JP2004506018A5 - - Google Patents

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Publication number
JP2004506018A5
JP2004506018A5 JP2002518994A JP2002518994A JP2004506018A5 JP 2004506018 A5 JP2004506018 A5 JP 2004506018A5 JP 2002518994 A JP2002518994 A JP 2002518994A JP 2002518994 A JP2002518994 A JP 2002518994A JP 2004506018 A5 JP2004506018 A5 JP 2004506018A5
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JP
Japan
Prior art keywords
nucleic acid
seq
purified
immunogenic composition
sequence
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002518994A
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English (en)
Japanese (ja)
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JP2004506018A (ja
JP5175417B2 (ja
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Priority claimed from PCT/IB2001/001808 external-priority patent/WO2002013855A2/en
Publication of JP2004506018A publication Critical patent/JP2004506018A/ja
Publication of JP2004506018A5 publication Critical patent/JP2004506018A5/ja
Application granted granted Critical
Publication of JP5175417B2 publication Critical patent/JP5175417B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2002518994A 2000-08-17 2001-08-15 リバビリンを含むワクチンおよびその使用方法 Expired - Fee Related JP5175417B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US22576700P 2000-08-17 2000-08-17
US60/225,767 2000-08-17
US22917500P 2000-08-29 2000-08-29
US60/229,175 2000-08-29
US70554700A 2000-11-03 2000-11-03
US09/705,547 2000-11-03
PCT/IB2001/001808 WO2002013855A2 (en) 2000-08-17 2001-08-15 Vaccines containing ribavirin and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2004506018A JP2004506018A (ja) 2004-02-26
JP2004506018A5 true JP2004506018A5 (cg-RX-API-DMAC7.html) 2008-10-02
JP5175417B2 JP5175417B2 (ja) 2013-04-03

Family

ID=27397520

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002518994A Expired - Fee Related JP5175417B2 (ja) 2000-08-17 2001-08-15 リバビリンを含むワクチンおよびその使用方法

Country Status (12)

Country Link
US (1) US6960569B2 (cg-RX-API-DMAC7.html)
EP (3) EP1947185B1 (cg-RX-API-DMAC7.html)
JP (1) JP5175417B2 (cg-RX-API-DMAC7.html)
KR (2) KR100801123B1 (cg-RX-API-DMAC7.html)
CN (1) CN100400101C (cg-RX-API-DMAC7.html)
AT (2) ATE517184T1 (cg-RX-API-DMAC7.html)
AU (4) AU9215101A (cg-RX-API-DMAC7.html)
CA (1) CA2419418A1 (cg-RX-API-DMAC7.html)
DE (1) DE60130998T2 (cg-RX-API-DMAC7.html)
ES (1) ES2296803T3 (cg-RX-API-DMAC7.html)
PL (1) PL360990A1 (cg-RX-API-DMAC7.html)
WO (2) WO2002013855A2 (cg-RX-API-DMAC7.html)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100400101C (zh) * 2000-08-17 2008-07-09 特里帕普股份公司 包含病毒唑的疫苗及其使用方法
US7022830B2 (en) * 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US6680059B2 (en) * 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
RU2286172C2 (ru) 2000-08-17 2006-10-27 Трипеп Аб Вакцины, содержащие рибавирин, и способы их использования
AU2002312487A1 (en) * 2001-06-15 2003-01-02 Ribapharm Nucleoside vaccine adjuvants
JP2005537032A (ja) * 2002-08-27 2005-12-08 コンパウンド セラピューティクス インコーポレーティッド アドザイムおよびその用途
WO2004048403A2 (en) * 2002-11-26 2004-06-10 Tripep Ab Hepatisis c virus nonstructural protein 4a (ns4a) is an enhancer element
US7419912B2 (en) 2004-04-01 2008-09-02 Cree, Inc. Laser patterning of light emitting devices
EP1591539B1 (en) * 2004-04-29 2007-10-03 F. Hoffmann-La Roche Ag NS5A nucleoside sequence variation as a marker
AU2012200012B8 (en) * 2004-09-29 2014-05-01 The Administrators Of The Tulane Educational Fund Inhibitors of hepatitis C virus
PL1797112T3 (pl) * 2004-09-29 2011-04-29 The Administrators Of The Tulane Educational Fund Inhibitory wirusa zapalenia wątroby typu C
CA2618429A1 (en) * 2005-05-25 2007-03-22 Tripep Ab A hepatitis c virus non-structural ns3/4a fusion gene
WO2008004992A2 (en) * 2005-05-25 2008-01-10 Tripep Ab Transdermal formulations containing hepatitis c virus immunogens and an ethoxylated oil
SI1949913T1 (sl) * 2005-10-07 2011-02-28 Proyecto Biomedicina Cima Sl Imunsko stimulacijska kombinacija za zaĺ äśito in zdravljenje hepatitisa c
ES2334472B1 (es) * 2006-06-09 2011-01-21 Proyecto De Biomedicina Cima, S.L. Combinacion inmunoestimuladora para profilaxis y tratamiento de hepatitis c.
WO2009022236A2 (en) 2007-08-16 2009-02-19 Tripep Ab Immunogen platform
WO2009079834A1 (en) * 2007-12-18 2009-07-02 Peking University People's Hospital An anti-hcv vaccine and preparation methods and uses thereof
WO2009130588A2 (en) * 2008-04-22 2009-10-29 Tripep Ab Immunogen platform
CN108148121B (zh) * 2018-03-06 2021-07-09 中美赛尔生物科技(广东)有限公司 丙型肝炎病毒抗原多肽组合物以及丙型肝炎病毒疫苗

