JP2004507564A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004507564A5 JP2004507564A5 JP2002525135A JP2002525135A JP2004507564A5 JP 2004507564 A5 JP2004507564 A5 JP 2004507564A5 JP 2002525135 A JP2002525135 A JP 2002525135A JP 2002525135 A JP2002525135 A JP 2002525135A JP 2004507564 A5 JP2004507564 A5 JP 2004507564A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- formula
- compound according
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 47
- 238000000034 method Methods 0.000 description 11
- 125000004429 atom Chemical group 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 102000005348 Neuraminidase Human genes 0.000 description 7
- 108010006232 Neuraminidase Proteins 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 208000036142 Viral infection Diseases 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 6
- 125000005842 heteroatom Chemical group 0.000 description 6
- 229910052717 sulfur Inorganic materials 0.000 description 6
- 230000009385 viral infection Effects 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 5
- 238000010511 deprotection reaction Methods 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229920000962 poly(amidoamine) Polymers 0.000 description 4
- 125000003118 aryl group Chemical group 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 3
- 239000000412 dendrimer Substances 0.000 description 3
- 229920000736 dendritic polymer Polymers 0.000 description 3
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 3
- 125000001072 heteroaryl group Chemical group 0.000 description 3
- 125000000623 heterocyclic group Chemical group 0.000 description 3
- 125000001183 hydrocarbyl group Chemical group 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 208000009620 Orthomyxoviridae Infections Diseases 0.000 description 2
- 239000002202 Polyethylene glycol Chemical group 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 230000002924 anti-infective effect Effects 0.000 description 2
- VTJUKNSKBAOEHE-UHFFFAOYSA-N calixarene Chemical group COC(=O)COC1=C(CC=2C(=C(CC=3C(=C(C4)C=C(C=3)C(C)(C)C)OCC(=O)OC)C=C(C=2)C(C)(C)C)OCC(=O)OC)C=C(C(C)(C)C)C=C1CC1=C(OCC(=O)OC)C4=CC(C(C)(C)C)=C1 VTJUKNSKBAOEHE-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 125000003827 glycol group Chemical group 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine group Chemical group NC(=N)N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- 208000037797 influenza A Diseases 0.000 description 2
- 208000037798 influenza B Diseases 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 229920001223 polyethylene glycol Chemical group 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 125000000547 substituted alkyl group Chemical group 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 description 1
- 229910000684 Cobalt-chrome Inorganic materials 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- NMEZJSDUZQOPFE-UHFFFAOYSA-N Cyclohex-1-enecarboxylic acid Chemical group OC(=O)C1=CCCCC1 NMEZJSDUZQOPFE-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920002873 Polyethylenimine Polymers 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000001298 alcohols Chemical group 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 1
- 229960003805 amantadine Drugs 0.000 description 1
