JP2004504826A5 - - Google Patents
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- JP2004504826A5 JP2004504826A5 JP2002515196A JP2002515196A JP2004504826A5 JP 2004504826 A5 JP2004504826 A5 JP 2004504826A5 JP 2002515196 A JP2002515196 A JP 2002515196A JP 2002515196 A JP2002515196 A JP 2002515196A JP 2004504826 A5 JP2004504826 A5 JP 2004504826A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- peptide
- acid residues
- promyostatin polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/628,112 US7566768B1 (en) | 1995-10-26 | 2000-07-27 | Promyostatin peptides and methods of using same |
| US09/628,112 | 2000-07-27 | ||
| PCT/US2001/023510 WO2002009641A2 (en) | 2000-07-27 | 2001-07-26 | Promyostatin peptides and methods of using same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004504826A JP2004504826A (ja) | 2004-02-19 |
| JP2004504826A5 true JP2004504826A5 (enExample) | 2008-09-11 |
| JP5149478B2 JP5149478B2 (ja) | 2013-02-20 |
Family
ID=24517522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002515196A Expired - Fee Related JP5149478B2 (ja) | 2000-07-27 | 2001-07-26 | プロミオスタチンペプチドおよびその使用法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7393682B1 (enExample) |
| EP (2) | EP1303534A4 (enExample) |
| JP (1) | JP5149478B2 (enExample) |
| CN (2) | CN101261277B (enExample) |
| AR (1) | AR030307A1 (enExample) |
| AU (2) | AU8079901A (enExample) |
| BR (1) | BRPI0112785B1 (enExample) |
| CA (1) | CA2416260A1 (enExample) |
| IL (2) | IL153970A0 (enExample) |
| MX (1) | MXPA03000786A (enExample) |
| NZ (2) | NZ542696A (enExample) |
| PL (1) | PL210158B1 (enExample) |
| WO (1) | WO2002009641A2 (enExample) |
| ZA (1) | ZA200300483B (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7566768B1 (en) | 1995-10-26 | 2009-07-28 | The Johns Hopkins University School Of Medicine | Promyostatin peptides and methods of using same |
| US7393682B1 (en) * | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| TWI329129B (en) | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| JP4429728B2 (ja) * | 2002-02-21 | 2010-03-10 | ワイス エルエルシー | フォリスタチン(follistatin)ドメイン含有タンパク質 |
| BR0307907A2 (pt) | 2002-02-21 | 2011-07-05 | Wyeth Corp | gasp1: proteìna contendo domìnio de folistatina |
| EP1578928B1 (en) | 2002-09-16 | 2010-03-17 | The Johns Hopkins University | Metalloprotease activation of myostatin, and methods of modulating myostatin activity |
| US7261893B2 (en) * | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
| US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| KR20110086881A (ko) * | 2002-12-20 | 2011-08-01 | 암겐 인코포레이티드 | 미오스타틴을 저해하는 결합제 |
| AU2013216655B2 (en) * | 2002-12-20 | 2016-05-26 | Amgen Inc. | Binding agents which inhibit myostatin |
| US9068234B2 (en) * | 2003-01-21 | 2015-06-30 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating gene expression |
| JP5110877B2 (ja) * | 2003-06-02 | 2012-12-26 | ワイス・エルエルシー | 神経筋障害を処置するための、コルチコステロイドと組み合わせたミオスタチン(gdf8)インヒビターの使用 |
| US20080118487A1 (en) | 2004-09-30 | 2008-05-22 | Orico Limited | Myostatin Isoform |
| EP1864138A2 (en) * | 2005-03-23 | 2007-12-12 | Wyeth | Detection of gdf-8 modulating agents |
| PL2407486T3 (pl) | 2005-08-19 | 2018-05-30 | Wyeth Llc | Przeciwciała antagonistyczne względem GDF-8 i zastosowania w leczeniu ALS i innych zaburzeń związanych z GDF-8 |
| ES2533464T3 (es) | 2005-10-06 | 2015-04-10 | Eli Lilly And Company | Anticuerpos anti-miostatina |
| UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| EP1968621A2 (en) * | 2005-12-06 | 2008-09-17 | Amgen Inc. | Uses of myostatin antagonists |
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| CA2693378C (en) | 2006-08-03 | 2020-04-14 | Myostin Therapeutics Pty Ltd | Myostatin antagonists |