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2933693A (en) 1957-05-03 1960-04-19 Lyle R Battersby Sensitivity control circuit
US4215051A (en) 1979-08-29 1980-07-29 Standard Oil Company (Indiana) Formation, purification and recovery of phthalic anhydride
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4818540A (en) 1985-02-25 1989-04-04 Rutgers, The State University Of New Jersey Transdermal fertility control system and process
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5643565A (en) * 1985-09-20 1997-07-01 Chiron Corporation Human IL-2 as a vaccine adjuvant
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US6171782B1 (en) * 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
US5679342A (en) * 1987-11-18 1997-10-21 Chiron Corporation Hepatitis C virus infected cell systems
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US5683864A (en) * 1987-11-18 1997-11-04 Chiron Corporation Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
US5698390A (en) * 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US5714596A (en) * 1987-11-18 1998-02-03 Chiron Corporation NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
DE318216T1 (de) 1987-11-18 1990-06-13 Chiron Corp., Emeryville, Calif. Nanbv-diagnostika und vakzine.
US5712088A (en) * 1987-11-18 1998-01-27 Chiron Corporation Methods for detecting Hepatitis C virus using polynucleotides specific for same
US5968775A (en) * 1987-11-18 1999-10-19 Chiron Corporation Hepatitis C virus infected cell systems
US4950647A (en) * 1988-10-04 1990-08-21 Nucleic Acid Research Institute T cell immunopotentiator
HU225068B1 (en) 1989-03-17 2006-05-29 Chiron Corp Process for producing diagnostics and vaccine of nanbh
US5703055A (en) * 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US6027729A (en) * 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
HUT59964A (en) 1989-05-18 1992-07-28 Chiron Corp Process for producing new nanbv diagnostica for determining hepatitis c virus
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
ES2110411T3 (es) 1989-08-25 1998-02-16 Chiron Corp Metodos para cultivar el virus de la hepatitis c (hcv) en lineas celulares de linfocitos b o t.
WO1991004262A1 (en) * 1989-09-15 1991-04-04 National Institute Of Health Of Japan New hcv isolates
US5372928A (en) * 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
US6194140B1 (en) * 1990-04-04 2001-02-27 Chiron Corporation HCV NS3 protein fragments having helicase activity and improved solubility
RO109916B1 (ro) 1990-04-04 1995-07-28 Chiron Corp Compozitie de antigeni ai hepatitei virale c
CA2079105C (en) * 1990-04-04 2000-06-13 Michael Houghton Hepatitis c virus protease
US5712087A (en) * 1990-04-04 1998-01-27 Chiron Corporation Immunoassays for anti-HCV antibodies employing combinations of hepatitis C virus (HCV) antigens
WO1992002642A1 (en) 1990-08-10 1992-02-20 Chiron Corporation Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus
CA2027434C (en) 1990-10-12 1999-01-05 George Jackowski Diagnostic kit for diagnosing and distinguishing chest pain in early onset thereof
US5604105B1 (en) 1990-10-12 1999-08-24 Spectral Diagnostics Inc Method and device for diagnosingand distinguishing chest pain in early onset thereof
US5710008B1 (en) 1990-10-12 1999-09-07 Spectral Diagnostics Inc Method and device for diagnosing and distinguishing chest pain in early onset thereof
DE69131882T3 (de) 1990-11-08 2007-05-24 Novartis Vaccines and Diagnostics, Inc., Emeryville Asiloglycoproteine des hepatitis c-virus
US6274148B1 (en) * 1990-11-08 2001-08-14 Chiron Corporation Hepatitis C virus asialoglycoproteins
JPH06504997A (ja) 1990-12-06 1994-06-09 アフィメトリックス, インコーポレイテッド 非常に大きい規模の固定化されたポリマーの合成
US6190864B1 (en) * 1991-05-08 2001-02-20 Chiron Corporation HCV genomic sequences for diagnostics and therapeutics
PL170151B1 (pl) 1991-05-08 1996-10-31 Chiron Corp Sposób wykrywania jednego lub wiecej genotypów wirusa zapalenia watroby C PL PL PL
FR2677372B1 (fr) * 1991-06-06 1994-11-10 Pasteur Institut Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques.
ATE229543T1 (de) 1991-06-24 2002-12-15 Chiron Corp Polypeptide des hepatitis c-virus (hiv)
RU2136311C1 (ru) * 1991-09-13 1999-09-10 Чирон Корпорейшн Иммуногенная полипептидная композиция, способ получения композиции, способ продуцирования и способ обнаружения антител, набор
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5795714A (en) 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
DE4239311C2 (de) 1992-11-23 1996-04-18 Guehring Joerg Dr Bohrer, insbesondere Spitzbohrwerkzeug mit austauschbarem Schneideinsatz
CA2153593C (en) 1993-01-26 2010-04-13 David B. Weiner Compositions and methods for delivery of genetic material
CA2662090A1 (en) * 1993-04-27 1994-11-10 N.V. Innogenetics S.A. New sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents
JPH09507121A (ja) 1993-10-26 1997-07-22 アフィマックス テクノロジーズ ナームロゼ ベノートスハップ 生物学的チップ上の核酸プローブアレー
EP0789590B1 (en) 1994-09-23 2002-09-04 Zonagen, Inc. Chitosan induced immunopotentiation
US6235888B1 (en) * 1994-10-05 2001-05-22 The General Hospital Corporation Hepatitis C virus vaccine
EP1076092A3 (en) * 1994-10-21 2001-03-28 Innogenetics N.V. Sequences of hepatitis C virus type10 and their use as prophylactic, therapeutic and diagnostic agents
FR2730935A1 (fr) 1994-12-21 1996-08-30 Vacsyn Sa Vaccin presentant une immunogenicite accrue
US5932556A (en) * 1995-09-17 1999-08-03 Tam; Robert C Methods and compositions for regulation of CD28 expression
WO1996028162A1 (en) 1995-03-14 1996-09-19 University Of Medicine & Dentistry Of New Jersey New drug combination for the treatment of viral diseases
US5767097A (en) * 1996-01-23 1998-06-16 Icn Pharmaceuticals, Inc. Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes
CA2246162C (en) 1996-01-23 2000-04-04 Icn Pharmaceuticals, Inc. Modulation of th1/th2 cytokine expression by ribavirin.rtm. and ribavirin.rtm. analogs in activated t-lymphocytes
US6150337A (en) * 1996-01-23 2000-11-21 Icn Pharmaceuticals, Inc. Specific modulation of Th1/Th2 cytokine expression by Ribavirin in activated T-lymphocytes
JP2000504575A (ja) 1996-02-08 2000-04-18 アフィメトリックス,インコーポレイテッド 微生物のチップベースの種分化および表現型特徴付け
EP1958955B1 (en) 1996-02-09 2013-09-04 Cornell Research Foundation, Inc. Spatially addressable oligonucleotide arrays and method of making the same
US6514731B1 (en) * 1996-05-24 2003-02-04 Chiron Corporation Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
AU717542B2 (en) * 1996-06-11 2000-03-30 Merck & Co., Inc. Synthetic hepatitis C genes
WO1998012332A1 (en) * 1996-09-17 1998-03-26 Chiron Corporation Compositions and methods for treating intracellular diseases
SI20076A (sl) * 1996-10-16 2000-04-30 Icn Pharmaceuticals, Inc. Monociklični L-nukleozidi, analogi in uporaba od teh
CZ126799A3 (cs) 1996-10-16 1999-07-14 Icn Pharmaceuticals Purinové L-nukleosidy a jejich analogy a farmaceutické prostředky, které je obsahují
IL119833A (en) 1996-12-15 2001-01-11 Lavie David Hypericum perforatum extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis
IL130497A0 (en) 1997-01-17 2000-06-01 Icn Pharmaceuticals Controlled release preparations to selectively modulate Th1 and Th2 responses
IL131131A0 (en) 1997-02-07 2001-01-28 Merck & Co Inc Synthetic hiv gag genes
WO1998037180A2 (en) 1997-02-22 1998-08-27 Abbott Laboratories Hcv fusion protease and polynucleotide encoding same
US6153421A (en) * 1997-07-18 2000-11-28 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Cloned genomes of infectious hepatitis C viruses and uses thereof
US6211338B1 (en) * 1997-11-28 2001-04-03 Schering Corporation Single-chain recombinant complexes of hepatitis C virus NS3 protease and NS4A cofactor peptide
US6541011B2 (en) 1998-02-11 2003-04-01 Maxygen, Inc. Antigen library immunization
WO1999054735A1 (en) * 1998-04-17 1999-10-28 Innogenetics N.V. Improved immunodiagnostic assays using reducing agents
GB9820525D0 (en) * 1998-09-21 1998-11-11 Allergy Therapeutics Ltd Formulation
US20020187945A1 (en) * 1999-01-29 2002-12-12 Robert Tam Modulation of immune response by ribavirin
RU2211698C2 (ru) 1999-01-29 2003-09-10 Ай-Си-Эн Фармасьютикалз, Инк. Модуляция иммунного ответа с помощью рибавирина
JP2003516732A (ja) * 1999-11-24 2003-05-20 カイロン コーポレイション 新規なhcv非構造ポリペプチド
ES2277932T5 (es) 2000-06-15 2010-06-28 Novartis Vaccines And Diagnostics, Inc. Ensayo de combinacion de antigeno/anticuerpo del vhc.
CN100400101C (zh) 2000-08-17 2008-07-09 特里帕普股份公司 包含病毒唑的疫苗及其使用方法
ATE467680T1 (de) 2001-10-11 2010-05-15 Merck Sharp & Dohme Hepatitis-c-virus-impfstoff
KR20140137679A (ko) 2013-05-23 2014-12-03 삼성전자주식회사 카드 소켓 장치
WO2021029686A1 (ko) 2019-08-14 2021-02-18 삼성전자 주식회사 무선 통신 시스템에서 rrm 측정을 수행하는 방법 및 단말

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