JP2003531129A - 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用 - Google Patents
炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用Info
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- JP2003531129A JP2003531129A JP2001576078A JP2001576078A JP2003531129A JP 2003531129 A JP2003531129 A JP 2003531129A JP 2001576078 A JP2001576078 A JP 2001576078A JP 2001576078 A JP2001576078 A JP 2001576078A JP 2003531129 A JP2003531129 A JP 2003531129A
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Landscapes
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55008200A | 2000-04-14 | 2000-04-14 | |
| US09/550,082 | 2000-04-14 | ||
| US09/748,960 | 2000-12-27 | ||
| US09/748,960 US20010046496A1 (en) | 2000-04-14 | 2000-12-27 | Method of administering an antibody |
| PCT/US2001/012234 WO2001078779A2 (en) | 2000-04-14 | 2001-04-13 | Antibody alpha4beta7 integrin and its use to treat inflammatory bowel disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2012105379A Division JP5764524B2 (ja) | 2000-04-14 | 2012-05-02 | 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用 |
Publications (2)
| Publication Number | Publication Date |
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| JP2003531129A true JP2003531129A (ja) | 2003-10-21 |
| JP2003531129A5 JP2003531129A5 (enrdf_load_html_response) | 2011-02-17 |
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| JP2001576078A Withdrawn JP2003531129A (ja) | 2000-04-14 | 2001-04-13 | 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用 |
| JP2012105379A Expired - Lifetime JP5764524B2 (ja) | 2000-04-14 | 2012-05-02 | 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用 |
| JP2015007655A Expired - Lifetime JP6021959B2 (ja) | 2000-04-14 | 2015-01-19 | 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用 |
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Country Status (15)
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Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1485127T1 (sl) | 2002-02-25 | 2011-09-30 | Elan Pharm Inc | Dajanje aktivne snovi za zdravljenje vnetja |
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| ES2351057T3 (es) * | 2005-07-08 | 2011-01-31 | Pfizer Limited | Anticuerpos contra madcam. |
| WO2007007152A2 (en) * | 2005-07-11 | 2007-01-18 | Pfizer Limited | Anti-madcam antibodies to treat metastatic cancers and chloroma |
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| MY162752A (en) * | 2009-03-20 | 2017-07-14 | Amgen Inc | Alpha-4-beta-7 heterodimer specific antagonist antibody |
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| DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| KR102014061B1 (ko) | 2011-10-03 | 2019-08-28 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도 |
| MX366936B (es) | 2011-11-23 | 2019-07-31 | Amgen Inc | Uso de un anticuerpo específico alfa4beta7. |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| EA034583B1 (ru) * | 2012-01-12 | 2020-02-21 | Милленниум Фармасьютикалз, Инк. | ПРИМЕНЕНИЯ АНТИ-α4β7 АНТИТЕЛА |
| US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| HK1206636A1 (zh) | 2012-04-02 | 2016-01-15 | Modernatx, Inc. | 用於制备肿瘤相关蛋白和多肽的修饰的多核苷酸 |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| SMT202200337T1 (it) | 2012-11-26 | 2022-09-14 | Modernatx Inc | Rna modificato al livello del terminale |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
| BR112016007255A2 (pt) | 2013-10-03 | 2017-09-12 | Moderna Therapeutics Inc | polinucleotídeos que codificam receptor de lipoproteína de baixa densidade |
