JP2004500320A5 - - Google Patents
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- JP2004500320A5 JP2004500320A5 JP2000593639A JP2000593639A JP2004500320A5 JP 2004500320 A5 JP2004500320 A5 JP 2004500320A5 JP 2000593639 A JP2000593639 A JP 2000593639A JP 2000593639 A JP2000593639 A JP 2000593639A JP 2004500320 A5 JP2004500320 A5 JP 2004500320A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- tweak
- composition
- monoclonal antibody
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000026278 immune system disease Diseases 0.000 description 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 4
- 101000830598 Homo sapiens Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 4
- 102000058177 human TNFSF12 Human genes 0.000 description 4
- 210000004408 hybridoma Anatomy 0.000 description 4
- 201000006417 multiple sclerosis Diseases 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 108010001857 Cell Surface Receptors Proteins 0.000 description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 102000006240 membrane receptors Human genes 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 206010001935 American trypanosomiasis Diseases 0.000 description 1
- 208000023328 Basedow disease Diseases 0.000 description 1
- 208000024699 Chagas disease Diseases 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 206010014950 Eosinophilia Diseases 0.000 description 1
- 206010018378 Glomerulonephritis rapidly progressive Diseases 0.000 description 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 1
- 208000015023 Graves' disease Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 101000830601 Mus musculus Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 description 1
- 206010036030 Polyarthritis Diseases 0.000 description 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 1
- 101710097155 Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 description 1
- 102100024584 Tumor necrosis factor ligand superfamily member 12 Human genes 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 206010046851 Uveitis Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 1
- 201000005637 crescentic glomerulonephritis Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000007475 hemolytic anemia Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 1
- 208000030428 polyarticular arthritis Diseases 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11616899P | 1999-01-15 | 1999-01-15 | |
| US60/116,168 | 1999-01-15 | ||
| PCT/US2000/001044 WO2000042073A1 (en) | 1999-01-15 | 2000-01-14 | Antagonists of tweak and of tweak receptor and their use to treat immunological disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010188938A Division JP5592195B2 (ja) | 1999-01-15 | 2010-08-25 | Ｔｗｅａｋのアンタゴニストおよびｔｗｅａｋレセプターのアンタゴニスト、ならびに免疫学的障害を処置するためのこれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004500320A JP2004500320A (ja) | 2004-01-08 |
| JP2004500320A5 true JP2004500320A5 (enExample) | 2009-08-20 |
| JP5550799B2 JP5550799B2 (ja) | 2014-07-16 |
Family
ID=22365656
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000593639A Expired - Fee Related JP5550799B2 (ja) | 1999-01-15 | 2000-01-14 | Ｔｗｅａｋのアンタゴニストおよびｔｗｅａｋレセプターのアンタゴニスト、ならびに免疫学的障害を処置するためのこれらの使用 |
| JP2010188938A Expired - Lifetime JP5592195B2 (ja) | 1999-01-15 | 2010-08-25 | Ｔｗｅａｋのアンタゴニストおよびｔｗｅａｋレセプターのアンタゴニスト、ならびに免疫学的障害を処置するためのこれらの使用 |
| JP2013006243A Withdrawn JP2013075916A (ja) | 1999-01-15 | 2013-01-17 | Ｔｗｅａｋのアンタゴニストおよびｔｗｅａｋレセプターのアンタゴニスト、ならびに免疫学的障害を処置するためのこれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010188938A Expired - Lifetime JP5592195B2 (ja) | 1999-01-15 | 2010-08-25 | Ｔｗｅａｋのアンタゴニストおよびｔｗｅａｋレセプターのアンタゴニスト、ならびに免疫学的障害を処置するためのこれらの使用 |
| JP2013006243A Withdrawn JP2013075916A (ja) | 1999-01-15 | 2013-01-17 | Ｔｗｅａｋのアンタゴニストおよびｔｗｅａｋレセプターのアンタゴニスト、ならびに免疫学的障害を処置するためのこれらの使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US20020015703A1 (enExample) |
| EP (1) | EP1141027A1 (enExample) |
| JP (3) | JP5550799B2 (enExample) |
| KR (1) | KR20010102978A (enExample) |
| CN (1) | CN1387538A (enExample) |
| AU (1) | AU2507700A (enExample) |
| BR (1) | BR0007556A (enExample) |
| CA (1) | CA2358684C (enExample) |
| CZ (1) | CZ20012548A3 (enExample) |
| EA (1) | EA004590B1 (enExample) |
