JP2004513608A5 - - Google Patents
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- JP2004513608A5 JP2004513608A5 JP2001565728A JP2001565728A JP2004513608A5 JP 2004513608 A5 JP2004513608 A5 JP 2004513608A5 JP 2001565728 A JP2001565728 A JP 2001565728A JP 2001565728 A JP2001565728 A JP 2001565728A JP 2004513608 A5 JP2004513608 A5 JP 2004513608A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- cells
- taste receptor
- cell
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 description 64
- 102000004196 processed proteins & peptides Human genes 0.000 description 64
- 108090000765 processed proteins & peptides Proteins 0.000 description 64
- 210000004027 cell Anatomy 0.000 description 62
- 108091005708 gustatory receptors Proteins 0.000 description 48
- 238000000034 method Methods 0.000 description 28
- 238000003556 assay Methods 0.000 description 26
- 108091028043 Nucleic acid sequence Proteins 0.000 description 22
- 150000007523 nucleic acids Chemical group 0.000 description 22
- 101100315287 Homo sapiens TAS1R3 gene Proteins 0.000 description 16
- 101000659774 Homo sapiens Taste receptor type 1 member 3 Proteins 0.000 description 16
- 102100035942 Taste receptor type 1 member 3 Human genes 0.000 description 16
- 150000001875 compounds Chemical class 0.000 description 15
- 230000000694 effects Effects 0.000 description 14
- 239000003446 ligand Substances 0.000 description 14
- 108091006027 G proteins Proteins 0.000 description 12
- 102000030782 GTP binding Human genes 0.000 description 12
- 108091000058 GTP-Binding Proteins 0.000 description 12
- 241000283984 Rodentia Species 0.000 description 11
- 210000004962 mammalian cell Anatomy 0.000 description 9
- 102000005962 receptors Human genes 0.000 description 7
- 108020003175 receptors Proteins 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 5
- 210000005253 yeast cell Anatomy 0.000 description 5
- 241000238631 Hexapoda Species 0.000 description 4
- 241000269370 Xenopus <genus> Species 0.000 description 4
- 230000027455 binding Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 230000003834 intracellular effect Effects 0.000 description 3
- 230000009870 specific binding Effects 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 101000659767 Homo sapiens Taste receptor type 1 member 1 Proteins 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 102100035941 Taste receptor type 1 member 1 Human genes 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 238000002875 fluorescence polarization Methods 0.000 description 1
- 239000003269 fluorescent indicator Substances 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 238000002825 functional assay Methods 0.000 description 1
- 238000012188 high-throughput screening assay Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- XOFLBQFBSOEHOG-UUOKFMHZSA-N γS-GTP Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=S)[C@@H](O)[C@H]1O XOFLBQFBSOEHOG-UUOKFMHZSA-N 0.000 description 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18754600P | 2000-03-07 | 2000-03-07 | |
| US60/187,546 | 2000-03-07 | ||
| US19553600P | 2000-04-07 | 2000-04-07 | |
| US60/195,536 | 2000-04-07 | ||
| US20984000P | 2000-06-06 | 2000-06-06 | |
| US60/209,840 | 2000-06-06 | ||
| US21421300P | 2000-06-23 | 2000-06-23 | |
| US60/214,213 | 2000-06-23 | ||
| US22644800P | 2000-08-17 | 2000-08-17 | |
| US60/226,448 | 2000-08-17 | ||
| US25922701P | 2001-01-03 | 2001-01-03 | |
| US60/259,227 | 2001-01-03 | ||