| JP2017537105A (ja) | 2014-11-26 | 2017-12-14 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 瘻孔を伴うクローン病の治療用ベドリズマブ |
| WO2016105572A1 (en) | 2014-12-24 | 2016-06-30 | Millennium Pharmaceuticals, Inc. | PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-α4β7 INTEGRIN ANTIBODY |
| MX2018011025A (es) | 2016-03-14 | 2019-01-10 | Millennium Pharm Inc | Metodos para tratar o prevenir la enfermedad del injerto contra huésped. |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998006248A2 (en) * | 1996-08-15 | 1998-02-19 | Leukosite, Inc. | HUMANIZED IMMUNOGLOBULIN REACTIVE WITH α4β7 INTEGRIN |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4172124A (en) | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| WO1988009344A1 (en) | 1987-05-21 | 1988-12-01 | Creative Biomolecules, Inc. | Targeted multifunctional proteins |
| US5403919A (en) * | 1987-08-11 | 1995-04-04 | Board Of Trustees Of The Leland Stanford Junior University Stanford University | Method to control leukocyte extravasation |
| US5538724A (en) * | 1987-08-11 | 1996-07-23 | The Board Of Trustees For The Leland Stanford Junior Univ. | Method of control leukocyte extravasation |
| WO1989007142A1 (en) | 1988-02-05 | 1989-08-10 | Morrison Sherie L | Domain-modified constant region antibodies |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| DK0463151T3 (da) | 1990-01-12 | 1996-07-01 | Cell Genesys Inc | Frembringelse af xenogene antistoffer |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
| US6407213B1 (en) * | 1991-06-14 | 2002-06-18 | Genentech, Inc. | Method for making humanized antibodies |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| DK0605522T3 (da) | 1991-09-23 | 2000-01-17 | Medical Res Council | Fremgangsmåde til fremstilling af humaniserede antistoffer |
| US5871734A (en) * | 1992-01-13 | 1999-02-16 | Biogen, Inc. | Treatment for asthma with VLA-4 blocking agents |
| US5932214A (en) * | 1994-08-11 | 1999-08-03 | Biogen, Inc. | Treatment for inflammatory bowel disease with VLA-4 blockers |
| NZ262615A (en) * | 1993-02-09 | 1996-02-27 | Biogen Inc | Treating insulin dependent diabetes (type i) with anti vla4 (very late antigen) antibodies |
| DE614989T1 (de) | 1993-02-17 | 1995-09-28 | Morphosys Proteinoptimierung | Verfahren für in vivo Selektion von Ligandenbindende Proteine. |
| JPH08511420A (ja) | 1993-06-16 | 1996-12-03 | セルテック・セラピューテイクス・リミテッド | 抗 体 |
| US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
| GB2292079B (en) * | 1994-08-12 | 1998-07-15 | Flexpharm Ltd | Coated prednisolone preparation for the treatment of inflamatory bowel disease |
| US6551593B1 (en) * | 1995-02-10 | 2003-04-22 | Millennium Pharmaceuticals, Inc. | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam |
| US6015662A (en) * | 1996-01-23 | 2000-01-18 | Abbott Laboratories | Reagents for use as calibrators and controls |
| KR100643058B1 (ko) | 1996-12-03 | 2006-11-13 | 아브게닉스, 인크. | 복수의 Ｖн 및 Ｖк 영역을 함유하는 인간 면역글로불린 유전자좌를 갖는 트랜스제닉 포유동물 및 이로부터 생성된 항체 |
| EP1113810B1 (en) * | 1998-09-14 | 2008-12-31 | Board of Regents, The University of Texas System | Methods of treating multiple myeloma and myeloma-induced bone resorption using antagonists of integrin / receptor binding |
-
2000
- 2000-12-27 US US09/748,960 patent/US20010046496A1/en not_active Abandoned
-
2001
- 2001-04-13 EP EP01925028A patent/EP1278543B1/en not_active Expired - Lifetime