| PL2066695T3 (pl) * | 2006-09-05 | 2013-08-30 | Lilly Co Eli | Przeciwciała przeciwko miostatynie |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| EP2275443B1 (en) | 2008-04-11 | 2015-12-02 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| JP2012021973A (ja) * | 2010-06-15 | 2012-02-02 | Nitto Denko Corp | Sprセンサセルおよびsprセンサ |
| TWI654204B (zh) | 2010-11-30 | 2019-03-21 | Chugai Seiyaku Kabushiki Kaisha | 具有鈣依存性的抗原結合能力之抗體 |
| WO2013125667A1 (ja) | 2012-02-24 | 2013-08-29 | 中外製薬株式会社 | FcγRIIBを介して抗原の消失を促進する抗原結合分子 |
| MY177331A (en) | 2012-06-15 | 2020-09-12 | Pfizer | Improved antagonist antibodies against gdf-8 and uses therefor |
| WO2014030750A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
| SG11201500873XA (en) | 2012-08-24 | 2015-04-29 | Chugai Pharmaceutical Co Ltd | Fcgriib-specific fc region variant |
| HUE043482T2 (hu) | 2012-09-13 | 2019-08-28 | Bristol Myers Squibb Co | Miosztatint megkötõ fibronektin alapú váz domén proteinek |
| TWI636062B (zh) | 2013-04-02 | 2018-09-21 | 中外製藥股份有限公司 | Fc region variant |
| US10092627B2 (en) | 2013-04-08 | 2018-10-09 | President And Fellows Of Harvard College | Methods and compositions for rejuvenating skeletal muscle stem cells |
| HUE052232T2 (hu) | 2013-05-06 | 2021-04-28 | Scholar Rock Inc | Készítmények és eljárások növekedési faktor modulálására |
| EP3007719B1 (en) | 2013-06-11 | 2021-03-17 | President and Fellows of Harvard College | Methods and compositions for increasing neurogenesis and angiogenesis |
| WO2016073879A2 (en) * | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Transforming growth factor-related antibodies and uses thereof |
| US10307480B2 (en) * | 2014-11-06 | 2019-06-04 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| NZ730607A (en) | 2014-12-19 | 2022-07-01 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| WO2016125495A1 (en) | 2015-02-05 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
| PT3922645T (pt) * | 2015-09-15 | 2025-05-29 | Scholar Rock Inc | ¿anticorpos anti-pró-miostatina/miostatina latente e suas utilizações |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| ES2893813T3 (es) | 2016-01-06 | 2022-02-10 | Harvard College | El tratamiento con GDF11 previene el aumento de peso, mejora la tolerancia a la glucosa y reduce la hepatoesteatosis |
| CN115814077A (zh) | 2016-01-08 | 2023-03-21 | 供石公司 | 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法 |
| KR20210082548A (ko) | 2016-06-13 | 2021-07-05 | 스칼러 락, 인크. | 미오스타틴 억제제의 용도 및 조합 요법 |
| BR112019001902A2 (pt) | 2016-08-05 | 2019-07-09 | Chugai Seiyaku Kabushiki Kaisha | composição para profilaxia ou tratamento de doenças relacionadas à il-8 |
| US11155611B2 (en) | 2017-01-06 | 2021-10-26 | Scholar Rock, Inc. | Compositions and methods for making and using anti-myostatin antibodies |
| CN111793123B (zh) * | 2019-04-08 | 2022-03-08 | 中国农业大学 | 一种肌肉生长抑制素mstn的突变体及其应用 |
| CN110192624A (zh) * | 2019-07-05 | 2019-09-03 | 福建冠丰生物科技有限公司 | 一种海参牡蛎营养物口服含片及其制备方法 |
| EP3839051A1 (en) * | 2019-12-19 | 2021-06-23 | Evonik Operations GmbH | Method for the fermentative production of guanidinoacetic acid |
| CA3184852A1 (en) | 2020-07-10 | 2022-01-13 | Lida Katsimpardi | Use of gdf11 to diagnose and treat anxiety and depression |
| WO2024107652A1 (en) * | 2022-11-14 | 2024-05-23 | John Mansell | Myostatin inhibition |
| AU2023413166A1 (en) | 2022-12-22 | 2025-07-03 | Scholar Rock, Inc. | Selective and potent inhibitory antibodies of myostatin activation |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US732575A (en) * | 1902-10-04 | 1903-06-30 | Louis G Mayer | Carriage-spring. |
