MXPA02008724A - Receptores del gusto t1r y genes que codifican los mismos. - Google Patents

Receptores del gusto t1r y genes que codifican los mismos.

Info

Publication number
MXPA02008724A
MXPA02008724A MXPA02008724A MXPA02008724A MXPA02008724A MX PA02008724 A MXPA02008724 A MX PA02008724A MX PA02008724 A MXPA02008724 A MX PA02008724A MX PA02008724 A MXPA02008724 A MX PA02008724A MX PA02008724 A MXPA02008724 A MX PA02008724A
Authority
MX
Mexico
Prior art keywords
methods
taste
genes
receptors
mammal
Prior art date
Application number
MXPA02008724A
Other languages
English (en)
Inventor
Lena Staszewski
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of MXPA02008724A publication Critical patent/MXPA02008724A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Confectionery (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Se describen receptores recientemente identificados acoplados a la proteina G especificos de celulas del gusto de mamiferos, y los genes y el ADNc que codifican a los receptores. Especificamente se describen, los receptores acoplados con la proteina G del T1R, activos en la senalizacion del gusto, y los genes y el ADNc que codifican a los mismos, junto con metodos para el aislamiento de tales genes y para el aislamiento y expresion de tales receptores. Tambien se describen, los metodos para representar la percepcion del gusto de un agente del gusto en particular en un mamifero, como lo son los metodos para generar moleculas novedosas o combinaciones de moleculas que obtienen una percepcion predeterminada del gusto en un mamifero, y metodos para simular uno o mas sabores. Ademas, se describen tambien metodos para estimular o bloquear la percepcion del gusto en un mamifero.
MXPA02008724A 2000-03-07 2001-03-07 Receptores del gusto t1r y genes que codifican los mismos. MXPA02008724A (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US18754600P 2000-03-07 2000-03-07
US19553600P 2000-04-07 2000-04-07
US20984000P 2000-06-06 2000-06-06
US21421300P 2000-06-23 2000-06-23
US22644800P 2000-08-17 2000-08-17
US25922701P 2001-01-03 2001-01-03
PCT/US2001/007265 WO2001066563A2 (en) 2000-03-07 2001-03-07 T1r taste receptors and genes encoding same

Publications (1)

Publication Number Publication Date
MXPA02008724A true MXPA02008724A (es) 2004-09-06

Family

ID=27558784

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02008724A MXPA02008724A (es) 2000-03-07 2001-03-07 Receptores del gusto t1r y genes que codifican los mismos.

Country Status (16)

