JP2003527832A5 - - Google Patents
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- Publication number
- JP2003527832A5 JP2003527832A5 JP2001528642A JP2001528642A JP2003527832A5 JP 2003527832 A5 JP2003527832 A5 JP 2003527832A5 JP 2001528642 A JP2001528642 A JP 2001528642A JP 2001528642 A JP2001528642 A JP 2001528642A JP 2003527832 A5 JP2003527832 A5 JP 2003527832A5
- Authority
- JP
- Japan
- Prior art keywords
- library
- human
- antibody
- antibody chains
- encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 16
- 102000039446 nucleic acids Human genes 0.000 description 15
- 108020004707 nucleic acids Proteins 0.000 description 15
- 150000007523 nucleic acids Chemical class 0.000 description 15
- 230000009261 transgenic effect Effects 0.000 description 8
- 210000004698 lymphocyte Anatomy 0.000 description 7
- 108700005091 Immunoglobulin Genes Proteins 0.000 description 5
- 230000002163 immunogen Effects 0.000 description 5
- 239000013604 expression vector Substances 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 101000941289 Homo sapiens Hepatic triacylglycerol lipase Proteins 0.000 description 1
- 101001047912 Homo sapiens Hydroxymethylglutaryl-CoA lyase, mitochondrial Proteins 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000000521 hyperimmunizing effect Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15741599P | 1999-10-02 | 1999-10-02 | |
| US60/157,415 | 1999-10-02 | ||
| US09/453,234 US6794132B2 (en) | 1999-10-02 | 1999-12-01 | Human antibodies |
| US09/453,234 | 1999-12-01 | ||
| PCT/US2000/027237 WO2001025492A1 (en) | 1999-10-02 | 2000-10-02 | Human antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003527832A JP2003527832A (ja) | 2003-09-24 |
| JP2003527832A5 true JP2003527832A5 (cg-RX-API-DMAC7.html) | 2007-11-22 |
Family
ID=26854113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001528642A Pending JP2003527832A (ja) | 1999-10-02 | 2000-10-02 | ヒト抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6794132B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1222314A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2003527832A (cg-RX-API-DMAC7.html) |
| AU (1) | AU783276B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2385709A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001025492A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6696251B1 (en) * | 1996-05-31 | 2004-02-24 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US7083786B2 (en) | 1997-04-03 | 2006-08-01 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
| US6759243B2 (en) * | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US20070111259A1 (en) * | 1999-10-02 | 2007-05-17 | Medarex, Inc. | Human antibodies |
| US7135287B1 (en) * | 1999-10-02 | 2006-11-14 | Biosite, Inc. | Human antibodies |
| US6680209B1 (en) | 1999-12-06 | 2004-01-20 | Biosite, Incorporated | Human antibodies as diagnostic reagents |
| US7560534B2 (en) | 2000-05-08 | 2009-07-14 | Celldex Research Corporation | Molecular conjugates comprising human monoclonal antibodies to dendritic cells |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
| KR100945108B1 (ko) | 2001-06-13 | 2010-03-02 | 젠맵 에이/에스 | 표피 성장 인자 수용체 (egfr)에 대한 인간모노클로날 항체 |
| US20060073095A1 (en) * | 2001-08-22 | 2006-04-06 | Steven Kessler | Methods for screening antibody-producing cells on heterogeneous antigen substrates |
| US20030044849A1 (en) * | 2001-08-22 | 2003-03-06 | Steven Kessler | Methods for screening monoclonal antibodies on heterogeneous antigen substrates |
| US20030186374A1 (en) * | 2001-10-01 | 2003-10-02 | Hufton Simon E. | Multi-chain eukaryotic display vectors and uses thereof |
| US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
| US7094579B2 (en) | 2002-02-13 | 2006-08-22 | Xoma Technology Ltd. | Eukaryotic signal sequences for prokaryotic expression |
| EP1590364B1 (en) * | 2002-12-16 | 2011-10-05 | Genmab A/S | Human monoclonal antibodies against interleukin 8 (il-8) |
| US9259459B2 (en) | 2003-01-31 | 2016-02-16 | Celldex Therapeutics Inc. | Antibody vaccine conjugates and uses therefor |
| WO2004074432A2 (en) | 2003-01-31 | 2004-09-02 | Celldex Therapeutics, Inc. | Antibody vaccine conjugates and uses therefor |
| AU2004236263A1 (en) * | 2003-05-06 | 2004-11-18 | Albert Einstein College Of Medicine Of Yeshiva University | Compositions and methods for treatment of cryptococcosis |
