CN1449386B - 作为血管升压素拮抗剂的非肽取代的螺苯并氮杂* - Google Patents

作为血管升压素拮抗剂的非肽取代的螺苯并氮杂* Download PDF

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Publication number
CN1449386B
CN1449386B CN018149278A CN01814927A CN1449386B CN 1449386 B CN1449386 B CN 1449386B CN 018149278 A CN018149278 A CN 018149278A CN 01814927 A CN01814927 A CN 01814927A CN 1449386 B CN1449386 B CN 1449386B
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substituted
alkyl
compound
phenyl
spiro
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Expired - Lifetime
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CN018149278A
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Chinese (zh)
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CN1449386A (zh
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R·H·陈
M·A·向
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3 Dimensional Pharmaceuticals Inc
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3 Dimensional Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN018149278A 2000-07-05 2001-07-02 作为血管升压素拮抗剂的非肽取代的螺苯并氮杂* Expired - Lifetime CN1449386B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21622000P 2000-07-05 2000-07-05
US60/216,220 2000-07-05
PCT/US2001/021080 WO2002002531A1 (en) 2000-07-05 2001-07-02 Nonpeptide substituted spirobenzoazepines as vasopressin antagonists

Publications (2)

Publication Number Publication Date
CN1449386A CN1449386A (zh) 2003-10-15
CN1449386B true CN1449386B (zh) 2012-07-04

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ID=22806231

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CN018149278A Expired - Lifetime CN1449386B (zh) 2000-07-05 2001-07-02 作为血管升压素拮抗剂的非肽取代的螺苯并氮杂*

Country Status (20)

Country Link
US (4) US7001898B2 (enExample)
EP (1) EP1307430B1 (enExample)
JP (1) JP4916639B2 (enExample)
CN (1) CN1449386B (enExample)
AT (1) ATE305454T1 (enExample)
AU (2) AU2001271780B2 (enExample)
BR (1) BR0112372A (enExample)
CA (1) CA2413945C (enExample)
DE (1) DE60113696T2 (enExample)
DK (1) DK1307430T3 (enExample)
ES (1) ES2250432T3 (enExample)
HU (1) HUP0301590A3 (enExample)
IL (2) IL153710A0 (enExample)
MX (1) MXPA03000135A (enExample)
MY (1) MY135101A (enExample)
NO (1) NO324499B1 (enExample)
NZ (1) NZ523450A (enExample)
TW (1) TWI316057B (enExample)
WO (1) WO2002002531A1 (enExample)
ZA (1) ZA200300972B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4916639B2 (ja) * 2000-07-05 2012-04-18 オーソーマクニール ファーマシューティカル， インコーポレイテッド バソプレシン拮抗質としての非ペプチド系置換スピロベンゾアゼピン
EP1364968A1 (en) * 2002-05-23 2003-11-26 Bayer Aktiengesellschaft Diagnostics and therapeutics for diseases associated with arginine vasopressin receptor 1 (AVPR1)
DK1633719T3 (da) * 2003-06-17 2010-01-04 Janssen Pharmaceutica Nv Substituerede spirobenzazepiner
HRP20051005A2 (en) * 2003-06-17 2006-09-30 Janssen Pharmaceutica N.V. Process for the preparation of nonpeptide substituted spirobenzoazepine derivatives
CA2637838A1 (en) * 2006-01-20 2007-07-26 Janssen Pharmaceutica N.V. Novel solid forms of (4r)-1-¬4-(2-chloro-5-fluorobenzoyl)amino-3-methoxybenzoyl|-1,2,3,5-tetrahydro-spiro¬4h-1-benzazepine-4,1'-¬2|cyclopentene|-3'-carboxylic acid
SI2078022T1 (sl) * 2006-09-22 2012-01-31 Janssen Pharmaceutica Nv Spiro benzazepini, uporabljeni kot antagonisti vazopresina
EP2076517A1 (en) * 2006-09-22 2009-07-08 Janssen Pharmaceutica N.V. Spiro benzazepines as vasopressin antagonists
AR066834A1 (es) * 2007-06-06 2009-09-16 Janssen Pharmaceutica Nv Espirobenzoazepanos como antagonistas de vasopresina, composiciones farmaceuticas que los contienen, proceso de preparacion y usos para el tratamiento de afecciones cardiacas, renales y del sistema nervioso central.
US20100093701A1 (en) * 2008-10-10 2010-04-15 Bruce Damiano Combination therapy comprising angiotensin receptor blockers and vasopressin receptor antagonists
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
JP7627343B2 (ja) * 2020-11-26 2025-02-05 シャンハイ ジェミンケア ファーマシューティカル カンパニー，リミティド 新規ベンズアゼピンスピロ環式誘導体
CN112939864B (zh) * 2021-01-29 2022-05-06 中国医科大学 螺[苯并[c]氮杂-1,1’-环己基]-3-酮类化合物