Country Link
US (25) US7244835B2 (es)
EP (4) EP2298802B1 (es)
JP (2) JP5403842B2 (es)
CN (3) CN1543474A (es)
AT (2) ATE456577T1 (es)
AU (2) AU4008601A (es)
CA (1) CA2402214C (es)
DE (3) DE60135229D1 (es)
DK (3) DK1309606T3 (es)
ES (3) ES2311508T3 (es)
HK (1) HK1139965A1 (es)
IL (1) IL151578A0 (es)
MX (1) MXPA02008724A (es)
NO (1) NO20024276L (es)
TW (1) TW201006846A (es)
WO (1) WO2001066563A2 (es)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69936453T2 (de) 1998-07-28 2008-03-06 The Regents Of The University Of California, Oakland Für einen g-protein gekoppelten rezeptor, der an der empfindungstransduktion beteiligt ist, kodierende nukleinsäuren
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
TW201006846A (en) * 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
JP2003531614A (ja) * 2000-04-28 2003-10-28 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 炭水化物化合物および他の甘味物質の感知に関連する遺伝子および配列変異
GB2364058A (en) * 2000-05-05 2002-01-16 Smithkline Beecham Corp AXOR79, a G-protein coupled receptor
WO2001090359A2 (en) * 2000-05-22 2001-11-29 Incyte Genomics, Inc. G-protein coupled receptors
JP2004513614A (ja) * 2000-06-16 2004-05-13 インサイト・ゲノミックス・インコーポレイテッド Gタンパク質結合受容体
US20040039170A1 (en) * 2000-09-25 2004-02-26 Sophia Kossida Regulation of human g protein-coupled receptor
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US6955887B2 (en) 2001-03-30 2005-10-18 Senomyx, Inc. Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
US7309577B2 (en) 2001-03-07 2007-12-18 Senomyx, Inc. Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste
US7301009B2 (en) 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US20080244761A1 (en) * 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US20040219632A1 (en) * 2001-04-20 2004-11-04 Robert Margolskee T1r3 a novel taste receptor
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
AU2002326315B2 (en) * 2001-06-26 2007-07-05 Senomyx, Inc. T1R hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
CA2452716C (en) 2001-07-03 2012-06-26 The Regents Of The University Of California Mammalian sweet and amino acid heterodimeric taste receptors
US20040029789A1 (en) * 2001-07-05 2004-02-12 Anderson David W. Novel proteins and nucleic acids encoding same
US7314725B2 (en) 2001-07-20 2008-01-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Phenylthiocarbamide (PTC) taste receptor
US7335487B2 (en) 2001-09-18 2008-02-26 Irm Llc Sweet taste receptors
WO2003102030A1 (en) * 2002-05-20 2003-12-11 Tvd Taste Virtual Dimensions, Inc. Antibodies and their use for the modulation of taste sensation___
EP1644528A2 (en) 2003-06-19 2006-04-12 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services, Variants of human taste receptor genes
MXPA06001510A (es) 2003-08-06 2006-09-04 Senomyx Inc Receptores de degustacion hetero-oligomericos t1r, lineas celulares que expresan tales receptores y compuestos de degustacion.
US20050244810A1 (en) * 2003-09-29 2005-11-03 Egan Josephine M Taste signaling in gastrointestinal cells
US20050106571A1 (en) 2003-10-02 2005-05-19 The Regents Of The University Of California Mammalian T1R3 sweet taste receptors
US20060045953A1 (en) * 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
WO2006068745A1 (en) 2004-12-22 2006-06-29 Cargill, Incorporated Methods for determining cellular response to stimuli
JP4734346B2 (ja) * 2005-02-04 2011-07-27 セノミックス インコーポレイテッド 連結ヘテロアリール部分を含む化合物、ならびに食用組成物のための新規なうまみフレーバー改変剤、味物質および味覚増強剤としての使用
JP2008530017A (ja) * 2005-02-04 2008-08-07 セノミックス インコーポレイテッド 食料用組成物のための風味調整剤として連結された有機部分を含む分子
WO2006113422A2 (en) 2005-04-13 2006-10-26 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Services Human sweet and umami taste receptor variants
US7851005B2 (en) 2005-05-23 2010-12-14 Cadbury Adams Usa Llc Taste potentiator compositions and beverages containing same
AR053296A1 (es) 2005-05-23 2007-04-25 Cadbury Adams Usa Llc Composiciones que potencian el sabor y golosinas comestibles y productos de goma de mascar que los contienen
CN101179943B (zh) 2005-05-23 2013-06-26 卡夫食品环球品牌有限责任公司 填充液体的咀嚼型胶基糖组合物
US7851006B2 (en) 2005-05-23 2010-12-14 Cadbury Adams Usa Llc Taste potentiator compositions and beverages containing same
TW200715993A (en) * 2005-06-15 2007-05-01 Senomyx Inc Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
US20110097741A1 (en) * 2006-04-20 2011-04-28 Jay Patrick Slack Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays
