JP2003519207A5 - - Google Patents
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- JP2003519207A5 JP2003519207A5 JP2001550189A JP2001550189A JP2003519207A5 JP 2003519207 A5 JP2003519207 A5 JP 2003519207A5 JP 2001550189 A JP2001550189 A JP 2001550189A JP 2001550189 A JP2001550189 A JP 2001550189A JP 2003519207 A5 JP2003519207 A5 JP 2003519207A5
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- JP
- Japan
- Prior art keywords
- formula
- compound
- defined above
- enriched
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 150000001875 compounds Chemical class 0.000 description 44
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 19
- 238000000034 method Methods 0.000 description 14
- 150000003839 salts Chemical class 0.000 description 13
- 229910052736 halogen Inorganic materials 0.000 description 6
- 150000002367 halogens Chemical class 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 150000002431 hydrogen Chemical class 0.000 description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- 150000001412 amines Chemical class 0.000 description 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 4
- 150000002440 hydroxy compounds Chemical class 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 3
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 3
- -1 methoxy, hydroxy, hydroxymethyl Chemical group 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000008707 rearrangement Effects 0.000 description 2
- 238000006268 reductive amination reaction Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 description 1
- 229960004045 tolterodine Drugs 0.000 description 1
- BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9904850-6 | 1999-12-30 | ||
| SE9904850A SE9904850D0 (sv) | 1999-12-30 | 1999-12-30 | Novel process and intermediates |
| PCT/SE2000/002662 WO2001049649A1 (en) | 1999-12-30 | 2000-12-22 | Process of preparing tolterodine and analogues there of as well as intermediates prepared in the process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003519207A JP2003519207A (ja) | 2003-06-17 |
| JP2003519207A5 true JP2003519207A5 (OSRAM) | 2007-12-06 |
Family
ID=20418365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001550189A Pending JP2003519207A (ja) | 1999-12-30 | 2000-12-22 | トルテロジンおよびその類似体の調製方法ならびにこの方法で調製される中間体 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6310248B2 (OSRAM) |
| EP (2) | EP1242361B1 (OSRAM) |
| JP (1) | JP2003519207A (OSRAM) |
| KR (1) | KR20020062669A (OSRAM) |
| CN (1) | CN1209342C (OSRAM) |
| AR (1) | AR027138A1 (OSRAM) |
| AT (1) | ATE282019T1 (OSRAM) |
| AU (1) | AU782796B2 (OSRAM) |
| BR (1) | BR0016785A (OSRAM) |
| CA (1) | CA2392832A1 (OSRAM) |
| CZ (1) | CZ20022255A3 (OSRAM) |
| DE (1) | DE60015799T2 (OSRAM) |
| DK (1) | DK1242361T3 (OSRAM) |
| EE (1) | EE200200325A (OSRAM) |
| ES (1) | ES2228658T3 (OSRAM) |
| HU (1) | HUP0203816A3 (OSRAM) |
| IL (1) | IL150275A0 (OSRAM) |
| MX (1) | MXPA02006415A (OSRAM) |
| MY (1) | MY118906A (OSRAM) |
| NO (1) | NO20023189L (OSRAM) |
| NZ (1) | NZ519079A (OSRAM) |
| PE (1) | PE20011123A1 (OSRAM) |
| PL (1) | PL355947A1 (OSRAM) |
| PT (1) | PT1242361E (OSRAM) |
| SE (1) | SE9904850D0 (OSRAM) |
| SK (1) | SK9392002A3 (OSRAM) |
| TW (1) | TWI225476B (OSRAM) |
| WO (1) | WO2001049649A1 (OSRAM) |
| ZA (1) | ZA200204066B (OSRAM) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0957073A1 (en) * | 1998-05-12 | 1999-11-17 | Schwarz Pharma Ag | Novel derivatives of 3,3-diphenylpropylamines |