- 150000001409 amidines Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 description 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000010952 cobalt-chrome Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 150000002118 epoxides Chemical class 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 150000002463 imidates Chemical class 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- BQINXKOTJQCISL-GRCPKETISA-N keto-neuraminic acid Chemical compound OC(=O)C(=O)C[C@H](O)[C@@H](N)[C@@H](O)[C@H](O)[C@H](O)CO BQINXKOTJQCISL-GRCPKETISA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- CERZMXAJYMMUDR-UHFFFAOYSA-N neuraminic acid Natural products NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO CERZMXAJYMMUDR-UHFFFAOYSA-N 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920001308 poly(aminoacid) Chemical group 0.000 description 1
- 229920000090 poly(aryl ether) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 229960000329 ribavirin Drugs 0.000 description 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 1
- 229960000888 rimantadine Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
- 125000005629 sialic acid group Chemical group 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR0010 | 2000-09-08 | ||
| AUPR0010A AUPR001000A0 (en) | 2000-09-08 | 2000-09-08 | Novel chemical compounds and their use |
| PCT/AU2001/001128 WO2002020514A1 (en) | 2000-09-08 | 2001-09-07 | Multivalent neuraminidase inhibitor conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004507564A JP2004507564A (ja) | 2004-03-11 |
| JP2004507564A5 true JP2004507564A5 (enExample) | 2008-11-06 |
| JP5095066B2 JP5095066B2 (ja) | 2012-12-12 |
Family
ID=3824061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002525135A Expired - Fee Related JP5095066B2 (ja) | 2000-09-08 | 2001-09-07 | 多価ノイラミニダーゼ阻害物質複合体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7205333B2 (enExample) |
| EP (1) | EP1315719A4 (enExample) |
| JP (1) | JP5095066B2 (enExample) |
| KR (1) | KR20030046406A (enExample) |
| AU (3) | AUPR001000A0 (enExample) |
| BR (1) | BR0113755A (enExample) |
| CA (1) | CA2416336A1 (enExample) |
| MX (1) | MXPA03002022A (enExample) |
| WO (1) | WO2002020514A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002092555A1 (en) * | 2001-05-11 | 2002-11-21 | Sankyo Company, Limited | Sialic acid derivatives |
| ATE399779T1 (de) * | 2001-09-07 | 2008-07-15 | Biota Scient Management | Zwischenprodukte für die herstellung von neuraminidase-inhibitor-konjugaten |
| AUPR879401A0 (en) | 2001-11-09 | 2001-12-06 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
| AUPR879601A0 (en) * | 2001-11-09 | 2001-12-06 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
| DK1451182T3 (da) | 2001-11-09 | 2008-10-27 | Biota Scient Management | Dimere forbindelser og deres anvendelse som antivirale midler |
| AUPR879501A0 (en) | 2001-11-09 | 2001-12-06 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
| AU2002336823B2 (en) * | 2001-11-09 | 2008-03-20 | Biota Scientific Management Pty Ltd | Dimeric compounds and their use as anti-viral agents |
| AU2002340635B2 (en) * | 2001-11-09 | 2008-03-13 | Biota Scientific Management Pty Ltd | Dimeric compounds and their use as anti-viral agents |
| AU2002340632B2 (en) * | 2001-11-09 | 2008-03-20 | Biota Scientific Management Pty Ltd | Dimeric compounds and their use as anti-viral agents |
| AUPR879701A0 (en) | 2001-11-09 | 2001-12-06 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
| EP1697543B1 (en) * | 2003-11-21 | 2014-08-20 | ANP Technologies, Inc. | Asymmetrically branched polymer conjugates and microarray assays |
