JP2004508064A5 - - Google Patents
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- Publication number
- JP2004508064A5 JP2004508064A5 JP2002526335A JP2002526335A JP2004508064A5 JP 2004508064 A5 JP2004508064 A5 JP 2004508064A5 JP 2002526335 A JP2002526335 A JP 2002526335A JP 2002526335 A JP2002526335 A JP 2002526335A JP 2004508064 A5 JP2004508064 A5 JP 2004508064A5
- Authority
- JP
- Japan
- Prior art keywords
- adenovirus
- adenoviral
- adenoviral vector
- vector
- hiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000013598 vector Substances 0.000 claims 89
- 241000701161 unidentified adenovirus Species 0.000 claims 51
- 229960005486 vaccine Drugs 0.000 claims 25
- 238000000034 method Methods 0.000 claims 23
- 230000002950 deficient Effects 0.000 claims 21
- 230000005030 transcription termination Effects 0.000 claims 21
- 230000014509 gene expression Effects 0.000 claims 20
- 230000010076 replication Effects 0.000 claims 20
- 239000002245 particle Substances 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 16
- 102000004169 proteins and genes Human genes 0.000 claims 13
- 229940033330 HIV vaccine Drugs 0.000 claims 12
- 229940021704 adenovirus vaccine Drugs 0.000 claims 10
- 230000004927 fusion Effects 0.000 claims 10
- 238000004806 packaging method and process Methods 0.000 claims 10
- 230000000295 complement effect Effects 0.000 claims 9
- 230000000694 effects Effects 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 108020004414 DNA Proteins 0.000 claims 8
- 230000004048 modification Effects 0.000 claims 8
- 238000012986 modification Methods 0.000 claims 8
- 239000013612 plasmid Substances 0.000 claims 8
- 101710185720 Putative ethidium bromide resistance protein Proteins 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 108010057360 Adenovirus E1 Proteins Proteins 0.000 claims 6
- 241000701022 Cytomegalovirus Species 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 230000008488 polyadenylation Effects 0.000 claims 5
- 230000024932 T cell mediated immunity Effects 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 4
- 108010006025 bovine growth hormone Proteins 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 238000001890 transfection Methods 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 108700026244 Open Reading Frames Proteins 0.000 claims 3
- 108700019146 Transgenes Proteins 0.000 claims 3
- 108010027225 gag-pol Fusion Proteins Proteins 0.000 claims 3
- 108010084873 Human Immunodeficiency Virus nef Gene Products Proteins 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 1
- 101710177291 Gag polyprotein Proteins 0.000 claims 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 claims 1
- 101710125418 Major capsid protein Proteins 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 108010089520 pol Gene Products Proteins 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23318000P | 2000-09-15 | 2000-09-15 | |
| PCT/US2001/028861 WO2002022080A2 (en) | 2000-09-15 | 2001-09-14 | Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol, nef and modifications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004508064A JP2004508064A (ja) | 2004-03-18 |
| JP2004508064A5 true JP2004508064A5 (OSRAM) | 2005-08-04 |
Family
ID=22876220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002526335A Withdrawn JP2004508064A (ja) | 2000-09-15 | 2001-09-14 | コドン最適化ｈｉｖ１−ｇａｇ、ｐｏｌ、ｎｅｆおよび修飾体を発現する増強された第１世代アデノウイルスワクチン |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1320621A4 (OSRAM) |
| JP (1) | JP2004508064A (OSRAM) |
| AU (2) | AU2001294562B2 (OSRAM) |
| CA (1) | CA2422882A1 (OSRAM) |
| WO (1) | WO2002022080A2 (OSRAM) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003516741A (ja) * | 1999-12-17 | 2003-05-20 | メルク エンド カムパニー インコーポレーテッド | コドン最適化ＨＩＶ−１Ｎｅｆ及び修飾ＨＩＶ−１Ｎｅｆを発現するポリヌクレオチドワクチン |
| DK1436397T3 (da) | 2001-10-11 | 2010-08-09 | Merck Sharp & Dohme | Hepatitis C virus vaccine |
