JP2004508399A5 - - Google Patents
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- Publication number
- JP2004508399A5 JP2004508399A5 JP2002526363A JP2002526363A JP2004508399A5 JP 2004508399 A5 JP2004508399 A5 JP 2004508399A5 JP 2002526363 A JP2002526363 A JP 2002526363A JP 2002526363 A JP2002526363 A JP 2002526363A JP 2004508399 A5 JP2004508399 A5 JP 2004508399A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- use according
- salt
- physiologically acceptable
- acceptable derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 8
- 238000011282 treatment Methods 0.000 description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 description 4
- 235000019136 lipoic acid Nutrition 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229960002663 thioctic acid Drugs 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 206010022489 Insulin Resistance Diseases 0.000 description 1
- 206010054805 Macroangiopathy Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 208000033679 diabetic kidney disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10045059A DE10045059A1 (de) | 2000-09-12 | 2000-09-12 | Therapeutische Kombination von Liponsäure und Konjuensäuren zur Behandlung diabetischer Störungen |
| PCT/EP2001/010501 WO2002022111A2 (de) | 2000-09-12 | 2001-09-11 | Kombination von liponsäure und konjuensäuren zur behandlung diabetischer störungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004508399A JP2004508399A (ja) | 2004-03-18 |
| JP2004508399A5 true JP2004508399A5 (enExample) | 2008-07-10 |
Family
ID=7655916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002526363A Pending JP2004508399A (ja) | 2000-09-12 | 2001-09-11 | 糖尿病性疾患の治療のためのリポ酸及び共役酸の組合せ |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20030187058A1 (enExample) |
| EP (1) | EP1317264B1 (enExample) |
| JP (1) | JP2004508399A (enExample) |
| CN (1) | CN1216602C (enExample) |
| AT (1) | ATE271866T1 (enExample) |
| AU (1) | AU2001284057A1 (enExample) |
| DE (2) | DE10045059A1 (enExample) |
| DK (1) | DK1317264T3 (enExample) |
| ES (1) | ES2225593T3 (enExample) |
| WO (1) | WO2002022111A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8647612B2 (en) * | 2008-03-05 | 2014-02-11 | Encore Health, Llc | Dithiol compounds, derivatives, and treatment of presbyopia |
| US7914815B2 (en) * | 2000-08-16 | 2011-03-29 | Encore Health, Llc | Method for delivery of pharmaceuticals for treating or preventing presbyopia |
| US7935332B2 (en) * | 2000-08-16 | 2011-05-03 | Encore Health, Llc | Presbyopia treatment by lens alteration |
| US20050112113A1 (en) * | 2000-08-16 | 2005-05-26 | Till Jonathan S. | Presbyopia treatment by lens alteration |
| US8697109B2 (en) * | 2000-08-16 | 2014-04-15 | Encore Health, Llc | Caged mercaptan and seleno-mercaptan compounds and methods of using them |
| US8147816B2 (en) * | 2000-08-16 | 2012-04-03 | Encore Health, Llc | Presbyopia treatment by lens alteration |
| ES2308056T3 (es) * | 2004-03-06 | 2008-12-01 | Cognis Ip Management Gmbh | Uso de acidos grasos insaturados par ala reduccion del apetito o de la ingesta de alimentos. |
| GB0426264D0 (en) * | 2004-11-30 | 2004-12-29 | Trigen Ltd | Compounds |
| JP4556061B2 (ja) * | 2006-07-27 | 2010-10-06 | ビーエイチエヌ株式会社 | ヒアルロン酸産生増強剤 |
| CN101396357B (zh) * | 2007-09-29 | 2010-12-29 | 中国科学院上海生命科学研究院 | 硫辛酰胺在防治胰岛素抵抗中的用途 |
| US9044439B2 (en) * | 2008-03-05 | 2015-06-02 | Encore Health, Llc | Low dose lipoic and pharmaceutical compositions and methods |
| WO2009111635A2 (en) * | 2008-03-05 | 2009-09-11 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
| EP2821405B1 (en) | 2009-06-15 | 2016-04-13 | Encore Health, LLC | Choline esters for treating presbyopia and cataract |
| EP3069612A3 (en) | 2009-06-15 | 2016-10-19 | Encore Health, LLC | Dithiol compounds, derivatives, and uses therefor |
| CN101671331B (zh) * | 2009-09-29 | 2011-06-01 | 寿光富康制药有限公司 | 硫辛酰维格列汀及其制备方法与应用 |
| JP5245061B2 (ja) * | 2010-05-12 | 2013-07-24 | ビーエイチエヌ株式会社 | 経口用老化防止剤及び美容方法 |
| EP3046566B1 (en) | 2013-09-19 | 2020-12-02 | The Research Foundation for The State University of New York | Methods and materials for treating liver steatosis |
| WO2015050809A1 (en) * | 2013-10-01 | 2015-04-09 | Novozymes A/S | Processes of producing fermentation products |
| AU2015227307A1 (en) | 2014-03-03 | 2016-10-13 | Encore Vision, Inc. | Lipoic acid choline ester compositions and methods of use |
| EP3273972A4 (en) | 2015-03-27 | 2018-10-31 | The Research Foundation for The State University of New York | Methods and materials for reducing amyloid beta levels within a mammal |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4343593C2 (de) * | 1993-12-21 | 1998-05-20 | Asta Medica Ag | Verwendung von R-(+)-alpha-Liponsäure, R-(-)-Dihydroliponsäure oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung kompensierter und dekompensierter Insulinresistenz |
| US5962030A (en) * | 1997-03-07 | 1999-10-05 | Akesis Pharmaceuticals, Inc. | Dietary supplement and method of treatment for diabetic control |
| CA2313626A1 (en) * | 1997-12-12 | 1999-06-17 | Purdue Research Foundation | Methods and compositions for treating diabetes |
| US6440931B1 (en) * | 1999-02-23 | 2002-08-27 | Natural Corporation | Conjugated linoleic acid in treatment and prophylaxis of diabetes |
| US6288106B1 (en) * | 1999-05-25 | 2001-09-11 | Chronorx, Llc | Processes for the synthesis and use of various α-lipoic acid complexes |
| WO2001056572A1 (en) * | 2000-02-02 | 2001-08-09 | Metagenics, Inc. | Compositions and methods for promoting healthy joints |
-
2000
- 2000-09-12 DE DE10045059A patent/DE10045059A1/de not_active Withdrawn
-
2001
- 2001-09-11 DE DE50103029T patent/DE50103029D1/de not_active Expired - Lifetime
- 2001-09-11 JP JP2002526363A patent/JP2004508399A/ja active Pending
- 2001-09-11 DK DK01963002T patent/DK1317264T3/da active
- 2001-09-11 CN CN018155413A patent/CN1216602C/zh not_active Expired - Fee Related
- 2001-09-11 US US10/363,658 patent/US20030187058A1/en not_active Abandoned
- 2001-09-11 ES ES01963002T patent/ES2225593T3/es not_active Expired - Lifetime
- 2001-09-11 EP EP01963002A patent/EP1317264B1/de not_active Expired - Lifetime
- 2001-09-11 AU AU2001284057A patent/AU2001284057A1/en not_active Abandoned
- 2001-09-11 WO PCT/EP2001/010501 patent/WO2002022111A2/de not_active Ceased
- 2001-09-11 AT AT01963002T patent/ATE271866T1/de active
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