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007526A1 (en) * 1987-03-27 1988-10-06 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
WO1994007496A1 (en) * 1992-10-07 1994-04-14 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
CN1107146A (zh) * 1989-10-20 1995-08-23 大制药株式会社 含苯并杂环化合物的药物组合物的制备方法
CN1107467A (zh) * 1993-07-30 1995-08-30 萨诺费公司 1-苯磺酰基-1，3-二氢-吲哚-2-酮衍生物，其制备及含有它们的药物组合物
WO1995025443A1 (en) * 1994-03-24 1995-09-28 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
WO1999037637A1 (en) * 1998-01-27 1999-07-29 Fujisawa Pharmaceutical Co., Ltd. Benzamide derivatives as vasopressin antagonists

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4617302A (en) * 1984-10-15 1986-10-14 Eli Lilly And Company Inotropic agents
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
US5985869A (en) * 1989-10-20 1999-11-16 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
CA2066104C (en) * 1991-04-19 2003-05-27 Hidenori Ogawa Benzazepine derivatives as vasopressin antagonists
US5849780A (en) 1992-01-30 1998-12-15 Sanofi 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
US5686624A (en) 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
US5663431A (en) 1992-01-30 1997-09-02 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
US5512563A (en) 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5753648A (en) 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5753715A (en) * 1995-06-02 1998-05-19 Ortho Pharmaceutical Corporation 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents
AR018818A1 (es) * 1998-04-03 2001-12-12 Yamano Masaki Una composicion farmaceutica para la terapia de un edema.
JP4916639B2 (ja) * 2000-07-05 2012-04-18 オーソーマクニール ファーマシューティカル， インコーポレイテッド バソプレシン拮抗質としての非ペプチド系置換スピロベンゾアゼピン

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007526A1 (en) * 1987-03-27 1988-10-06 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
CN1107146A (zh) * 1989-10-20 1995-08-23 大制药株式会社 含苯并杂环化合物的药物组合物的制备方法
WO1994007496A1 (en) * 1992-10-07 1994-04-14 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
CN1107467A (zh) * 1993-07-30 1995-08-30 萨诺费公司 1-苯磺酰基-1，3-二氢-吲哚-2-酮衍生物，其制备及含有它们的药物组合物
WO1995025443A1 (en) * 1994-03-24 1995-09-28 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
WO1999037637A1 (en) * 1998-01-27 1999-07-29 Fujisawa Pharmaceutical Co., Ltd. Benzamide derivatives as vasopressin antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ohkawa, Takehiko 等.Synthesis and characterization of orally active nonpeptide vasopressin V2 receptor antagonists.《Chem. pharm. bull.》.1999,第47卷(第4期),501-510. *

Also Published As

Publication number Publication date
CA2413945A1 (en) 2002-01-10
CA2413945C (en) 2011-05-17
CN1449386A (zh) 2003-10-15
DE60113696D1 (de) 2006-02-09
IL153710A (en) 2010-12-30
US20030045517A1 (en) 2003-03-06
NO324499B1 (no) 2007-10-29
EP1307430A1 (en) 2003-05-07
HUP0301590A2 (hu) 2003-09-29
JP2004502677A (ja) 2004-01-29
ATE305454T1 (de) 2005-10-15
US20070135409A1 (en) 2007-06-14
NZ523450A (en) 2004-11-26
US7691844B2 (en) 2010-04-06
JP4916639B2 (ja) 2012-04-18
NO20030028D0 (no) 2003-01-03
US20070117790A1 (en) 2007-05-24
TWI316057B (en) 2009-10-21
AU7178001A (en) 2002-01-14
HUP0301590A3 (en) 2005-01-28
US7365062B2 (en) 2008-04-29
NO20030028L (no) 2003-03-03
US7238687B2 (en) 2007-07-03
EP1307430B1 (en) 2005-09-28
BR0112372A (pt) 2003-07-22
IL153710A0 (en) 2003-07-06
ZA200300972B (en) 2004-05-04
ES2250432T3 (es) 2006-04-16
US20060111567A1 (en) 2006-05-25
MY135101A (en) 2008-02-29
US7001898B2 (en) 2006-02-21
MXPA03000135A (es) 2005-02-17
WO2002002531A1 (en) 2002-01-10
DK1307430T3 (da) 2006-01-30
DE60113696T2 (de) 2006-07-13
AU2001271780B2 (en) 2006-09-14

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Granted publication date: 20120704