DK3235811T3 (en) 2006-04-21 2018-11-12 Senomyx Inc PROCEDURE FOR THE PREPARATION OF OXALAMIDS
EP2015638A4 (en) * 2006-04-28 2010-09-29 Redpoint Bio Corp TRIARYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS TASTE INHIBITORS
WO2008008224A2 (en) * 2006-07-10 2008-01-17 Duke University Sour taste receptor compositions and methods
CA2666825A1 (en) * 2006-11-15 2008-05-22 Redpoint Bio Corporation Spicematrix technology for taste compound identification
US8633186B2 (en) 2007-06-08 2014-01-21 Senomyx Inc. Modulation of chemosensory receptors and ligands associated therewith
US9603848B2 (en) * 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US7928111B2 (en) 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
GB0713297D0 (en) * 2007-07-10 2007-08-15 Cadbury Schweppes Plc Chocolate compositions having improved flavour characteristics
WO2009018467A2 (en) * 2007-07-31 2009-02-05 Massachusetts Institute Of Technology Bio-sensing nanodevice
WO2010014666A2 (en) 2008-07-31 2010-02-04 Senomyx, Inc. Processes and intermediates for making sweet taste enhancers
US8609173B2 (en) 2008-07-31 2013-12-17 Senomyx Inc. Compositions comprising sweetness enhancers and methods of making them
WO2010014903A1 (en) 2008-07-31 2010-02-04 Massachusetts Institute Of Technology Multiplexed olfactory receptor-based microsurface plasmon polariton detector
US20120184465A1 (en) * 2009-07-20 2012-07-19 Verdezyne, Inc. Combinatorial methods for optimizing engineered microorganism function
WO2011067202A1 (en) 2009-12-02 2011-06-09 Unilever Nv Improved method for screening a potential modulator compound of a taste receptor
CN106107406B (zh) 2010-08-12 2020-06-09 弗门尼舍公司 提高甜味增强剂的稳定性的方法和包含稳定的甜味增强剂的组合物
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
MX365710B (es) 2011-04-29 2019-06-11 Intercontinental Great Brands Llc Acido encapsulado, metodo para la preparacion del mismo y goma de mascar que comprende el mismo.
US9128079B2 (en) 2011-08-08 2015-09-08 The Coca-Cola Company Methods of using lung or bronchial epithelial cells to identify bitter taste modulators
US9042596B2 (en) 2012-06-14 2015-05-26 Medibotics Llc Willpower watch (TM)—a wearable food consumption monitor
US9456916B2 (en) 2013-03-12 2016-10-04 Medibotics Llc Device for selectively reducing absorption of unhealthy food
US9442100B2 (en) 2013-12-18 2016-09-13 Medibotics Llc Caloric intake measuring system using spectroscopic and 3D imaging analysis
US10314492B2 (en) 2013-05-23 2019-06-11 Medibotics Llc Wearable spectroscopic sensor to measure food consumption based on interaction between light and the human body
US9536449B2 (en) 2013-05-23 2017-01-03 Medibotics Llc Smart watch and food utensil for monitoring food consumption
US9254099B2 (en) 2013-05-23 2016-02-09 Medibotics Llc Smart watch and food-imaging member for monitoring food consumption
KR20200028050A (ko) 2012-08-06 2020-03-13 피르메니히 인코포레이티드 단맛 향미 개질제
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
US9011365B2 (en) 2013-03-12 2015-04-21 Medibotics Llc Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food
US9067070B2 (en) 2013-03-12 2015-06-30 Medibotics Llc Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives
US9529385B2 (en) 2013-05-23 2016-12-27 Medibotics Llc Smart watch and human-to-computer interface for monitoring food consumption
US9826662B2 (en) 2013-12-12 2017-11-21 General Electric Company Reusable phase-change thermal interface structures
US10660571B2 (en) * 2013-12-19 2020-05-26 Kent State University Thermochromic fabrics utilizing cholesteric liquid crystal material
US9936723B2 (en) 2014-02-12 2018-04-10 Senomyx, Inc. Process for the synthesis of substituted 1-benzyl-3-(1-(isoxazol-4-ylmethyl)-1h-pyrazol-4-yl)imidazolidine-2,4-diones
WO2015163905A1 (en) 2014-04-25 2015-10-29 General Mills, Inc. Food products having sweetness enhancer
JP6383704B2 (ja) * 2015-07-02 2018-08-29 日立オートモティブシステムズ株式会社 電池制御装置
JP7453210B2 (ja) 2018-08-07 2024-03-19 フィルメニッヒ インコーポレイテッド 5-置換4-アミノ-1H-ベンゾ[c][1,2,6]チアジアジン2,2-ジオキシド並びにその配合物及び使用
US11783920B2 (en) 2019-02-06 2023-10-10 Tata Consultancy Services Limited System and method for evaluation of at least one potential tastant from a plurality of tastants
WO2021150686A1 (en) 2020-01-22 2021-07-29 Firmenich Incorporated High-sensitivity detection of gpcr activity and uses thereof
KR20230028496A (ko) * 2020-06-25 2023-02-28 마이코테크놀로지, 인코포레이티드 트러플 유래 감미 단백질
CN116554350B (zh) * 2023-04-26 2024-01-09 之江实验室 基于人类甜味受体蛋白的生物传感器及其应用

