大学董事会 | 编码与感觉转导有关的g－蛋白偶联受体的核酸 |
| EP1100811B1 (en) | 1998-07-28 | 2007-07-04 | The Regents Of The University Of California | Nucleic acids encoding a g-protein coupled receptor involved in sensory transduction |
| BR9912455A (pt) | 1998-07-28 | 2001-04-17 | Univ California | ácidos nucléicos codificadores de proteìnas envolvidas em transdução sensória |
| US6106555A (en) | 1998-12-15 | 2000-08-22 | Av Healing Llc | Method for tissue fixation |
| EP1139793B1 (en) | 1998-12-23 | 2009-10-14 | Mount Sinai School of Medicine of New York University | Inhibitors of the bitter taste response |
| US6558910B2 (en) | 1999-09-10 | 2003-05-06 | The Regents Of The University Of California | SF, a novel family of taste receptors |
| JP4339542B2 (ja) | 1999-09-10 | 2009-10-07 | ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、カリフォルニア | Ｔ２ｒ、すなわち味覚受容体の新規ファミリー |
| US20030036089A1 (en) * | 1999-12-20 | 2003-02-20 | Applera Corporation | Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof |
| WO2001064882A2 (en) * | 2000-02-29 | 2001-09-07 | Millennium Pharmaceuticals, Inc. | 1983, 52881, 2398, 45449, 50289, and 52872, g protein-coupled receptors and uses therefor |
| TW201006846A (en) | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
| US6608176B2 (en) | 2000-03-31 | 2003-08-19 | University Of Miami | Taste receptor for umami (monosodium glutamate) taste |
| JP2003530098A (ja) | 2000-04-07 | 2003-10-14 | セノミックス、インコーポレイテッド | Ｔ２ｒ味覚受容体及びそれをコードする遺伝子 |
| EP1280899A2 (en) | 2000-04-28 | 2003-02-05 | Warner-Lambert Company | Gene and sequence variation associated with sensing carbohydrate compounds and other sweeteners |
| DE60138808D1 (de) | 2000-06-16 | 2009-07-09 | Incyte Corp | G-protein gekoppelte rezeptoren |
| TW201022287A (en) * | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
| US7309577B2 (en) * | 2001-03-07 | 2007-12-18 | Senomyx, Inc. | Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste |
| US7301009B2 (en) | 2001-06-26 | 2007-11-27 | Senomyx, Inc. | Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli |
| US7368285B2 (en) | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
| US6955887B2 (en) | 2001-03-30 | 2005-10-18 | Senomyx, Inc. | Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling |
| US7763431B1 (en) | 2001-03-07 | 2010-07-27 | Senomyx, Inc. | Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste |
| US20080244761A1 (en) | 2001-03-07 | 2008-10-02 | Senomyx, Inc. | T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
| DK2327985T3 (en) | 2001-06-26 | 2016-09-05 | Senomyx Inc | H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds |
| CN100489102C (zh) | 2001-06-26 | 2009-05-20 | 塞诺米克斯公司 | T1r异源寡聚的味觉受体和表达所述受体的细胞系及其在鉴定味觉化合物中的用途 |
| EP1585954B1 (en) | 2001-07-03 | 2014-03-26 | The Regents of The University of California | Mammalian sweet and amino acid heterodimeric taste receptors |
| US7022488B2 (en) * | 2003-02-03 | 2006-04-04 | Senomyx, Inc. | Functional coupling of T1Rs and T2Rs by Gi proteins, and cells-based assays for the identification of T1R and T2R modulators |
| WO2003025137A2 (en) | 2001-09-18 | 2003-03-27 | Irm, Llc | Sweet taste receptors |
| WO2003040156A1 (en) * | 2001-11-08 | 2003-05-15 | Hokko Chemical Industry Co., Ltd. | Production processes for triorganomonoalkoxysilanes and triorganomonochlorosilanes |
| US7208290B2 (en) * | 2001-12-14 | 2007-04-24 | Senomyx, Inc. | Methods of co-expressing umami taste receptors and chimeric Gα15 variants |
| US7107837B2 (en) * | 2002-01-22 | 2006-09-19 | Baxter International Inc. | Capacitance fluid volume measurement |
| US7441104B2 (en) | 2002-03-30 | 2008-10-21 | Hewlett-Packard Development Company, L.P. | Parallel subword instructions with distributed results |
| US9314194B2 (en) * | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US20070142748A1 (en) * | 2002-04-19 | 2007-06-21 | Ajay Deshmukh | Tissue penetration device |
| AU2003261280B2 (en) | 2002-07-29 | 2009-02-05 | Senomyx, Inc. | Identification of a novel bitter taste receptor, T2R76 |
