AU2001280799B2 - Promyostatin peptides and methods of using same - Google Patents

Promyostatin peptides and methods of using same Download PDF

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Publication number
AU2001280799B2
AU2001280799B2 AU2001280799A AU2001280799A AU2001280799B2 AU 2001280799 B2 AU2001280799 B2 AU 2001280799B2 AU 2001280799 A AU2001280799 A AU 2001280799A AU 2001280799 A AU2001280799 A AU 2001280799A AU 2001280799 B2 AU2001280799 B2 AU 2001280799B2
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AU
Australia
Prior art keywords
amino acid
myostatin
seq
set forth
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2001280799A
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English (en)
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AU2001280799A1 (en
Inventor
Se-Jin Lee
Alexandra C. Mcpherron
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Johns Hopkins University
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Johns Hopkins University
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Filing date
Publication date
Priority claimed from US09/628,112 external-priority patent/US7566768B1/en
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of AU2001280799A1 publication Critical patent/AU2001280799A1/en
Application granted granted Critical
Publication of AU2001280799B2 publication Critical patent/AU2001280799B2/en
Priority to AU2006209266A priority Critical patent/AU2006209266A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2001280799A 2000-07-27 2001-07-26 Promyostatin peptides and methods of using same Ceased AU2001280799B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2006209266A AU2006209266A1 (en) 2000-07-27 2006-09-08 Promyostatin peptides and methods of using same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/628,112 2000-07-27
US09/628,112 US7566768B1 (en) 1995-10-26 2000-07-27 Promyostatin peptides and methods of using same
PCT/US2001/023510 WO2002009641A2 (en) 2000-07-27 2001-07-26 Promyostatin peptides and methods of using same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2006209266A Division AU2006209266A1 (en) 2000-07-27 2006-09-08 Promyostatin peptides and methods of using same

Publications (2)

Publication Number Publication Date
AU2001280799A1 AU2001280799A1 (en) 2002-05-09
AU2001280799B2 true AU2001280799B2 (en) 2006-06-08

Family

ID=24517522

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001280799A Ceased AU2001280799B2 (en) 2000-07-27 2001-07-26 Promyostatin peptides and methods of using same
AU8079901A Pending AU8079901A (en) 2000-07-27 2001-07-26 Promyostatin peptides and methods of using same

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU8079901A Pending AU8079901A (en) 2000-07-27 2001-07-26 Promyostatin peptides and methods of using same

Country Status (14)

Country Link
US (3) US7393682B1 (enExample)
EP (2) EP1303534A4 (enExample)
JP (1) JP5149478B2 (enExample)
CN (2) CN101261277B (enExample)
AR (1) AR030307A1 (enExample)
AU (2) AU2001280799B2 (enExample)
BR (1) BRPI0112785B1 (enExample)
CA (1) CA2416260A1 (enExample)
IL (2) IL153970A0 (enExample)
MX (1) MXPA03000786A (enExample)
NZ (2) NZ542696A (enExample)
PL (1) PL210158B1 (enExample)
WO (1) WO2002009641A2 (enExample)
ZA (1) ZA200300483B (enExample)

