JP2003527430A5 - - Google Patents
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- Publication number
- JP2003527430A5 JP2003527430A5 JP2001568431A JP2001568431A JP2003527430A5 JP 2003527430 A5 JP2003527430 A5 JP 2003527430A5 JP 2001568431 A JP2001568431 A JP 2001568431A JP 2001568431 A JP2001568431 A JP 2001568431A JP 2003527430 A5 JP2003527430 A5 JP 2003527430A5
- Authority
- JP
- Japan
- Prior art keywords
- keto
- prostaglandin compound
- prostaglandin
- compound
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 description 20
- 125000000217 alkyl group Chemical group 0.000 description 7
- 125000000143 2-carboxyethyl group Chemical group [H]OC(=O)C([H])([H])C([H])([H])* 0.000 description 5
- 125000003545 alkoxy group Chemical group 0.000 description 4
- 125000000623 heterocyclic group Chemical group 0.000 description 4
- -1 13,14-dihydro-15-keto-prostaglandin compound Chemical class 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 125000004043 oxo group Chemical group O=* 0.000 description 3
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 125000004104 aryloxy group Chemical group 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 229940088872 Apoptosis inhibitor Drugs 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 239000000158 apoptosis inhibitor Substances 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19175500P | 2000-03-24 | 2000-03-24 | |
| US60/191,755 | 2000-03-24 | ||
| PCT/JP2001/002307 WO2001070233A2 (en) | 2000-03-24 | 2001-03-23 | Apoptosis inhibiting composition comprising a 15-keto-prostaglandin or derivative thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003527430A JP2003527430A (ja) | 2003-09-16 |
| JP2003527430A5 true JP2003527430A5 (cg-RX-API-DMAC7.html) | 2007-12-27 |
Family
ID=22706808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001568431A Pending JP2003527430A (ja) | 2000-03-24 | 2001-03-23 | １５−ケトプロスタグランジンまたはその誘導体を含むアポトーシス抑制剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7129272B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1267882B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2003527430A (cg-RX-API-DMAC7.html) |
| KR (1) | KR100788226B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1443070A (cg-RX-API-DMAC7.html) |
| AR (1) | AR030275A1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE428429T1 (cg-RX-API-DMAC7.html) |
| AU (2) | AU2001239551B8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2403086C (cg-RX-API-DMAC7.html) |
| DE (1) | DE60138371D1 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ521464A (cg-RX-API-DMAC7.html) |
| TW (1) | TWI284535B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001070233A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0212233A (pt) | 2001-08-31 | 2004-10-05 | Sucampo Ag | Abridor de canal de cloreto |
| CN1605336A (zh) * | 2003-10-10 | 2005-04-13 | 中国医学科学院药物研究所 | 左旋丁基苯酞在制备预防和治疗脑梗塞的药物中的应用 |
| AU2006209072B2 (en) * | 2005-01-27 | 2011-02-24 | Sucampo Ag | Method and composition for treating central nervous system disorders |
| CN101151034B (zh) * | 2005-03-31 | 2012-06-06 | 旭硝子株式会社 | 含有前列腺素F2α衍生物作为有效成分的视网膜神经细胞保护剂 |
| CA2604956A1 (en) | 2005-04-13 | 2006-10-26 | Ube Industries, Ltd. | Protective agent for retinal neuronal cell comprising indazole derivative as active ingredient |
| EP1803809A3 (en) * | 2005-08-12 | 2007-12-19 | Abgenomics Corporation | Modulation of peroxisome proliferator-activated receptors |
| US8871752B2 (en) | 2008-02-19 | 2014-10-28 | Sucampo Ag | Method for modulating stem cell growth |
| US9089720B2 (en) * | 2008-09-04 | 2015-07-28 | Santen Pharmaceutical Co., Ltd. | Hair growth promoting agent containing 15,15-difluoroprostaglandin F2α derivative as active ingredient |
| US9084815B2 (en) * | 2009-09-16 | 2015-07-21 | Sucampo Ag | Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1322749C (en) | 1987-01-28 | 1993-10-05 | Ryuzo Ueno | Prostaglandins of the d series, and tranquilizers and soporifics containing the same |
| US5166174A (en) | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
| US5221763A (en) | 1987-04-30 | 1993-06-22 | R-Tech Ueno, Ltd. | Prostaglandins of the F series |
| EP0455264B1 (en) * | 1987-09-18 | 1994-07-13 | R-Tech Ueno Ltd. | Ocular hypotensive agents |
| JPH0761944B2 (ja) * | 1989-11-22 | 1995-07-05 | 株式会社アールテック・ウエノ | 脳機能改善処置剤 |
| CA2030345C (en) * | 1989-11-22 | 1998-12-08 | Ryuji Ueno | Use of 15-keto-prostaglandin compound for improvement of encephalic function |
| TW249226B (cg-RX-API-DMAC7.html) | 1990-04-04 | 1995-06-11 | Aderk Ueno Kk | |
| CA2150287C (en) | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
| JP3625946B2 (ja) * | 1995-03-10 | 2005-03-02 | 株式会社アールテック・ウエノ | 視神経障害改善剤 |
| JPH08277222A (ja) * | 1995-04-05 | 1996-10-22 | Green Cross Corp:The | 神経疾患の予防治療剤 |
| JP3964060B2 (ja) * | 1997-10-21 | 2007-08-22 | 独立行政法人科学技術振興機構 | アポトーシス抑制剤 |
| US6087395A (en) | 1997-10-21 | 2000-07-11 | Japan Science And Technology Corporation | Isocarbacyclin derivatives as apoptosis inhibitors |
| JP2000169394A (ja) * | 1998-12-04 | 2000-06-20 | Yoshitomi Pharmaceut Ind Ltd | アポトーシス誘導剤 |
-
2001
- 2001-03-23 KR KR1020027012410A patent/KR100788226B1/ko not_active Expired - Fee Related
- 2001-03-23 AR ARP010101368A patent/AR030275A1/es unknown
- 2001-03-23 CA CA2403086A patent/CA2403086C/en not_active Expired - Fee Related
- 2001-03-23 AU AU2001239551A patent/AU2001239551B8/en not_active Ceased
- 2001-03-23 JP JP2001568431A patent/JP2003527430A/ja active Pending
- 2001-03-23 TW TW090107002A patent/TWI284535B/zh not_active IP Right Cessation
- 2001-03-23 DE DE60138371T patent/DE60138371D1/de not_active Expired - Lifetime
- 2001-03-23 AU AU3955101A patent/AU3955101A/xx active Pending
- 2001-03-23 NZ NZ521464A patent/NZ521464A/en not_active IP Right Cessation
- 2001-03-23 EP EP01914192A patent/EP1267882B1/en not_active Expired - Lifetime
- 2001-03-23 CN CN01809737A patent/CN1443070A/zh active Pending
- 2001-03-23 WO PCT/JP2001/002307 patent/WO2001070233A2/en not_active Ceased
- 2001-03-23 AT AT01914192T patent/ATE428429T1/de not_active IP Right Cessation
- 2001-03-26 US US09/816,655 patent/US7129272B2/en not_active Expired - Fee Related
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