JP2004504802A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004504802A5 JP2004504802A5 JP2001520922A JP2001520922A JP2004504802A5 JP 2004504802 A5 JP2004504802 A5 JP 2004504802A5 JP 2001520922 A JP2001520922 A JP 2001520922A JP 2001520922 A JP2001520922 A JP 2001520922A JP 2004504802 A5 JP2004504802 A5 JP 2004504802A5
- Authority
- JP
- Japan
- Prior art keywords
- activity
- pharmaceutical composition
- modulator
- therapeutic agent
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 29
- 102000000589 Interleukin-1 Human genes 0.000 description 20
- 108010002352 Interleukin-1 Proteins 0.000 description 20
- 230000000694 effects Effects 0.000 description 17
- 239000008194 pharmaceutical composition Substances 0.000 description 12
- 102000054766 genetic haplotypes Human genes 0.000 description 11
- 239000003814 drug Substances 0.000 description 9
- 238000009396 hybridization Methods 0.000 description 9
- 229940124597 therapeutic agent Drugs 0.000 description 9
- 108700028369 Alleles Proteins 0.000 description 6
- 208000010392 Bone Fractures Diseases 0.000 description 6
- 206010065687 Bone loss Diseases 0.000 description 6
- 108091034117 Oligonucleotide Proteins 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 108020004707 nucleic acids Proteins 0.000 description 6
- 102000039446 nucleic acids Human genes 0.000 description 6
- 150000007523 nucleic acids Chemical class 0.000 description 6
- 206010017076 Fracture Diseases 0.000 description 4
- 208000001132 Osteoporosis Diseases 0.000 description 4
- 230000009245 menopause Effects 0.000 description 4
- 101710163270 Nuclease Proteins 0.000 description 3
- 239000000556 agonist Substances 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 239000005557 antagonist Substances 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 238000001976 enzyme digestion Methods 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 239000000816 peptidomimetic Substances 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108091008146 restriction endonucleases Proteins 0.000 description 3
- 238000012163 sequencing technique Methods 0.000 description 3
- 150000003384 small molecules Chemical class 0.000 description 3
- 102100026018 Interleukin-1 receptor antagonist protein Human genes 0.000 description 2
- 101710144554 Interleukin-1 receptor antagonist protein Proteins 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 101000599048 Homo sapiens Interleukin-6 receptor subunit alpha Proteins 0.000 description 1
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 206010036601 premature menopause Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15146099P | 1999-08-30 | 1999-08-30 | |
| PCT/US2000/023844 WO2001016377A2 (en) | 1999-08-30 | 2000-08-30 | Diagnostics and therapeutics for osteoporosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004504802A JP2004504802A (ja) | 2004-02-19 |
| JP2004504802A5 true JP2004504802A5 (enExample) | 2007-04-12 |
Family
ID=22538869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001520922A Pending JP2004504802A (ja) | 1999-08-30 | 2000-08-30 | 骨粗鬆症の診断および療法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6558905B1 (enExample) |
| EP (1) | EP1212464B1 (enExample) |
| JP (1) | JP2004504802A (enExample) |
| AT (1) | ATE318328T1 (enExample) |
| AU (2) | AU785040B2 (enExample) |
| BR (1) | BR0014150A (enExample) |
| CA (1) | CA2382848C (enExample) |
| DE (1) | DE60026150T2 (enExample) |
| ES (1) | ES2261239T3 (enExample) |
| MX (1) | MXPA02002251A (enExample) |
| WO (1) | WO2001016377A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL147182A0 (en) * | 1999-06-30 | 2002-08-14 | Interleukin Genetics Inc | Diagnostics and therapeutics for diseases associated with an il-1 inflammatory haplorype |
