JP2004502773A5 - - Google Patents
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- Publication number
- JP2004502773A5 JP2004502773A5 JP2002509312A JP2002509312A JP2004502773A5 JP 2004502773 A5 JP2004502773 A5 JP 2004502773A5 JP 2002509312 A JP2002509312 A JP 2002509312A JP 2002509312 A JP2002509312 A JP 2002509312A JP 2004502773 A5 JP2004502773 A5 JP 2004502773A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- formula
- aryl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 102
- 125000003118 aryl group Chemical group 0.000 description 49
- 125000003710 aryl alkyl group Chemical group 0.000 description 24
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 22
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 19
- 125000005018 aryl alkenyl group Chemical group 0.000 description 19
- -1 cinnamoylamino Chemical group 0.000 description 17
- 229910052736 halogen Inorganic materials 0.000 description 17
- 150000002367 halogens Chemical class 0.000 description 17
- 125000000217 alkyl group Chemical group 0.000 description 15
- 125000003545 alkoxy group Chemical group 0.000 description 12
- 229910052757 nitrogen Inorganic materials 0.000 description 12
- 229910052739 hydrogen Inorganic materials 0.000 description 11
- 150000002829 nitrogen Chemical group 0.000 description 10
- 125000000524 functional group Chemical group 0.000 description 9
- 125000000623 heterocyclic group Chemical group 0.000 description 9
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 description 8
- 125000000304 alkynyl group Chemical group 0.000 description 8
- 125000004429 atoms Chemical group 0.000 description 8
- 229910052799 carbon Inorganic materials 0.000 description 8
- 125000001188 haloalkyl group Chemical group 0.000 description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 201000011510 cancer Diseases 0.000 description 7
- 125000001424 substituent group Chemical group 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 125000003277 amino group Chemical group 0.000 description 5
- 125000001309 chloro group Chemical group Cl* 0.000 description 5
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 5
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 description 5
- 125000006216 methylsulfinyl group Chemical group [H]C([H])([H])S(*)=O 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 0 *C(c1ccnc(*)n1)(c1nc(C=I)ncc1)c1c(*)nccc1* Chemical compound *C(c1ccnc(*)n1)(c1nc(C=I)ncc1)c1c(*)nccc1* 0.000 description 4
- 210000000481 Breast Anatomy 0.000 description 4
- 210000003734 Kidney Anatomy 0.000 description 4
- 206010025650 Malignant melanoma Diseases 0.000 description 4
- 210000002307 Prostate Anatomy 0.000 description 4
- 125000003342 alkenyl group Chemical group 0.000 description 4
- 125000003282 alkyl amino group Chemical group 0.000 description 4
- 125000004432 carbon atoms Chemical group C* 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 125000001072 heteroaryl group Chemical group 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 201000001441 melanoma Diseases 0.000 description 4
- 230000002611 ovarian Effects 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 239000011593 sulfur Substances 0.000 description 4
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- WBYWAXJHAXSJNI-VOTSOKGWSA-N (2E)-3-phenylprop-2-enoic acid Chemical group OC(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000005236 alkanoylamino group Chemical group 0.000 description 2
- 125000004414 alkyl thio group Chemical group 0.000 description 2
- 125000001769 aryl amino group Chemical group 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- 125000001589 carboacyl group Chemical group 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N lithium Chemical group [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 125000006239 protecting group Chemical group 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- AQRLNPVMDITEJU-UHFFFAOYSA-N triethylsilane Chemical compound CC[SiH](CC)CC AQRLNPVMDITEJU-UHFFFAOYSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- KDFQYGBJUYYWDJ-UHFFFAOYSA-N azane;sodium Chemical compound N.[Na] KDFQYGBJUYYWDJ-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000002346 iodo group Chemical group I* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000001590 oxidative Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0017055A GB0017055D0 (en) | 2000-07-11 | 2000-07-11 | Synthesis |
