AR030307A1 - Peptidos de promiostatina y metodos para utilizarlos - Google Patents
Peptidos de promiostatina y metodos para utilizarlosInfo
- Publication number
- AR030307A1 AR030307A1 ARP010103594A ARP010103594A AR030307A1 AR 030307 A1 AR030307 A1 AR 030307A1 AR P010103594 A ARP010103594 A AR P010103594A AR P010103594 A ARP010103594 A AR P010103594A AR 030307 A1 AR030307 A1 AR 030307A1
- Authority
- AR
- Argentina
- Prior art keywords
- promiostatin
- polypeptide
- myostatin
- peptide
- domain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente suministra porciones de péptidos sustancialmente purificadas de un polipéptido de promiostatina. Por ejemplo, la presente suministra fragmentos proteolíticos de un polipéptido de promiostatina como un prodominio de miostatina o un péptido de miostatina madura, como también porciones del péptido funcional de un prodominio de miostatina. También se suministra un polipéptido de promiostatina mutante, que es resistente a ruptura proteolítica, por ejemplo, ruptura en un prodominio de miostatina y un péptido de miostatina madura. La presente también suministra un polinucleotido que codifica una porcion de péptido de un polipéptido de promiostatina. Además, se suministran anticuerpos que se unen en forma específica a un polipéptido de promiostatina. La presente suministra, además, métodos para identificar una porcion de péptido funcional de un polipéptido de promiostatina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/628,112 US7566768B1 (en) | 1995-10-26 | 2000-07-27 | Promyostatin peptides and methods of using same |
Publications (1)
Publication Number | Publication Date |
---|---|
AR030307A1 true AR030307A1 (es) | 2003-08-20 |
Family
ID=24517522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010103594A AR030307A1 (es) | 2000-07-27 | 2001-07-27 | Peptidos de promiostatina y metodos para utilizarlos |
Country Status (14)
Country | Link |
---|---|
US (3) | US7393682B1 (es) |
EP (2) | EP1303534A4 (es) |
JP (1) | JP5149478B2 (es) |
CN (2) | CN100429225C (es) |
AR (1) | AR030307A1 (es) |
AU (2) | AU2001280799B2 (es) |
BR (1) | BRPI0112785B1 (es) |
CA (1) | CA2416260A1 (es) |
IL (2) | IL153970A0 (es) |
MX (1) | MXPA03000786A (es) |
NZ (2) | NZ542696A (es) |
PL (1) | PL210158B1 (es) |
WO (1) | WO2002009641A2 (es) |
ZA (1) | ZA200300483B (es) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7566768B1 (en) | 1995-10-26 | 2009-07-28 | The Johns Hopkins University School Of Medicine | Promyostatin peptides and methods of using same |
US7393682B1 (en) * | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
TW200526779A (en) | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
MXPA04008150A (es) | 2002-02-21 | 2005-06-17 | Wyeth Corp | Gasp1: una proteina que contiene dominio de folistatina. |
KR20040096592A (ko) | 2002-02-21 | 2004-11-16 | 와이어쓰 | 폴리스타틴 도메인을 포함하는 단백질 |
US20040138118A1 (en) * | 2002-09-16 | 2004-07-15 | Neil Wolfman | Metalloprotease activation of myostatin, and methods of modulating myostatin activity |
US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
US7511012B2 (en) * | 2002-12-20 | 2009-03-31 | Amgen Inc. | Myostatin binding agents |
AU2013216655B2 (en) * | 2002-12-20 | 2016-05-26 | Amgen Inc. | Binding agents which inhibit myostatin |
US9068234B2 (en) * | 2003-01-21 | 2015-06-30 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating gene expression |
CA2526669A1 (en) * | 2003-06-02 | 2004-12-16 | Wyeth | Use of myostatin (gdf8) inhibitors in conjunction with corticosteroids for treating neuromuscular disorders |
CA2582940A1 (en) * | 2004-09-30 | 2006-04-06 | Orico Limited | Myostatin isoform |
MX2007011400A (es) * | 2005-03-23 | 2007-10-11 | Wyeth Corp | Deteccion de agentes moduladores de crecimiento y la diferenciacion del factor 8 (gdf 8). |