| EP1808428B1 (en) | 2006-01-16 | 2010-12-22 | Research Institute of Petroleum Industry (RIPI) | Descaling solutions comprising EDDH |
| US7875747B2 (en) * | 2006-10-10 | 2011-01-25 | Afton Chemical Corporation | Branched succinimide dispersant compounds and methods of making the compounds |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| JP2010537997A (ja) * | 2007-08-27 | 2010-12-09 | マサチューセッツ インスティテュート オブ テクノロジー | 二機能性ポリマーに結合させたインフルエンザウイルス阻害剤 |
| EP2296711A2 (en) * | 2008-05-29 | 2011-03-23 | MDRNA, Inc. | Multi-arm amines and uses thereof |
| US8680020B2 (en) | 2008-07-15 | 2014-03-25 | Academia Sinica | Glycan arrays on PTFE-like aluminum coated glass slides and related methods |
| JP2012532894A (ja) * | 2009-07-16 | 2012-12-20 | グリフィス ユニバーシティ | 抗インフルエンザ薬 |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10338069B2 (en) | 2010-04-12 | 2019-07-02 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| EP2885311B1 (en) | 2012-08-18 | 2020-01-01 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| EP3013365B1 (en) | 2013-06-26 | 2019-06-05 | Academia Sinica | Rm2 antigens and use thereof |
| US9981030B2 (en) | 2013-06-27 | 2018-05-29 | Academia Sinica | Glycan conjugates and use thereof |
| KR102298172B1 (ko) | 2013-09-06 | 2021-09-06 | 아카데미아 시니카 | 변화된 글리코실 그룹을 갖는 당지질을 사용한 인간 iNKT 세포 활성화 |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| KR20160104727A (ko) | 2014-01-16 | 2016-09-05 | 아카데미아 시니카 | 암의 치료 및 검출을 위한 조성물 및 방법 |
| CN103819665B (zh) * | 2014-02-27 | 2015-10-28 | 中国科学院微生物研究所 | 四价扎那米韦及其制备方法与应用 |
| TWI797430B (zh) | 2014-03-27 | 2023-04-01 | 中央研究院 | 反應性標記化合物及其用途 |
| KR20240096599A (ko) | 2014-05-27 | 2024-06-26 | 아카데미아 시니카 | 항-ｃｄ20 글리코항체 및 이의 용도 |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| AU2015267052A1 (en) | 2014-05-27 | 2016-12-15 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| US10005847B2 (en) | 2014-05-27 | 2018-06-26 | Academia Sinica | Anti-HER2 glycoantibodies and uses thereof |
| JP7063538B2 (ja) | 2014-05-28 | 2022-05-09 | アカデミア シニカ | 抗ＴＮＦα糖操作抗体群およびその使用 |
| CN107001404B (zh) | 2014-09-08 | 2021-06-29 | 中央研究院 | 使用醣脂激活人类iNKT细胞 |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| TWI736523B (zh) | 2015-01-24 | 2021-08-21 | 中央研究院 | 新穎聚醣結合物及其使用方法 |
| EP3377487B1 (en) * | 2015-11-20 | 2022-01-12 | AusVir Therapeutics Pty Ltd | Compounds for medicinal applications |
| CA3016170A1 (en) | 2016-03-08 | 2017-09-14 | Academia Sinica | Methods for modular synthesis of n-glycans and arrays thereof |
| AU2017316663B2 (en) | 2016-08-22 | 2024-02-22 | CHO Pharma Inc. | Antibodies, binding fragments, and methods of use |
| TWI861205B (zh) * | 2019-09-06 | 2024-11-11 | 美商席達拉醫療有限公司 | 用於治療病毒感染之組合物及方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP249A (en) | 1990-04-24 | 1993-03-17 | Biota Scient Management Pty Ltd | Anti-viral compounds. |
| GB9400206D0 (en) | 1994-01-07 | 1994-03-02 | Glaxo Group Ltd | Chemical compound |
| AUPM354694A0 (en) | 1994-01-27 | 1994-02-17 | Biota Scientific Management Pty Ltd | Chemical compounds |
| AUPM623994A0 (en) * | 1994-06-15 | 1994-07-07 | Biomolecular Research Institute Limited | Antiviral dendrimers |
| SI9620042A (sl) | 1995-02-27 | 1998-12-31 | Gilead Sciences, Inc. | Novi selektivni inhibitorji virusnih ali bakterijskih neuraminidaz |
| GB9516276D0 (en) | 1995-08-08 | 1995-10-11 | Biota Scient Management | Chemical compounds |
| US6242582B1 (en) * | 1996-03-01 | 2001-06-05 | Biota Scientific Management Pty Ltd. | Method of detection of influenza virus and compounds for use therein |