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US788470A (en) * 1903-06-16 1905-04-25 Edouard Jehn Changing mechanism for picture-exhibitors.
US1733847A (en) * 1927-03-11 1929-10-29 Variety Fire Door Company Door-latch retainer
JPS5825980B2 (ja) 1976-02-12 1983-05-31 ヤマサ醤油株式会社 サイクリックヌクレオチドの定量法
US4391904A (en) 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
US4661768A (en) * 1983-09-14 1987-04-28 Johnson Service Company Capacitance transducing method and apparatus
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
EP1482053A3 (en) 1989-12-22 2007-10-17 Laboratoires Serono SA Eukaryotic host cell line in which an endogenous gene has been activated, and uses thereof
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
EP0466874A1 (fr) 1990-02-09 1992-01-22 Asulab S.A. Micromoteur electrostatique a champ radial realise par microfabrication photolithographique et procede de realisation d'un tel micromoteur
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
AU669107B2 (en) 1991-04-05 1996-05-30 Trustees Of Columbia University In The City Of New York, The Odorant receptors and uses thereof
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
PT101031B (pt) 1991-11-05 2002-07-31 Transkaryotic Therapies Inc Processo para o fornecimento de proteinas por terapia genetica
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US6664107B1 (en) 1993-05-26 2003-12-16 Ontario Cancer Institute, University Health Network CD45 disrupted nucleic acid
US5426039A (en) 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
US6228610B1 (en) * 1993-09-20 2001-05-08 Novartis Corporation Human metabotropic glutamate receptor subtypes (hmR4, hmR6, hmR7) and related DNA compounds
IL108205A0 (en) 1993-12-28 1994-04-12 Yeda Res & Dev Olfactory genes and receptors
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
AU698739B2 (en) 1995-06-06 1998-11-05 Isis Pharmaceuticals, Inc. Oligonucleotides having phosphorothioate linkages of high chiral purity
US5985662A (en) 1995-07-13 1999-11-16 Isis Pharmaceuticals Inc. Antisense inhibition of hepatitis B virus replication
WO1997017444A2 (en) 1995-11-09 1997-05-15 Johns Hopkins University School Of Medicine Novel sperm receptors
US5874243A (en) 1997-03-28 1999-02-23 Smithkline Beecham Corporation OLRCC15 receptor
US5993778A (en) 1997-05-07 1999-11-30 Firestein; Stuart J. Functional expression of, and assay for, functional cellular receptors in vivo
US5940153A (en) * 1998-04-03 1999-08-17 Motorola, Inc. Display assembly having LCD and seal captured between interlocking lens cover and lightpipe
FR2780405B1 (fr) 1998-06-25 2001-12-28 Centre Nat Rech Scient Nouveaux recepteurs olfactifs et leurs utilisations
ATE283912T1 (de) 1998-07-28 2004-12-15 Victoria Ann Heslop Faulanlage
CA2776054C (en) 1998-07-28 2016-08-30 Charles S. Zuker Nucleic acids encoding a g-protein coupled receptor involved in sensory transduction
EP1100893A1 (en) 1998-07-28 2001-05-23 The Regents of the University of California Nucleic acids encoding proteins involved in sensory transduction
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
DE69936453T2 (de) 1998-07-28 2008-03-06 The Regents Of The University Of California, Oakland Für einen g-protein gekoppelten rezeptor, der an der empfindungstransduktion beteiligt ist, kodierende nukleinsäuren
AU5022399A (en) 1998-07-28 2000-02-21 Canadian Inovatech, Inc. Methods and compositions for inhibiting microbial growth in wine
US6106555A (en) 1998-12-15 2000-08-22 Av Healing Llc Method for tissue fixation
ES2337322T3 (es) 1998-12-23 2010-04-22 Mount Sinai School Of Medicine Of New York University Inhibidores de la respuesta al sabor amargo.
US6558910B2 (en) 1999-09-10 2003-05-06 The Regents Of The University Of California SF, a novel family of taste receptors
EP1214343A2 (en) 1999-09-10 2002-06-19 The Regents Of The University Of California T2r taste receptor family