| WO2003064501A1 (en) * | 2002-01-31 | 2003-08-07 | Clarke Slemon | Conformationally restricted compounds as dendrimer cores |
| US6703504B2 (en) | 2002-02-11 | 2004-03-09 | Clarke Slemon | Conformationally constrained compounds as dendrimer cores |
| EP1424079A1 (en) * | 2002-11-27 | 2004-06-02 | Boehringer Ingelheim International GmbH | Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine |
| DE10315917A1 (de) * | 2003-04-08 | 2004-11-18 | Schwarz Pharma Ag | Hochreine Basen von 3,3-Diphenylpropylaminmonoestern |
| ITMI20031354A1 (it) * | 2003-07-02 | 2005-01-03 | Istituto Di Chimica Biomolecolare D El Cnr Sezione | Sintesis enantioselettiva di composti enantiomericamente arricchiti. |
| ES2235648B1 (es) * | 2003-12-22 | 2006-11-01 | Ragactives, S.L. | Procedimiento para la obtencion de tolterodina. |
| ITMI20040616A1 (it) * | 2004-03-30 | 2004-06-30 | Dinamite Dipharma S P A In For | Processo per la preparazione di tolterodina e suoi intermedi |
| EP1629834A1 (en) | 2004-08-27 | 2006-03-01 | KRKA, D.D., Novo Mesto | Sustained release pharmaceutical composition of tolterodine |
| ITMI20041920A1 (it) * | 2004-10-11 | 2005-01-11 | Chemi Spa | Processo per la preparazione di n, n-diisopropil-3-2-idrossi-5-metilfenil-3-fenil-propabammina |
| JP4513535B2 (ja) * | 2004-12-03 | 2010-07-28 | 住友化学株式会社 | トルテロジンの製造方法 |
| WO2006066931A1 (en) * | 2004-12-24 | 2006-06-29 | Lek Pharmaceuticals D.D. | Process for preparation of 3-(2-hydroxy-5-methylphenyl)-n,n-diisopropyl-3phenylpropylamine |
| US7528267B2 (en) | 2005-08-01 | 2009-05-05 | Girindus America, Inc. | Method for enantioselective hydrogenation of chromenes |
| ES2268987B1 (es) | 2005-08-05 | 2008-02-01 | Ragactives, S.L. | Procedimiento para la obtencion de 3,3-difenilpropilaminas. |
| KR100647068B1 (ko) | 2005-09-15 | 2006-11-23 | 하나제약 주식회사 | 라세믹ｎ,ｎ-디이소프로필-3-(2-히드록시-5-메틸페닐)-3-페닐프로판아민의 제조방법 |
| KR100686351B1 (ko) * | 2006-01-12 | 2007-02-22 | 주식회사 카이로제닉스 | 톨테로딘 라세미체의 제조방법 |
| ATE480531T1 (de) | 2006-05-24 | 2010-09-15 | Pfizer Ltd | Verfahren zur herstellung von benzopyran-2- olderivaten |
| EA018376B1 (ru) | 2006-06-12 | 2013-07-30 | Шварц Фарма Аг | Новые хиральные промежуточные продукты, способ их получения и их применение в производстве толтеродина, фезотеродина или их активных метаболитов |
| KR100717361B1 (ko) * | 2006-08-07 | 2007-05-11 | 주식회사 카이로제닉스 | 톨테로딘 라세미체 및 이의 중간체의 제조방법 |
| EP2175843B1 (en) | 2007-08-08 | 2014-10-08 | Inventia Healthcare Private Limited | Extended release compositions comprising tolterodine |
| EP2334378B1 (en) | 2008-08-19 | 2014-04-09 | XenoPort, Inc. | Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use |
| NZ593676A (en) | 2008-12-24 | 2012-06-29 | Daiichi Sankyo Co Ltd | Calcium-sensing receptor antagonists |
| EP2374794B1 (en) | 2008-12-24 | 2015-11-04 | Daiichi Sankyo Company, Limited | Cyclic amine compounds |
| KR101275984B1 (ko) * | 2010-10-18 | 2013-06-18 | 경기대학교 산학협력단 | 광학활성을 갖는 크로만계 유도체 및 이의 제조방법 |
| WO2012063843A1 (ja) * | 2010-11-09 | 2012-05-18 | 株式会社カネカ | ハロゲン化インデノン類及びそれを用いた光学活性インダノン類又は光学活性インダノール類の製造方法 |
| WO2012098044A1 (en) | 2011-01-17 | 2012-07-26 | Cambrex Profarmaco Milano S.R.L. | Process for the preparation of n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate |
| EP2476665A1 (en) | 2011-01-17 | 2012-07-18 | Cambrex Profarmaco Milano S.r.l. | Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate |
| EA024651B1 (ru) | 2011-06-20 | 2016-10-31 | Х. Лундбекк А/С | Дейтерированные 1-пиперазино-3-фенилинданы, применяемые для лечения шизофрении |