| PCT/US2001/007265 WO2001066563A2 (en) | 2000-03-07 | 2001-03-07 | T1r taste receptors and genes encoding same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013156284A Division JP5903078B2 (ja) | 2000-03-07 | 2013-07-29 | Ｔ１ｒ味覚受容体とこれをコードする遺伝子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004513608A JP2004513608A (ja) | 2004-05-13 |
| JP2004513608A5 true JP2004513608A5 (enExample) | 2008-05-01 |
| JP5403842B2 JP5403842B2 (ja) | 2014-01-29 |
Family
ID=27558784
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001565728A Expired - Lifetime JP5403842B2 (ja) | 2000-03-07 | 2001-03-07 | Ｔ１ｒ味覚受容体とこれをコードする遺伝子 |
| JP2013156284A Expired - Lifetime JP5903078B2 (ja) | 2000-03-07 | 2013-07-29 | Ｔ１ｒ味覚受容体とこれをコードする遺伝子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013156284A Expired - Lifetime JP5903078B2 (ja) | 2000-03-07 | 2013-07-29 | Ｔ１ｒ味覚受容体とこれをコードする遺伝子 |
Country Status (15)
| Country | Link |
|---|---|
| US (25) | US7244835B2 (enExample) |
| EP (4) | EP1944319B1 (enExample) |
| JP (2) | JP5403842B2 (enExample) |
| CN (3) | CN1766108A (enExample) |
| AT (2) | ATE403669T1 (enExample) |
| AU (2) | AU2001240086B2 (enExample) |
| CA (1) | CA2402214C (enExample) |
| DE (3) | DE60135229D1 (enExample) |
| DK (3) | DK1944319T3 (enExample) |
| ES (3) | ES2311508T3 (enExample) |
| IL (1) | IL151578A0 (enExample) |
| MX (1) | MXPA02008724A (enExample) |
| NO (1) | NO20024276L (enExample) |
| TW (1) | TW201006846A (enExample) |
| WO (1) | WO2001066563A2 (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU764180B2 (en) | 1998-07-28 | 2003-08-14 | Regents Of The University Of California, The | Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction |
| US7402400B2 (en) | 2001-07-03 | 2008-07-22 | Regents Of The University Of California | Mammalian sweet taste receptors |
| TW201006846A (en) * | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
| JP2003531614A (ja) * | 2000-04-28 | 2003-10-28 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 炭水化物化合物および他の甘味物質の感知に関連する遺伝子および配列変異 |
| GB2364058A (en) * | 2000-05-05 | 2002-01-16 | Smithkline Beecham Corp | AXOR79, a G-protein coupled receptor |
| EP1301595A2 (en) * | 2000-05-22 | 2003-04-16 | Incyte Genomics, Inc. | G-protein coupled receptors |
| AU2001266975A1 (en) * | 2000-06-16 | 2002-01-02 | Incyte Genomics, Inc. | G-protein coupled receptors |
| EP1322758A2 (en) * | 2000-09-25 | 2003-07-02 | Bayer Aktiengesellschaft | Regulation of human g protein-coupled receptor |
| TW201022287A (en) * | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
| US20080244761A1 (en) * | 2001-03-07 | 2008-10-02 | Senomyx, Inc. | T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
| US7301009B2 (en) | 2001-06-26 | 2007-11-27 | Senomyx, Inc. | Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli |
| US6955887B2 (en) | 2001-03-30 | 2005-10-18 | Senomyx, Inc. | Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling |
| US7763431B1 (en) | 2001-03-07 | 2010-07-27 | Senomyx, Inc. | Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste |
| US7309577B2 (en) | 2001-03-07 | 2007-12-18 | Senomyx, Inc. | Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste |
| US7368285B2 (en) * | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
| US7803982B2 (en) | 2001-04-20 | 2010-09-28 | The Mount Sinai School Of Medicine Of New York University | T1R3 transgenic animals, cells and related methods |
| WO2002086079A2 (en) * | 2001-04-20 | 2002-10-31 | Mount Sinai School Of Medicine | T1r3 a novel taste receptor |
