JP2004502421A5 - - Google Patents
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- Publication number
- JP2004502421A5 JP2004502421A5 JP2002507891A JP2002507891A JP2004502421A5 JP 2004502421 A5 JP2004502421 A5 JP 2004502421A5 JP 2002507891 A JP2002507891 A JP 2002507891A JP 2002507891 A JP2002507891 A JP 2002507891A JP 2004502421 A5 JP2004502421 A5 JP 2004502421A5
- Authority
- JP
- Japan
- Prior art keywords
- ser
- amino acid
- acid sequence
- gly
- asp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims description 12
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 2
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 101100504320 Caenorhabditis elegans mcp-1 gene Proteins 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0016138.0A GB0016138D0 (en) | 2000-06-30 | 2000-06-30 | Organic compounds |
| PCT/EP2001/007468 WO2002002640A2 (en) | 2000-06-30 | 2001-06-29 | Antibodies to human mcp-1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006314441A Division JP2007054079A (ja) | 2000-06-30 | 2006-11-21 | ヒトｍｃｐ−１に対する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004502421A JP2004502421A (ja) | 2004-01-29 |
| JP2004502421A5 true JP2004502421A5 (https=) | 2007-03-01 |
| JP3920215B2 JP3920215B2 (ja) | 2007-05-30 |
Family
ID=9894801
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002507891A Expired - Fee Related JP3920215B2 (ja) | 2000-06-30 | 2001-06-29 | ヒトｍｃｐ−１に対する抗体 |
| JP2006314441A Pending JP2007054079A (ja) | 2000-06-30 | 2006-11-21 | ヒトｍｃｐ−１に対する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006314441A Pending JP2007054079A (ja) | 2000-06-30 | 2006-11-21 | ヒトｍｃｐ−１に対する抗体 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20040047860A1 (https=) |
| EP (1) | EP1299421B1 (https=) |
| JP (2) | JP3920215B2 (https=) |
| KR (1) | KR100603899B1 (https=) |
| CN (1) | CN100486996C (https=) |
| AR (1) | AR046379A1 (https=) |
| AT (1) | ATE426616T1 (https=) |
| AU (2) | AU2001283903B2 (https=) |
| BR (1) | BR0112086A (https=) |
| CA (1) | CA2412775A1 (https=) |
| CZ (1) | CZ20024256A3 (https=) |
| DE (1) | DE60138102D1 (https=) |
| EC (1) | ECSP024402A (https=) |
| ES (1) | ES2322643T3 (https=) |
| GB (1) | GB0016138D0 (https=) |
| HU (1) | HUP0301477A3 (https=) |
| IL (1) | IL153721A0 (https=) |
| MX (1) | MXPA03000201A (https=) |
| NO (1) | NO20026063L (https=) |
| NZ (1) | NZ523195A (https=) |
| PE (1) | PE20020125A1 (https=) |
| PL (1) | PL207133B1 (https=) |
| PT (1) | PT1299421E (https=) |
| RU (1) | RU2314316C2 (https=) |
| SK (1) | SK18122002A3 (https=) |
| WO (1) | WO2002002640A2 (https=) |
| ZA (1) | ZA200300199B (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0108923B8 (pt) | 2000-03-03 | 2021-05-25 | Cambridge Antibody Tech Limited | elemento de ligação específico, ácido nucleico isolado, célula hospedeira, métodos para produzir um elemento de ligação específico ou domínio vh ou vl de anticorpo, e, para obter um elemento de ligação específico que liga eotaxina |
| US6946546B2 (en) | 2000-03-06 | 2005-09-20 | Cambridge Antibody Technology Limited | Human antibodies against eotaxin |