US20030036089A1 (en) 1999-12-20 2003-02-20 Applera Corporation Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof
WO2001064882A2 (en) * 2000-02-29 2001-09-07 Millennium Pharmaceuticals, Inc. 1983, 52881, 2398, 45449, 50289, and 52872, g protein-coupled receptors and uses therefor
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
US6608176B2 (en) 2000-03-31 2003-08-19 University Of Miami Taste receptor for umami (monosodium glutamate) taste
JP2003530098A (ja) 2000-04-07 2003-10-14 セノミックス、インコーポレイテッド T2r味覚受容体及びそれをコードする遺伝子
JP2003531614A (ja) * 2000-04-28 2003-10-28 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 炭水化物化合物および他の甘味物質の感知に関連する遺伝子および配列変異
JP2004513614A (ja) * 2000-06-16 2004-05-13 インサイト・ゲノミックス・インコーポレイテッド Gタンパク質結合受容体
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7301009B2 (en) 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US6955887B2 (en) 2001-03-30 2005-10-18 Senomyx, Inc. Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling
US20080244761A1 (en) 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US7309577B2 (en) 2001-03-07 2007-12-18 Senomyx, Inc. Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
AU2002326315B2 (en) 2001-06-26 2007-07-05 Senomyx, Inc. T1R hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
CA2452716C (en) 2001-07-03 2012-06-26 The Regents Of The University Of California Mammalian sweet and amino acid heterodimeric taste receptors
US7022488B2 (en) * 2003-02-03 2006-04-04 Senomyx, Inc. Functional coupling of T1Rs and T2Rs by Gi proteins, and cells-based assays for the identification of T1R and T2R modulators
US7335487B2 (en) 2001-09-18 2008-02-26 Irm Llc Sweet taste receptors
WO2003040156A1 (fr) * 2001-11-08 2003-05-15 Hokko Chemical Industry Co., Ltd. Procedes de production de triorganomonoalkoxysilanes et de triorganomonochlorosilanes
US7208290B2 (en) 2001-12-14 2007-04-24 Senomyx, Inc. Methods of co-expressing umami taste receptors and chimeric Gα15 variants
US7107837B2 (en) * 2002-01-22 2006-09-19 Baxter International Inc. Capacitance fluid volume measurement
US7441104B2 (en) 2002-03-30 2008-10-21 Hewlett-Packard Development Company, L.P. Parallel subword instructions with distributed results
US20070142748A1 (en) * 2002-04-19 2007-06-21 Ajay Deshmukh Tissue penetration device
US9314194B2 (en) * 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
EP1572960A4 (en) 2002-07-29 2009-03-18 Senomyx Inc IDENTIFICATION OF A NEW BITTER RECEPTOR, T2R76
MXPA06001510A (es) 2003-08-06 2006-09-04 Senomyx Inc Receptores de degustacion hetero-oligomericos t1r, lineas celulares que expresan tales receptores y compuestos de degustacion.
US7906627B2 (en) 2003-08-06 2011-03-15 Senomyx, Inc. Chimeric human sweet-umami and umami-sweet taste receptors
US20050106571A1 (en) 2003-10-02 2005-05-19 The Regents Of The University Of California Mammalian T1R3 sweet taste receptors
WO2005037095A1 (en) * 2003-10-14 2005-04-28 Pelikan Technologies, Inc. Method and apparatus for a variable user interface
EP1737345A1 (en) * 2004-04-15 2007-01-03 Roche Diagnostics GmbH Integrated spot monitoring device with fluid sensor
US20060045953A1 (en) 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
TWI399228B (zh) * 2006-07-21 2013-06-21 Alcon Inc 低黏性的眼科與耳鼻喉科裝置材料(二)
US20080047764A1 (en) * 2006-08-28 2008-02-28 Cypress Semiconductor Corporation Temperature compensation method for capacitive sensors
US20090061456A1 (en) 2007-08-30 2009-03-05 Allard William J Method for predicting progression free and overall survival at each follow-up time point during therapy of metastatic breast cancer patients using circulating tumor cells
US7936111B2 (en) 2008-08-07 2011-05-03 Samsung Electronics Co., Ltd. Apparatus for generating electrical energy and method for manufacturing the same
TWI552751B (zh) 2011-06-20 2016-10-11 H 朗德貝克公司 投予4-((1r,3s)-6-氯-3-苯基-二氫茚-1-基)-1,2,2-三甲基-哌及其鹽用於治療精神分裂症的方法