| US20050106667A1 (en) * | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
| EP1664115A2 (en) * | 2003-08-01 | 2006-06-07 | Genentech, Inc. | Antibody cdr polypeptide sequences with restricted diversity |
| AR045563A1 (es) * | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| CN1878793A (zh) * | 2003-09-11 | 2006-12-13 | 鉴定医疗有限公司 | 拮抗hmgb1的单克隆抗体 |
| AU2004309373A1 (en) * | 2003-12-22 | 2005-07-14 | Amgen Inc. | Methods for identifying functional antibodies |
| US7973139B2 (en) * | 2004-03-26 | 2011-07-05 | Human Genome Sciences, Inc. | Antibodies against nogo receptor |
| US7919094B2 (en) * | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| TWI380996B (zh) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | 抗ox40l抗體 |
| US8604174B2 (en) | 2005-04-20 | 2013-12-10 | Amgen Inc. | High affinity fully human monoclonal antibodies to interleukin-8 |
| NZ562234A (en) * | 2005-04-26 | 2009-09-25 | Pfizer | P-cadherin antibodies |
| KR101461263B1 (ko) | 2005-10-21 | 2014-11-17 | 노파르티스 아게 | Il-13에 대항한 인간 항체 및 치료적 용도 |
| ES2577292T3 (es) | 2005-11-07 | 2016-07-14 | Genentech, Inc. | Polipéptidos de unión con secuencias hipervariables de VH/VL diversificadas y consenso |
| EP1973951A2 (en) * | 2005-12-02 | 2008-10-01 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| BRPI0707126A2 (pt) | 2006-01-12 | 2011-04-19 | Alexion Pharma Inc | anticorpos para ox-2/cd200 e uso destes |
| US8252547B2 (en) | 2006-03-20 | 2012-08-28 | Japan Science And Technology Agency | In vitro control of protein synthesis in mammalian cells by IP3 receptor-binding protein |
| AU2007235496B2 (en) | 2006-03-31 | 2013-11-21 | E. R. Squibb & Sons, L.L.C. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
| NL1031818C2 (nl) * | 2006-05-15 | 2007-11-23 | Pfizer | P-Cadherineantilichamen. |
| RS55740B1 (sr) | 2006-10-02 | 2017-07-31 | Squibb & Sons Inc | Humana antitela koja se vezuju za cxcr4 i njihove upotrebe |
| KR101552735B1 (ko) | 2006-12-01 | 2015-09-14 | 메다렉스, 엘.엘.시. | 씨디22에 결합하는 인간 항체 및 이의 용도 |
| CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
| NZ578354A (en) | 2006-12-14 | 2012-01-12 | Medarex Inc | Antibody-partner molecule conjugates that bind cd70 and uses thereof |
| US20100173277A1 (en) * | 2007-02-15 | 2010-07-08 | Fukuoka University | Agent for Suppressing Rejection in Organ Transplantation Comprising Anti-HMGB-1 Antibody |
| JP5241518B2 (ja) * | 2007-02-15 | 2013-07-17 | 国立大学法人九州大学 | 抗hmgb−1抗体を含む間質性肺疾患治療剤 |
| WO2008099913A1 (ja) * | 2007-02-15 | 2008-08-21 | Kumamoto University | ヒトhmgb-1に特異的に結合する抗体を有効成分として含有する治療剤 |
| ME00832B (me) | 2007-03-22 | 2012-03-20 | Ucb Biopharma Sprl | Vezivni proteini uključujući antitjela, derivate antitjela i fragmente antitjela, koji specifično vezuju cd154 i njihova upotreba |
| CA2704583A1 (en) | 2007-11-07 | 2009-05-14 | Celldex Therapeutics Inc. | Antibodies that bind human dendritic and epithelial cell 205 receptor(dec-205) |
| EP3629022A1 (en) | 2008-07-25 | 2020-04-01 | Richard W. Wagner | Protein screening methods |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| KR102362774B1 (ko) | 2008-09-30 | 2022-02-15 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 인간 이외의 포유동물 |
| DK2364366T3 (da) | 2008-11-05 | 2014-03-31 | Morphosys Ag | Affoldningsmetode |
| BRPI0921237A2 (pt) | 2008-11-10 | 2015-09-22 | Alexion Pharma Inc | métodos e composições para o tratamento de distúrbios associados ao complemento |
| MX2012008108A (es) | 2010-01-11 | 2012-10-03 | Alexion Pharma Inc | Biomarcadores de efectos de inmunomodulacion en seres humanos tratados con anticuerpos anti-cd200. |
| ES2641920T3 (es) | 2010-03-31 | 2017-11-14 | Ablexis, Llc | Ingeniería genética de animales no humanos para la producción de anticuerpos quiméricos |
| BR112012027900A2 (pt) | 2010-04-30 | 2020-05-12 | Alexion Pharmaceuticals, Inc. | Anticorpos anti-c5a e métodos para usar os anticorpos |
| US20130288910A1 (en) * | 2010-06-16 | 2013-10-31 | Jef D. Boeke | Methods and systems for generating, validating and using monoclonal antibodies |
| CA2803588A1 (en) | 2010-06-22 | 2011-12-29 | The Regents Of The University Of Colorado, A Body Corporate | Antibodies to the c3d fragment of complement component 3 |
| AU2011275749C1 (en) * | 2010-07-09 | 2015-09-17 | Aduro Biotech Holdings, Europe B.V. | Agonistic antibody to CD27 |
| MX360336B (es) | 2010-07-16 | 2018-10-30 | Adimab Llc Star | Colecciones de anticuerpos. |