| CN103159657B (zh) * | 2011-12-08 | 2016-06-29 | 重庆华邦胜凯制药有限公司 | 一种定向合成不饱和共轭醇的方法 |
| AR094054A1 (es) * | 2012-12-19 | 2015-07-08 | H Lundbeck As | 6-cloro-3-(fenil-d₅)-inden-1-ona y uso de la misma |
| KR101380982B1 (ko) | 2013-04-29 | 2014-04-10 | 경기대학교 산학협력단 | 광학활성을 갖는 크로만-2-올 유도체 및 이의 제조방법 |
| WO2017137955A1 (en) | 2016-02-14 | 2017-08-17 | Celestis Pharmaceuticals Pvt. Ltd. | Novel (r) and rac 3-(2-(allyloxy)-5-methylphenyl)-n,n-diisopropyl-3- phenylpropan-1-amine and its use for synthesis of (r) and rac-2-(3- (diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol |
| WO2018013739A2 (en) * | 2016-07-12 | 2018-01-18 | Chromocell Corporation | Compounds, compositions, and methods for modulating sweet taste |
| EP3891134A1 (en) | 2018-12-03 | 2021-10-13 | H. Lundbeck A/S | Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8800207D0 (sv) * | 1988-01-22 | 1988-01-22 | Kabivitrum Ab | Nya aminer, deras anvendning och framstellning |
| SE9203318D0 (sv) * | 1992-11-06 | 1992-11-06 | Kabi Pharmacia Ab | Novel 3,3-diphenylpropylamines, their use and preparation |
| ZA969363B (en) | 1995-11-08 | 1997-11-18 | Smithkline Beecham Corp | An improved process for preparing aromatic ring-fused cyclopentane derivatives. |
| KR20000057548A (ko) | 1996-12-13 | 2000-09-25 | 알프레드 엘. 미첼슨 | 광학적 전송물질 및 결합재 |
| EP0957073A1 (en) * | 1998-05-12 | 1999-11-17 | Schwarz Pharma Ag | Novel derivatives of 3,3-diphenylpropylamines |
-
1999
- 1999-12-30 SE SE9904850A patent/SE9904850D0/xx unknown
-
2000
- 2000-12-20 MY MYPI20005976A patent/MY118906A/en unknown
- 2000-12-22 CN CNB008180067A patent/CN1209342C/zh not_active Expired - Fee Related
- 2000-12-22 PL PL00355947A patent/PL355947A1/xx not_active Application Discontinuation
- 2000-12-22 SK SK939-2002A patent/SK9392002A3/sk unknown
- 2000-12-22 ES ES00990151T patent/ES2228658T3/es not_active Expired - Lifetime
- 2000-12-22 BR BR0016785-1A patent/BR0016785A/pt active Search and Examination
- 2000-12-22 PT PT00990151T patent/PT1242361E/pt unknown
- 2000-12-22 WO PCT/SE2000/002662 patent/WO2001049649A1/en not_active Ceased
- 2000-12-22 CZ CZ20022255A patent/CZ20022255A3/cs unknown
- 2000-12-22 JP JP2001550189A patent/JP2003519207A/ja active Pending
- 2000-12-22 EP EP00990151A patent/EP1242361B1/en not_active Expired - Lifetime
- 2000-12-22 MX MXPA02006415A patent/MXPA02006415A/es active IP Right Grant
- 2000-12-22 NZ NZ519079A patent/NZ519079A/en unknown
- 2000-12-22 AT AT00990151T patent/ATE282019T1/de not_active IP Right Cessation
- 2000-12-22 AU AU27190/01A patent/AU782796B2/en not_active Ceased
- 2000-12-22 DK DK00990151T patent/DK1242361T3/da active
- 2000-12-22 KR KR1020027008466A patent/KR20020062669A/ko not_active Withdrawn
- 2000-12-22 IL IL15027500A patent/IL150275A0/xx unknown
- 2000-12-22 EE EEP200200325A patent/EE200200325A/xx unknown
- 2000-12-22 EP EP04014454A patent/EP1496045A3/en not_active Withdrawn
- 2000-12-22 DE DE60015799T patent/DE60015799T2/de not_active Expired - Lifetime
- 2000-12-22 CA CA002392832A patent/CA2392832A1/en not_active Abandoned
- 2000-12-22 US US09/748,042 patent/US6310248B2/en not_active Expired - Fee Related
- 2000-12-22 HU HU0203816A patent/HUP0203816A3/hu unknown
- 2000-12-27 PE PE2000001404A patent/PE20011123A1/es not_active Application Discontinuation
- 2000-12-28 TW TW089128081A patent/TWI225476B/zh active
- 2000-12-28 AR ARP000106999A patent/AR027138A1/es unknown
-
2002
- 2002-05-22 ZA ZA200204066A patent/ZA200204066B/en unknown
- 2002-07-01 NO NO20023189A patent/NO20023189L/no not_active Application Discontinuation