Also Published As

Publication number Publication date
TW201006846A (en) 2010-02-16
EP1944319B1 (en) 2010-01-27
CN101445800A (zh) 2009-06-03
EP2298802A1 (en) 2011-03-23
US20090233807A1 (en) 2009-09-17
US7842785B2 (en) 2010-11-30
JP2004513608A (ja) 2004-05-13
US7452685B2 (en) 2008-11-18
US20150299293A1 (en) 2015-10-22
US20040171042A1 (en) 2004-09-02
CA2402214A1 (en) 2001-09-13
US20190085051A1 (en) 2019-03-21
WO2001066563A8 (en) 2004-06-24
DE60135229D1 (de) 2008-09-18
US20080233596A1 (en) 2008-09-25
US7834165B2 (en) 2010-11-16
US9637536B2 (en) 2017-05-02
US8263341B2 (en) 2012-09-11
US9040247B2 (en) 2015-05-26
CA2402214C (en) 2013-10-15
DK2298802T3 (da) 2013-01-02
US20130171727A1 (en) 2013-07-04
US20080213880A1 (en) 2008-09-04
US7507544B2 (en) 2009-03-24
US20080026404A1 (en) 2008-01-31
US20040191805A1 (en) 2004-09-30
AU2001240086B9 (en) 2001-09-17
US7223551B2 (en) 2007-05-29
US8247542B2 (en) 2012-08-21
JP5403842B2 (ja) 2014-01-29
US20090053730A1 (en) 2009-02-26
US7799905B2 (en) 2010-09-21
EP1944319A1 (en) 2008-07-16
CN1543474A (zh) 2004-11-03
US20090029455A1 (en) 2009-01-29
US10093718B2 (en) 2018-10-09
US8314224B2 (en) 2012-11-20
US20090093051A1 (en) 2009-04-09
ES2396681T3 (es) 2013-02-25
US7790848B2 (en) 2010-09-07
US20040132075A1 (en) 2004-07-08
US20030008344A1 (en) 2003-01-09
EP1309606A1 (en) 2003-05-14
US7524637B2 (en) 2009-04-28
US10544204B2 (en) 2020-01-28
US8802379B2 (en) 2014-08-12
EP1309606B1 (en) 2008-08-06
AU4008601A (en) 2001-09-17
US7244835B2 (en) 2007-07-17
US8816057B2 (en) 2014-08-26
US20100330590A1 (en) 2010-12-30
ATE456577T1 (de) 2010-02-15
US20110207133A1 (en) 2011-08-25
US20110244563A1 (en) 2011-10-06
US7772385B2 (en) 2010-08-10
ES2311508T3 (es) 2009-02-16
IL151578A0 (en) 2003-04-10
US20110081658A1 (en) 2011-04-07
US20090176657A1 (en) 2009-07-09
US20080038741A1 (en) 2008-02-14
US20090004676A1 (en) 2009-01-01
US7705121B2 (en) 2010-04-27
DK1944319T3 (da) 2010-05-10
US20170313761A1 (en) 2017-11-02
WO2001066563A3 (en) 2004-05-27
CN1766108A (zh) 2006-05-03
NO20024276L (no) 2002-11-06
DE60141237D1 (de) 2010-03-18
US7737254B2 (en) 2010-06-15
ES2338497T3 (es) 2010-05-07
DK1309606T3 (da) 2008-11-24
US20130065235A1 (en) 2013-03-14
EP2298802B1 (en) 2012-10-24
JP2013247957A (ja) 2013-12-12
WO2001066563A2 (en) 2001-09-13
EP1309606A4 (en) 2004-06-09
US7927823B2 (en) 2011-04-19
NO20024276D0 (no) 2002-09-06
HK1139965A1 (en) 2010-09-30
US8815525B2 (en) 2014-08-26
JP5903078B2 (ja) 2016-04-13
AU2001240086B2 (en) 2008-01-03
US20110207212A1 (en) 2011-08-25
DE01914732T1 (de) 2004-04-15
EP2143732B1 (en) 2012-10-03
ATE403669T1 (de) 2008-08-15
EP2143732A1 (en) 2010-01-13
US7847080B2 (en) 2010-12-07
US20040229239A1 (en) 2004-11-18