| EE (1) | EE200100372A (enExample) |
| HK (1) | HK1038755A1 (enExample) |
| HU (1) | HUP0105044A3 (enExample) |
| IL (1) | IL144007A0 (enExample) |
| IS (1) | IS5986A (enExample) |
| MX (1) | MXPA01007163A (enExample) |
| NO (1) | NO20013340L (enExample) |
| NZ (1) | NZ529355A (enExample) |
| SK (1) | SK10042001A3 (enExample) |
| TR (1) | TR200102021T2 (enExample) |
| WO (1) | WO2000042073A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7129061B1 (en) * | 1996-08-07 | 2006-10-31 | Biogen Idec Ma Inc. | Tumor necrosis factor related ligand |
| US7001992B2 (en) * | 1997-05-30 | 2006-02-21 | Human Genome Sciences, Inc. | Antibodies to secreted protein HEMCM42 |
| AU2507700A (en) * | 1999-01-15 | 2000-08-01 | Biogen, Inc. | Antagonists of tweak and of tweak receptor and their use to treat immunological disorders |
| AU782067B2 (en) | 1999-12-20 | 2005-06-30 | Immunex Corporation | TWEAK receptor |
| US7495086B2 (en) | 1999-12-20 | 2009-02-24 | Immunex Corporation | TWEAK receptor |
| US6727225B2 (en) | 1999-12-20 | 2004-04-27 | Immunex Corporation | TWEAK receptor |
| US6943146B2 (en) | 2000-05-08 | 2005-09-13 | Biogen Idec Ma Inc. | Method for promoting neovascularization |
| US7208151B2 (en) * | 2001-09-12 | 2007-04-24 | Biogen Idec Ma Inc. | Tweak receptor agonists as anti-angiogenic agents |
| CA2422095A1 (en) * | 2000-09-14 | 2002-03-21 | Biogen, Inc. | Tweak receptor agonists as anti-angiogenic agents |
| SI1997512T1 (sl) * | 2002-04-09 | 2014-03-31 | Biogen Idec Ma Inc. | Postopki za zdravljenje stanj, povezanih s TWEAK-om |
| CN101899106A (zh) | 2002-10-29 | 2010-12-01 | 阿纳福公司 | 三聚细胞因子的三聚结合蛋白 |
| ATE364050T1 (de) | 2003-07-24 | 2007-06-15 | Amgen Inc | Zusammensetzungen und verfahren, die multimere und oligomere lösliche fragmente des tweak- rezeptors betreffen |
| CA2536086C (en) * | 2003-08-20 | 2013-03-19 | University Of Miami | Inhibition of dr3 in the treatment of allergic lung inflammation |
| EP1566636A1 (en) * | 2004-02-23 | 2005-08-24 | AXARON Bioscience AG | Use of Tweak modulators and inhibitors for the treatment of neurological conditions |
| WO2006052926A2 (en) * | 2004-11-08 | 2006-05-18 | University Of Maryland, Baltimore | Tweak as a therapeutic target for treating central nervous system diseases associated with cerebral edema and and cell death |
| US7939490B2 (en) | 2004-12-13 | 2011-05-10 | University Of Maryland, Baltimore | TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| WO2006088890A2 (en) * | 2005-02-17 | 2006-08-24 | Biogen Idec Ma Inc. | Treating stroke |
| DK2529619T3 (en) * | 2005-02-17 | 2016-01-11 | Biogen Ma Inc | Treatment of neurological disorders |
| CN101171035A (zh) * | 2005-03-07 | 2008-04-30 | 健泰科生物技术公司 | 用于调控tweak和fn14活性的方法和组合物 |
| CA2607697C (en) * | 2005-05-10 | 2015-01-06 | Biogen Idec Ma Inc. | Treating and evaluating inflammatory disorders |
| WO2006130429A2 (en) * | 2005-05-27 | 2006-12-07 | Biogen Idec Ma Inc. | Treatment of cancer |
| AU2013200995B2 (en) * | 2005-05-27 | 2016-08-04 | Biogen Ma Inc. | Tweak binding antibodies |
| EP2460832A3 (en) * | 2005-05-27 | 2012-10-31 | Biogen Idec MA Inc. | TWEAK binding antibodies |
| WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
| CA2621083C (en) | 2005-08-30 | 2017-04-11 | University Of Miami | Immunomodulating tumor necrosis factor receptor 25 (tnfr25) agonists, antagonists and immunotoxins |
| WO2008048924A2 (en) * | 2006-10-16 | 2008-04-24 | Biogen Idec Ma Inc. | Biomarkers of multiple sclerosis |
| KR20100053607A (ko) | 2007-08-03 | 2010-05-20 | 패시트 바이오테크 코포레이션 | 항-ｔｗｅａｋ 수용체 항체의 치료 용도 |
| US20110152173A1 (en) * | 2008-07-02 | 2011-06-23 | Emergent Product Development Seattle ,LLC | TNF-a ANTAGONIST MULTI-TARGET BINDING PROTEINS |
| US20110177070A1 (en) * | 2008-07-02 | 2011-07-21 | Emergent Product Development Seatlle, LLC | TGF-Beta Antagonist Multi-Target Binding Proteins |
| US20130124426A1 (en) * | 2008-10-02 | 2013-05-16 | ecoATM, Inc. | Method And Apparatus For Recycling Electronic Devices |
| US8093006B2 (en) | 2009-04-02 | 2012-01-10 | Hoffmann-La Roche Inc. | Antibodies against human tweak and uses thereof |
| JP2013501057A (ja) | 2009-08-03 | 2013-01-10 | ユニバーシティー・オブ・マイアミ | 制御性ｔ細胞のｉｎｖｉｖｏにおける増殖 |
