JP2003523389A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003523389A5 JP2003523389A5 JP2001561317A JP2001561317A JP2003523389A5 JP 2003523389 A5 JP2003523389 A5 JP 2003523389A5 JP 2001561317 A JP2001561317 A JP 2001561317A JP 2001561317 A JP2001561317 A JP 2001561317A JP 2003523389 A5 JP2003523389 A5 JP 2003523389A5
- Authority
- JP
- Japan
- Prior art keywords
- substituents selected
- pharmaceutical composition
- alkyl
- optionally substituted
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000001424 substituent group Chemical group 0.000 description 34
- 239000008194 pharmaceutical composition Substances 0.000 description 30
- 125000003118 aryl group Chemical group 0.000 description 23
- 150000001875 compounds Chemical class 0.000 description 17
- 125000000623 heterocyclic group Chemical group 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 9
- 125000000217 alkyl group Chemical group 0.000 description 9
- 201000011510 cancer Diseases 0.000 description 9
- 229910052736 halogen Inorganic materials 0.000 description 9
- 150000002367 halogens Chemical class 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- 125000003342 alkenyl group Chemical group 0.000 description 5
- 125000000304 alkynyl group Chemical group 0.000 description 5
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 description 4
- 239000004037 angiogenesis inhibitor Substances 0.000 description 4
- 229940121369 angiogenesis inhibitor Drugs 0.000 description 4
- 239000002834 estrogen receptor modulator Substances 0.000 description 4
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 description 3
- 125000005865 C2-C10alkynyl group Chemical group 0.000 description 3
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 3
- 230000001028 anti-proliverative effect Effects 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000002254 cytotoxic agent Substances 0.000 description 3
- 229940127089 cytotoxic agent Drugs 0.000 description 3
- 231100000599 cytotoxic agent Toxicity 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 239000004030 hiv protease inhibitor Substances 0.000 description 3
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 description 3
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000027483 retinoid hormone receptors Human genes 0.000 description 3
- 108091008679 retinoid hormone receptors Proteins 0.000 description 3
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 description 3
- 239000000849 selective androgen receptor modulator Substances 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 239000003558 transferase inhibitor Substances 0.000 description 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 2
- 102100025306 Integrin alpha-IIb Human genes 0.000 description 2
- 101710149643 Integrin alpha-IIb Proteins 0.000 description 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 208000027866 inflammatory disease Diseases 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 description 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- IRAUOUBGYSKULF-UHFFFAOYSA-N 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-quinolin-2-one Chemical compound C1=NC=C2NC(C3=CC4=CC=CC=C4NC3=O)=CC2=C1 IRAUOUBGYSKULF-UHFFFAOYSA-N 0.000 description 1
- FABIXNWMMUTTHQ-UHFFFAOYSA-N 3-(1h-pyrrolo[3,2-b]pyridin-2-yl)-1h-quinolin-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=CC=C4NC3=O)=CC2=N1 FABIXNWMMUTTHQ-UHFFFAOYSA-N 0.000 description 1
- VFBIWRXQJRQOHU-UHFFFAOYSA-N 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-quinolin-2-one Chemical compound N1=CC=C2NC(C3=CC4=CC=CC=C4NC3=O)=CC2=C1 VFBIWRXQJRQOHU-UHFFFAOYSA-N 0.000 description 1