Similar Documents

Publication Publication Date Title
MXPA02008724A (es) Receptores del gusto t1r y genes que codifican los mismos.
MXPA03005989A (es) Receptores de sabor t1r y genes para su codificacion.
MXPA02009843A (es) Receptores t2r del sabor y genes que codifican para los mismos.
WO2001068805A3 (en) Human olfactory receptors and genes encoding same
WO2003104418A3 (en) RECONSTITUTED POLYPEPTIDES
DK0986361T3 (da) Et nyt kompositmateriale og dets anvendelse
WO1999000137A3 (en) Induction of an activated myeloid dendritic cell phenotype
SI1525320T1 (sl) Postopek za ekspresijo rekombinantnega proteina vCHO celicah
DE60129695D1 (de) Steigerung von durch antikörper-zytokin-fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme
MXPA01006006A (es) Cadena receptora de citocina.
MX2021000421A (es) Métodos y composiciones que usan células dendríticas recombinantes para el tratamiento del cáncer.
ATE290789T1 (de) Verwendungsmethoden von einkernigen phagozyten zur förderung der axonalen regeneration
AU7511101A (en) Use of activity-dependent neurotrophic factor-derived polypeptides for enhancinglearning and memory: pre- and post-natal administration
WO2002010350A1 (fr) Technique de proliferation de cellules tueuses naturelles
DE60238435D1 (de) Gezielte thrombose durch gewebefaktor polypeptiden
WO2004030634A3 (en) Therapeutic compositions
AR006150A1 (es) Proteina de via complementaria natural modificada capaz de formar una convertasa c3 resistente a la regulacion descendente, secuencias de adn quecodifican dicha proteina, usos de dicha proteina y composiciones que la contienen
WO2000044898A3 (en) Novel agouti and agouti-related peptide analogs
WO2005060375A3 (en) Methods of therapy and diagnosis using targeting of cells that express killer cell immunoglobulin-like receptor-like protein
TW200504218A (en) Methods for preventing gluconoylation of proteins
DE60128252D1 (de) Membranfraktionen von mit 1,2-sn-Diacylglycerol angereicherten Zellen
UA36540A (uk) Спосіб проведення кліматооздоровчих процедур з використанням галотерапії та установка для його здійснення

Legal Events

Date Code Title Description
FG Grant or registration