JP2003532636A5 - - Google Patents
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- Publication number
- JP2003532636A5 JP2003532636A5 JP2001562555A JP2001562555A JP2003532636A5 JP 2003532636 A5 JP2003532636 A5 JP 2003532636A5 JP 2001562555 A JP2001562555 A JP 2001562555A JP 2001562555 A JP2001562555 A JP 2001562555A JP 2003532636 A5 JP2003532636 A5 JP 2003532636A5
- Authority
- JP
- Japan
- Prior art keywords
- ion exchange
- reverse phase
- phase hplc
- exchange chromatography
- method described
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 13
- 238000004255 ion exchange chromatography Methods 0.000 description 7
- 238000004007 reversed phase HPLC Methods 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 238000010828 elution Methods 0.000 description 3
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
- 239000005695 Ammonium acetate Substances 0.000 description 2
- 229920002271 DEAE-Sepharose Polymers 0.000 description 2
- 229920002684 Sepharose Polymers 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- LVXHNCUCBXIIPE-UHFFFAOYSA-L disodium;hydrogen phosphate;hydrate Chemical compound O.[Na+].[Na+].OP([O-])([O-])=O LVXHNCUCBXIIPE-UHFFFAOYSA-L 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000004720 fertilization Effects 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00103692 | 2000-02-22 | ||
| EP00103692.0 | 2000-02-22 | ||
| PCT/EP2001/000666 WO2001062774A2 (en) | 2000-02-22 | 2001-01-22 | Purified lh |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003532636A JP2003532636A (ja) | 2003-11-05 |
| JP2003532636A5 true JP2003532636A5 (https=) | 2008-03-21 |
| JP4959898B2 JP4959898B2 (ja) | 2012-06-27 |
Family
ID=8167926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001562555A Expired - Lifetime JP4959898B2 (ja) | 2000-02-22 | 2001-01-22 | Ｌｈの精製 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US7053054B2 (https=) |
| EP (2) | EP1261622B1 (https=) |
| JP (1) | JP4959898B2 (https=) |
| KR (1) | KR100808149B1 (https=) |
| CN (1) | CN100480258C (https=) |
| AT (1) | ATE356138T1 (https=) |
| AU (1) | AU780377B2 (https=) |
| BG (1) | BG65761B1 (https=) |
| BR (2) | BRPI0108553B8 (https=) |
| CA (1) | CA2399100C (https=) |
| CY (1) | CY1108056T1 (https=) |
| CZ (1) | CZ303274B6 (https=) |
| DE (1) | DE60127100T2 (https=) |
| DK (1) | DK1261622T3 (https=) |
| EA (1) | EA004385B1 (https=) |
| EE (1) | EE04932B1 (https=) |
| ES (1) | ES2278722T3 (https=) |
| HR (1) | HRP20020651B1 (https=) |
| HU (1) | HU227007B1 (https=) |
| IL (2) | IL151309A0 (https=) |
| MX (1) | MXPA02007867A (https=) |
| NO (1) | NO328693B1 (https=) |
| PL (1) | PL207728B1 (https=) |
| PT (1) | PT1261622E (https=) |
| RS (1) | RS50416B (https=) |
| SI (1) | SI1261622T1 (https=) |
| SK (1) | SK287041B6 (https=) |
| UA (2) | UA92145C2 (https=) |
| WO (1) | WO2001062774A2 (https=) |
| ZA (1) | ZA200206108B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ303274B6 (cs) * | 2000-02-22 | 2012-07-11 | Merck Serono Sa | Zpusob vycištení luteinizacního hormonu |
| DE10235168A1 (de) * | 2002-08-01 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Verfahren zur Reinigung von Preproinsulin |
| CA2518268C (en) * | 2003-03-04 | 2013-12-10 | Aspenbio, Inc. | Methods and kits for maintaining pregnancy, treating follicular cysts, and synchronizing ovulation using luteinizing hormone |
| CN1283792C (zh) * | 2003-11-14 | 2006-11-08 | 余伟明 | 生物大分子组分相分离法 |
| EP1697412B1 (en) * | 2003-12-22 | 2009-10-21 | Ares Trading S.A. | Method for purifying fsh |
| ATE469912T1 (de) * | 2004-10-04 | 2010-06-15 | Novetide Ltd | Gegenionenaustauschverfahren für peptide |
| DE602005009856D1 (de) * | 2004-11-09 | 2008-10-30 | Ares Trading Sa | Verfahren zur reinigung von fsh |
| WO2007022799A1 (en) * | 2005-08-26 | 2007-03-01 | Ares Trading S.A. | Process for the preparation of glycosylated interferon beta |
| EP1960419B1 (en) | 2005-12-09 | 2016-03-16 | Ares Trading S.A. | Method for purifying fsh or a fsh mutant |
| WO2009053360A1 (en) * | 2007-10-22 | 2009-04-30 | Merck Serono S.A. | Method for purifying an fc-containing protein |
| US20100249381A1 (en) * | 2007-10-22 | 2010-09-30 | David Delvaille | Method for Purifying FC-Fusion Proteins |
