JP2003534349A5 - - Google Patents
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- Publication number
- JP2003534349A5 JP2003534349A5 JP2001586317A JP2001586317A JP2003534349A5 JP 2003534349 A5 JP2003534349 A5 JP 2003534349A5 JP 2001586317 A JP2001586317 A JP 2001586317A JP 2001586317 A JP2001586317 A JP 2001586317A JP 2003534349 A5 JP2003534349 A5 JP 2003534349A5
- Authority
- JP
- Japan
- Prior art keywords
- same
- pharmaceutically acceptable
- acid
- lysate
- eluate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 6
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 239000006166 lysate Substances 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000004042 decolorization Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000MI001158A IT1318535B1 (it) | 2000-05-25 | 2000-05-25 | Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina. |
| ITMI2000A001158 | 2000-05-25 | ||
| IT2000A001158 | 2000-05-25 | ||
| PCT/EP2001/003633 WO2001090130A1 (en) | 2000-05-25 | 2001-03-30 | Process for the preparation of pharmaceutically acceptable salts of (ss-rs)-s-adenosyl-l-methionine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003534349A JP2003534349A (ja) | 2003-11-18 |
| JP2003534349A5 true JP2003534349A5 (https=) | 2008-05-08 |
| JP4777588B2 JP4777588B2 (ja) | 2011-09-21 |
Family
ID=11445118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001586317A Expired - Lifetime JP4777588B2 (ja) | 2000-05-25 | 2001-03-30 | （ｓｓ，ｒｓ）−ｓ−アデノシル−ｌ−メチオニンの薬剤として許容される塩の調製方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20020010147A1 (https=) |
| EP (1) | EP1283845B1 (https=) |
| JP (1) | JP4777588B2 (https=) |
| KR (1) | KR100737193B1 (https=) |
| AT (1) | ATE256695T1 (https=) |
| AU (2) | AU2001265848B8 (https=) |
| CA (1) | CA2407559C (https=) |
| DE (1) | DE60101575T2 (https=) |
| DK (1) | DK1283845T3 (https=) |
| ES (1) | ES2208610T3 (https=) |
| IT (1) | IT1318535B1 (https=) |
| PT (1) | PT1283845E (https=) |
| TR (1) | TR200302297T4 (https=) |
| WO (1) | WO2001090130A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7033815B2 (en) | 2001-03-30 | 2006-04-25 | Board Of Regents, The University Of Texas System | Biosynthesis of S-adenosylmethionine in a recombinant yeast strain |
| CN100398659C (zh) * | 2002-09-16 | 2008-07-02 | 上海青瑞生物医药技术有限公司 | 旋光纯(s,s)-腺甘甲硫氨酸制备的方法 |
| US20050272687A1 (en) * | 2004-06-08 | 2005-12-08 | Hebert Rolland F | Stable S-adenosyl-l-methionine |
| US20090012036A1 (en) * | 2005-05-24 | 2009-01-08 | Hebert Rolland F | Stable S-adenosyl-L-methionine |
| ES2406412T3 (es) | 2005-06-09 | 2013-06-06 | Gnosis S.P.A. | Células de Saccharomyces cerevisiae secas, liofilizadas y/o microencapsuladas con un alto contenido de (S)-(+)-S-adenosil-metionina |
| ITRM20050344A1 (it) * | 2005-06-30 | 2007-01-01 | Luca Maria De | Sali o complessi di sostanze metil-donatrici con acido fitico o suoi derivati e relativo metodo di sintesi. |
| CN1955306B (zh) * | 2005-10-28 | 2011-03-16 | 上海医药工业研究院 | 酵母菌生物合成、生产旋光纯腺苷甲硫氨酸的方法及其培养液 |
| ITMI20060629A1 (it) | 2006-03-31 | 2007-10-01 | Daniele Giovannone | Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento |
| US8202515B2 (en) | 2006-05-10 | 2012-06-19 | Mitsubishi Gas Chemical Company, Inc. | Method of producing dry yeast containing S-adenosyl-L-methionine and composition for oral intake |
| US20070265211A1 (en) * | 2006-05-12 | 2007-11-15 | Matthias Rath | Novel composition and method effective in inhibiting the atherogenic process |
| ITMI20071374A1 (it) * | 2007-07-10 | 2009-01-11 | Gnosis Spa | Sali stabili di s-adenosilmetionina e processo per il loro ottenimento. |
| US20100004191A1 (en) * | 2008-07-01 | 2010-01-07 | Rolland F Hebert | Compositions of S-adenosyl-L-methionine. |
| US9534010B2 (en) | 2013-01-16 | 2017-01-03 | Hebert Sam-E Llc | Stable indole-3-propionate salts of S-adenosyl-L-methionine |
| ITMI20130426A1 (it) * | 2013-03-20 | 2014-09-21 | Gnosis Spa | S-adenosilmetionina sterile ad alto contenuto di isomero attivo per soluzioni iniettabili e procedimento per ottenerla |
| CN106349311B (zh) * | 2016-08-23 | 2018-04-13 | 北京金阳利康医药有限公司 | 从酵母发酵液中提取s‑腺苷蛋氨酸的方法 |
| IT201700074957A1 (it) | 2017-07-04 | 2019-01-04 | Gnosis Spa | Sale di (ss)-adenosil metionina con inositolo esafosfato e procedimento per ottenerlo |
| CN110396120B (zh) * | 2019-02-13 | 2020-05-12 | 山东惠仕莱生物科技有限公司 | 一种从s-腺苷蛋氨酸发酵液中提取分离s-腺苷蛋氨酸的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE39517B1 (en) * | 1973-06-27 | 1978-10-25 | Bioresearch Sas | Double salts of s-adenosyl-l-methhionine |
| JPS56145299A (en) * | 1980-04-11 | 1981-11-11 | Kanegafuchi Chem Ind Co Ltd | Purification of s-adenosyl-l-methionine |
| JPS5929700A (ja) * | 1982-08-13 | 1984-02-16 | Nippon Zeon Co Ltd | Ｓ−アデノシル−ｌ−メチオニンの精製法 |
| IT1169773B (it) | 1983-08-24 | 1987-06-03 | Bioresearch Spa | Processo per la produzione di sali stabili della solfo-adenosil-l-metionina |
| IT1173990B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale |
-
2000
- 2000-05-25 IT IT2000MI001158A patent/IT1318535B1/it active
-
2001
- 2001-03-30 ES ES01943206T patent/ES2208610T3/es not_active Expired - Lifetime
- 2001-03-30 WO PCT/EP2001/003633 patent/WO2001090130A1/en not_active Ceased
- 2001-03-30 EP EP01943206A patent/EP1283845B1/en not_active Expired - Lifetime
- 2001-03-30 JP JP2001586317A patent/JP4777588B2/ja not_active Expired - Lifetime
- 2001-03-30 AT AT01943206T patent/ATE256695T1/de active
- 2001-03-30 DK DK01943206T patent/DK1283845T3/da active
- 2001-03-30 PT PT01943206T patent/PT1283845E/pt unknown
- 2001-03-30 CA CA002407559A patent/CA2407559C/en not_active Expired - Lifetime
- 2001-03-30 TR TR2003/02297T patent/TR200302297T4/xx unknown
- 2001-03-30 AU AU2001265848A patent/AU2001265848B8/en not_active Expired
- 2001-03-30 KR KR1020027015667A patent/KR100737193B1/ko not_active Expired - Lifetime
- 2001-03-30 AU AU6584801A patent/AU6584801A/xx active Pending
- 2001-03-30 DE DE60101575T patent/DE60101575T2/de not_active Expired - Lifetime
- 2001-04-11 US US09/829,906 patent/US20020010147A1/en not_active Abandoned
-
2002
- 2002-05-13 US US10/142,876 patent/US6958233B2/en not_active Expired - Lifetime
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