| EP0889041B1 (en) * | 1996-03-06 | 2002-07-24 | TSUMURA & CO. | Novel iridoid derivatives and neovascularization inhibitors containing the same as active ingredient |
| ES2263179T3 (es) | 1996-06-14 | 2006-12-01 | Biocryst Pharmaceuticals Inc. | Compuestos de clopentano sustituido como inhibidores de la neuraminidasa. |
| AUPO104396A0 (en) | 1996-07-17 | 1996-08-08 | Biomolecular Research Institute Limited | Antiviral linear polymers |
| PT823428E (pt) | 1996-07-22 | 2002-04-29 | Sankyo Co | Derivados do acido neuraminico sua preparacao e sua utilizacao em medicina |
| PT934939E (pt) | 1996-08-13 | 2003-07-31 | Sankyo Co | Compostos de acido neuraminico |
| TR199901081T2 (xx) * | 1996-11-14 | 1999-08-23 | Biota Scientific Management Pty.Ltd. | Y�ntem ve bu y�ntemde kullan�lan yeni bile�imler. |
| BR9813480A (pt) | 1997-12-17 | 2000-10-10 | Biocryst Pharm Inc | Compostos inibidores de neuraminidase de ciclopentano substituìdo, composição e métodos de inibição da neuraminidase do vìrus da influenza- e de tratamento de infecção por vìrus da influenza- |
| AUPP913999A0 (en) | 1999-03-12 | 1999-04-01 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
-
2000
- 2000-09-08 AU AUPR0010A patent/AUPR001000A0/en not_active Abandoned
-
2001
- 2001-09-07 MX MXPA03002022A patent/MXPA03002022A/es active IP Right Grant
- 2001-09-07 CA CA002416336A patent/CA2416336A1/en not_active Abandoned
- 2001-09-07 WO PCT/AU2001/001128 patent/WO2002020514A1/en not_active Ceased
- 2001-09-07 AU AU2001285601A patent/AU2001285601B2/en not_active Ceased
- 2001-09-07 JP JP2002525135A patent/JP5095066B2/ja not_active Expired - Fee Related
- 2001-09-07 EP EP01964755A patent/EP1315719A4/en not_active Withdrawn
- 2001-09-07 AU AU8560101A patent/AU8560101A/xx active Pending
- 2001-09-07 BR BR0113755-7A patent/BR0113755A/pt not_active IP Right Cessation
- 2001-09-07 US US10/363,988 patent/US7205333B2/en not_active Expired - Fee Related
- 2001-09-07 KR KR10-2003-7001793A patent/KR20030046406A/ko not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004507564A5 (enExample) | ||
| JP5160000B2 (ja) | 二量体化合物およびニューラミニダーゼ阻害剤として | |
| JP5095066B2 (ja) | 多価ノイラミニダーゼ阻害物質複合体 | |
| JP2002539204A5 (enExample) | ||
| CN101715343B (zh) | 流感治疗药 | |
| AU2014237232B9 (en) | Amine functional polyamides | |
| US8323669B2 (en) | Polymer conjugate of taxane | |
| JP2018172387A5 (enExample) | ||
| US20240285598A1 (en) | Compounds for the treatment of sars | |
| JP2012502904A5 (enExample) | ||
| US20230159516A1 (en) | Compounds for the treatment of sars | |
| JP2010285436A (ja) | 二量体化合物および抗ウイルス薬としてのそれらの使用 | |
| JP2021506915A (ja) | 最適化化合物 | |
| AU2007324044A1 (en) | Biphosphonate inhalant formulations and methods for using the same | |
| CA2462337A1 (en) | Dimeric compounds and their use as anti-viral agents | |
| US20110112130A1 (en) | Opioid-Nornicotine Codrugs Combinations for Pain Management | |
| US20230263900A1 (en) | Dendrimer-drug conjugate | |
| JPH09249560A (ja) | 抗ウイルス剤と抗菌剤 | |
| JP5327839B2 (ja) | シアル酸誘導体の製造方法とインフルエンザウィルス阻害剤としての利用 | |
| JP6073202B2 (ja) | 静脈におけるウイルスの治療 | |
| CA2462345A1 (en) | Dimeric compounds and their use as anti-viral agents | |
| EP3450427A1 (en) | Cyclohexene derivative or pharmaceutically acceptable salt thereof, and application of same | |
| CN117024479A (zh) | 一种聚乙二醇化磷酸前药及其制备与应用 | |
| CA2463865A1 (en) | Dimeric compounds and their use as anti-viral agents | |
| JP2011016804A5 (enExample) |