JP2004510813A5 - - Google Patents
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- Publication number
- JP2004510813A5 JP2004510813A5 JP2002533848A JP2002533848A JP2004510813A5 JP 2004510813 A5 JP2004510813 A5 JP 2004510813A5 JP 2002533848 A JP2002533848 A JP 2002533848A JP 2002533848 A JP2002533848 A JP 2002533848A JP 2004510813 A5 JP2004510813 A5 JP 2004510813A5
- Authority
- JP
- Japan
- Prior art keywords
- azabicyclo
- oct
- ene
- benzothienyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SURHOQQBDZIWSO-UHFFFAOYSA-N 8-azabicyclo[3.2.1]oct-3-ene Chemical class N1C2CCC1C=CC2 SURHOQQBDZIWSO-UHFFFAOYSA-N 0.000 description 2
- -1 2-benzothienyl Chemical group 0.000 description 1
- PPHKDTUWXDGPOO-UHFFFAOYSA-N 3-(1-benzothiophen-2-yl)-8-ethyl-8-azabicyclo[3.2.1]oct-3-ene Chemical compound C1=CC=C2SC(C3=CC4CCC(C3)N4CC)=CC2=C1 PPHKDTUWXDGPOO-UHFFFAOYSA-N 0.000 description 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001535 | 2000-10-13 | ||
| US24214600P | 2000-10-23 | 2000-10-23 | |
| PCT/DK2001/000661 WO2002030405A2 (en) | 2000-10-13 | 2001-10-10 | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008009961A Division JP2008156364A (ja) | 2000-10-13 | 2008-01-21 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004510813A JP2004510813A (ja) | 2004-04-08 |
| JP2004510813A5 true JP2004510813A5 (OSRAM) | 2006-09-28 |
| JP4312456B2 JP4312456B2 (ja) | 2009-08-12 |
Family
ID=26068892
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002533848A Expired - Fee Related JP4312456B2 (ja) | 2000-10-13 | 2001-10-10 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
| JP2008009961A Pending JP2008156364A (ja) | 2000-10-13 | 2008-01-21 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008009961A Pending JP2008156364A (ja) | 2000-10-13 | 2008-01-21 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7307087B2 (OSRAM) |
| EP (2) | EP1358177B1 (OSRAM) |
| JP (2) | JP4312456B2 (OSRAM) |
| CN (1) | CN100398103C (OSRAM) |
| AT (1) | ATE334979T1 (OSRAM) |
| AU (2) | AU9543601A (OSRAM) |
| CA (1) | CA2425638C (OSRAM) |
| DE (1) | DE60122015T2 (OSRAM) |
| DK (1) | DK1358177T3 (OSRAM) |
| ES (1) | ES2269467T3 (OSRAM) |
| MX (1) | MXPA03003264A (OSRAM) |
| NZ (1) | NZ524202A (OSRAM) |
| PT (1) | PT1358177E (OSRAM) |
| WO (1) | WO2002030405A2 (OSRAM) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000064885A1 (en) * | 1999-04-26 | 2000-11-02 | Neurosearch A/S | Heteroaryl diazacycloalkanes, their preparation and use |
| EP1506205B1 (en) * | 2002-05-07 | 2008-07-16 | Neurosearch A/S | Novel azacyclic ethynyl derivatives |
| JP2006504634A (ja) * | 2002-05-15 | 2006-02-09 | アボット・ラボラトリーズ | 神経障害性疼痛の治療 |
| CN102657651A (zh) * | 2002-12-06 | 2012-09-12 | 范因斯坦医学研究院 | 用α 7受体结合胆碱能激动剂抑制炎症 |
| CA2515584A1 (en) * | 2003-02-12 | 2004-08-26 | Neurosearch A/S | 8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US7550485B2 (en) | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
| TW201207390A (en) * | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Method for screening agent for antidepressant activity |
| CA2580855A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| BRPI0515483A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos para o tratamento de doenças mediadas por enzimas estearoil-coa desaturase |
| AU2005286728A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| TW200626155A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| CN101084211A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为治疗剂的用途 |
| WO2006034441A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| JP4958785B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体およびステアロイル−ＣｏＡデサチュラーゼインヒビターとしてのそれらの使用 |
| CA2589106C (en) | 2004-11-02 | 2015-07-21 | Northwestern University | Pyridazine compounds, compositions and methods and their use in treating inflammatory diseases |