| US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4766073A (en) * | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| US5206347A (en) | 1985-08-06 | 1993-04-27 | La Jolla Cancer Research Foundation | Isolation and use of receptors binding to a peptide column |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5011912A (en) | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
| US5162215A (en) | 1988-09-22 | 1992-11-10 | Amgen Inc. | Method of gene transfer into chickens and other avian species |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| ES2083469T3 (es) | 1989-11-22 | 1996-04-16 | Genentech Inc | Peptido asociado a una latencia y utilizaciones del mismo. |
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| SG46445A1 (en) | 1990-01-26 | 1998-02-20 | Immunomedics Inc | Vaccines against cancer and infectious diseases |
| AU7312891A (en) | 1990-02-12 | 1991-09-03 | Board Of Regents, The University Of Texas System | Satellite cell proliferation in adult skeletal muscle |
| US5265030A (en) | 1990-04-24 | 1993-11-23 | Scripps Clinic And Research Foundation | System and method for determining three-dimensional structures of proteins |
| US5750342A (en) | 1990-06-11 | 1998-05-12 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands of tissue target |
| US5264563A (en) | 1990-08-24 | 1993-11-23 | Ixsys Inc. | Process for synthesizing oligonucleotides with random codons |
| US5314695A (en) | 1990-11-13 | 1994-05-24 | Corvas International, Inc. | Tissue factor based prothrombin time reagent |
| US5885794A (en) | 1991-05-10 | 1999-03-23 | The Salk Institute For Biological Studies | Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily |
| WO1993001484A1 (en) | 1991-07-11 | 1993-01-21 | The Regents Of The University Of California | A method to identify protein sequences that fold into a known three-dimensional structure |
| US5585479A (en) * | 1992-07-24 | 1996-12-17 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human ELAM-I RNA |
| JP3415643B2 (ja) * | 1992-12-04 | 2003-06-09 | 株式会社ミノファーゲン製薬 | 筋ジストロフィー症治療薬 |
| US5395619A (en) | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
| US20030074680A1 (en) * | 1993-03-19 | 2003-04-17 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| US5994618A (en) * | 1997-02-05 | 1999-11-30 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 transgenic mice |
| ES2201076T3 (es) | 1993-03-19 | 2004-03-16 | The Johns Hopkins University School Of Medicine | Factor-8 de diferenciacion del crecimiento. |
| US7393682B1 (en) * | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| US6465239B1 (en) * | 1993-03-19 | 2002-10-15 | The John Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species |
| US6607884B1 (en) * | 1993-03-19 | 2003-08-19 | The Johns Hopkins University School Of Medicine | Methods of detecting growth differentiation factor-8 |
| DK0698094T3 (da) * | 1993-05-12 | 2004-05-03 | Inst Genetics Llc | BMP-11-sammensætninger |
| US7332575B2 (en) | 1994-03-18 | 2008-02-19 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species |
| WO1996001845A1 (en) | 1994-07-08 | 1996-01-25 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-11 |
| US5616561A (en) | 1995-03-31 | 1997-04-01 | Regents Of The University Of California | TGF-β antagonists as mitigators of radiation-induced tissue damage |
| CA2223061C (en) * | 1995-06-06 | 2008-04-22 | Jan Vijg | Method of and apparatus for diagnostic dna testing |
| US5622699A (en) | 1995-09-11 | 1997-04-22 | La Jolla Cancer Research Foundation | Method of identifying molecules that home to a selected organ in vivo |
| DE19626982C1 (de) | 1996-07-04 | 1997-09-25 | Siemens Ag | Elektromagnetisches Relais und Verfahren zu dessen Herstellung |