| EP1461300B1 (en) | 2001-11-30 | 2011-07-27 | Biogen Idec MA Inc. | Antibodies against monocyte chemotactic proteins |
| CA2496419A1 (en) * | 2002-08-19 | 2004-02-26 | Abgenix, Inc. | Antibodies directed to monocyte chemo-attractant protein-1 (mcp-1) and uses thereof |
| KR20050042801A (ko) * | 2002-09-12 | 2005-05-10 | 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 | 인간형 항인간 ｍｃｐ-1 항체 및 그의 항체 단편 |
| CA2544924A1 (en) * | 2003-11-05 | 2005-05-19 | Centocor, Inc. | Methods and compositions for treating mcp-1 related pathologies |
| US20080299130A1 (en) * | 2004-05-04 | 2008-12-04 | University Of Kentucky Research Foundation | Methods And Compositions For The Treatment Of Ocular Neovascularization |
| GB0412400D0 (en) * | 2004-06-03 | 2004-07-07 | Univ Newcastle | Treatment of inflammatory conditions |
| PE20061444A1 (es) * | 2005-05-19 | 2007-01-15 | Centocor Inc | Anticuerpo anti-mcp-1, composiciones, metodos y usos |
| US8114964B2 (en) * | 2005-05-19 | 2012-02-14 | Centocor, Inc. | Anti-MCP-1 antibodies, compositions, methods and uses |
| WO2007147026A2 (en) * | 2006-06-15 | 2007-12-21 | Centocor, Inc. | Ccr2 antagonists for chronic organ transplantation rejection |
| AU2007278054B2 (en) * | 2006-07-24 | 2012-11-22 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising CCL2 and use of same for the treatment of inflammation |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| KR20090074787A (ko) * | 2006-10-05 | 2009-07-07 | 센토코 오르토 바이오테크 인코포레이티드 | 섬유증 치료용 ｃｃｒ2 길항제 |
| WO2008077945A2 (en) * | 2006-12-22 | 2008-07-03 | Ablynx N.V. | Anti-chemokine (ccl2, ccl3, ccl5, cxcl11, cxcl12) single-domain antibodies |
| AU2008269954A1 (en) * | 2007-06-29 | 2009-01-08 | Centocor Ortho Biotech Inc. | Anti- MCP-1 antibodies, compositions, methods and uses |
| WO2009061830A1 (en) * | 2007-11-06 | 2009-05-14 | Massachusetts Eye & Ear Infirmary | Methods and compositions for treating conditions associated with angiogenesis using a vascular adhesion protein-1 (vap-1) inhibitor |
| JP5685535B2 (ja) | 2008-08-18 | 2015-03-18 | ファイザー インコーポレイティッド | Ｃｃｒ２に対する抗体 |
| ES2533493T3 (es) | 2008-08-20 | 2015-04-10 | Probiodrug Ag | Anticuerpos dirigidos contra la proteína 1 quimioatrayente de monocitos (MCP-1 N1pE) de piroglutamato |
| CN102459643B (zh) * | 2009-06-25 | 2016-06-01 | 弗雷德哈钦森癌症研究中心 | 检测获得性免疫的方法 |
| HK1208236A1 (en) | 2012-06-22 | 2016-02-26 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind ccr2 |
| CN107073112A (zh) * | 2014-08-15 | 2017-08-18 | 皮克萨尔比奥公司 | 用于在患有脊髓损伤的对象中抑制炎症的组合物及其使用方法 |
| CN104198727A (zh) * | 2014-08-22 | 2014-12-10 | 广西南宁隆吉维特生物科技有限公司 | 人血清ccl2酶联免疫检测试剂盒及其制备和使用方法 |
| ES2764840T3 (es) | 2015-01-28 | 2020-06-04 | Univ Bordeaux | Uso de plerixafor para tratar y/o prevenir exacerbaciones agudas de la enfermedad pulmonar obstructiva crónica |
| CN105695495B (zh) * | 2015-12-07 | 2020-02-18 | 中国石油大学(华东) | 一种高活性人趋化因子的制备方法及用途 |
| US10610104B2 (en) | 2016-12-07 | 2020-04-07 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| CA3045310A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| CN108048408B (zh) * | 2018-01-26 | 2020-02-07 | 扬州大学 | 牛单核细胞趋化蛋白-1杂交瘤细胞株、其分泌的单克隆抗体及应用 |
| US20220249814A1 (en) | 2018-11-19 | 2022-08-11 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