- IWHQVGWQVDOGRI-UHFFFAOYSA-N 3-(5-methoxy-1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-quinolin-2-one Chemical compound C1=CC=C2NC(=O)C(C3=CC=4C=C(N=CC=4N3)OC)=CC2=C1 IWHQVGWQVDOGRI-UHFFFAOYSA-N 0.000 description 1
- MWHFZGLXSQQPEW-UHFFFAOYSA-N 3-(5-methoxy-1h-pyrrolo[3,2-b]pyridin-2-yl)-1h-quinolin-2-one Chemical compound C1=CC=C2NC(=O)C(C=3NC4=CC=C(N=C4C=3)OC)=CC2=C1 MWHFZGLXSQQPEW-UHFFFAOYSA-N 0.000 description 1
- VJSLZUPGUKJBHM-UHFFFAOYSA-N 3-(5-oxo-1,4-dihydropyrrolo[3,2-b]pyridin-2-yl)-1h-quinolin-2-one Chemical compound C1=CC=C2NC(=O)C(C=3NC=4C=CC(NC=4C=3)=O)=CC2=C1 VJSLZUPGUKJBHM-UHFFFAOYSA-N 0.000 description 1
- OGGZWELJIMBJTL-UHFFFAOYSA-N 3-(5-oxo-1,6-dihydropyrrolo[2,3-c]pyridin-2-yl)-1h-quinolin-2-one Chemical compound C1=CC=C2NC(=O)C(C3=CC4=CC(NC=C4N3)=O)=CC2=C1 OGGZWELJIMBJTL-UHFFFAOYSA-N 0.000 description 1
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 1
- 102000012936 Angiostatins Human genes 0.000 description 1
- 108010079709 Angiostatins Proteins 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- HVXBOLULGPECHP-WAYWQWQTSA-N Combretastatin A4 Chemical compound C1=C(O)C(OC)=CC=C1\C=C/C1=CC(OC)=C(OC)C(OC)=C1 HVXBOLULGPECHP-WAYWQWQTSA-N 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 102000013462 Interleukin-12 Human genes 0.000 description 1
- 108010065805 Interleukin-12 Proteins 0.000 description 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 description 1
- 206010023825 Laryngeal cancer Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 229940124761 MMP inhibitor Drugs 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 208000022873 Ocular disease Diseases 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 206010041067 Small cell lung cancer Diseases 0.000 description 1
- UIRKNQLZZXALBI-MSVGPLKSSA-N Squalamine Chemical compound C([C@@H]1C[C@H]2O)[C@@H](NCCCNCCCCN)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CC[C@H](C(C)C)OS(O)(=O)=O)[C@@]2(C)CC1 UIRKNQLZZXALBI-MSVGPLKSSA-N 0.000 description 1
- UIRKNQLZZXALBI-UHFFFAOYSA-N Squalamine Natural products OC1CC2CC(NCCCNCCCCN)CCC2(C)C2C1C1CCC(C(C)CCC(C(C)C)OS(O)(=O)=O)C1(C)CC2 UIRKNQLZZXALBI-UHFFFAOYSA-N 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 206010064930 age-related macular degeneration Diseases 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- -1 carboxamide triazole Chemical class 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 229960005537 combretastatin A-4 Drugs 0.000 description 1
- HVXBOLULGPECHP-UHFFFAOYSA-N combretastatin A4 Natural products C1=C(O)C(OC)=CC=C1C=CC1=CC(OC)=C(OC)C(OC)=C1 HVXBOLULGPECHP-UHFFFAOYSA-N 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 229940111134 coxibs Drugs 0.000 description 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 229940117681 interleukin-12 Drugs 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 206010023841 laryngeal neoplasm Diseases 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 201000004962 larynx cancer Diseases 0.000 description 1
- 201000005249 lung adenocarcinoma Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 210000004324 lymphatic system Anatomy 0.000 description 1
- 201000007275 lymphatic system cancer Diseases 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000002757 morpholinyl group Chemical group 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 229940043138 pentosan polysulfate Drugs 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 229960004622 raloxifene Drugs 0.000 description 1
- GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 description 1
- 201000006845 reticulosarcoma Diseases 0.000 description 1
- 208000029922 reticulum cell sarcoma Diseases 0.000 description 1
- 230000004263 retinal angiogenesis Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
- 229950001248 squalamine Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 229960003433 thalidomide Drugs 0.000 description 1
- COKMIXFXJJXBQG-NRFANRHFSA-N tirofiban Chemical group C1=CC(C[C@H](NS(=O)(=O)CCCC)C(O)=O)=CC=C1OCCCCC1CCNCC1 COKMIXFXJJXBQG-NRFANRHFSA-N 0.000 description 1
- 229960003425 tirofiban Drugs 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 229960000575 trastuzumab Drugs 0.000 description 1
- 208000027930 type IV hypersensitivity disease Diseases 0.000 description 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18502300P | 2000-02-25 | 2000-02-25 | |
| US60/185,023 | 2000-02-25 | ||
| PCT/US2001/005482 WO2001062251A1 (en) | 2000-02-25 | 2001-02-21 | Tyrosine kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003523389A JP2003523389A (ja) | 2003-08-05 |
| JP2003523389A5 true JP2003523389A5 (https=) | 2008-02-07 |
Family
ID=22679236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001561317A Withdrawn JP2003523389A (ja) | 2000-02-25 | 2001-02-21 | チロシンキナーゼ阻害薬 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6420382B2 (https=) |
| EP (1) | EP1259235B1 (https=) |
| JP (1) | JP2003523389A (https=) |
| AT (1) | ATE368457T1 (https=) |
| AU (2) | AU3857501A (https=) |
| CA (1) | CA2400875A1 (https=) |
| DE (1) | DE60129672T2 (https=) |
| ES (1) | ES2288928T3 (https=) |
| WO (1) | WO2001062251A1 (https=) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010034660A1 (en) * | 2000-02-09 | 2001-10-25 | Heinz Heumann | Goods and services referring by location |
| EP1259236A4 (en) * | 2000-02-25 | 2004-11-03 | Merck & Co Inc | Tyrosine kinase inhibitors |
| ATE448226T1 (de) | 2000-09-01 | 2009-11-15 | Novartis Vaccines & Diagnostic | Aza heterocyclische derivate und ihre therapeutische verwendung |
| DE60115069T2 (de) * | 2000-09-11 | 2006-08-03 | Chiron Corp., Emeryville | Chinolinonderivate als tyrosin-kinase inhibitoren |
| US20030028018A1 (en) * | 2000-09-11 | 2003-02-06 | Chiron Coporation | Quinolinone derivatives |
| US20090118139A1 (en) * | 2000-11-07 | 2009-05-07 | Caliper Life Sciences, Inc. | Microfluidic method and system for enzyme inhibition activity screening |
| DE60237917D1 (de) * | 2001-06-05 | 2010-11-18 | Exelixis Inc | Gfats als modifikatoren des p53-wegs und verwendungsverfahren |
| WO2003003006A2 (en) * | 2001-06-29 | 2003-01-09 | Ab Science | New potent, selective and non toxic c-kit inhibitors |
| JP2004537542A (ja) | 2001-06-29 | 2004-12-16 | アブ サイエンス | 炎症性腸疾患（ｉｂｄ）を治療するための、チロシンキナーゼ阻害剤の使用 |
| ES2274993T3 (es) * | 2001-06-29 | 2007-06-01 | Ab Science | Utilizacion de inhibidores de tirosina cinasa para el tratamiento de enfermedades alergicas. |
| ES2266553T3 (es) * | 2001-06-29 | 2007-03-01 | Ab Science | Utilizacion de derivados de la n-fenil-2-pirimidina-amina para tratar las enfermedades inflamatorias. |
| EP1427379B1 (en) * | 2001-09-20 | 2008-08-13 | AB Science | Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis |
| EP1461032B1 (en) * | 2001-09-20 | 2008-07-16 | AB Science | Use of c-kit inhibitors for promoting hair growth |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
| US20030147813A1 (en) * | 2002-02-07 | 2003-08-07 | John Lyons | Method for treating chronic myelogenous leukemia |
| US6822097B1 (en) | 2002-02-07 | 2004-11-23 | Amgen, Inc. | Compounds and methods of uses |