| DK2327985T3 (en) | 2001-06-26 | 2016-09-05 | Senomyx Inc | H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds |
| EP2327985B2 (en) * | 2001-06-26 | 2019-08-21 | Senomyx, Inc. | T1R Hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
| AU2002320294B2 (en) | 2001-07-03 | 2009-01-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Mammalian sweet and amino acid heterodimeric taste receptors |
| US20040029789A1 (en) * | 2001-07-05 | 2004-02-12 | Anderson David W. | Novel proteins and nucleic acids encoding same |
| EP1523308A4 (en) | 2001-07-20 | 2007-01-10 | Us Gov Health & Human Serv | PHENYL THIOCARBAMIDE (PTC) TREATMENT RECEPTOR |
| WO2003025137A2 (en) * | 2001-09-18 | 2003-03-27 | Irm, Llc | Sweet taste receptors |
| WO2003102030A1 (en) * | 2002-05-20 | 2003-12-11 | Tvd Taste Virtual Dimensions, Inc. | Antibodies and their use for the modulation of taste sensation___ |
| WO2005007891A2 (en) | 2003-06-19 | 2005-01-27 | The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services | Variants of human taste receptor genes |
| NZ619746A (en) | 2003-08-06 | 2014-05-30 | Senomyx Inc | Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
| US20050244810A1 (en) * | 2003-09-29 | 2005-11-03 | Egan Josephine M | Taste signaling in gastrointestinal cells |
| US20050106571A1 (en) * | 2003-10-02 | 2005-05-19 | The Regents Of The University Of California | Mammalian T1R3 sweet taste receptors |
| US20060045953A1 (en) * | 2004-08-06 | 2006-03-02 | Catherine Tachdjian | Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers |
| WO2006068745A1 (en) | 2004-12-22 | 2006-06-29 | Cargill, Incorporated | Methods for determining cellular response to stimuli |
| TW200638882A (en) * | 2005-02-04 | 2006-11-16 | Senomyx Inc | Molecules comprising linked organic moieties as flavor modifiers for comestible compositions |
| MY158077A (en) * | 2005-02-04 | 2016-08-30 | Senomyx Inc | Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers tastants and taste enhancers for comestible compositions |
| US8796441B2 (en) | 2005-04-13 | 2014-08-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Human sweet and umami taste receptor variants |
| ES2399059T3 (es) | 2005-05-23 | 2013-03-25 | Kraft Foods Global Brands Llc | Composiciones potenciadoras del dulzor |
| CN101179943B (zh) | 2005-05-23 | 2013-06-26 | 卡夫食品环球品牌有限责任公司 | 填充液体的咀嚼型胶基糖组合物 |
| US7851006B2 (en) | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
| US7851005B2 (en) | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
| AR055329A1 (es) * | 2005-06-15 | 2007-08-15 | Senomyx Inc | Amidas bis-aromaticas y sus usos como modificadores de sabor dulce, saborizantes, y realzadores de sabor |
| US20110097741A1 (en) * | 2006-04-20 | 2011-04-28 | Jay Patrick Slack | Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays |
| US8148536B2 (en) | 2006-04-21 | 2012-04-03 | Senomyx, Inc. | Comestible compositions comprising high potency savory flavorants, and processes for producing them |
| EP2015638A4 (en) * | 2006-04-28 | 2010-09-29 | Redpoint Bio Corp | TRIARYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS TASTE INHIBITORS |
| WO2008008224A2 (en) | 2006-07-10 | 2008-01-17 | Duke University | Sour taste receptor compositions and methods |
| US20080124753A1 (en) * | 2006-11-15 | 2008-05-29 | Lee Seunghun Paul | SpiceMatrix Technology for Taste Compound Identification |
| US7928111B2 (en) * | 2007-06-08 | 2011-04-19 | Senomyx, Inc. | Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors |
| US9603848B2 (en) * | 2007-06-08 | 2017-03-28 | Senomyx, Inc. | Modulation of chemosensory receptors and ligands associated therewith |
| US8633186B2 (en) | 2007-06-08 | 2014-01-21 | Senomyx Inc. | Modulation of chemosensory receptors and ligands associated therewith |
| GB0713297D0 (en) * | 2007-07-10 | 2007-08-15 | Cadbury Schweppes Plc | Chocolate compositions having improved flavour characteristics |
| US9714941B2 (en) * | 2007-07-31 | 2017-07-25 | Massachusetts Institute Of Technology | Bio-sensing nanodevice |
| WO2010014903A1 (en) | 2008-07-31 | 2010-02-04 | Massachusetts Institute Of Technology | Multiplexed olfactory receptor-based microsurface plasmon polariton detector |
| EP2323997B1 (en) | 2008-07-31 | 2017-09-06 | Senomyx, Inc. | Processes and intermediates for making sweet taste enhancers |
| CN102170797B (zh) | 2008-07-31 | 2014-02-19 | 西诺米克斯公司 | 包含甜味增强剂的组合物和它们的制备方法 |
| US20120184465A1 (en) * | 2009-07-20 | 2012-07-19 | Verdezyne, Inc. | Combinatorial methods for optimizing engineered microorganism function |
| US8795977B2 (en) | 2009-12-02 | 2014-08-05 | Conopco, Inc. | Method for screening a potential modulator compound of a taste receptor |
| US9000054B2 (en) | 2010-08-12 | 2015-04-07 | Senomyx, Inc. | Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer |
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| MX365710B (es) | 2011-04-29 | 2019-06-11 | Intercontinental Great Brands Llc | Acido encapsulado, metodo para la preparacion del mismo y goma de mascar que comprende el mismo. |
| WO2013022948A1 (en) | 2011-08-08 | 2013-02-14 | The Coca-Cola Company | Cell lines comprising endogenous taste receptors and their uses |
| US9042596B2 (en) | 2012-06-14 | 2015-05-26 | Medibotics Llc | Willpower watch (TM)—a wearable food consumption monitor |
| US10314492B2 (en) | 2013-05-23 | 2019-06-11 | Medibotics Llc | Wearable spectroscopic sensor to measure food consumption based on interaction between light and the human body |
| US9536449B2 (en) | 2013-05-23 | 2017-01-03 | Medibotics Llc | Smart watch and food utensil for monitoring food consumption |
| US9254099B2 (en) | 2013-05-23 | 2016-02-09 | Medibotics Llc | Smart watch and food-imaging member for monitoring food consumption |
| US9442100B2 (en) | 2013-12-18 | 2016-09-13 | Medibotics Llc | Caloric intake measuring system using spectroscopic and 3D imaging analysis |
| US9456916B2 (en) | 2013-03-12 | 2016-10-04 | Medibotics Llc | Device for selectively reducing absorption of unhealthy food |
| EP3593648B1 (en) | 2012-08-06 | 2021-07-14 | Firmenich Incorporated | Sweet flavor modifier |
| JO3155B1 (ar) | 2013-02-19 | 2017-09-20 | Senomyx Inc | معدِّل نكهة حلوة |
| US9011365B2 (en) | 2013-03-12 | 2015-04-21 | Medibotics Llc | Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food |
| US9067070B2 (en) | 2013-03-12 | 2015-06-30 | Medibotics Llc | Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type |
| US9804157B1 (en) | 2013-03-15 | 2017-10-31 | Senomyx, Inc. | Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives |
| US9529385B2 (en) | 2013-05-23 | 2016-12-27 | Medibotics Llc | Smart watch and human-to-computer interface for monitoring food consumption |
| US9826662B2 (en) | 2013-12-12 | 2017-11-21 | General Electric Company | Reusable phase-change thermal interface structures |
| US10660571B2 (en) * | 2013-12-19 | 2020-05-26 | Kent State University | Thermochromic fabrics utilizing cholesteric liquid crystal material |
