JP2003534000A5 - - Google Patents
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- Publication number
- JP2003534000A5 JP2003534000A5 JP2001587002A JP2001587002A JP2003534000A5 JP 2003534000 A5 JP2003534000 A5 JP 2003534000A5 JP 2001587002 A JP2001587002 A JP 2001587002A JP 2001587002 A JP2001587002 A JP 2001587002A JP 2003534000 A5 JP2003534000 A5 JP 2003534000A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antibody according
- tse
- peptide
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 6
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 208000010544 human prion disease Diseases 0.000 description 5
- 102100034452 Alternative prion protein Human genes 0.000 description 4
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 description 4
- 102000029797 Prion Human genes 0.000 description 4
- 108091000054 Prion Proteins 0.000 description 4
- 229960005486 vaccine Drugs 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 210000004408 hybridoma Anatomy 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 description 2
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00111108.7 | 2000-05-23 | ||
| EP00111108A EP1158003B2 (en) | 2000-05-23 | 2000-05-23 | Antibodies capable to selectively detect prion PrP Sc isoforms |
| PCT/IB2001/001666 WO2001090191A2 (en) | 2000-05-23 | 2001-05-15 | ANTIBODIES CAPABLE TO SELECTIVELY DETECT PRION PrPSc ISOFORMS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003534000A JP2003534000A (ja) | 2003-11-18 |
| JP2003534000A5 true JP2003534000A5 (https=) | 2008-06-26 |
| JP5042430B2 JP5042430B2 (ja) | 2012-10-03 |
Family
ID=8168816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001587002A Expired - Fee Related JP5042430B2 (ja) | 2000-05-23 | 2001-05-15 | プリオンＰｒＰＳｃイソ型を選択的に検出し得る抗体 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1158003B2 (https=) |
| JP (1) | JP5042430B2 (https=) |
| KR (1) | KR100829447B1 (https=) |
| CN (1) | CN1250572C (https=) |
| AR (1) | AR029098A1 (https=) |
| AT (1) | ATE312848T1 (https=) |
| AU (2) | AU2001284355B2 (https=) |
| CA (1) | CA2407905C (https=) |
| DE (1) | DE60024787T3 (https=) |
| DK (1) | DK1158003T4 (https=) |
| ES (1) | ES2253156T5 (https=) |
| HU (1) | HU229454B1 (https=) |
| PL (1) | PL208292B1 (https=) |
| WO (1) | WO2001090191A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003059386A2 (en) * | 2002-01-18 | 2003-07-24 | Cytos Biotechnology Ag | Prion protein carrier-conjugates |
| EP1596199A1 (en) * | 2004-05-14 | 2005-11-16 | Prionics AG | Method for the detection of disease-related prion |
| JP4246777B1 (ja) * | 2007-11-20 | 2009-04-02 | 森永乳業株式会社 | 異常型プリオン蛋白質結合剤および異常型プリオン蛋白質の検出方法 |
| EP2135880A1 (en) * | 2008-06-17 | 2009-12-23 | Heinrich-Heine-Universität Düsseldorf | Anti-prion protein antibody fragment |
| AU2009301580B2 (en) | 2008-10-06 | 2015-11-26 | The University Of British Columbia | Methods and systems for predicting misfolded protein epitopes |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ246059A (en) * | 1991-12-03 | 1995-08-28 | Proteus Molecular Design | Synthetic polypeptides with at least one antigenic site of a prion protein, methods of their use and manufacture, antibodies thereto, compositions and kits |
| DE852011T1 (de) * | 1995-09-14 | 2001-10-11 | Scripps Res Inst La Jolla | Für natives prp-sc spezifische antikörper |
| EP0861900A1 (en) † | 1997-02-21 | 1998-09-02 | Erziehungsdirektion Of The Canton Zurich | Immunological detection of prions |
| DE19741607A1 (de) * | 1997-09-20 | 1999-03-25 | Prionics Ag | Synthetische Polypeptide zur Diagnose und Therapie von Prionerkrankungen |
-
2000
- 2000-05-23 EP EP00111108A patent/EP1158003B2/en not_active Expired - Lifetime
- 2000-05-23 ES ES00111108T patent/ES2253156T5/es not_active Expired - Lifetime
- 2000-05-23 DE DE60024787T patent/DE60024787T3/de not_active Expired - Lifetime
- 2000-05-23 DK DK00111108.7T patent/DK1158003T4/da active
- 2000-05-23 AT AT00111108T patent/ATE312848T1/de active
-
2001
- 2001-05-15 PL PL360139A patent/PL208292B1/pl unknown
- 2001-05-15 CA CA2407905A patent/CA2407905C/en not_active Expired - Fee Related
- 2001-05-15 WO PCT/IB2001/001666 patent/WO2001090191A2/en not_active Ceased
- 2001-05-15 KR KR1020027015692A patent/KR100829447B1/ko not_active Expired - Fee Related
- 2001-05-15 AU AU2001284355A patent/AU2001284355B2/en not_active Ceased
- 2001-05-15 HU HU0302413A patent/HU229454B1/hu not_active IP Right Cessation
- 2001-05-15 AU AU8435501A patent/AU8435501A/xx active Pending
- 2001-05-15 CN CNB01809936XA patent/CN1250572C/zh not_active Expired - Fee Related
- 2001-05-15 JP JP2001587002A patent/JP5042430B2/ja not_active Expired - Fee Related
- 2001-05-23 AR ARP010102453A patent/AR029098A1/es active IP Right Grant
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