JP2004508366A5 - - Google Patents
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- Publication number
- JP2004508366A5 JP2004508366A5 JP2002525134A JP2002525134A JP2004508366A5 JP 2004508366 A5 JP2004508366 A5 JP 2004508366A5 JP 2002525134 A JP2002525134 A JP 2002525134A JP 2002525134 A JP2002525134 A JP 2002525134A JP 2004508366 A5 JP2004508366 A5 JP 2004508366A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydro
- solvate
- salt
- functional derivative
- physiologically functional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- KMHXVUCYJPXSIV-DHDCSXOGSA-N (3z)-3-[[4-(1,2,4-triazol-1-yl)anilino]methylidene]-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C\NC(C=C1)=CC=C1N1C=NC=N1 KMHXVUCYJPXSIV-DHDCSXOGSA-N 0.000 claims 1
- XAHMAJJMFALGCW-ZROIWOOFSA-N (3z)-3-[[4-(1h-1,2,4-triazol-5-yl)anilino]methylidene]-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C\NC(C=C1)=CC=C1C=1N=CNN=1 XAHMAJJMFALGCW-ZROIWOOFSA-N 0.000 claims 1
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 claims 1
- HSHFQBBHYFYCQC-LGMDPLHJSA-N 3-ethyl-3-[4-[[(z)-(2-oxo-1h-indol-3-ylidene)methyl]amino]phenyl]piperidine-2,6-dione Chemical compound C=1C=C(N\C=C/2C3=CC=CC=C3NC\2=O)C=CC=1C1(CC)CCC(=O)NC1=O HSHFQBBHYFYCQC-LGMDPLHJSA-N 0.000 claims 1
- WPAUHINVDSQAEQ-FLIBITNWSA-N 5-[[(z)-(2-oxo-1h-indol-3-ylidene)methyl]amino]-1,3-dihydrobenzimidazol-2-one Chemical compound C1=C2NC(=O)NC2=CC(N/C=C2/C3=CC=CC=C3NC2=O)=C1 WPAUHINVDSQAEQ-FLIBITNWSA-N 0.000 claims 1
- 101150111783 NTRK1 gene Proteins 0.000 claims 1
- JUULZRNMGDKYCG-YFHOEESVSA-N O1C(N)=NN=C1C1=CC=CC(N\C=C/2C3=C4N=NNC4=CC=C3NC\2=O)=C1 Chemical compound O1C(N)=NN=C1C1=CC=CC(N\C=C/2C3=C4N=NNC4=CC=C3NC\2=O)=C1 JUULZRNMGDKYCG-YFHOEESVSA-N 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003226 mitogen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 230000035790 physiological processes and functions Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22996600P | 2000-09-01 | 2000-09-01 | |
| PCT/US2001/026286 WO2002020513A1 (en) | 2000-09-01 | 2001-08-23 | Oxindole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004508366A JP2004508366A (ja) | 2004-03-18 |
| JP2004508366A5 true JP2004508366A5 (https=) | 2005-05-19 |
Family
ID=22863416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002525134A Pending JP2004508366A (ja) | 2000-09-01 | 2001-08-23 | オキシインドール誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US6964977B2 (https=) |
| EP (1) | EP1317446A1 (https=) |
| JP (1) | JP2004508366A (https=) |
| AU (1) | AU8664701A (https=) |
| WO (1) | WO2002020513A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9904933D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US7255860B2 (en) | 2002-10-08 | 2007-08-14 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody |
| ZA200502612B (en) | 2002-10-08 | 2007-07-25 | Rinat Neuroscience Corp | Methods for treating post-surgical pain by administering a nerve crowth factor antagonist and compositions containing the same |
| US7569364B2 (en) | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| CN101014364B (zh) | 2002-12-24 | 2012-01-18 | 里纳特神经系统学公司 | 抗ngf抗体及其使用方法 |
| US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| ATE461264T1 (de) | 2003-06-23 | 2010-04-15 | Shell Int Research | Verfahren zur herstellung eines schmierbaseöls |
| JP5301152B2 (ja) | 2004-04-07 | 2013-09-25 | ライナット ニューロサイエンス コーポレイション | 神経成長因子アンタゴニストを投与することによって骨癌の疼痛を処置するための方法 |
| WO2005118551A2 (en) * | 2004-05-28 | 2005-12-15 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
| JP4728340B2 (ja) * | 2004-10-25 | 2011-07-20 | リガンド・ファーマシューティカルズ・インコーポレイテッド | トロンボポエチン活性を変調する化合物および変調方法 |
| DK1846394T3 (da) | 2005-02-04 | 2012-01-16 | Astrazeneca Ab | Pyrazolylaminopyridinderivater, der er egnede som kinaseinhibitorer |
| PT1853588E (pt) | 2005-02-16 | 2008-08-25 | Astrazeneca Ab | Compostos químicos |
| EP1899323A2 (en) | 2005-05-16 | 2008-03-19 | AstraZeneca AB | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors |
| WO2007049041A1 (en) | 2005-10-28 | 2007-05-03 | Astrazeneca Ab | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer |
| JP5182088B2 (ja) | 2006-04-19 | 2013-04-10 | アステラス製薬株式会社 | アゾールカルボキサミド誘導体 |
| TW200826937A (en) * | 2006-11-01 | 2008-07-01 | Astrazeneca Ab | New use |
| RU2461551C2 (ru) | 2007-10-24 | 2012-09-20 | Астеллас Фарма Инк. | Азолкарбоксамидное соединение или его фармацевтически приемлемая соль |
| EP2292089A1 (en) | 2008-01-11 | 2011-03-09 | Astellas Pharma Inc. | Model animal having both pain in testis or testis-related discomfort actions and frequent urination |
| WO2009135000A2 (en) * | 2008-04-30 | 2009-11-05 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Inhibition of shp2/ptpn11 protein tyrosine phosphatase by nsc-117199 and analogs |
| TWI585088B (zh) | 2012-06-04 | 2017-06-01 | 第一三共股份有限公司 | 作爲激酶抑制劑之咪唑并［１，２－ｂ］嗒衍生物 |
| US9718775B2 (en) * | 2014-03-14 | 2017-08-01 | Milliken & Company | Oxindole compounds and compositions comprising the same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| DE19824922A1 (de) * | 1998-06-04 | 1999-12-09 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6498176B1 (en) * | 1999-03-04 | 2002-12-24 | Smithklinebeecham Corporation | 3-(anilinomethylene) oxindoles as protein tyrosine kinase and protein serine/threonine kinase inhibitors |
| US6624171B1 (en) * | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
| US6492398B1 (en) * | 1999-03-04 | 2002-12-10 | Smithkline Beechman Corporation | Thiazoloindolinone compounds |
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6620818B1 (en) * | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
| ATE343575T1 (de) | 2001-09-27 | 2006-11-15 | Smithkline Beecham Corp | Azaoxoindol derivate als trk protein kinase hemmstoffe zur behandlung von krebs und chronischem schmerz |
-
2001
- 2001-08-23 WO PCT/US2001/026286 patent/WO2002020513A1/en not_active Ceased
- 2001-08-23 AU AU8664701A patent/AU8664701A/xx active Pending
- 2001-08-23 EP EP01966107A patent/EP1317446A1/en not_active Withdrawn
- 2001-08-23 US US10/362,739 patent/US6964977B2/en not_active Expired - Fee Related
- 2001-08-23 JP JP2002525134A patent/JP2004508366A/ja active Pending
-
2005
- 2005-08-03 US US11/196,597 patent/US20050282810A1/en not_active Abandoned
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