| CN101928342B (zh) * | 2009-06-18 | 2013-05-08 | 上海天伟生物制药有限公司 | 一种高纯度绝经期促性腺素及其制备方法和用途 |
| WO2015168622A1 (en) * | 2014-05-01 | 2015-11-05 | Virginia Tech Intellectual Properties, Inc. | Keratin nanomaterials and methods of production |
| CN104569441B (zh) * | 2015-01-19 | 2016-02-03 | 成都大熊猫繁育研究基地 | 大熊猫尿液促黄体素的酶联检测方法及其应用 |
| CA3140267A1 (en) | 2019-05-16 | 2020-11-19 | Ceva Sante Animale | Compositions and methods for increasing reproduction performance in non-human mammals using recombinant luteinizing hormone |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0394363A1 (en) * | 1988-09-02 | 1990-10-31 | Integrated Genetics, Inc. | Heteropolymeric protein |
| JP3045539B2 (ja) * | 1989-02-21 | 2000-05-29 | ワシントン ユニバーシティ | 改変型生殖ホルモン |
| US5087615A (en) * | 1989-03-17 | 1992-02-11 | Applied Research Systems Ars Holding N.V. | Novel method of ovulation induction in humans |
| IT1250075B (it) * | 1991-12-18 | 1995-03-30 | Serono Cesare Ist Ricerca | Composizioni farmaceutiche contenenti gonadotropine. |
| IT1287138B1 (it) | 1996-11-07 | 1998-08-04 | Ibsa Inst Biochimique Sa | Procedimento per la separazione e purificazione di fsh e lh |
| IL122732A0 (en) * | 1997-01-15 | 1998-08-16 | Akzo Nobel Nv | Liquid gonadotropin-containing formulation its preparation and a device containing same |
| ES2332931T3 (es) * | 1997-06-25 | 2010-02-15 | Merck Serono Sa | Analogos de hormonas glicoproteinicas entrelazadas por disulfuro, su preparacion y uso. |
| CZ303274B6 (cs) * | 2000-02-22 | 2012-07-11 | Merck Serono Sa | Zpusob vycištení luteinizacního hormonu |
-
2001
- 2001-01-22 CZ CZ20022856A patent/CZ303274B6/cs not_active IP Right Cessation
- 2001-01-22 UA UAA200612399A patent/UA92145C2/uk unknown
- 2001-01-22 ES ES01907476T patent/ES2278722T3/es not_active Expired - Lifetime
- 2001-01-22 PT PT01907476T patent/PT1261622E/pt unknown
- 2001-01-22 IL IL15130901A patent/IL151309A0/xx unknown
- 2001-01-22 AU AU35436/01A patent/AU780377B2/en not_active Expired
- 2001-01-22 HU HU0301814A patent/HU227007B1/hu unknown
- 2001-01-22 KR KR1020027010624A patent/KR100808149B1/ko not_active Expired - Lifetime
- 2001-01-22 EA EA200200893A patent/EA004385B1/ru not_active IP Right Cessation
- 2001-01-22 CA CA2399100A patent/CA2399100C/en not_active Expired - Fee Related
- 2001-01-22 SK SK1205-2002A patent/SK287041B6/sk not_active IP Right Cessation
- 2001-01-22 PL PL362891A patent/PL207728B1/pl unknown
- 2001-01-22 CN CNB018053645A patent/CN100480258C/zh not_active Expired - Lifetime
- 2001-01-22 SI SI200130709T patent/SI1261622T1/sl unknown
- 2001-01-22 EE EEP200200464A patent/EE04932B1/xx unknown
- 2001-01-22 WO PCT/EP2001/000666 patent/WO2001062774A2/en not_active Ceased
- 2001-01-22 UA UA2002086889A patent/UA78676C2/xx unknown
- 2001-01-22 MX MXPA02007867A patent/MXPA02007867A/es active IP Right Grant
- 2001-01-22 DE DE60127100T patent/DE60127100T2/de not_active Expired - Lifetime
- 2001-01-22 RS YUP-603/02A patent/RS50416B/sr unknown
- 2001-01-22 AT AT01907476T patent/ATE356138T1/de active
- 2001-01-22 EP EP01907476A patent/EP1261622B1/en not_active Expired - Lifetime
- 2001-01-22 JP JP2001562555A patent/JP4959898B2/ja not_active Expired - Lifetime
- 2001-01-22 BR BRPI0108553A patent/BRPI0108553B8/pt not_active IP Right Cessation
- 2001-01-22 EP EP06016629A patent/EP1777231A3/en not_active Withdrawn
- 2001-01-22 DK DK01907476T patent/DK1261622T3/da active
- 2001-01-22 HR HR20020651A patent/HRP20020651B1/xx not_active IP Right Cessation
- 2001-01-22 US US10/204,554 patent/US7053054B2/en not_active Expired - Lifetime
- 2001-01-22 BR BR122012018280A patent/BR122012018280B8/pt not_active IP Right Cessation
-
2002
- 2002-07-31 ZA ZA200206108A patent/ZA200206108B/en unknown
- 2002-08-14 BG BG107001A patent/BG65761B1/bg unknown
- 2002-08-18 IL IL151309A patent/IL151309A/en active IP Right Grant
- 2002-08-20 NO NO20023963A patent/NO328693B1/no not_active IP Right Cessation
-
2005
- 2005-11-28 US US11/287,341 patent/US20060079460A1/en not_active Abandoned
-
2007
- 2007-05-10 CY CY20071100638T patent/CY1108056T1/el unknown
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