| CN103275058B (zh) | 2003-08-06 | 2016-02-24 | 西诺米克斯公司 | 调味剂、味道调节剂、促味剂、味觉增强剂、鲜味剂或甜味剂和/或增强剂及其用途 |
| US7906627B2 (en) | 2003-08-06 | 2011-03-15 | Senomyx, Inc. | Chimeric human sweet-umami and umami-sweet taste receptors |
| US20050106571A1 (en) * | 2003-10-02 | 2005-05-19 | The Regents Of The University Of California | Mammalian T1R3 sweet taste receptors |
| EP1680014A4 (en) * | 2003-10-14 | 2009-01-21 | Pelikan Technologies Inc | METHOD AND APPARATUS PROVIDING A VARIABLE USER INTERFACE |
| EP1737345A1 (en) * | 2004-04-15 | 2007-01-03 | Roche Diagnostics GmbH | Integrated spot monitoring device with fluid sensor |
| US20060045953A1 (en) | 2004-08-06 | 2006-03-02 | Catherine Tachdjian | Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers |
| TWI399228B (zh) * | 2006-07-21 | 2013-06-21 | Alcon Inc | 低黏性的眼科與耳鼻喉科裝置材料（二） |
| US20080047764A1 (en) * | 2006-08-28 | 2008-02-28 | Cypress Semiconductor Corporation | Temperature compensation method for capacitive sensors |
| US20090061456A1 (en) | 2007-08-30 | 2009-03-05 | Allard William J | Method for predicting progression free and overall survival at each follow-up time point during therapy of metastatic breast cancer patients using circulating tumor cells |
| US7936111B2 (en) | 2008-08-07 | 2011-05-03 | Samsung Electronics Co., Ltd. | Apparatus for generating electrical energy and method for manufacturing the same |
| JO3421B1 (ar) | 2011-06-20 | 2019-10-20 | H Lundbeck As | طريقة لإعطاء 1-((1ار.3س)-6-كلورو-3-فينيل-اندان-1-ايل)-1.2.2-ترايميثيل- بيبيرازين واملاجها لمعالجة انفصام الشخصية |
-
2001
- 2001-03-06 TW TW098134804A patent/TW201006846A/zh unknown
- 2001-03-07 CA CA2402214A patent/CA2402214C/en not_active Expired - Lifetime
- 2001-03-07 JP JP2001565728A patent/JP5403842B2/ja not_active Expired - Lifetime
- 2001-03-07 EP EP09174166A patent/EP2143732B1/en not_active Expired - Lifetime
- 2001-03-07 AU AU2001240086A patent/AU2001240086B2/en not_active Ceased
- 2001-03-07 EP EP01914732A patent/EP1309606B1/en not_active Expired - Lifetime
- 2001-03-07 ES ES08152887T patent/ES2338497T3/es not_active Expired - Lifetime
- 2001-03-07 DK DK01914732T patent/DK1309606T3/da active
- 2001-03-07 DK DK10180329.4T patent/DK2298802T3/da active
- 2001-03-07 DE DE60141237T patent/DE60141237D1/de not_active Expired - Lifetime
- 2001-03-07 MX MXPA02008724A patent/MXPA02008724A/es active IP Right Grant
- 2001-03-07 CN CNA2005101133938A patent/CN1766108A/zh active Pending
- 2001-03-07 CN CNA018079830A patent/CN1543474A/zh active Pending
- 2001-03-07 IL IL15157801A patent/IL151578A0/xx unknown
- 2001-03-07 EP EP08152887A patent/EP1944319B1/en not_active Expired - Lifetime
- 2001-03-07 DE DE0001309606T patent/DE01914732T1/de active Pending
- 2001-03-07 ES ES01914732T patent/ES2311508T3/es not_active Expired - Lifetime
- 2001-03-07 DK DK08152887.9T patent/DK1944319T3/da active
- 2001-03-07 US US09/799,629 patent/US7244835B2/en not_active Expired - Lifetime
- 2001-03-07 WO PCT/US2001/007265 patent/WO2001066563A2/en not_active Ceased
- 2001-03-07 DE DE60135229T patent/DE60135229D1/de not_active Expired - Lifetime
- 2001-03-07 AU AU4008601A patent/AU4008601A/xx active Pending
- 2001-03-07 AT AT01914732T patent/ATE403669T1/de active
- 2001-03-07 ES ES10180329T patent/ES2396681T3/es not_active Expired - Lifetime
- 2001-03-07 AT AT08152887T patent/ATE456577T1/de active
- 2001-03-07 CN CNA2008101749661A patent/CN101445800A/zh active Pending
- 2001-03-07 EP EP10180329A patent/EP2298802B1/en not_active Expired - Lifetime
-
2002
- 2002-09-06 NO NO20024276A patent/NO20024276L/no not_active Application Discontinuation
-
2003
- 2003-12-01 US US10/724,223 patent/US7524637B2/en not_active Expired - Lifetime
- 2003-12-01 US US10/724,222 patent/US7452685B2/en not_active Expired - Lifetime
- 2003-12-02 US US10/725,081 patent/US7507544B2/en not_active Expired - Lifetime
- 2003-12-04 US US10/726,568 patent/US7223551B2/en not_active Expired - Lifetime