| KR20070089170A (ko) | 2004-12-17 | 2007-08-30 | 뉴로서치 에이/에스 | 3-헤테로아릴-8ｈ-8-아자비사이클로(3.2.1)옥트-2-엔의에난티오머 및 모노아민 신경전달물질 재흡수 억제제로서의이의 용도 |
| WO2007130075A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| FR2889847B1 (fr) | 2005-08-18 | 2007-10-05 | Sanofi Aventis Sa | Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique. |
| US8633218B2 (en) * | 2008-11-18 | 2014-01-21 | Aniona Aps | 8-azabicyclo[3.2.1]oct-2-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9501567D0 (sv) | 1995-04-27 | 1995-04-27 | Astra Ab | A new combination |
| HUP9802433A3 (en) | 1995-10-13 | 2000-03-28 | Neurosearch As | 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use |
| DE69811070T2 (de) * | 1997-05-30 | 2003-10-02 | Neurosearch A/S, Ballerup | 9-azabicyclo(3.3.1)non-2-ene und nonanderivate als liganden der nicotinergen rezeptoren |
| DK0984965T3 (da) | 1997-05-30 | 2004-09-27 | Neurosearch As | 8-azabicyclo[3.2.1]oct-2-enderivater som cholinerge ligander ved nikotin-ACh-receptorer |
| US5948807A (en) * | 1997-09-03 | 1999-09-07 | Regents Of The University Of Minnesota | Spiroindanamines and Spiroindanimides |
| ATE278670T1 (de) * | 1997-10-27 | 2004-10-15 | Neurosearch As | Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren |
| JP2002501921A (ja) | 1998-01-28 | 2002-01-22 | ニューロサーチ、アクティーゼルスカブ | 標識された形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体及び標識された及び標識されていない形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体の使用方法 |
| JP2002518331A (ja) | 1998-06-19 | 2002-06-25 | イーライ・リリー・アンド・カンパニー | セロトニン再取り込みの阻害 |
| SE9803155D0 (sv) | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803156D0 (sv) | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803157D0 (sv) | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803732D0 (sv) | 1998-11-02 | 1998-11-02 | Maria Carlsson | Nicotine treatment for obsessive compulsive disorder |
| ATE259804T1 (de) | 1998-11-27 | 2004-03-15 | Neurosearch As | 8-azabicyclo(3.2.1)okt-2-en- und -oktanderivate |
| ATE258176T1 (de) | 1999-01-28 | 2004-02-15 | Neurosearch As | Neue azabicyclo derivate und ihre verwendung |
| FR2788982B1 (fr) * | 1999-02-02 | 2002-08-02 | Synthelabo | Compositions pharmaceutiques contenant de la nicotine et leur application dans le sevrage tabagique |
| WO2000064885A1 (en) * | 1999-04-26 | 2000-11-02 | Neurosearch A/S | Heteroaryl diazacycloalkanes, their preparation and use |
-
2001
- 2001-10-10 MX MXPA03003264A patent/MXPA03003264A/es active IP Right Grant
- 2001-10-10 US US10/380,653 patent/US7307087B2/en not_active Expired - Fee Related
- 2001-10-10 AU AU9543601A patent/AU9543601A/xx active Pending
- 2001-10-10 CA CA2425638A patent/CA2425638C/en not_active Expired - Fee Related
- 2001-10-10 DK DK01976043T patent/DK1358177T3/da active
- 2001-10-10 WO PCT/DK2001/000661 patent/WO2002030405A2/en not_active Ceased
- 2001-10-10 PT PT01976043T patent/PT1358177E/pt unknown
- 2001-10-10 EP EP01976043A patent/EP1358177B1/en not_active Expired - Lifetime
- 2001-10-10 JP JP2002533848A patent/JP4312456B2/ja not_active Expired - Fee Related
- 2001-10-10 NZ NZ524202A patent/NZ524202A/en unknown
- 2001-10-10 AU AU2001295436A patent/AU2001295436B2/en not_active Ceased
- 2001-10-10 ES ES01976043T patent/ES2269467T3/es not_active Expired - Lifetime
- 2001-10-10 EP EP06116505A patent/EP1757600A2/en not_active Withdrawn
- 2001-10-10 DE DE60122015T patent/DE60122015T2/de not_active Expired - Lifetime
- 2001-10-10 CN CNB018168035A patent/CN100398103C/zh not_active Expired - Fee Related
- 2001-10-10 AT AT01976043T patent/ATE334979T1/de active
-
2007
- 2007-07-24 US US11/782,385 patent/US20070265241A1/en not_active Abandoned
-
2008
- 2008-01-21 JP JP2008009961A patent/JP2008156364A/ja active Pending
-
2010
- 2010-05-21 US US12/784,890 patent/US20100267739A1/en not_active Abandoned
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