| US8440195B2 (en) * | 2010-11-12 | 2013-05-14 | National University Corporation Chiba University | Inhibition of CD69 for treatment of inflammatory conditions |
| WO2012106634A1 (en) | 2011-02-03 | 2012-08-09 | Alexion Pharmaceuticals, Inc. | Use of an anti-cd200 antibody for prolonging the survival of allografts |
| KR101870915B1 (ko) | 2011-04-08 | 2018-06-25 | 유니버시티 오브 레스터 | Masp-2 의존적 보체 활성화와 관련된 질병을 치료하는 방법 |
| US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| WO2012172346A2 (en) * | 2011-06-13 | 2012-12-20 | Ith Immune Therapy Holdings | Treating respiratory conditions |
| US9726666B2 (en) | 2011-06-13 | 2017-08-08 | Tla Targeted Immunotherapies Ab | Diagnosing and treating inflammatory diseases |
| DK2776032T3 (en) | 2011-11-09 | 2019-02-04 | Bristol Myers Squibb Co | TREATMENT OF HEMATOLOGICAL MALIGNITIES WITH ANTI-CXCR4 ANTIBODY |
| KR101566539B1 (ko) * | 2012-06-08 | 2015-11-05 | 국립암센터 | 신규한 Th2 세포 전환용 에피토프 및 이의 용도 |
| UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
| CN105026573A (zh) | 2012-11-28 | 2015-11-04 | 艾布维兹生物公司 | 用于单引物扩增的基因特异模板的制备 |
| US20140199319A1 (en) * | 2012-12-14 | 2014-07-17 | Abbvie, Inc. | Methods for increasing the efficiency of hybridoma generation |
| KR101759687B1 (ko) * | 2013-01-25 | 2017-07-19 | 타이몬, 엘엘씨 | 순환하는 생물활성 가용성 tnf의 선택적 감소를 위한 조성물 및 tnf-매개 질환의 치료 방법 |
| BR112016001420A2 (pt) | 2013-08-02 | 2018-01-23 | Aduro Biotech Holdings Europe B V | combinação de agonistas de cd27 e inibição pontual imune para estimulação imune |
| JOP20190055A1 (ar) | 2016-09-26 | 2019-03-24 | Merck Sharp & Dohme | أجسام مضادة ضد cd27 |
| KR20190117467A (ko) | 2017-02-10 | 2019-10-16 | 주식회사 유틸렉스 | IFN-γ-유도성 조절 T 세포 전환가능 항암 (IRTCA) 항체 및 그의 용도 |
| EP3737696A1 (en) | 2018-01-12 | 2020-11-18 | Bristol-Myers Squibb Company | Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer |
| WO2021050989A1 (en) * | 2019-09-13 | 2021-03-18 | Duke University | Zika antibodies and their use |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4486530A (en) | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
| US5173418A (en) | 1985-05-10 | 1992-12-22 | Benzon Pharma, A/S | Production in Escherichia coli of extracellular Serratia spp. hydrolases |
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| DK1471142T3 (da) | 1991-04-10 | 2009-03-09 | Scripps Research Inst | Heterodimere receptor-biblioteker under anvendelse af fagemider |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US5914241A (en) | 1993-01-19 | 1999-06-22 | Biosite Diagnostics, Inc. | Assays and kits for detecting analytes in the presence of cross-reacting substances |
| WO1994026787A1 (en) | 1993-05-07 | 1994-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Method for generating cell type specific phage antibody libraries |
| DE69534347T2 (de) | 1994-01-31 | 2006-05-24 | Trustees Of Boston University, Boston | Bibliotheken aus Polyklonalen Antikörpern |
| ATE390933T1 (de) | 1995-04-27 | 2008-04-15 | Amgen Fremont Inc | Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8 |
| US5766905A (en) | 1996-06-14 | 1998-06-16 | Associated Universities Inc. | Cytoplasmic bacteriophage display system |
| DE19632549A1 (de) | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| WO1998047343A2 (en) | 1997-04-04 | 1998-10-29 | Biosite Diagnostics, Inc. | Antibodies or binding protein libraries displayed on phage, cells, or other replicatable genetic packages |
| US6057098A (en) * | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
| EP0934953A2 (en) | 1997-12-03 | 1999-08-11 | Boehringer Mannheim Corporation | Complex specific antibodies, method of preparation and uses thereof |
| US5939807A (en) | 1997-12-16 | 1999-08-17 | Reliance Electric Industrial Company | Cap mounted drive for a brushless DC motor |
| US20020029391A1 (en) * | 1998-04-15 | 2002-03-07 | Claude Geoffrey Davis | Epitope-driven human antibody production and gene expression profiling |
-
1999
- 1999-12-01 US US09/453,234 patent/US6794132B2/en not_active Expired - Fee Related
-
2000
- 2000-10-02 JP JP2001528642A patent/JP2003527832A/ja active Pending
- 2000-10-02 WO PCT/US2000/027237 patent/WO2001025492A1/en not_active Ceased
- 2000-10-02 CA CA002385709A patent/CA2385709A1/en not_active Abandoned
- 2000-10-02 EP EP00968612A patent/EP1222314A4/en not_active Withdrawn
- 2000-10-02 AU AU78496/00A patent/AU783276B2/en not_active Ceased
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