| US20090023147A1 (en) * | 1999-08-30 | 2009-01-22 | Kenneth Kornman | Diagnostics and therapeutics for osteoporosis |
| WO2004065939A2 (en) * | 2003-01-16 | 2004-08-05 | Decode Genetics Ehf. | Methods for diagnosing osteoporosis or a susceptibility to osteoporosis based on haplotype association |
| US20030152947A1 (en) * | 2001-06-15 | 2003-08-14 | Crossman David C. | Methods for detecting and treating the early onset of aging-related conditions |
| US20070264645A1 (en) * | 2002-01-25 | 2007-11-15 | Kenneth Kornman | IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes |
| JP2005529585A (ja) * | 2002-01-25 | 2005-10-06 | インターリューキン ジェネティックス インコーポレイテッド | Ｉｌ−１遺伝子群ならびに関連する炎症性多型およびハプロタイプ |
| WO2004018642A2 (en) * | 2002-08-24 | 2004-03-04 | Creighton University | Methods for detecting genes associated with bone properties and/or height |
| CN1863928A (zh) * | 2003-08-08 | 2006-11-15 | 英特利金遗传学有限公司 | 骨质疏松的诊断和治疗 |
| US7309589B2 (en) | 2004-08-20 | 2007-12-18 | Vironix Llc | Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing |
| RU2271827C1 (ru) * | 2004-09-28 | 2006-03-20 | Федеральное государственное учреждение"Санкт-Петербургский научно-исследовательский институт уха, горла, носа и речи Федерального агенства по здравоохранению и социальному развитию"(ФГУ "СПбНИИ ЛОР Росздрава") | Способ определения тактики лечения рекомбинантным цитокином, регулирующим воспаление |
| US8590329B2 (en) | 2004-12-22 | 2013-11-26 | Johnson Controls Technology Company | Medium voltage power controller |
| US7353662B2 (en) * | 2004-12-22 | 2008-04-08 | York International Corporation | Medium voltage starter for a chiller unit |
| WO2007050794A2 (en) * | 2005-10-25 | 2007-05-03 | Interleuken Genetics, Inc. | The il-1 gene cluster and associated inflammatory polymorphisms and haplotypes |
| ES2431671T3 (es) * | 2006-11-15 | 2013-11-27 | Interleukin Genetics, Inc. | El complejo génico de IL-1 y resistencia a la insulina: polimorfismos asociados, haplotipos y métodos para usarlos |
| WO2017123696A1 (en) | 2016-01-12 | 2017-07-20 | Interleukin Genetics, Inc. | Methods for predicting response to treatment |
| US10329620B2 (en) | 2017-01-12 | 2019-06-25 | Cardioforecast Ltd. | Methods and kits for treating cardiovascular disease |
| EP3980561A1 (en) | 2019-06-06 | 2022-04-13 | Sitokine Limited | Compositions and methods for treating lung, colorectal and breast cancer |
| WO2021028469A1 (en) | 2019-08-12 | 2021-02-18 | Sitokine Limited | Compositions and methods for treating cytokine release syndrome and neurotoxicity |
| WO2021205013A1 (en) | 2020-04-09 | 2021-10-14 | Sitokine Limited | Compositions and methods for treating covid-19 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8311018D0 (en) | 1983-04-22 | 1983-05-25 | Amersham Int Plc | Detecting mutations in dna |
| CA1316520C (en) | 1987-05-19 | 1993-04-20 | Larry C. Hamilton | Valve |
| FR2650840B1 (fr) | 1989-08-11 | 1991-11-29 | Bertin & Cie | Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications |
| WO1993011149A1 (en) | 1991-12-03 | 1993-06-10 | Thomas Jefferson University | Methods of detecting a genetic predisposition for osteoporosis |
| CA2141300C (en) | 1992-07-31 | 2006-03-14 | Nigel Alexander Morrison | Assessment of vitamin d receptors allelic variation |
| EP0675903B1 (en) | 1992-12-28 | 2004-09-29 | David J Baylink | Bone resorption assay |
| IL108947A0 (en) | 1993-03-12 | 1994-06-24 | Osteopharm Ltd | Bone stimulating factor |