-
2007
- 2007-05-01 US US11/797,156 patent/US7834165B2/en not_active Expired - Lifetime
- 2007-05-01 US US11/797,155 patent/US7705121B2/en not_active Expired - Fee Related
- 2007-05-15 US US11/798,576 patent/US7790848B2/en not_active Expired - Fee Related
- 2007-10-23 US US11/877,210 patent/US7842785B2/en not_active Expired - Lifetime
- 2007-10-23 US US11/877,195 patent/US7772385B2/en not_active Expired - Lifetime
- 2007-10-24 US US11/877,835 patent/US7737254B2/en not_active Expired - Fee Related
- 2007-10-24 US US11/877,844 patent/US7847080B2/en not_active Expired - Fee Related
-
2008
- 2008-10-15 US US12/251,770 patent/US7799905B2/en not_active Expired - Fee Related
-
2009
- 2009-02-25 US US12/392,143 patent/US8815525B2/en not_active Expired - Fee Related
- 2009-02-25 US US12/392,191 patent/US20090233807A1/en not_active Abandoned
-
2010
- 2010-04-23 US US12/766,121 patent/US7927823B2/en not_active Expired - Lifetime
- 2010-09-02 US US12/874,581 patent/US8802379B2/en not_active Expired - Fee Related
-
2011
- 2011-02-09 US US13/023,836 patent/US8314224B2/en not_active Expired - Fee Related
- 2011-04-15 US US13/087,556 patent/US8247542B2/en not_active Expired - Lifetime
- 2011-04-22 US US13/092,598 patent/US8263341B2/en not_active Expired - Lifetime
-
2012
- 2012-08-31 US US13/600,377 patent/US9040247B2/en not_active Expired - Fee Related
- 2012-11-15 US US13/677,431 patent/US8816057B2/en not_active Expired - Lifetime
-
2013
- 2013-07-29 JP JP2013156284A patent/JP5903078B2/ja not_active Expired - Lifetime
-
2015
- 2015-04-27 US US14/696,896 patent/US9637536B2/en not_active Expired - Fee Related
-
2017
- 2017-04-10 US US15/483,353 patent/US10093718B2/en not_active Expired - Fee Related
-
2018
- 2018-09-12 US US16/128,633 patent/US10544204B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004513608A5 (enExample) | ||
| Wang et al. | Identification of a domain in the angiotensin II type 1 receptor determining Gq coupling by the use of receptor chimeras | |
| AU773600B2 (en) | T2R, taste receptor family | |
| US20030022278A1 (en) | T2R, a novel family of taste receptors | |
| CA2452716C (en) | Mammalian sweet and amino acid heterodimeric taste receptors | |
| US7241880B2 (en) | T1R taste receptors and genes encoding same | |
| Flanagan et al. | Alkaline phosphatase fusion proteins for molecular characterization and cloning of receptors and their ligands | |
| US20030040045A1 (en) | Mammalian sweet taste receptors | |
| Touhara | Deorphanizing vertebrate olfactory receptors: recent advances in odorant-response assays | |
| AU2003228956B2 (en) | Constitutively translocating cell line | |
| US7208290B2 (en) | Methods of co-expressing umami taste receptors and chimeric Gα15 variants | |
| Su et al. | Identifying key juxtamembrane interactions in cell membranes using AraC-based transcriptional reporter assay (AraTM) | |
| Milligan et al. | G protein-coupled receptor fusion proteins in drug discovery | |
| WO2024250926A1 (zh) | 嗅觉受体的正向调节剂及含有它的重组细胞或重组细胞系和检测气味化合物的方法 | |
| JP2005500053A5 (enExample) | ||
| JP6808842B2 (ja) | Ｆｇｆ２１応答性レポーター遺伝子細胞株 | |
| US10281467B2 (en) | Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives | |
| Heitz et al. | Expression of human M2 muscarinic receptors in Sf9 cells: characterisation and reconstitution with G-proteins | |
| JP2010516232A5 (enExample) | ||
| US9244081B2 (en) | Cell-based fluorescent assays for identifying alpha and delta ENaC modulators | |
| US20040253675A1 (en) | Method for GPCR assay with a coexpressed Galpha protein | |
| US20050085625A1 (en) | Chimeric Galpha 15 variants and their use in the analysis and discovery of modulators of G-protein coupled receptors | |
| US9658208B2 (en) | Methods and G proteins for screening and identifying ligands of G protein-coupled receptors | |
| US20090176243A1 (en) | Novel monkey GPR103 and monkey QRFP and method of evaluating compound by using GPR103 | |
| JP2002529075A5 (enExample) |