| ES2802376T3 (es) | 2014-02-12 | 2021-01-19 | Firmenich Incorporated | Procedimiento mejorado para la síntesis de 1-bencil-3-(1-(isoxazol-4-ilmetil)-1h-pirazol-4-il)imidazolidin-2,4-dionas sustituidas |
| WO2015163905A1 (en) | 2014-04-25 | 2015-10-29 | General Mills, Inc. | Food products having sweetness enhancer |
| JP6383704B2 (ja) * | 2015-07-02 | 2018-08-29 | 日立オートモティブシステムズ株式会社 | 電池制御装置 |
| CN112703193A (zh) | 2018-08-07 | 2021-04-23 | 弗门尼舍公司 | 5-取代的4-氨基-1H-苯并[c][1,2,6]噻二嗪2,2-二氧化物及其制剂和用途 |
| EP3693975A1 (en) | 2019-02-06 | 2020-08-12 | Tata Consultancy Services Limited | System and method for evaluation of at least one potential tastant from a plurality of tastants |
| WO2021150686A1 (en) | 2020-01-22 | 2021-07-29 | Firmenich Incorporated | High-sensitivity detection of gpcr activity and uses thereof |
| CN116355916B (zh) | 2020-06-25 | 2024-12-24 | 麦可科技有限公司 | 甜蛋白及其多核苷酸、表达载体、制备方法和纯化方法 |
| US12319933B2 (en) | 2023-03-01 | 2025-06-03 | Alcheme Bio Inc. | Systems, methods, and compositions for production of cellular agriculture products |
| CN116554350B (zh) * | 2023-04-26 | 2024-01-09 | 之江实验室 | 基于人类甜味受体蛋白的生物传感器及其应用 |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US788470A (en) * | 1903-06-16 | 1905-04-25 | Edouard Jehn | Changing mechanism for picture-exhibitors. |
| US1733847A (en) * | 1927-03-11 | 1929-10-29 | Variety Fire Door Company | Door-latch retainer |
| JPS5825980B2 (ja) | 1976-02-12 | 1983-05-31 | ヤマサ醤油株式会社 | サイクリックヌクレオチドの定量法 |
| US4391904A (en) | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4517288A (en) | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
| US4661768A (en) * | 1983-09-14 | 1987-04-28 | Johnson Service Company | Capacitance transducing method and apparatus |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| CA1291031C (en) | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
| US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| HK1000547A1 (en) | 1989-12-22 | 1998-04-03 | Merck Serono Sa | Endogenous gene expression modification with regulatory element by way of homologous recombination |
| US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| WO1991012650A1 (fr) | 1990-02-09 | 1991-08-22 | Asulab S.A. | Micromoteur electrostatique a champ radial realise par microfabrication photolithographique et procede de realisation d'un tel micromoteur |
| IE66205B1 (en) | 1990-06-14 | 1995-12-13 | Paul A Bartlett | Polypeptide analogs |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
| EP0578784A4 (en) | 1991-04-05 | 1994-11-02 | Univ Columbia | RECEPTORS OF SMELLING SUBSTANCES AND THEIR USES. |
| NZ245015A (en) | 1991-11-05 | 1995-12-21 | Transkaryotic Therapies Inc | Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US6270989B1 (en) | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US6664107B1 (en) | 1993-05-26 | 2003-12-16 | Ontario Cancer Institute, University Health Network | CD45 disrupted nucleic acid |
| US5426039A (en) | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
| EP1199359B1 (en) * | 1993-09-20 | 2011-08-31 | Novartis AG | Human metabotropic glutamate receptor subtypes ( HMR6) and related DNA compounds |
| IL108205A0 (en) | 1993-12-28 | 1994-04-12 | Yeda Res & Dev | Olfactory genes and receptors |
| US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
| US5593853A (en) | 1994-02-09 | 1997-01-14 | Martek Corporation | Generation and screening of synthetic drug libraries |