| WO2011097500A2 (en) | 2010-02-04 | 2011-08-11 | University Of Louisville Research Foundation, Inc. | The tweak/fn14 system regulates skeletal muscle atrophy and regeneration |
| SG188605A1 (en) | 2010-10-05 | 2013-04-30 | Hoffmann La Roche | Antibodies against human tweak and uses thereof |
| EP2683740B1 (en) | 2011-03-10 | 2018-07-04 | Omeros Corporation | Generation of anti-fn14 monoclonal antibodies by ex-vivo accelerated antibody evolution |
| US9456755B2 (en) | 2011-04-29 | 2016-10-04 | Medtronic, Inc. | Method and device to monitor patients with kidney disease |
| PE20142422A1 (es) | 2012-04-05 | 2015-01-21 | Hoffmann La Roche | Anticuerpos biespecificos contra tweak humana e il 17 humana y usos de los mismos |
| US20140193410A1 (en) | 2013-01-09 | 2014-07-10 | University Of Miami | Compositions and Methods for the Regulation of T Regulatory Cells Using TL1A-Ig Fusion Protein |
| US9797882B2 (en) | 2013-07-09 | 2017-10-24 | The Translational Genomics Research Institute | Method of screening for a compound for inhibitory activity of FN14-tweak interaction |
| US9238034B2 (en) | 2013-07-09 | 2016-01-19 | The Translational Genomics Research Institute | FN14 antagonists and therapeutic uses thereof |
| JP2017029001A (ja) * | 2013-12-19 | 2017-02-09 | 国立研究開発法人産業技術総合研究所 | プロテインｇの細胞膜外ドメインの新規な改変型タンパク質 |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US9512229B2 (en) * | 2015-03-03 | 2016-12-06 | Kymab Limited | Synergistic combinations of OX40L antibodies for the treatment of GVHD |
| WO2017131972A1 (en) * | 2016-01-25 | 2017-08-03 | Oxytec Llc | Soil and water remediation method and apparatus for treatment of recalcitrant halogenated substances |
| BR112018076260A2 (pt) | 2016-06-20 | 2019-03-26 | Kymab Limited | anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina |
| US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
| US11661360B2 (en) | 2020-06-18 | 2023-05-30 | Wp&E Technologies And Solutions, Llc | System for removing per- and polyfluorinated alkyl substances from contaminated aqueous streams, via chemical aided filtration, and methods of use thereof |
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2000
- 2000-01-14 AU AU25077/00A patent/AU2507700A/en not_active Abandoned
- 2000-01-14 HK HK02100180.8A patent/HK1038755A1/zh unknown
- 2000-01-14 MX MXPA01007163A patent/MXPA01007163A/es unknown
- 2000-01-14 SK SK1004-2001A patent/SK10042001A3/sk unknown
- 2000-01-14 HU HU0105044A patent/HUP0105044A3/hu unknown
- 2000-01-14 KR KR1020017008956A patent/KR20010102978A/ko not_active Withdrawn
- 2000-01-14 CA CA2358684A patent/CA2358684C/en not_active Expired - Lifetime
- 2000-01-14 TR TR2001/02021T patent/TR200102021T2/xx unknown
- 2000-01-14 CN CN00804735A patent/CN1387538A/zh active Pending
- 2000-01-14 CZ CZ20012548A patent/CZ20012548A3/cs unknown
- 2000-01-14 BR BR0007556-6A patent/BR0007556A/pt not_active Application Discontinuation
- 2000-01-14 JP JP2000593639A patent/JP5550799B2/ja not_active Expired - Fee Related
- 2000-01-14 EE EEP200100372A patent/EE200100372A/xx unknown
- 2000-01-14 WO PCT/US2000/001044 patent/WO2000042073A1/en not_active Ceased
- 2000-01-14 EA EA200100780A patent/EA004590B1/ru not_active IP Right Cessation
- 2000-01-14 NZ NZ529355A patent/NZ529355A/en not_active IP Right Cessation
- 2000-01-14 IL IL14400700A patent/IL144007A0/xx unknown
- 2000-01-14 EP EP00903307A patent/EP1141027A1/en not_active Withdrawn
-
2001
- 2001-06-29 IS IS5986A patent/IS5986A/is unknown
- 2001-07-05 NO NO20013340A patent/NO20013340L/no not_active Application Discontinuation
- 2001-07-13 US US09/905,810 patent/US20020015703A1/en not_active Abandoned
-
2004
- 2004-08-11 US US10/916,141 patent/US7169387B2/en not_active Expired - Lifetime
-
2006
- 2006-10-04 US US11/542,745 patent/US7579001B2/en not_active Expired - Fee Related
-
2009
- 2009-07-20 US US12/506,006 patent/US20100061985A1/en not_active Abandoned
-
2010
- 2010-08-25 JP JP2010188938A patent/JP5592195B2/ja not_active Expired - Lifetime
-
2011
- 2011-06-30 US US13/173,604 patent/US8440189B2/en not_active Expired - Fee Related
-
2013
- 2013-01-17 JP JP2013006243A patent/JP2013075916A/ja not_active Withdrawn
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