EP2407486B1 (en) * | 2005-08-19 | 2017-11-22 | Wyeth LLC | Antagonist antibodies against GDF-8 and uses in treatment of ALS and other GDF-8-associated disorders |
CA2624976A1 (en) | 2005-10-06 | 2007-04-19 | Eli Lilly And Company | Anti-myostatin antibodies |
UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
EP1968621A2 (en) * | 2005-12-06 | 2008-09-17 | Amgen Inc. | Uses of myostatin antagonists |
EP4001409A1 (en) | 2006-03-31 | 2022-05-25 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
BRPI0715072A2 (pt) | 2006-08-03 | 2013-06-25 | Orico Ltd | antagonistas de miostatina |
JP5058261B2 (ja) * | 2006-09-05 | 2012-10-24 | イーライ リリー アンド カンパニー | 抗ミオスタチン抗体 |
DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
EP3521311A1 (en) | 2008-04-11 | 2019-08-07 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
JP2012021973A (ja) * | 2010-06-15 | 2012-02-02 | Nitto Denko Corp | Sprセンサセルおよびsprセンサ |
CA2819356C (en) | 2010-11-30 | 2023-01-24 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
MX364738B (es) | 2012-06-15 | 2019-05-03 | Pfizer | Anticuerpos antagonistas mejorados contra factor-8 de crecimiento y diferenciacion y usos de los mismos. |
US11236168B2 (en) | 2012-08-24 | 2022-02-01 | Chugai Seiyaku Kabushiki Kaisha | Mouse FcγammaRII-specific Fc antibody |
KR20230110836A (ko) | 2012-08-24 | 2023-07-25 | 추가이 세이야쿠 가부시키가이샤 | FcγRIIb 특이적 Fc영역 개변체 |
CN104768969B (zh) | 2012-09-13 | 2021-04-16 | 百时美施贵宝公司 | 结合至肌生成抑制素的基于纤连蛋白的支架结构域蛋白 |
EP2982689B1 (en) | 2013-04-02 | 2020-08-26 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
JP2016518357A (ja) | 2013-04-08 | 2016-06-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 骨格筋幹細胞を若返らせる方法および組成物 |
CA2911514A1 (en) | 2013-05-06 | 2014-11-13 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
US20160220640A1 (en) | 2013-06-11 | 2016-08-04 | The Brigham And Women's Hospital, Inc. | Methods and compositions for increasing neurogenesis and angiogenesis |
CA3005158A1 (en) * | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
WO2016073906A2 (en) * | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Transforming growth factor-related immunoassays |
NZ730607A (en) | 2014-12-19 | 2022-07-01 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
EA201791754A1 (ru) | 2015-02-05 | 2019-01-31 | Чугаи Сейяку Кабусики Кайся | АНТИТЕЛА, СОДЕРЖАЩИЕ ЗАВИСЯЩИЙ ОТ КОНЦЕНТРАЦИИ ИОНОВ АНТИГЕНСВЯЗЫВАЮЩИЙ ДОМЕН, ВАРИАНТЫ Fc-ОБЛАСТИ, IL-8-СВЯЗЫВАЮЩИЕ АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ |
CN113896789A (zh) | 2015-09-15 | 2022-01-07 | 供石公司 | 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其用途 |
JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | 抗ミオスタチン抗体および使用方法 |
JP6948331B2 (ja) | 2016-01-06 | 2021-10-13 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Gdf11での処置は、体重増加を防止し、耐糖能を改善し、そして脂肪肝を低減する |
AU2017206069A1 (en) * | 2016-01-08 | 2018-07-19 | Scholar Rock, Inc. | Anti-pro/latent myostatin antibodies and methods of use thereof |
PT3368069T (pt) | 2016-06-13 | 2020-11-11 | Scholar Rock Inc | Uso de inibidores da miostatina e terapias de combinação |
CN109689099B (zh) | 2016-08-05 | 2023-02-28 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
EP4218817A3 (en) | 2017-01-06 | 2023-09-06 | Scholar Rock, Inc. | Methods for treating metabolic diseases by inhibiting myostatin activation |
CN111793123B (zh) * | 2019-04-08 | 2022-03-08 | 中国农业大学 | 一种肌肉生长抑制素mstn的突变体及其应用 |
CN110192624A (zh) * | 2019-07-05 | 2019-09-03 | 福建冠丰生物科技有限公司 | 一种海参牡蛎营养物口服含片及其制备方法 |
WO2022008976A1 (en) | 2020-07-10 | 2022-01-13 | Institut Pasteur | Use of gdf11 to diagnose and treat anxiety and depression |
WO2024107652A1 (en) * | 2022-11-14 | 2024-05-23 | John Mansell | Myostatin inhibition |
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US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
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US5011912A (en) | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