| CA2164498C (en) | 1993-07-09 | 2007-09-11 | Paul A. Price | Assay for ykl-40 as a marker for degradation of mammalian connective tissue matrices |
| US5698399A (en) * | 1996-04-05 | 1997-12-16 | Duff; Gordon W. | Detecting genetic predisposition for osteoporosis |
| GB9706359D0 (en) | 1997-03-27 | 1997-05-14 | Gemini International Holdings | Polymorphisms of an il-1 receptor antagonist gene |
| GB9711040D0 (en) * | 1997-05-29 | 1997-07-23 | Duff Gordon W | Prediction of inflammatory disease |
-
2000
- 2000-08-30 ES ES00961425T patent/ES2261239T3/es not_active Expired - Lifetime
- 2000-08-30 EP EP00961425A patent/EP1212464B1/en not_active Expired - Lifetime
- 2000-08-30 AT AT00961425T patent/ATE318328T1/de not_active IP Right Cessation
- 2000-08-30 DE DE60026150T patent/DE60026150T2/de not_active Expired - Lifetime
- 2000-08-30 JP JP2001520922A patent/JP2004504802A/ja active Pending
- 2000-08-30 AU AU73380/00A patent/AU785040B2/en not_active Ceased
- 2000-08-30 MX MXPA02002251A patent/MXPA02002251A/es unknown
- 2000-08-30 BR BR0014150-0A patent/BR0014150A/pt not_active Application Discontinuation
- 2000-08-30 CA CA2382848A patent/CA2382848C/en not_active Expired - Fee Related
- 2000-08-30 WO PCT/US2000/023844 patent/WO2001016377A2/en not_active Ceased
- 2000-08-30 US US09/650,785 patent/US6558905B1/en not_active Expired - Lifetime
-
2003
- 2003-05-02 US US10/428,333 patent/US20040110168A1/en not_active Abandoned
-
2006
- 2006-07-19 AU AU2006203097A patent/AU2006203097B2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2382848A1 (en) | Diagnostics and therapeutics for osteoporosis | |
| JP2003508022A5 (enExample) | ||
| JP2002533096A5 (enExample) | ||
| KR101953176B1 (ko) | 미처리 혈액을 사용한 ｐｃｒ 및 ｈｌａ 타이핑 방법 | |
| EP1375672A1 (en) | Method of detecting nucleic acid relating to disease | |
| CA2435917A1 (en) | Highly sensitive method for the detection of cytosine methylation patterns | |
| JP2003530860A (ja) | 新生又は非新生細胞の検出方法 | |
| JP2014530819A5 (enExample) | ||
| KR102050637B1 (ko) | 약물 부작용과 관련된 대립유전자 및 이의 검출 방법 | |
| RU2009147281A (ru) | Способы и композиции для диагностики и лечения волчанки | |
| EP2423324A1 (en) | Probe set for identification of nucleotide mutation, and method for identification of nucleotide mutation | |
| Cintado et al. | Increase in neurokinin B expression and in tachykinin NK3 receptor-mediated response and expression in the rat uterus with age | |
| HUP0003264A2 (hu) | Prolaktin receptor gén, mint a megnövekedett sertés alomméret genetikai markere | |
| JP2003516162A (ja) | 核酸分析に基づく薬物スクリーニングのための装置および方法 | |
| EP1054066A2 (en) | Method for anticipating sensitivity to medicine for osteoporosis and a reagent therefor | |
| Koh et al. | Oestrogen receptor α genotype, and interactions between vitamin D receptor and transforming growth factor‐β1 genotypes are associated with quantitative calcaneal ultrasound in postmenopausal women | |
| EP1436756B1 (en) | Polymorphic marker that can be used to assess the efficacy of interferon therapy | |
| RU2005127807A (ru) | Применение нового полиморфизма в гене hsgki для диагностики гипертонии и применение генов семейства sgk для диагностики и терапии синдрома удлиненного q/t-периода | |
| US20180371542A1 (en) | Opioid receptor blockade in treating alcohol use disorders | |
| DE69833104D1 (de) | Glaukom diagnose und behandlung | |
| CN1814794A (zh) | 瘦素和瘦素受体基因多态性检测芯片及其制备方法和用途 | |
| US20030219775A1 (en) | Nucleic acid diagnostic reagents and methods for detecting nucleic acids, polynucleotides and oligonucleotides | |
| JP2001286288A (ja) | 診断法 | |
| JP2001333798A (ja) | ビタミンｄ受容体遺伝子、アポリポタンパクｅ遺伝子およびエストロゲン受容体遺伝子の遺伝子多型同時検出用試薬および該遺伝子多型同時検出方法 | |
| RU2005114525A (ru) | Маркерный ген |