| AU2002363189A1 (en) | 2001-10-31 | 2003-05-12 | The South African Medical Research Council | Hiv-1 subtype isolate regulatory/accessory genes, and modifications and derivatives thereof |
| CA2478651A1 (en) * | 2002-03-13 | 2003-09-25 | Merck & Co., Inc. | Method of inducing an enhanced immune response against hiv |
| WO2003085138A1 (en) | 2002-03-29 | 2003-10-16 | Merck & Co., Inc. | Methods of virus production |
| US7326555B2 (en) | 2002-05-14 | 2008-02-05 | Merck & Co., Inc. | Methods of adenovirus purification |
| CN1490056A (zh) * | 2002-10-18 | 2004-04-21 | ��¡���ɵ°��̲��о����� | 针对hiv-1的免疫方法和组合物 |
| US20080153083A1 (en) | 2003-10-23 | 2008-06-26 | Crucell Holland B.V. | Settings for recombinant adenoviral-based vaccines |
| WO2004037294A2 (en) * | 2002-10-23 | 2004-05-06 | Crucell Holland B.V. | New settings for recombinant adenoviral-based vaccines |
| AU2003298361B2 (en) | 2002-12-17 | 2009-05-14 | Crucell Holland B.V. | Recombinant viral-based malaria vaccines |
| US7282365B2 (en) | 2003-01-03 | 2007-10-16 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Rhesus HER2/neu, nucleotides encoding same, and uses thereof |
| RU2397249C2 (ru) | 2003-07-21 | 2010-08-20 | Иституто Ди Ричерке Ди Биолоджиа Молеколаре П Анджелетти Спа | СИНТЕТИЧЕСКАЯ МОЛЕКУЛА НУКЛЕИНОВОЙ КИСЛОТЫ (ВАРИАНТЫ), ЭКСПРЕССИОННЫЙ ВЕКТОР ДЛЯ КЛЕТОК МЛЕКОПИТАЮЩЕГО, КЛЕТКА МЛЕКОПИТАЮЩЕГО ХОЗЯИНА И СПОСОБ ЭКСПРЕССИИ ЧЕЛОВЕЧЕСКОГО БЕЛКА АНТИГЕНА ЭПИДЕРМАЛЬНОГО ФАКТОРА РОСТА-2 (HER2/neu) ИЛИ ЕГО УКОРОЧЕННОЙ ФОРМЫ |
| GB2406336A (en) * | 2003-09-24 | 2005-03-30 | Oxxon Pharmaccines Ltd | HIV Pharmaccines |
| EP1716173B8 (en) | 2004-02-11 | 2012-06-27 | Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. | Carcinoembryonic antigen fusion protein and uses thereof |
| JP2007522814A (ja) | 2004-02-23 | 2007-08-16 | クルセル ホランド ベー ヴェー | ウイルスの精製方法 |
| CN1972958B (zh) * | 2004-04-12 | 2013-01-23 | 美国政府卫生与公共服务部 | 应用腺病毒载体诱导免疫应答的方法 |
| GB0417494D0 (en) | 2004-08-05 | 2004-09-08 | Glaxosmithkline Biolog Sa | Vaccine |
| AU2005293568B2 (en) | 2004-10-13 | 2010-10-28 | Beth Israel Deaconess Medical Center Inc. | Improved adenoviral vectors and uses thereof |
| DK1869171T4 (en) | 2005-04-11 | 2016-01-18 | Crucell Holland Bv | Virus cleaning using ultrafiltration |
| AU2012201827B2 (en) * | 2005-05-12 | 2014-09-04 | Glaxo Group Limited | Vaccine composition |
| CN103088060A (zh) * | 2005-05-12 | 2013-05-08 | 葛兰素集团有限公司 | 疫苗组合物 |
| CA2623531C (en) | 2005-10-07 | 2013-12-10 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Matrix metalloproteinase 11 vaccine |
| LT2137210T (lt) * | 2007-03-02 | 2016-12-27 | Glaxosmithkline Biologicals Sa | Naujas būdas ir kompozicijos |
| US9717788B2 (en) | 2007-03-02 | 2017-08-01 | Glaxosmithkline Biologicals Sa | Method of inducing an immune response against HIV employing HIV immunogens, adenoviral vectors encoding said immunogens, and adjuvant |
| WO2009019612A2 (en) | 2007-08-03 | 2009-02-12 | Institut Pasteur | Lentiviral gene transfer vectors and their medicinal applications |
| EP2047861B1 (en) * | 2007-10-12 | 2019-07-31 | Institut Pasteur | Lentiviral gene transfer vectors suitable for iterative administration and their medicinal applications |
| EP2185195A2 (en) | 2007-08-16 | 2010-05-19 | Tripep Ab | Immunogen platform |
| ES2699685T3 (es) * | 2008-11-18 | 2019-02-12 | Beth Israel Deaconess Medical Ct Inc | Vacunas antivíricas con inmunogenicidad celular mejorada |
| MX343037B (es) | 2011-04-06 | 2016-10-20 | Biovaxim Ltd | Composiciones farmaceuticas para evitar y/o tratar una enfermedad de vih en humanos. |
| DK2825640T3 (en) | 2012-03-12 | 2016-08-01 | Crucell Holland Bv | BATCHES OF RECOMBINANT ADENOVIRUS WITH CHANGED TERMINAL END |
| US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| EP4631509A2 (en) | 2012-11-16 | 2025-10-15 | Beth Israel Deaconess Medical Center, Inc. | Recombinant adenoviruses and use thereof |
| SI3271729T1 (sl) | 2015-03-18 | 2021-04-30 | Janssen Vaccines & Prevention B.V. | Testi za rekombinantne ekspresijske sisteme |
