JP2004512514A - 再スポット機能を有する高精度知能型バイオチップアレイヤー - Google Patents

再スポット機能を有する高精度知能型バイオチップアレイヤー Download PDF

Info

Publication number
JP2004512514A
JP2004512514A JP2002537913A JP2002537913A JP2004512514A JP 2004512514 A JP2004512514 A JP 2004512514A JP 2002537913 A JP2002537913 A JP 2002537913A JP 2002537913 A JP2002537913 A JP 2002537913A JP 2004512514 A JP2004512514 A JP 2004512514A
Authority
JP
Japan
Prior art keywords
biochip
substrate
spot
arrayer
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002537913A
Other languages
English (en)
Japanese (ja)
Inventor
パク、フイ・ジェ
キム、ジュン・ファン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DIACHIP Ltd
Original Assignee
DIACHIP Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DIACHIP Ltd filed Critical DIACHIP Ltd
Publication of JP2004512514A publication Critical patent/JP2004512514A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00387Applications using probes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00527Sheets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547Bar codes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547Bar codes
    • B01J2219/005492-dimensional
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547Bar codes
    • B01J2219/005513-dimensional
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00585Parallel processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/0059Sequential processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608DNA chips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • B01J2219/00689Automatic using computers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00693Means for quality control
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00695Synthesis control routines, e.g. using computer programs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00702Processes involving means for analysing and characterising the products
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/0074Biological products
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/025Align devices or objects to ensure defined positions relative to each other
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0819Microarrays; Biochips
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2002537913A 2000-10-23 2000-10-23 再スポット機能を有する高精度知能型バイオチップアレイヤー Pending JP2004512514A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2000/001200 WO2002034944A1 (fr) 2000-10-23 2000-10-23 Agenceur de biopuces de haute precision et intelligent possedant une fonction de respotting

Publications (1)

Publication Number Publication Date
JP2004512514A true JP2004512514A (ja) 2004-04-22

Family

ID=19198291

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002537913A Pending JP2004512514A (ja) 2000-10-23 2000-10-23 再スポット機能を有する高精度知能型バイオチップアレイヤー

Country Status (3)

Country Link
JP (1) JP2004512514A (fr)
AU (1) AU2001210599A1 (fr)
WO (1) WO2002034944A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007088921A1 (fr) 2006-02-02 2007-08-09 Musashi Engineering, Inc. Palette de fixation de pieces a travailler et appareil applicateur de liquide muni de celle-ci
JP2016537998A (ja) * 2013-11-17 2016-12-08 クアンタム−エスアイ インコーポレイテッドQuantum−Si Incorporated 分子をプローブし、検出し、分析するための光学システム及びアッセイ・チップ
CN106226540A (zh) * 2016-08-31 2016-12-14 贵州金玖生物技术有限公司 全自动蛋白质芯片分析仪
WO2018070447A1 (fr) * 2016-10-13 2018-04-19 東京エレクトロン株式会社 Dispositif de liaison de récipient de culture, système de culture et procédé de lavage d'aiguille
KR102078567B1 (ko) * 2018-10-01 2020-02-19 주식회사 이바이오젠 이미지 인식 기술을 적용한 비접촉식 마이크로어레이어
JP2023002641A (ja) * 2012-09-28 2023-01-10 ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー 生体分子解析のための方法、システム、およびアレイ

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7823535B2 (en) 2002-09-27 2010-11-02 Shimadzu Corporation Liquid portioning method and device
DE10327380A1 (de) * 2003-06-18 2005-01-13 Eppendorf Ag System zum Dosieren von Probenflüssigkeit
CN107478476A (zh) * 2017-07-31 2017-12-15 成都博奥晶芯生物科技有限公司 一种碟式芯片点样仪及其使用方法
CN117302942A (zh) * 2022-06-24 2023-12-29 深圳拜尔洛克生物技术有限公司 一种生物芯片移动装置
WO2024182388A1 (fr) * 2023-02-27 2024-09-06 Arizona Board Of Regents On Behalf Of Arizona State University Appareil contenant de multiples dispositifs de dosage microfluidique avec des régions d'échafaudage

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US6188783B1 (en) * 1997-07-25 2001-02-13 Affymetrix, Inc. Method and system for providing a probe array chip design database
US6215894B1 (en) * 1999-02-26 2001-04-10 General Scanning, Incorporated Automatic imaging and analysis of microarray biochips