| US6998391B2 (en) * | 2002-02-07 | 2006-02-14 | Supergen.Inc. | Method for treating diseases associated with abnormal kinase activity |
| DE60313339T2 (de) * | 2002-07-31 | 2008-01-03 | Critical Outcome Technologies, Inc. | Protein tyrosin kinase inhibitoren |
| US20050256157A1 (en) * | 2002-08-23 | 2005-11-17 | Chiron Corporation | Combination therapy with CHK1 inhibitors |
| US7825132B2 (en) * | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
| EP1539754A4 (en) * | 2002-08-23 | 2009-02-25 | Novartis Vaccines & Diagnostic | BENZIMIDAZOCHINOLINONE AND ITS USE |
| US7629347B2 (en) * | 2002-10-09 | 2009-12-08 | Critical Outcome Technologies, Inc. | Protein tyrosine kinase inhibitors |
| SG148864A1 (en) * | 2002-11-13 | 2009-01-29 | Chiron Corp | Methods of treating cancer and related methods |
| EP1660087A2 (en) * | 2003-07-22 | 2006-05-31 | Janssen Pharmaceutica N.V. | Quinolinone derivatives as inhibitors of c-fms kinase |
| US20050043346A1 (en) * | 2003-08-08 | 2005-02-24 | Pharmacia Italia S.P.A. | Pyridylpyrrole derivatives active as kinase inhibitors |
| US20050209247A1 (en) * | 2003-11-07 | 2005-09-22 | Chiron Corporation | Pharmaceutically acceptable salts of quinolinone compounds having improved pharmaceutical properties |
| EP1718306A2 (en) * | 2004-02-20 | 2006-11-08 | Chiron Corporation | Modulation of inflammatory and metastatic processes |
| EP2301546B1 (en) | 2005-01-27 | 2014-09-10 | Novartis AG | Treatment of metastasized tumors |
| EP1885187B1 (en) | 2005-05-13 | 2013-09-25 | Novartis AG | Methods for treating drug resistant cancer |
| EP2465857B1 (en) * | 2005-05-17 | 2014-06-04 | Novartis AG | Methods for synthesizing heterocyclic compounds |
| BRPI0611375A2 (pt) * | 2005-05-23 | 2010-08-31 | Novartis Ag | formas cristalinas e outras de sais de ácido láctico de 4-amino-5-flúor-3-[6-(4-metilpiperazin-1-il)-1h-benzimid azol-2-il]-1h-quinolin-2-ona |
| US8658633B2 (en) * | 2006-02-16 | 2014-02-25 | Massachusetts Eye And Ear Infirmary | Methods and compositions for treating conditions of the eye |
| US8246966B2 (en) * | 2006-08-07 | 2012-08-21 | University Of Georgia Research Foundation, Inc. | Trypanosome microsome system and uses thereof |
| WO2008066755A2 (en) | 2006-11-22 | 2008-06-05 | University Of Georgia Research Foundation, Inc. | Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents |
| EP2121681B1 (en) | 2007-01-11 | 2015-04-15 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
| CA2710039C (en) | 2007-12-26 | 2018-07-03 | Critical Outcome Technologies, Inc. | Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer |
| EP2318406B1 (en) | 2008-07-17 | 2016-01-27 | Critical Outcome Technologies, Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
| PT2769737T (pt) | 2009-07-20 | 2017-06-29 | Bristol Myers Squibb Co | Combinação de um anticorpo anti-ctla4 com etopósido para o tratamento sinérgico de doenças proliferativas |
| DK2491385T3 (en) | 2009-10-20 | 2017-08-28 | Diatech Holdings Inc | PROXIMITY-MEDIED ASSAYS FOR DETECTING ONCOGEN FUSION PROTEINS |
| EP2552915B1 (en) | 2010-04-01 | 2017-07-19 | Critical Outcome Technologies Inc. | Compounds for the treatment of hiv |
| AU2012254154B2 (en) | 2011-02-17 | 2015-11-05 | Société des Produits Nestlé S.A. | Apparatus and method for isolating leukocytes and tumor cells by filtration |
| RU2737765C2 (ru) | 2012-05-04 | 2020-12-02 | Пфайзер Инк. | Простатоассоциированные антигены и иммунотерапевтические схемы на основе вакцин |
| ES2675720T3 (es) | 2013-01-10 | 2018-07-12 | Pulmokine, Inc. | Inhibidores de quinasa no selectivos |