| US10570417B2 (en) | 2015-04-14 | 2020-02-25 | Janssen Vaccines & Prevention B.V. | Recombinant adenovirus expressing two transgenes with a bidirectional promoter |
| AU2017283118B2 (en) | 2016-06-20 | 2019-02-07 | Janssen Vaccines & Prevention B.V. | Potent and balanced bidirectional promoter |
| KR20200083510A (ko) | 2017-10-31 | 2020-07-08 | 얀센 백신스 앤드 프리벤션 비.브이. | 아데노바이러스 및 이의 용도 |
| WO2019086461A1 (en) | 2017-10-31 | 2019-05-09 | Janssen Vaccines & Prevention B.V. | Adenovirus vectors and uses thereof |
| KR20200077559A (ko) | 2017-10-31 | 2020-06-30 | 얀센 백신스 앤드 프리벤션 비.브이. | 아데노바이러스 및 이의 용도 |
| MX2020004488A (es) | 2017-10-31 | 2020-08-13 | Janssen Vaccines & Prevention Bv | Adenovirus y usos de estos. |
| EP3723771A4 (en) | 2017-12-11 | 2022-04-06 | Beth Israel Deaconess Medical Center, Inc. | Recombinant adenoviruses and uses thereof |
| CN111057716B (zh) * | 2019-07-27 | 2022-04-15 | 中国人民解放军军事科学院军事医学研究院 | 用于包装重组人4型腺病毒的单质粒载体系统及其应用 |
| IL291852A (en) | 2019-10-03 | 2022-06-01 | Janssen Vaccines & Prevention Bv | Adenovirus vectors and their use |
| CN112522276B (zh) * | 2020-12-15 | 2022-07-15 | 武汉纽福斯生物科技有限公司 | 一种emc1核苷酸序列及其应用 |
| WO2025242657A1 (en) | 2024-05-21 | 2025-11-27 | Shape Biopharmaceuticals Ag | Lipopeptide building blocks and aggregates |
| CN120158438A (zh) * | 2024-10-14 | 2025-06-17 | 南京诺唯赞生物科技股份有限公司 | Rna聚合酶变体及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643579A (en) * | 1984-11-01 | 1997-07-01 | American Home Products Corporation | Oral vaccines |
| FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| WO1996009399A2 (en) * | 1994-09-23 | 1996-03-28 | Somatix Therapy Corporation | Chimeric adenovirus for gene delivery |
| US5872005A (en) * | 1994-11-03 | 1999-02-16 | Cell Genesys Inc. | Packaging cell lines for adeno-associated viral vectors |
| US6019978A (en) * | 1995-06-05 | 2000-02-01 | The Wistar Institute Of Anatomy And Biology | Replication-defective adenovirus human type 5 recombinant as a vaccine carrier |
| WO1996039178A1 (en) * | 1995-06-05 | 1996-12-12 | The Wistar Institute Of Anatomy And Biology | A replication-defective adenovirus human type 5 recombinant as a vaccine carrier |
| JP2001509375A (ja) * | 1997-07-10 | 2001-07-24 | ヘパヴェック アーゲー フュール ゲンテルアピエ | 最小アデノウイルスベクターを作製するためのクローニングベクター |
| GB9803351D0 (en) * | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| US6670188B1 (en) * | 1998-04-24 | 2003-12-30 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| WO2000015819A1 (en) * | 1998-09-11 | 2000-03-23 | The Children's Medical Center Corporation | Packaging cell lines for hiv-derived retroviral vector particles |
| EP2206785A1 (en) * | 1998-12-31 | 2010-07-14 | Novartis Vaccines and Diagnostics, Inc. | Improved expression of HIV polypeptides and production of virus-like particles |
| GB9906177D0 (en) * | 1999-03-17 | 1999-05-12 | Oxford Biomedica Ltd | Anti-viral vectors |
| GB9912965D0 (en) * | 1999-06-03 | 1999-08-04 | Oxford Biomedica Ltd | In vivo selection method |
| AU779951B2 (en) * | 1999-12-22 | 2005-02-24 | Merck & Co., Inc. | Polynucleotide vaccines expressing codon optimized HIV-1 pol and modified HIV-1 pol |
| DE60026199T2 (de) * | 2000-05-18 | 2006-11-23 | Geneart Ag | Synthetische Gene für gagpol und deren Verwendungen |
| CA2419822C (en) * | 2000-08-14 | 2011-02-08 | Gary J. Nabel | Modifications of hiv env, gag, and pol enhance immunogenicity for genetic immunization |
-
2001
- 2001-09-14 CA CA002422882A patent/CA2422882A1/en not_active Abandoned
- 2001-09-14 JP JP2002526335A patent/JP2004508064A/ja not_active Withdrawn
- 2001-09-14 AU AU2001294562A patent/AU2001294562B2/en not_active Ceased
- 2001-09-14 AU AU9456201A patent/AU9456201A/xx active Pending
- 2001-09-14 WO PCT/US2001/028861 patent/WO2002022080A2/en not_active Ceased
- 2001-09-14 EP EP01975214A patent/EP1320621A4/en not_active Withdrawn
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