- 2001-04-13 EP EP16191558.2A patent/EP3167902B1/en not_active Revoked
- 2001-04-13 DK DK10010997.4T patent/DK2298348T3/en active
- 2001-04-13 JP JP2001576078A patent/JP2003531129A/ja not_active Withdrawn
- 2001-04-13 EP EP10010997.4A patent/EP2298348B9/en not_active Expired - Lifetime
- 2001-04-13 AU AU2001251629A patent/AU2001251629A1/en not_active Abandoned
- 2001-04-13 ES ES10010997.4T patent/ES2609689T3/es not_active Expired - Lifetime
- 2001-04-13 DK DK01925028.1T patent/DK1278543T3/da active
- 2001-04-13 PT PT100109974T patent/PT2298348T/pt unknown
- 2001-04-13 MX MXPA02010059A patent/MXPA02010059A/es active IP Right Grant
- 2001-04-13 WO PCT/US2001/012234 patent/WO2001078779A2/en active Application Filing
- 2001-04-13 ES ES01925028T patent/ES2398096T3/es not_active Expired - Lifetime
- 2001-04-13 CA CA2406220A patent/CA2406220C/en not_active Expired - Lifetime
-
2003
- 2003-12-15 US US10/735,863 patent/US20050095238A1/en not_active Abandoned
-
2011
- 2011-08-05 US US13/204,139 patent/US20120034243A1/en not_active Abandoned
-
2012
- 2012-05-02 JP JP2012105379A patent/JP5764524B2/ja not_active Expired - Lifetime
- 2012-12-18 CY CY20121101236T patent/CY1113489T1/el unknown
-
2014
- 2014-02-03 US US14/171,161 patent/US20140186345A1/en not_active Abandoned
- 2014-11-11 NL NL300702C patent/NL300702I1/nl unknown
- 2014-11-13 FR FR14C0080C patent/FR14C0080I2/fr active Active
- 2014-11-17 CY CY2014046C patent/CY2014046I1/el unknown
-
2015
- 2015-01-19 JP JP2015007655A patent/JP6021959B2/ja not_active Expired - Lifetime
-
2017
- 2017-01-05 CY CY20171100013T patent/CY1118429T1/el unknown
- 2017-04-11 LU LU00014C patent/LUC00014I2/fr unknown
- 2017-04-11 BE BE2017C009C patent/BE2017C009I2/nl unknown
-
2018
- 2018-11-02 US US16/179,157 patent/US20200002423A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998006248A2 (en) * | 1996-08-15 | 1998-02-19 | Leukosite, Inc. | HUMANIZED IMMUNOGLOBULIN REACTIVE WITH α4β7 INTEGRIN |
Non-Patent Citations (2)
| Title |
|---|
| JPN5002028637; ＧＯＲＤＯＮ ＦＩＯＮＡ Ｈ: ＧＡＳＴＲＯＥＮＴＥＲＯＬＯＧＹ Ｖｏｌ．１１６ Ｎｏ．４ ＰＡＲＴ．２, 199904, ｐ．Ａ７２６ * |
| JPN5002028638; ＧＯＲＤＯＮ ＦＩＯＮＡ Ｈ: ＧＡＳＴＲＯＥＮＴＥＲＯＬＯＧＹ Ｖｏｌ．１１６ Ｎｏ．４ ＰＡＲＴ．２, 199904, ｐ．Ａ７２６ * |
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| JP2009005695A (ja) * | 2004-01-09 | 2009-01-15 | Pfizer Inc | ＭＡｄＣＡＭに対する抗体 |
| JP2010042025A (ja) * | 2004-01-09 | 2010-02-25 | Pfizer Inc | ＭＡｄＣＡＭに対する抗体 |
| JP2012250982A (ja) * | 2004-01-09 | 2012-12-20 | Pfizer Inc | ＭＡｄＣＡＭに対する抗体 |
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| JP2021113223A (ja) * | 2011-05-02 | 2021-08-05 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | 抗α４β７抗体のための製剤 |
| JP7107997B2 (ja) | 2011-05-02 | 2022-07-27 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | 抗α４β７抗体のための製剤 |
| JP2022132430A (ja) * | 2011-05-02 | 2022-09-08 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | 抗α４β７抗体のための製剤 |
| JP7258941B2 (ja) | 2011-05-02 | 2023-04-17 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | 抗α４β７抗体のための製剤 |
| JP2023076616A (ja) * | 2011-05-02 | 2023-06-01 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | 抗α４β７抗体のための製剤 |
| JP7492057B2 (ja) | 2011-05-02 | 2024-05-28 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | 抗α４β７抗体のための製剤 |
| JP2024098027A (ja) * | 2011-05-02 | 2024-07-19 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | 抗α４β７抗体のための製剤 |
| JP7636651B2 (ja) | 2011-05-02 | 2025-02-27 | 武田薬品工業株式会社 | 抗α４β７抗体のための製剤 |
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