| CA2919790C (en) | 2013-08-02 | 2018-06-19 | Pfizer Inc. | Anti-cxcr4 antibodies and antibody-drug conjugates |
| US9925184B2 (en) | 2013-10-11 | 2018-03-27 | Pulmokine, Inc. | Spray-dry formulations |
| US10704104B2 (en) | 2014-10-20 | 2020-07-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for screening a subject for a cancer |
| JP6864953B2 (ja) | 2014-12-09 | 2021-04-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Ａｘｌに対するヒトモノクローナル抗体 |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
| JP2018525029A (ja) | 2015-07-07 | 2018-09-06 | インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） | ミオシン１８ａに対する特異性を有する抗体およびその使用 |
| JP6791951B2 (ja) | 2015-08-27 | 2020-11-25 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 肺ガンを患っている患者の生存時間を予測するための方法 |
| WO2017055324A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of cells of monocytic origin in a tissue sample |
| WO2017055327A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of endothelial cells in a tissue sample |
| WO2017055326A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of myeloid dendritic cells in a tissue sample |
| WO2017055322A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of neutrophils in a tissue sample |
| MX2018010295A (es) | 2016-02-26 | 2019-06-06 | Inst Nat Sante Rech Med | Anticuerpos que tienen especificidad para atenuador de linfocitos b y t (btla) y usos de los mismos. |
| CN116376812A (zh) | 2016-05-25 | 2023-07-04 | 国家医疗保健研究所 | 治疗癌症的方法和组合物 |
| WO2018011166A2 (en) | 2016-07-12 | 2018-01-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of myeloid dendritic cells in a tissue sample |
| ES3041722T3 (en) | 2016-07-29 | 2025-11-14 | Inst Nat Sante Rech Med | Antibodies targeting tumor associated macrophages and uses thereof |
| SI3529262T1 (sl) | 2016-10-21 | 2021-12-31 | Inserm - Institut National De La Sante Et De La Recherche Medicale | Postopki za spodbujanje odgovora T-celic |
| CA3041679A1 (en) | 2016-10-27 | 2018-05-03 | Lawrence S. ZISMAN | Combination therapy for treating pulmonary hypertension |
| US20190345500A1 (en) | 2016-11-14 | 2019-11-14 | |Nserm (Institut National De La Santé Et De La Recherche Médicale) | Methods and pharmaceutical compositions for modulating stem cells proliferation or differentiation |
| CN110392697A (zh) | 2017-03-02 | 2019-10-29 | 国家医疗保健研究所 | 对nectin-4具有特异性的抗体及其用途 |
| WO2018185516A1 (en) | 2017-04-05 | 2018-10-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cardiovascular toxicity induced by anti-cancer therapy |
| WO2018189403A1 (en) | 2017-04-14 | 2018-10-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cancer |
| US11389434B2 (en) | 2017-05-18 | 2022-07-19 | Inserm | Methods and pharmaceutical compositions for the treatment of mast cell diseases |
| WO2019072888A1 (en) | 2017-10-11 | 2019-04-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS OF PREDICTING THE THERAPEUTIC RESPONSE IN HEPATOCELLULAR CANCER |
| WO2019072885A1 (en) | 2017-10-11 | 2019-04-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | MAGNETIC NANOPARTICLES FOR THE TREATMENT OF CANCER |
| JP7408036B2 (ja) | 2017-11-24 | 2024-01-05 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | ガンを処置するための方法及び組成物 |
| US11814686B2 (en) | 2017-12-07 | 2023-11-14 | Institut National de la Santéde la Recherche Médicale | Method for screening and treating a subject for a cancer |
| US20210047696A1 (en) | 2018-03-28 | 2021-02-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
| WO2019197683A1 (en) | 2018-04-13 | 2019-10-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting outcome and treatment of patients suffering from prostate cancer or breast cancer |