| US5691188A (en) | 1994-02-14 | 1997-11-25 | American Cyanamid Company | Transformed yeast cells expressing heterologous G-protein coupled receptor |
| US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
| CA2223103A1 (en) | 1995-06-06 | 1996-12-12 | Isis Pharmaceuticals Inc. | Oligonucleotides having phosphorothioate linkages of high chiral purity |
| US5985662A (en) | 1995-07-13 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense inhibition of hepatitis B virus replication |
| AU1118197A (en) | 1995-11-09 | 1997-05-29 | Johns Hopkins University School Of Medicine, The | Novel sperm receptors |
| US5874243A (en) | 1997-03-28 | 1999-02-23 | Smithkline Beecham Corporation | OLRCC15 receptor |
| US5993778A (en) | 1997-05-07 | 1999-11-30 | Firestein; Stuart J. | Functional expression of, and assay for, functional cellular receptors in vivo |
| US5940153A (en) * | 1998-04-03 | 1999-08-17 | Motorola, Inc. | Display assembly having LCD and seal captured between interlocking lens cover and lightpipe |
| US20020061522A1 (en) * | 2000-02-29 | 2002-05-23 | Glucksmann Maria Alexandra | 1983, 52881, 2398, 45449, 50289, and 52872 novel G protein-coupled receptors and uses therefor |
| FR2780405B1 (fr) | 1998-06-25 | 2001-12-28 | Centre Nat Rech Scient | Nouveaux recepteurs olfactifs et leurs utilisations |
| AU5022399A (en) | 1998-07-28 | 2000-02-21 | Canadian Inovatech, Inc. | Methods and compositions for inhibiting microbial growth in wine |
| AU764180B2 (en) | 1998-07-28 | 2003-08-14 | Regents Of The University Of California, The | Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction |
| US7402400B2 (en) | 2001-07-03 | 2008-07-22 | Regents Of The University Of California | Mammalian sweet taste receptors |
| AU4926699A (en) | 1998-07-28 | 2000-02-21 | Victoria Ann Heslop | A digester |
| AU5323999A (en) | 1998-07-28 | 2000-02-21 | Regents Of The University Of California, The | Nucleic acids encoding proteins involved in sensory transduction |
| CN1198836C (zh) * | 1998-07-28 | 2005-04-27 | 加利福尼亚大学董事会 | 编码与感觉转导有关的g－蛋白偶联受体的核酸 |
| US6106555A (en) | 1998-12-15 | 2000-08-22 | Av Healing Llc | Method for tissue fixation |
| WO2000038536A2 (en) | 1998-12-23 | 2000-07-06 | Mount Sinai School Of Medicine Of New York University | Inhibitors of the bitter taste response |
| US6558910B2 (en) | 1999-09-10 | 2003-05-06 | The Regents Of The University Of California | SF, a novel family of taste receptors |
| WO2001018050A2 (en) | 1999-09-10 | 2001-03-15 | The Regents Of The University Of California | T2r taste receptor family |
| US20030036089A1 (en) | 1999-12-20 | 2003-02-20 | Applera Corporation | Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof |
| TW201006846A (en) | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
| US6608176B2 (en) | 2000-03-31 | 2003-08-19 | University Of Miami | Taste receptor for umami (monosodium glutamate) taste |
| AU2001251258B2 (en) | 2000-04-07 | 2008-06-05 | Senomyx, Inc. | T2r taste receptors and genes encoding same |
| JP2003531614A (ja) * | 2000-04-28 | 2003-10-28 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 炭水化物化合物および他の甘味物質の感知に関連する遺伝子および配列変異 |
| AU2001266975A1 (en) | 2000-06-16 | 2002-01-02 | Incyte Genomics, Inc. | G-protein coupled receptors |
| TW201022287A (en) | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
| US6955887B2 (en) | 2001-03-30 | 2005-10-18 | Senomyx, Inc. | Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling |
| US7301009B2 (en) | 2001-06-26 | 2007-11-27 | Senomyx, Inc. | Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli |
| US7763431B1 (en) | 2001-03-07 | 2010-07-27 | Senomyx, Inc. | Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste |
| US7368285B2 (en) | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
| US20080244761A1 (en) * | 2001-03-07 | 2008-10-02 | Senomyx, Inc. | T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
| US7309577B2 (en) | 2001-03-07 | 2007-12-18 | Senomyx, Inc. | Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste |
| DK2327985T3 (en) | 2001-06-26 | 2016-09-05 | Senomyx Inc | H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds |
| EP2327985B2 (en) | 2001-06-26 | 2019-08-21 | Senomyx, Inc. | T1R Hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
| AU2002320294B2 (en) | 2001-07-03 | 2009-01-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Mammalian sweet and amino acid heterodimeric taste receptors |
| WO2003025137A2 (en) | 2001-09-18 | 2003-03-27 | Irm, Llc | Sweet taste receptors |
| CN1296374C (zh) * | 2001-11-08 | 2007-01-24 | 北兴化学工业株式会社 | 生产三有机基－单烷氧基硅烷的方法以及生产三有机基－单氯硅烷的方法 |
| US7208290B2 (en) | 2001-12-14 | 2007-04-24 | Senomyx, Inc. | Methods of co-expressing umami taste receptors and chimeric Gα15 variants |
| US7107837B2 (en) * | 2002-01-22 | 2006-09-19 | Baxter International Inc. | Capacitance fluid volume measurement |
| US7441104B2 (en) | 2002-03-30 | 2008-10-21 | Hewlett-Packard Development Company, L.P. | Parallel subword instructions with distributed results |
| US20070142748A1 (en) * | 2002-04-19 | 2007-06-21 | Ajay Deshmukh | Tissue penetration device |
| US9314194B2 (en) * | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| CA2488863A1 (en) | 2002-07-29 | 2004-02-05 | Senomyx, Inc. | Identification of a novel bitter taste receptor, t2r76 |
| WO2004069191A2 (en) * | 2003-02-03 | 2004-08-19 | Senomyx Inc. | Identification of t1r and t2r modulators |
| US7906627B2 (en) | 2003-08-06 | 2011-03-15 | Senomyx, Inc. | Chimeric human sweet-umami and umami-sweet taste receptors |
| NZ619746A (en) | 2003-08-06 | 2014-05-30 | Senomyx Inc | Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
| US20050106571A1 (en) | 2003-10-02 | 2005-05-19 | The Regents Of The University Of California | Mammalian T1R3 sweet taste receptors |
| WO2005037095A1 (en) * | 2003-10-14 | 2005-04-28 | Pelikan Technologies, Inc. | Method and apparatus for a variable user interface |
| WO2005104949A1 (en) * | 2004-04-15 | 2005-11-10 | Roche Diagnostics Gmbh | Integrated spot monitoring device with fluid sensor |
| US20060045953A1 (en) | 2004-08-06 | 2006-03-02 | Catherine Tachdjian | Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers |
| TWI399228B (zh) * | 2006-07-21 | 2013-06-21 | Alcon Inc | 低黏性的眼科與耳鼻喉科裝置材料（二） |
| US20080047764A1 (en) * | 2006-08-28 | 2008-02-28 | Cypress Semiconductor Corporation | Temperature compensation method for capacitive sensors |
| US20090061456A1 (en) | 2007-08-30 | 2009-03-05 | Allard William J | Method for predicting progression free and overall survival at each follow-up time point during therapy of metastatic breast cancer patients using circulating tumor cells |
| US7936111B2 (en) | 2008-08-07 | 2011-05-03 | Samsung Electronics Co., Ltd. | Apparatus for generating electrical energy and method for manufacturing the same |
| JO3421B1 (ar) | 2011-06-20 | 2019-10-20 | H Lundbeck As | طريقة لإعطاء 1-((1ار.3س)-6-كلورو-3-فينيل-اندان-1-ايل)-1.2.2-ترايميثيل- بيبيرازين واملاجها لمعالجة انفصام الشخصية |
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