JP2004502677A5 - - Google Patents
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- Publication number
- JP2004502677A5 JP2004502677A5 JP2002507788A JP2002507788A JP2004502677A5 JP 2004502677 A5 JP2004502677 A5 JP 2004502677A5 JP 2002507788 A JP2002507788 A JP 2002507788A JP 2002507788 A JP2002507788 A JP 2002507788A JP 2004502677 A5 JP2004502677 A5 JP 2004502677A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- heteroaryl
- phenyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000547 substituted alkyl group Chemical group 0.000 description 28
- 125000000217 alkyl group Chemical group 0.000 description 27
- 125000001072 heteroaryl group Chemical group 0.000 description 27
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 20
- 229910052739 hydrogen Inorganic materials 0.000 description 18
- 150000002431 hydrogen Chemical class 0.000 description 18
- 239000001257 hydrogen Substances 0.000 description 18
- -1 amino, substituted amino, hydroxy Chemical group 0.000 description 13
- 125000000623 heterocyclic group Chemical group 0.000 description 12
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 10
- 125000003118 aryl group Chemical group 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- 125000004414 alkyl thio group Chemical group 0.000 description 6
- 125000005362 aryl sulfone group Chemical group 0.000 description 6
- 125000005110 aryl thio group Chemical group 0.000 description 6
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 125000003107 substituted aryl group Chemical group 0.000 description 6
- 125000003545 alkoxy group Chemical group 0.000 description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 5
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 5
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 3
- 125000005360 alkyl sulfoxide group Chemical group 0.000 description 3
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 description 3
- 125000005361 aryl sulfoxide group Chemical group 0.000 description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 3
- 229910052794 bromium Inorganic materials 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 3
- 125000001624 naphthyl group Chemical group 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 description 2
- 108010004977 Vasopressins Proteins 0.000 description 2
- 102000002852 Vasopressins Human genes 0.000 description 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 2
- 125000005157 alkyl carboxy group Chemical group 0.000 description 2
- 230000006315 carbonylation Effects 0.000 description 2
- 238000005810 carbonylation reaction Methods 0.000 description 2
- 125000001475 halogen functional group Chemical group 0.000 description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 2
- 229960003726 vasopressin Drugs 0.000 description 2
- HGZORUNWJQFEJI-UHFFFAOYSA-N CC(C)C[n]1nccc1 Chemical compound CC(C)C[n]1nccc1 HGZORUNWJQFEJI-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000001593 cAMP accumulation Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21622000P | 2000-07-05 | 2000-07-05 | |
| US60/216,220 | 2000-07-05 | ||
| PCT/US2001/021080 WO2002002531A1 (en) | 2000-07-05 | 2001-07-02 | Nonpeptide substituted spirobenzoazepines as vasopressin antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004502677A JP2004502677A (ja) | 2004-01-29 |
| JP2004502677A5 true JP2004502677A5 (enExample) | 2012-01-12 |
| JP4916639B2 JP4916639B2 (ja) | 2012-04-18 |
Family
ID=22806231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002507788A Expired - Lifetime JP4916639B2 (ja) | 2000-07-05 | 2001-07-02 | バソプレシン拮抗質としての非ペプチド系置換スピロベンゾアゼピン |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US7001898B2 (enExample) |
| EP (1) | EP1307430B1 (enExample) |
| JP (1) | JP4916639B2 (enExample) |
| CN (1) | CN1449386B (enExample) |
| AT (1) | ATE305454T1 (enExample) |
| AU (2) | AU2001271780B2 (enExample) |
| BR (1) | BR0112372A (enExample) |
| CA (1) | CA2413945C (enExample) |
| DE (1) | DE60113696T2 (enExample) |
| DK (1) | DK1307430T3 (enExample) |
| ES (1) | ES2250432T3 (enExample) |
| HU (1) | HUP0301590A3 (enExample) |
| IL (2) | IL153710A0 (enExample) |
| MX (1) | MXPA03000135A (enExample) |
| MY (1) | MY135101A (enExample) |
| NO (1) | NO324499B1 (enExample) |
| NZ (1) | NZ523450A (enExample) |
| TW (1) | TWI316057B (enExample) |
| WO (1) | WO2002002531A1 (enExample) |
| ZA (1) | ZA200300972B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2250432T3 (es) * | 2000-07-05 | 2006-04-16 | Ortho-Mcneil Pharmaceutical, Inc. | Espirobenzoazepinas no peptidicas sustituidas, antagonistas de la vasopresina. |
| EP1364968A1 (en) * | 2002-05-23 | 2003-11-26 | Bayer Aktiengesellschaft | Diagnostics and therapeutics for diseases associated with arginine vasopressin receptor 1 (AVPR1) |
| CA2529513A1 (en) * | 2003-06-17 | 2005-01-06 | Janssen Pharmaceutica N.V. | Process for the preparation of nonpeptide substituted spirobenzoazepine derivatives |
| SI1633719T1 (sl) * | 2003-06-17 | 2010-01-29 | Janssen Pharmaceutica Nv | Substituirani spirobenzazepini |