| WO2019211369A1 (en) | 2018-05-03 | 2019-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
| WO2019211370A1 (en) | 2018-05-03 | 2019-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
| CA3101694A1 (en) | 2018-05-30 | 2019-12-05 | David MACHOVER | Methods and pharmaceutical compositions for treating cancer |
| CN112839648B (zh) | 2018-06-07 | 2025-04-04 | 达萨玛治疗公司 | Sarm1抑制剂 |
| WO2019234221A1 (en) | 2018-06-08 | 2019-12-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for stratification and treatment of a patient suffering from chronic lymphocytic leukemia |
| CN112703011A (zh) | 2018-08-06 | 2021-04-23 | 国家医疗保健研究所 | 用于治疗癌症的方法和组合物 |
| WO2020053122A1 (en) | 2018-09-10 | 2020-03-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination of her2/neu antibody with heme for treating cancer |
| EP3897670A4 (en) | 2018-12-19 | 2022-09-07 | Disarm Therapeutics, Inc. | MRSA1 INHIBITORS IN COMBINATION WITH NEUROPROTECTIVE AGENTS |
| EP3924520A1 (en) | 2019-02-13 | 2021-12-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for selecting a cancer treatment in a subject suffering from cancer |
| JP7579798B2 (ja) | 2019-03-06 | 2024-11-08 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Ｃｍｍｒｄの診断方法 |
| EP3972997A1 (en) | 2019-05-20 | 2022-03-30 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Novel anti-cd25 antibodies |
| US20220290244A1 (en) | 2019-08-02 | 2022-09-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for screening a subject for a cancer |
| EP3800201A1 (en) | 2019-10-01 | 2021-04-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cd28h stimulation enhances nk cell killing activities |
| EP4072682A1 (en) | 2019-12-09 | 2022-10-19 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Antibodies having specificity to her4 and uses thereof |
| CA3180683A1 (en) | 2020-05-12 | 2021-11-18 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | New method to treat cutaneous t-cell lymphomas and tfh derived lymphomas |
| WO2022101463A1 (en) | 2020-11-16 | 2022-05-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of the last c-terminal residues m31/41 of zikv m ectodomain for triggering apoptotic cell death |
| JP2024508633A (ja) | 2021-01-29 | 2024-02-28 | インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） | Ｍｓｉ癌を診断する方法 |
| US20220389104A1 (en) | 2021-05-28 | 2022-12-08 | Ose Immunotherapeutics | Method for Treating CD127-Positive Cancers by Administering an Anti-CD127 Agent |
| WO2024052503A1 (en) | 2022-09-08 | 2024-03-14 | Institut National de la Santé et de la Recherche Médicale | Antibodies having specificity to ltbp2 and uses thereof |
| WO2024061930A1 (en) | 2022-09-22 | 2024-03-28 | Institut National de la Santé et de la Recherche Médicale | New method to treat and diagnose peripheral t-cell lymphoma (ptcl) |
| WO2024127053A1 (en) | 2022-12-14 | 2024-06-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to predict a response to immune checkpoint inhibitors in patient with msi cancer |
| WO2024161015A1 (en) | 2023-02-03 | 2024-08-08 | Institut National de la Santé et de la Recherche Médicale | Method to treat age-related diseases |
| WO2025012417A1 (en) | 2023-07-13 | 2025-01-16 | Institut National de la Santé et de la Recherche Médicale | Anti-neurotensin long fragment and anti-neuromedin n long fragment antibodies and uses thereof |
| WO2025073890A1 (en) | 2023-10-06 | 2025-04-10 | Institut National de la Santé et de la Recherche Médicale | Method to capture circulating tumor extracellular vesicles |