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ATE305036T1 (de) | 1994-07-08 | 2005-10-15 | Univ Johns Hopkins Med | Wachstums-differenzierungsfaktor-11 |
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US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
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US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
US5885779A (en) | 1997-09-09 | 1999-03-23 | University Of British Columbia | Repressed trans-activator system for characterization of protein-protein interactions |
DE19800422A1 (de) | 1998-01-08 | 1999-07-15 | Bosch Gmbh Robert | Bremsvorrichtung für Fahrzeuge |
AU2586199A (en) | 1998-02-05 | 1999-08-23 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-8 |
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US6004937A (en) | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
DE69941116D1 (de) | 1998-05-06 | 2009-08-27 | Metamorphix Inc | G von gdf-8 |
JP2003517580A (ja) * | 1999-01-21 | 2003-05-27 | メタモーフイクス・インコーポレーテツド | 増殖分化因子インヒビター及びそれらの用途 |
AU778470B2 (en) * | 1999-07-20 | 2004-12-09 | Pharmexa A/S | Method for down-regulating GDF-8 activity |
-
2000
- 2000-11-07 US US09/708,693 patent/US7393682B1/en not_active Expired - Fee Related
-
2001
- 2001-07-26 PL PL365780A patent/PL210158B1/pl unknown
- 2001-07-26 NZ NZ542696A patent/NZ542696A/en not_active IP Right Cessation
- 2001-07-26 WO PCT/US2001/023510 patent/WO2002009641A2/en active Application Filing
- 2001-07-26 CN CNB018149073A patent/CN100429225C/zh not_active Expired - Fee Related
- 2001-07-26 CN CN200710199696.5A patent/CN101261277B/zh not_active Expired - Fee Related
- 2001-07-26 IL IL15397001A patent/IL153970A0/xx unknown
- 2001-07-26 NZ NZ523672A patent/NZ523672A/en not_active IP Right Cessation
- 2001-07-26 BR BRPI0112785A patent/BRPI0112785B1/pt not_active IP Right Cessation
- 2001-07-26 JP JP2002515196A patent/JP5149478B2/ja not_active Expired - Fee Related
- 2001-07-26 EP EP01959217A patent/EP1303534A4/en not_active Withdrawn
- 2001-07-26 EP EP10185291A patent/EP2360259A3/en not_active Withdrawn
- 2001-07-26 AU AU2001280799A patent/AU2001280799B2/en not_active Ceased
- 2001-07-26 AU AU8079901A patent/AU8079901A/xx active Pending
- 2001-07-26 MX MXPA03000786A patent/MXPA03000786A/es active IP Right Grant
- 2001-07-26 CA CA002416260A patent/CA2416260A1/en not_active Abandoned
- 2001-07-27 AR ARP010103594A patent/AR030307A1/es not_active Application Discontinuation
-
2003
- 2003-01-15 IL IL153970A patent/IL153970A/en active IP Right Grant
- 2003-01-17 ZA ZA200300483A patent/ZA200300483B/en unknown
-
2008
- 2008-07-01 US US12/166,035 patent/US8323964B2/en not_active Expired - Fee Related
-
2011
- 2011-01-26 US US13/014,623 patent/US20110239317A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1303534A4 (en) | 2004-09-01 |
IL153970A (en) | 2012-08-30 |
US8323964B2 (en) | 2012-12-04 |
BR0112785A (pt) | 2003-07-01 |
PL210158B1 (pl) | 2011-12-30 |
AU8079901A (en) | 2002-02-13 |
ZA200300483B (en) | 2004-02-19 |
NZ542696A (en) | 2008-02-29 |
JP2004504826A (ja) | 2004-02-19 |
AU2001280799B2 (en) | 2006-06-08 |
IL153970A0 (en) | 2003-07-31 |
US7393682B1 (en) | 2008-07-01 |
WO2002009641A9 (en) | 2003-03-20 |
NZ523672A (en) | 2006-02-24 |
EP2360259A2 (en) | 2011-08-24 |
BRPI0112785B1 (pt) | 2016-07-12 |
CA2416260A1 (en) | 2002-02-07 |
US20110239317A1 (en) | 2011-09-29 |
PL365780A1 (en) | 2005-01-10 |
EP2360259A3 (en) | 2011-11-16 |
CN101261277B (zh) | 2014-03-12 |
MXPA03000786A (es) | 2004-05-21 |
CN101261277A (zh) | 2008-09-10 |
WO2002009641A2 (en) | 2002-02-07 |
JP5149478B2 (ja) | 2013-02-20 |
EP1303534A2 (en) | 2003-04-23 |
WO2002009641A3 (en) | 2002-05-10 |
CN100429225C (zh) | 2008-10-29 |
US20090017522A1 (en) | 2009-01-15 |
CN1449409A (zh) | 2003-10-15 |
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