| US5776689A (en) | 1996-07-19 | 1998-07-07 | The Regents Of The University Of California | Protein recruitment system |
| AU6274298A (en) | 1997-02-05 | 1998-08-25 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-8 |
| US5827533A (en) | 1997-02-06 | 1998-10-27 | Duke University | Liposomes containing active agents aggregated with lipid surfactants |
| US5933819C1 (en) | 1997-05-23 | 2001-11-13 | Scripps Research Inst | Prediction of relative binding motifs of biologically active peptides and peptide mimetics |
| PT2045322E (pt) | 1997-07-14 | 2015-10-16 | Université de Liège | Musculatura dupla em mamíferos |
| US6103466A (en) * | 1997-07-14 | 2000-08-15 | University Of Liege | Double-muscling in mammals |
| AU8666398A (en) | 1997-08-01 | 1999-02-22 | Johns Hopkins University School Of Medicine, The | Methods to identify growth differentiation factor (gdf) receptors |
| US6891082B2 (en) * | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| US6656475B1 (en) * | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| US6696260B1 (en) * | 1997-08-01 | 2004-02-24 | The Johns Hopkins University School Of Medicine | Methods to identify growth differentiation factor (GDF) binding proteins |
| US5885779A (en) | 1997-09-09 | 1999-03-23 | University Of British Columbia | Repressed trans-activator system for characterization of protein-protein interactions |
| DE19800422A1 (de) | 1998-01-08 | 1999-07-15 | Bosch Gmbh Robert | Bremsvorrichtung für Fahrzeuge |
| CA2319703C (en) | 1998-02-05 | 2005-09-20 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| US6369201B1 (en) | 1998-02-19 | 2002-04-09 | Metamorphix International, Inc. | Myostatin multimers |
| US6004937A (en) | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
| DE69941116D1 (de) | 1998-05-06 | 2009-08-27 | Metamorphix Inc | G von gdf-8 |
| NZ513642A (en) * | 1999-01-21 | 2004-02-27 | Metamorphix Inc | Growth differentiation factor inhibitors and uses therefor |
| SK722002A3 (en) * | 1999-07-20 | 2003-02-04 | Pharmexa As | Method for down-regulating GDF-8 activity |
-
2000
- 2000-11-07 US US09/708,693 patent/US7393682B1/en not_active Expired - Fee Related
-
2001
- 2001-07-26 CN CN200710199696.5A patent/CN101261277B/zh not_active Expired - Fee Related
- 2001-07-26 NZ NZ542696A patent/NZ542696A/en not_active IP Right Cessation
- 2001-07-26 MX MXPA03000786A patent/MXPA03000786A/es active IP Right Grant
- 2001-07-26 AU AU8079901A patent/AU8079901A/xx active Pending
- 2001-07-26 EP EP01959217A patent/EP1303534A4/en not_active Withdrawn
- 2001-07-26 CA CA002416260A patent/CA2416260A1/en not_active Abandoned
- 2001-07-26 CN CNB018149073A patent/CN100429225C/zh not_active Expired - Fee Related
- 2001-07-26 IL IL15397001A patent/IL153970A0/xx unknown
- 2001-07-26 EP EP10185291A patent/EP2360259A3/en not_active Withdrawn
- 2001-07-26 WO PCT/US2001/023510 patent/WO2002009641A2/en not_active Ceased
- 2001-07-26 BR BRPI0112785A patent/BRPI0112785B1/pt not_active IP Right Cessation
- 2001-07-26 AU AU2001280799A patent/AU2001280799B2/en not_active Ceased
- 2001-07-26 JP JP2002515196A patent/JP5149478B2/ja not_active Expired - Fee Related
- 2001-07-26 PL PL365780A patent/PL210158B1/pl unknown
- 2001-07-26 NZ NZ523672A patent/NZ523672A/en not_active IP Right Cessation
- 2001-07-27 AR ARP010103594A patent/AR030307A1/es not_active Application Discontinuation
-
2003
- 2003-01-15 IL IL153970A patent/IL153970A/en active IP Right Grant
- 2003-01-17 ZA ZA200300483A patent/ZA200300483B/en unknown
-
2008
- 2008-07-01 US US12/166,035 patent/US8323964B2/en not_active Expired - Fee Related
-
2011
- 2011-01-26 US US13/014,623 patent/US20110239317A1/en not_active Abandoned
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