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007088921A1 (fr) 2006-02-02 2007-08-09 Musashi Engineering, Inc. Palette de fixation de pieces a travailler et appareil applicateur de liquide muni de celle-ci
US8034194B2 (en) 2006-02-02 2011-10-11 Musashi Engineering, Inc. Pallet for fixing work and liquid applying apparatus provided with same
JP2023002641A (ja) * 2012-09-28 2023-01-10 ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー 生体分子解析のための方法、システム、およびアレイ
JP7457770B2 (ja) 2012-09-28 2024-03-28 ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー 生体分子解析のための方法、システム、およびアレイ
JP2016537998A (ja) * 2013-11-17 2016-12-08 クアンタム−エスアイ インコーポレイテッドQuantum−Si Incorporated 分子をプローブし、検出し、分析するための光学システム及びアッセイ・チップ
US10533945B2 (en) 2013-11-17 2020-01-14 Quantum-Si Incorporated Optical system and assay chip for probing, detecting and analyzing molecules
US11287382B2 (en) 2013-11-17 2022-03-29 Quantum-Si Incorporated Optical system and assay chip for probing, detecting and analyzing molecules
CN106226540A (zh) * 2016-08-31 2016-12-14 贵州金玖生物技术有限公司 全自动蛋白质芯片分析仪
WO2018070447A1 (fr) * 2016-10-13 2018-04-19 東京エレクトロン株式会社 Dispositif de liaison de récipient de culture, système de culture et procédé de lavage d'aiguille
JPWO2018070447A1 (ja) * 2016-10-13 2019-07-25 シンフォニアテクノロジー株式会社 培養容器連結装置、培養システムおよびニードルの洗浄方法
US11377631B2 (en) 2016-10-13 2022-07-05 Sinfonia Technology Co., Ltd. Culture container linkage device, culture system, and method for washing needle
KR102078567B1 (ko) * 2018-10-01 2020-02-19 주식회사 이바이오젠 이미지 인식 기술을 적용한 비접촉식 마이크로어레이어

Also Published As

Publication number Publication date
WO2002034944A1 (fr) 2002-05-02
AU2001210599A1 (en) 2002-05-06

Similar Documents

Publication Publication Date Title
CN1137999C (zh) 集成式微阵列装置
EP1246698B1 (fr) Systemes et procedes d'echantillonnage et d'analyse a rendement ultra eleve
JP4028964B2 (ja) バイオチップ及びバイオチップの使用方法
US20050135974A1 (en) Device for preparing multiple assay samples using multiple array surfaces
JP2004510148A (ja) 生体分子アレイを処理するための方法および装置
JP5538726B2 (ja) 表面処理されていない基質にプローブを固定するためのゾル−ゲルバイオチップ用のゾル組成物及びそのスクリーニング方法
WO2001014425A1 (fr) Systemes de diagnostic a fins multiples utilisant des puces a proteines
JP2003107083A (ja) 棒状担体およびこれを具備するシリンダー反応容器
JP2004532983A (ja) 高スループットマイクロアレイスポッティングシステムおよび方法
JP2004512514A (ja) 再スポット機能を有する高精度知能型バイオチップアレイヤー
AU2021211980B2 (en) Methods, tools, and tool assemblies for biomolecular analysis using microarrays
US20040043494A1 (en) Apparatus for studying arrays
US20040265181A1 (en) Method and apparatus for manufacturing beads array chip
US8374818B2 (en) System, method and apparatus for calibrating inspection tools
US20030044320A1 (en) High throughput screening micro array platform
KR20030045123A (ko) 재스팟 기능을 가지는 고정밀 지능형 바이오 칩 어레이어
JP2003232791A (ja) プローブ固相化反応アレイ
JP4262512B2 (ja) プローブ固相化反応アレイ
WO2003091731A1 (fr) Systeme et procede d'analyse multiparametrique de substances a analyser
JP4167431B2 (ja) 生化学的検査用の検査基板
JP2004325329A (ja) 分注方法及び分注装置
WO2021182434A1 (fr) Appareil de fabrication de puce d'analyse, procédé d'exploitation d'appareil de fabrication de puce d'analyse et procédé de fabrication de puce d'analyse
JP2023035963A (ja) 分析チップの製造装置、分析チップの製造装置の作動方法及び分析チップの製造方法
CN115201481A (zh) 一种新型的可视化定位固相蛋白芯片
Dawson et al. Membrane-based microarrays