JP2004500303A5 - - Google Patents
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- Publication number
- JP2004500303A5 JP2004500303A5 JP2000517942A JP2000517942A JP2004500303A5 JP 2004500303 A5 JP2004500303 A5 JP 2004500303A5 JP 2000517942 A JP2000517942 A JP 2000517942A JP 2000517942 A JP2000517942 A JP 2000517942A JP 2004500303 A5 JP2004500303 A5 JP 2004500303A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- fluoro
- hydrogen
- substituted
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001153 fluoro group Chemical group F* 0.000 claims 30
- 229910052739 hydrogen Inorganic materials 0.000 claims 25
- 239000001257 hydrogen Substances 0.000 claims 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 18
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 12
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 12
- -1 2- (2-furyl) ethyl Chemical group 0.000 claims 12
- 125000001309 chloro group Chemical group Cl* 0.000 claims 12
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000004973 1-butenyl group Chemical group C(=CCC)* 0.000 claims 6
- 125000003602 2-(3-thienyl)ethoxy group Chemical group [H]C1=C([H])C(=C([H])S1)C([H])([H])C([H])([H])O* 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 6
- 125000004344 phenylpropyl group Chemical group 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000006241 alcohol protecting group Chemical group 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95773697A | 1997-10-24 | 1997-10-24 | |
| PCT/US1998/022585 WO1999021830A1 (en) | 1997-10-24 | 1998-10-26 | Process for stereoselective synthesis of prostacyclin derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004500303A JP2004500303A (ja) | 2004-01-08 |
| JP2004500303A5 true JP2004500303A5 (enExample) | 2005-01-20 |
| JP3717053B2 JP3717053B2 (ja) | 2005-11-16 |
Family
ID=25500067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000517942A Expired - Fee Related JP3717053B2 (ja) | 1997-10-24 | 1998-10-26 | プロスタサイクリン誘導体の立体選択的合成法 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1025083B1 (enExample) |
| JP (1) | JP3717053B2 (enExample) |
| KR (1) | KR100447022B1 (enExample) |
| CN (1) | CN1264819C (enExample) |
| AT (1) | ATE245628T1 (enExample) |
| CA (2) | CA2847985C (enExample) |
| DE (1) | DE69816642T2 (enExample) |
| DK (1) | DK1025083T3 (enExample) |
| ES (1) | ES2198760T3 (enExample) |
| PT (1) | PT1025083E (enExample) |
| WO (1) | WO1999021830A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6700025B2 (en) * | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| ES2622471T5 (es) | 2003-05-22 | 2020-07-23 | United Therapeutics Corp | Compuestos y procedimientos para la administración de análogos de prostaciclina |
| CA2698721A1 (en) | 2007-09-07 | 2009-03-12 | United Therapeutics Corporation | Buffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same |
| CA2710205C (en) * | 2007-12-17 | 2016-04-26 | United Therapeutics Corporation | An improved process to prepare treprostinil, the active ingredient in remodulin |
| CN101891596B (zh) * | 2009-05-22 | 2013-12-11 | 上海天伟生物制药有限公司 | 一种化合物及其制备方法和用途 |
| CN103261142B (zh) * | 2010-06-03 | 2014-12-10 | 联合治疗公司 | 曲前列环素的制备 |
| CA2710725C (en) | 2010-07-22 | 2017-08-01 | Alphora Research Inc. | Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation |
| CA2726599C (en) | 2010-12-30 | 2017-07-25 | Alphora Research Inc. | Process for treprostinil salt preparation |
| US20130345471A1 (en) * | 2011-03-02 | 2013-12-26 | United Therapeutics Corporation | Synthesis of intermediate for treprostinil production |
| US8524939B2 (en) * | 2011-08-24 | 2013-09-03 | Chirogate International Inc. | Intermediates for the synthesis of benzindene prostaglandins and preparations thereof |
| CN103193627B (zh) * | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN103193626B (zh) * | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CA3125504C (en) | 2013-03-14 | 2023-10-24 | United Therapeutics Corporation | Solid forms of treprostinil |
| HU231184B1 (hu) * | 2014-10-08 | 2021-07-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Treprostinil-nátrium-monohidrát és eljárás ennek előállítására |
| WO2016064764A1 (en) | 2014-10-20 | 2016-04-28 | United Therapeutics Corporation | Synthesis of intermediate for producing prostacyclin derivatives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306075A (en) * | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| US4486598A (en) * | 1982-02-22 | 1984-12-04 | The Upjohn Company | Carbacyclin analogs |
| DE19708496A1 (de) * | 1997-03-03 | 1998-09-10 | Hoechst Ag | Verfahren zur enantionmerenreinen Anthracylin-Synthese |
-
1998
- 1998-10-26 DK DK98953972T patent/DK1025083T3/da active
- 1998-10-26 ES ES98953972T patent/ES2198760T3/es not_active Expired - Lifetime
- 1998-10-26 WO PCT/US1998/022585 patent/WO1999021830A1/en not_active Ceased
- 1998-10-26 DE DE69816642T patent/DE69816642T2/de not_active Expired - Lifetime
- 1998-10-26 CA CA2847985A patent/CA2847985C/en not_active Expired - Lifetime
- 1998-10-26 PT PT98953972T patent/PT1025083E/pt unknown
- 1998-10-26 CN CNB988126397A patent/CN1264819C/zh not_active Expired - Lifetime
- 1998-10-26 CA CA2307163A patent/CA2307163C/en not_active Expired - Lifetime
- 1998-10-26 AT AT98953972T patent/ATE245628T1/de active
- 1998-10-26 JP JP2000517942A patent/JP3717053B2/ja not_active Expired - Fee Related
- 1998-10-26 KR KR10-2000-7004300A patent/KR100447022B1/ko not_active Expired - Lifetime
- 1998-10-26 EP EP98953972A patent/EP1025083B1/en not_active Expired - Lifetime
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