| EP1984342A2 (en) * | 2006-01-20 | 2008-10-29 | Janssen Pharmaceutica, N.V. | Novel solid forms of (4r)-1-[4-(2-chloro-5-fluorobenzoyl)amino-3-methoxybenzoyl]-1,2,3,5-tetrahydro-spiro[4h-1-benzazepine-4,1'-[2]cyclopentene]-3'-carboxylic acid |
| WO2008036755A1 (en) * | 2006-09-22 | 2008-03-27 | Janssen Pharmaceutica N.V. | Spiro benzazepines used as vasopressin antagonists |
| EP2076517A1 (en) | 2006-09-22 | 2009-07-08 | Janssen Pharmaceutica N.V. | Spiro benzazepines as vasopressin antagonists |
| AR066834A1 (es) * | 2007-06-06 | 2009-09-16 | Janssen Pharmaceutica Nv | Espirobenzoazepanos como antagonistas de vasopresina, composiciones farmaceuticas que los contienen, proceso de preparacion y usos para el tratamiento de afecciones cardiacas, renales y del sistema nervioso central. |
| EA201170549A1 (ru) * | 2008-10-10 | 2012-01-30 | Янссен Фармацевтика Нв | Комбинированная терапия с использованием блокаторов рецепторов ангиотензина и антагонистов рецепторов вазопрессина |
| TW201938171A (zh) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物 |
| HU231206B1 (hu) | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepinek |
| JP7627343B2 (ja) * | 2020-11-26 | 2025-02-05 | シャンハイ ジェミンケア ファーマシューティカル カンパニー，リミティド | 新規ベンズアゼピンスピロ環式誘導体 |
| CN112939864B (zh) * | 2021-01-29 | 2022-05-06 | 中国医科大学 | 螺[苯并[c]氮杂-1,1’-环己基]-3-酮类化合物 |
| KR102954172B1 (ko) | 2021-03-05 | 2026-04-17 | 상하이 제유 파마슈티칼 컴퍼니 리미티드 | 신규 벤자제핀 융합 고리 유도체 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4617302A (en) * | 1984-10-15 | 1986-10-14 | Eli Lilly And Company | Inotropic agents |
| ZA882080B (en) * | 1987-03-27 | 1989-04-26 | Schering Corp | Substituted benzazepines,their preparation and pharmaceutical compositions containing them |
| KR0167349B1 (ko) * | 1989-10-20 | 1999-02-18 | 오스카 아끼히꼬 | 벤조헤테로 고리 화합물 |
| US5985869A (en) | 1989-10-20 | 1999-11-16 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
| US5258510A (en) | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
| TW198715B (enExample) * | 1991-04-19 | 1993-01-21 | Dtsuka Seiyaku Kk | |
| US5849780A (en) | 1992-01-30 | 1998-12-15 | Sanofi | 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| US5663431A (en) | 1992-01-30 | 1997-09-02 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| US5686624A (en) | 1992-01-30 | 1997-11-11 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| JPH08502474A (ja) * | 1992-10-07 | 1996-03-19 | メルク エンド カンパニー インコーポレーテッド | トコリティックオキシトシンレセプターアンタゴニスト |
| US5512563A (en) * | 1993-07-29 | 1996-04-30 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5464788A (en) * | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| US5753648A (en) | 1995-01-17 | 1998-05-19 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5753715A (en) | 1995-06-02 | 1998-05-19 | Ortho Pharmaceutical Corporation | 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents |
| AUPP150098A0 (en) * | 1998-01-27 | 1998-02-19 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide derivatives |
| AR018818A1 (es) * | 1998-04-03 | 2001-12-12 | Yamano Masaki | Una composicion farmaceutica para la terapia de un edema. |
| ES2250432T3 (es) | 2000-07-05 | 2006-04-16 | Ortho-Mcneil Pharmaceutical, Inc. | Espirobenzoazepinas no peptidicas sustituidas, antagonistas de la vasopresina. |
-
2001
- 2001-07-02 ES ES01950821T patent/ES2250432T3/es not_active Expired - Lifetime
- 2001-07-02 AU AU2001271780A patent/AU2001271780B2/en not_active Expired
- 2001-07-02 HU HU0301590A patent/HUP0301590A3/hu unknown
- 2001-07-02 US US09/897,206 patent/US7001898B2/en not_active Expired - Lifetime
- 2001-07-02 AT AT01950821T patent/ATE305454T1/de active
- 2001-07-02 BR BR0112372-6A patent/BR0112372A/pt not_active Application Discontinuation
- 2001-07-02 JP JP2002507788A patent/JP4916639B2/ja not_active Expired - Lifetime
- 2001-07-02 MX MXPA03000135A patent/MXPA03000135A/es active IP Right Grant
- 2001-07-02 AU AU7178001A patent/AU7178001A/xx active Pending
- 2001-07-02 WO PCT/US2001/021080 patent/WO2002002531A1/en not_active Ceased
- 2001-07-02 NZ NZ523450A patent/NZ523450A/en not_active IP Right Cessation
- 2001-07-02 CN CN018149278A patent/CN1449386B/zh not_active Expired - Lifetime
- 2001-07-02 CA CA2413945A patent/CA2413945C/en not_active Expired - Lifetime
- 2001-07-02 DE DE60113696T patent/DE60113696T2/de not_active Expired - Lifetime
- 2001-07-02 EP EP01950821A patent/EP1307430B1/en not_active Expired - Lifetime
- 2001-07-02 DK DK01950821T patent/DK1307430T3/da active
- 2001-07-02 IL IL15371001A patent/IL153710A0/xx unknown
- 2001-07-05 MY MYPI20013213A patent/MY135101A/en unknown
- 2001-07-05 TW TW090116416A patent/TWI316057B/zh not_active IP Right Cessation
-
2002
- 2002-12-27 IL IL153710A patent/IL153710A/en active IP Right Grant
-
2003
- 2003-01-03 NO NO20030028A patent/NO324499B1/no not_active IP Right Cessation
- 2003-02-04 ZA ZA200300972A patent/ZA200300972B/en unknown
- 2003-05-19 US US10/440,914 patent/US7238687B2/en not_active Expired - Lifetime
-
2006
- 2006-10-16 US US11/549,678 patent/US7691844B2/en not_active Expired - Lifetime
- 2006-11-29 US US11/564,471 patent/US7365062B2/en not_active Expired - Lifetime
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