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US7566768B1 (en) 1995-10-26 2009-07-28 The Johns Hopkins University School Of Medicine Promyostatin peptides and methods of using same
TWI329129B (en) * 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
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BR0307907A2 (pt) 2002-02-21 2011-07-05 Wyeth Corp gasp1: proteìna contendo domìnio de folistatina
PL374966A1 (en) * 2002-02-21 2005-11-14 Wyeth Follistatin domain containing proteins
EP1578928B1 (en) * 2002-09-16 2010-03-17 The Johns Hopkins University Metalloprotease activation of myostatin, and methods of modulating myostatin activity
AR047392A1 (es) * 2002-10-22 2006-01-18 Wyeth Corp Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines
US20040223966A1 (en) * 2002-10-25 2004-11-11 Wolfman Neil M. ActRIIB fusion polypeptides and uses therefor
ATE496938T1 (de) * 2002-12-20 2011-02-15 Amgen Inc Myostatin hemmende bindungsstoffe
AU2013216655B2 (en) * 2002-12-20 2016-05-26 Amgen Inc. Binding agents which inhibit myostatin
US9068234B2 (en) * 2003-01-21 2015-06-30 Ptc Therapeutics, Inc. Methods and agents for screening for compounds capable of modulating gene expression
JP5110877B2 (ja) * 2003-06-02 2012-12-26 ワイス・エルエルシー 神経筋障害を処置するための、コルチコステロイドと組み合わせたミオスタチン（ｇｄｆ８）インヒビターの使用
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WO2006102574A2 (en) * 2005-03-23 2006-09-28 Wyeth Detection of gdf-8 modulating agents
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JP5052517B2 (ja) 2005-10-06 2012-10-17 イーライ リリー アンド カンパニー 抗ミオスタチン抗体
UA92504C2 (en) 2005-10-12 2010-11-10 Эли Лилли Энд Компани Anti-myostatin monoclonal antibody
JP2009518422A (ja) * 2005-12-06 2009-05-07 アムジェン インコーポレイテッド ミオスタチン・アンタゴニストの使用
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CN101511871B (zh) * 2006-09-05 2012-07-18 伊莱利利公司 抗肌肉生长抑制因子抗体
DK2202245T3 (en) 2007-09-26 2016-11-21 Chugai Pharmaceutical Co Ltd A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR
UA121453C2 (uk) 2008-04-11 2020-06-10 Чугей Сейяку Кабусікі Кайся Спосіб одержання фармацевтичної композиції, яка містить антитіло
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KR102385507B1 (ko) 2010-11-30 2022-04-12 추가이 세이야쿠 가부시키가이샤 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자
KR101704893B1 (ko) 2012-06-15 2017-02-08 화이자 인코포레이티드 Gdf-8에 대한 개선된 길항물질 항체 및 그의 용도
JP6774164B2 (ja) 2012-08-24 2020-10-21 中外製薬株式会社 マウスＦｃγＲＩＩ特異的Ｆｃ抗体
AU2013306700B2 (en) 2012-08-24 2019-05-02 Chugai Seiyaku Kabushiki Kaisha FcgammaRIIb-specific Fc region variant
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WO2014163101A1 (ja) 2013-04-02 2014-10-09 中外製薬株式会社 Ｆｃ領域改変体
JP2016518357A (ja) 2013-04-08 2016-06-23 プレジデント アンド フェローズ オブ ハーバード カレッジ 骨格筋幹細胞を若返らせる方法および組成物
PT2981822T (pt) 2013-05-06 2020-12-07 Scholar Rock Inc Composições e métodos para modulação do fator de crescimento
WO2014201143A1 (en) 2013-06-11 2014-12-18 President And Fellows Of Harvard College Methods and compositions for increasing neurogenesis and angiogenesis
AU2015342936B2 (en) 2014-11-06 2020-10-08 Scholar Rock, Inc. Anti-pro/latent-Myostatin antibodies and uses thereof
WO2016073879A2 (en) * 2014-11-06 2016-05-12 Scholar Rock, Inc. Transforming growth factor-related antibodies and uses thereof
JP6227191B1 (ja) 2014-12-19 2017-11-08 中外製薬株式会社 抗ミオスタチン抗体、変異Ｆｃ領域を含むポリペプチド、および使用方法
CN114773470A (zh) 2015-02-05 2022-07-22 中外制药株式会社 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用
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CN111793123B (zh) * 2019-04-08 2022-03-08 中国农业大学 一种肌肉生长抑制素mstn的突变体及其应用
CN110192624A (zh) * 2019-07-05 2019-09-03 福建冠丰生物科技有限公司 一种海参牡蛎营养物口服含片及其制备方法
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US20230241171A1 (en) 2020-07-10 2023-08-03 Institut Pasteur Use of gdf11 to diagnose and treat anxiety and depression
WO2024107652A1 (en) * 2022-11-14 2024-05-23 John Mansell Myostatin inhibition
TW202430247A (zh) 2022-12-22 2024-08-01 美商供石公司 肌肉生長抑制素活化之選擇性及強效抑制劑

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Also Published As

Publication number Publication date
WO2002009641A2 (en) 2002-02-07
US20110239317A1 (en) 2011-09-29
IL153970A (en) 2012-08-30
MXPA03000786A (es) 2004-05-21
ZA200300483B (en) 2004-02-19
EP1303534A4 (en) 2004-09-01
JP2004504826A (ja) 2004-02-19
WO2002009641A9 (en) 2003-03-20
JP5149478B2 (ja) 2013-02-20
WO2002009641A3 (en) 2002-05-10
EP2360259A3 (en) 2011-11-16
AU8079901A (en) 2002-02-13
PL210158B1 (pl) 2011-12-30
CA2416260A1 (en) 2002-02-07
EP2360259A2 (en) 2011-08-24
CN100429225C (zh) 2008-10-29
PL365780A1 (en) 2005-01-10
BR0112785A (pt) 2003-07-01
NZ523672A (en) 2006-02-24
EP1303534A2 (en) 2003-04-23
CN101261277B (zh) 2014-03-12
IL153970A0 (en) 2003-07-31
US20090017522A1 (en) 2009-01-15
NZ542696A (en) 2008-02-29
BRPI0112785B1 (pt) 2016-07-12
AR030307A1 (es) 2003-08-20
CN1449409A (zh) 2003-10-15
US7393682B1 (en) 2008-07-01
US8323964B2 (en) 2012-12-04
CN101261277A (zh) 2008-09-10

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