| GB0030689A GB0030689D0 (en) | 2000-12-15 | 2000-12-15 | Synthesis |
| PCT/GB2001/003111 WO2002004447A1 (en) | 2000-07-11 | 2001-07-11 | Variolin derivatives as anti-cancer agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004502773A JP2004502773A (ja) | 2004-01-29 |
| JP2004502773A5 true JP2004502773A5 (da) | 2008-08-28 |
Family
ID=26244637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002509312A Pending JP2004502773A (ja) | 2000-07-11 | 2001-07-11 | 抗癌剤としてのバリオリン誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7320981B2 (da) |
| EP (1) | EP1299388B1 (da) |
| JP (1) | JP2004502773A (da) |
| KR (1) | KR100886161B1 (da) |
| CN (1) | CN1324028C (da) |
| AT (1) | ATE431349T1 (da) |
| AU (3) | AU7078301A (da) |
| BR (1) | BR0112413A (da) |
| CA (1) | CA2414200C (da) |
| CY (1) | CY1109283T1 (da) |
| DE (1) | DE60138707D1 (da) |
| DK (1) | DK1299388T3 (da) |
| ES (1) | ES2327210T3 (da) |
| IL (2) | IL153682A0 (da) |
| MX (1) | MXPA03000341A (da) |
| NZ (1) | NZ523491A (da) |
| PT (1) | PT1299388E (da) |
| RU (1) | RU2299884C2 (da) |
| SI (1) | SI1299388T1 (da) |
| WO (1) | WO2002004447A1 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0019117D0 (en) * | 2000-08-03 | 2000-09-27 | Univ Barcelona | Derivatives of variolin B |
| GB0116966D0 (en) | 2001-07-11 | 2001-09-05 | Pharma Mar Sa | Anittumoral compounds |
| DE10260235B4 (de) | 2002-12-20 | 2010-10-28 | Infineon Technologies Ag | Verfahren zum Strukturieren einer Resistschicht und Negativ-Resistschicht |
| MXPA05012377A (es) | 2003-05-15 | 2006-05-25 | Arqule Inc | Derivados de imidazotiazoles e imidazoxazol como inhibidores de p38. |
| US7829560B2 (en) | 2004-07-08 | 2010-11-09 | Arqule, Inc. | 1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase |
| JP2008517064A (ja) | 2004-10-19 | 2008-05-22 | アークル インコーポレイテッド | Ｐ３８ｍａｐキナーゼのイミダゾオキサゾールおよびイミダゾチアゾール阻害剤の合成 |
| EP1666467A1 (en) * | 2004-11-08 | 2006-06-07 | Evotec AG | 11Beta-HSD1 Inhibitors |
| JP5025270B2 (ja) * | 2005-01-12 | 2012-09-12 | 株式会社クラレ | 樹脂組成物及びそれからなるフィルム |
| US20080300267A1 (en) * | 2005-05-16 | 2008-12-04 | Barun Okram | Compounds and Compositions as Protein Kinase Inhibitors |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0019117D0 (en) * | 2000-08-03 | 2000-09-27 | Univ Barcelona | Derivatives of variolin B |
| GB0116966D0 (en) | 2001-07-11 | 2001-09-05 | Pharma Mar Sa | Anittumoral compounds |
-
2001
- 2001-07-11 KR KR1020027018072A patent/KR100886161B1/ko not_active IP Right Cessation
- 2001-07-11 CA CA2414200A patent/CA2414200C/en not_active Expired - Fee Related
- 2001-07-11 US US10/332,562 patent/US7320981B2/en not_active Expired - Fee Related
- 2001-07-11 PT PT01949663T patent/PT1299388E/pt unknown
- 2001-07-11 DE DE60138707T patent/DE60138707D1/de not_active Expired - Lifetime
- 2001-07-11 ES ES01949663T patent/ES2327210T3/es not_active Expired - Lifetime
- 2001-07-11 JP JP2002509312A patent/JP2004502773A/ja active Pending
- 2001-07-11 NZ NZ523491A patent/NZ523491A/en unknown
- 2001-07-11 MX MXPA03000341A patent/MXPA03000341A/es active IP Right Grant
- 2001-07-11 AU AU7078301A patent/AU7078301A/xx active Pending
- 2001-07-11 CN CNB018153666A patent/CN1324028C/zh not_active Expired - Fee Related
- 2001-07-11 RU RU2003103856/04A patent/RU2299884C2/ru not_active IP Right Cessation
- 2001-07-11 AT AT01949663T patent/ATE431349T1/de not_active IP Right Cessation
- 2001-07-11 DK DK01949663T patent/DK1299388T3/da active
- 2001-07-11 SI SI200130927T patent/SI1299388T1/sl unknown
- 2001-07-11 EP EP01949663A patent/EP1299388B1/en not_active Expired - Lifetime
- 2001-07-11 WO PCT/GB2001/003111 patent/WO2002004447A1/en active IP Right Grant
- 2001-07-11 IL IL15368201A patent/IL153682A0/xx unknown
- 2001-07-11 AU AU2001270783A patent/AU2001270783B2/en not_active Revoked
- 2001-07-11 BR BR0112413-7A patent/BR0112413A/pt not_active Application Discontinuation
-
2002
- 2002-12-26 IL IL153682A patent/IL153682A/en not_active IP Right Cessation
-
2006
- 2006-09-13 AU AU2006213946A patent/AU2006213946B2/en not_active Ceased
-
2009
- 2009-08-11 CY CY20091100849T patent/CY1109283T1/el unknown
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