| WO2025114411A1 (en) | 2023-11-29 | 2025-06-05 | Institut National de la Santé et de la Recherche Médicale | New method to treat brain or neurologic disorders |
| WO2025224297A1 (en) | 2024-04-26 | 2025-10-30 | Institut National de la Santé et de la Recherche Médicale | Antibodies having specificity to tgfbi and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG64322A1 (en) | 1991-05-10 | 1999-04-27 | Rhone Poulenc Rorer Int | Bis mono and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase |
| US5578609A (en) | 1994-03-25 | 1996-11-26 | The Dupont Merck Pharmaceutical Company | 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents |
| GB9524104D0 (en) | 1995-11-24 | 1996-01-24 | Smithkline Beecham Spa | Novel compounds |
| AU3071397A (en) | 1996-05-20 | 1997-12-09 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| WO1998023613A1 (en) | 1996-11-27 | 1998-06-04 | Pfizer Inc. | Fused bicyclic pyrimidine derivatives |
| PT1107964E (pt) | 1998-08-11 | 2010-06-11 | Novartis Ag | Derivados de isoquinolina com actividade inibidora da angiogénese |
| CA2387351C (en) * | 1999-10-19 | 2009-09-08 | Merck & Co., Inc. | Indole derivatives as tyrosine kinase inhibitors |
-
2001
- 2001-02-20 US US09/788,718 patent/US6420382B2/en not_active Expired - Fee Related
- 2001-02-21 JP JP2001561317A patent/JP2003523389A/ja not_active Withdrawn
- 2001-02-21 AU AU3857501A patent/AU3857501A/xx active Pending
- 2001-02-21 EP EP01911031A patent/EP1259235B1/en not_active Expired - Lifetime
- 2001-02-21 AT AT01911031T patent/ATE368457T1/de not_active IP Right Cessation
- 2001-02-21 WO PCT/US2001/005482 patent/WO2001062251A1/en not_active Ceased
- 2001-02-21 AU AU2001238575A patent/AU2001238575B2/en not_active Ceased
- 2001-02-21 DE DE60129672T patent/DE60129672T2/de not_active Expired - Fee Related
- 2001-02-21 ES ES01911031T patent/ES2288928T3/es not_active Expired - Lifetime
- 2001-02-21 CA CA002400875A patent/CA2400875A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003523389A5 (https=) | ||
| JP7560546B2 (ja) | Ｓｈｐ２ホスファターゼ阻害剤並びにその作製方法及び使用方法 | |
| JP2003512353A5 (https=) | ||
| JP7212956B2 (ja) | 皮膚障害の処置用のピロロピリジン－アニリン化合物 | |
| JP5511786B2 (ja) | ベンゾピランおよびベンゾキセピンｐｉ３ｋ阻害剤化合物および使用方法 | |
| RU2650895C2 (ru) | Соединения замещенных пиразолонов и способы использования | |
| AU2015317327B9 (en) | Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors | |
| KR102279999B1 (ko) | 선택적 에스트로겐 수용체 분해제로서의 벤조티오펜 유도체 및 그의 조성물 | |
| RU2665036C2 (ru) | Гетероароматические соединения-модуляторы фосфоинозидит-3-киназы и способы применения | |
| CN104736535B (zh) | 用于治疗疾病的hif活性的杂环调节剂 | |
| RU2672910C2 (ru) | Гетероароматические соединения как модуляторы фосфоинозитид-3-киназы | |
| CN105980386A (zh) | 吡唑并化合物及其用途 | |
| KR20120097512A (ko) | 키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증 | |
| TW201026703A (en) | Thiolactams and uses thereof | |
| KR20210003764A (ko) | 전사 활성화 단백질의 이미다조피페라진 억제제 | |
| JP2013532688A (ja) | Ｃｙｐ１７阻害剤として有用なスルホンアミド化合物 | |
| WO2020106304A1 (en) | Topical formulations | |
| JP2022511127A (ja) | あざの処置のためのアリールアニリンおよびヘテロアリールアニリン化合物 | |
| JP2015535276A (ja) | ドーパミンｄ１リガンドとしての複素芳香族化合物 | |
| JP7237941B2 (ja) | 皮膚障害の処置用の融合複素環式芳香族アニリン化合物 | |
| CN101711249A (zh) | 作为PI3K-α的抑制剂用于治疗癌症的吡啶并[2,3-D]嘧啶-7-酮化合物 | |
| CN119215031A (zh) | 用于治疗皮肤癌的芳基苯胺和杂芳基苯胺化合物 | |
| JP7064515B2 (ja) | １５β－［３－プロパンアミド］－置換エストラ－１，３，５（１０）－トリエン－１７－オン化合物および１７β－ヒドロキシステロイドデヒドロゲナ－ゼの阻害に使用するためのそれらの１７－オキシム | |
| AU2009315930A1 (en) | Heteroaromatic compounds for use as HIF inhibitors | |
| EP4399196A1 (en) | Pi3k-alpha inhibitors and methods of use thereof |