| IL287220B2 (en) | 2019-04-17 | 2026-03-01 | Univ Hiroshima | A therapeutic agent for urological cancer characterized by administering an IL-6 inhibitor in combination with a CCR2 inhibitor |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| MX2022007479A (es) * | 2019-12-18 | 2022-06-29 | Hoffmann La Roche | Anticuerpos anti-ccl2 biespecificos. |
| CN112358547A (zh) * | 2020-09-30 | 2021-02-12 | 浙江大学 | 抗人cxcl-2单克隆抗体3-d3及其编码基因和应用 |
| CN119684454B (zh) * | 2024-12-25 | 2025-09-12 | 武汉爱博泰克生物科技有限公司 | 针对人mcp-1蛋白的抗体、抗体对和试剂盒及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9019552D0 (en) * | 1990-09-07 | 1990-10-24 | Unilever Plc | Specific binding agents |
| GB9115364D0 (en) * | 1991-07-16 | 1991-08-28 | Wellcome Found | Antibody |
| CA2572289A1 (en) * | 2004-06-30 | 2006-08-17 | Centocor, Inc. | Anti-mcp-1 antibodies, compositions, methods and uses |
-
2000
- 2000-06-30 GB GBGB0016138.0A patent/GB0016138D0/en not_active Ceased
-
2001
- 2001-06-28 PE PE2001000649A patent/PE20020125A1/es not_active Application Discontinuation
- 2001-06-28 AR ARP010103086A patent/AR046379A1/es not_active Application Discontinuation
- 2001-06-29 KR KR1020027017405A patent/KR100603899B1/ko not_active Expired - Fee Related
- 2001-06-29 CN CNB018120652A patent/CN100486996C/zh not_active Expired - Fee Related
- 2001-06-29 PL PL359854A patent/PL207133B1/pl not_active IP Right Cessation
- 2001-06-29 US US10/312,022 patent/US20040047860A1/en not_active Abandoned
- 2001-06-29 AT AT01962800T patent/ATE426616T1/de not_active IP Right Cessation
- 2001-06-29 MX MXPA03000201A patent/MXPA03000201A/es active IP Right Grant
- 2001-06-29 DE DE60138102T patent/DE60138102D1/de not_active Expired - Lifetime
- 2001-06-29 JP JP2002507891A patent/JP3920215B2/ja not_active Expired - Fee Related
- 2001-06-29 BR BR0112086-7A patent/BR0112086A/pt not_active IP Right Cessation
- 2001-06-29 WO PCT/EP2001/007468 patent/WO2002002640A2/en not_active Ceased
- 2001-06-29 EP EP01962800A patent/EP1299421B1/en not_active Expired - Lifetime
- 2001-06-29 CZ CZ20024256A patent/CZ20024256A3/cs unknown
- 2001-06-29 NZ NZ523195A patent/NZ523195A/en unknown
- 2001-06-29 IL IL15372101A patent/IL153721A0/xx unknown
- 2001-06-29 PT PT01962800T patent/PT1299421E/pt unknown
- 2001-06-29 RU RU2003100512/13A patent/RU2314316C2/ru not_active IP Right Cessation
- 2001-06-29 HU HU0301477A patent/HUP0301477A3/hu unknown
- 2001-06-29 AU AU2001283903A patent/AU2001283903B2/en not_active Ceased
- 2001-06-29 AU AU8390301A patent/AU8390301A/xx active Pending
- 2001-06-29 SK SK1812-2002A patent/SK18122002A3/sk unknown
- 2001-06-29 CA CA002412775A patent/CA2412775A1/en not_active Abandoned
- 2001-06-29 ES ES01962800T patent/ES2322643T3/es not_active Expired - Lifetime
-
2002
- 2002-12-17 NO NO20026063A patent/NO20026063L/no not_active Application Discontinuation
- 2002-12-24 EC EC2002004402A patent/ECSP024402A/es unknown
-
2003
- 2003-01-08 ZA ZA200300199A patent/ZA200300199B/en unknown
-
2006
- 2006-11-21 JP JP2006314441A patent/JP2007054079A/ja active Pending
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