JP2005517384A5 - - Google Patents

Info

Publication number

JP2005517384A5

JP2005517384A5 JP2003521777A JP2003521777A JP2005517384A5 JP 2005517384 A5 JP2005517384 A5 JP 2005517384A5 JP 2003521777 A JP2003521777 A JP 2003521777A JP 2003521777 A JP2003521777 A JP 2003521777A JP 2005517384 A5 JP2005517384 A5 JP 2005517384A5

Authority

JP

Japan

Prior art keywords

seq

antibody

lcvr

hcvr

disease

Prior art date

2002-08-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
• 208000035475 disorder Diseases 0.000 claims 12
• 229920001184 polypeptide Polymers 0.000 claims 11
• 102000004196 processed proteins & peptides Human genes 0.000 claims 11
• 108090000765 processed proteins & peptides Proteins 0.000 claims 11
• 230000000694 effects Effects 0.000 claims 7
• 239000012634 fragment Substances 0.000 claims 6
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• 210000000056 organ Anatomy 0.000 claims 6
• 208000009329 Graft vs Host Disease Diseases 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 4
• 206010052779 Transplant rejections Diseases 0.000 claims 4
• 201000011510 cancer Diseases 0.000 claims 4
• 208000024908 graft versus host disease Diseases 0.000 claims 4
• 208000015181 infectious disease Diseases 0.000 claims 4
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 4
• 235000001014 amino acid Nutrition 0.000 claims 3
• 239000005022 packaging material Substances 0.000 claims 3
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• 206010009900 Colitis ulcerative Diseases 0.000 claims 2
• 208000035473 Communicable disease Diseases 0.000 claims 2
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• 208000007984 Female Infertility Diseases 0.000 claims 2
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
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• 208000016604 Lyme disease Diseases 0.000 claims 2
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
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• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
• 201000004681 Psoriasis Diseases 0.000 claims 2
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
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• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Chemical group CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
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• 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
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• 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
• 238000002054 transplantation Methods 0.000 claims 2
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
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• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
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