JP2003522768A5 - - Google Patents
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- Publication number
- JP2003522768A5 JP2003522768A5 JP2001558442A JP2001558442A JP2003522768A5 JP 2003522768 A5 JP2003522768 A5 JP 2003522768A5 JP 2001558442 A JP2001558442 A JP 2001558442A JP 2001558442 A JP2001558442 A JP 2001558442A JP 2003522768 A5 JP2003522768 A5 JP 2003522768A5
- Authority
- JP
- Japan
- Prior art keywords
- signs
- administered
- makovec
- bronchoconstriction
- ovalbumin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 2
- 230000036912 Bioavailability Effects 0.000 description 1
- 206010006482 Bronchospasm Diseases 0.000 description 1
- 229940092253 Ovalbumin Drugs 0.000 description 1
- 108010058846 Ovalbumin Proteins 0.000 description 1
- 230000003187 abdominal Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000035514 bioavailability Effects 0.000 description 1
- 230000003435 bronchoconstrictive Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
Description
これらの特性の両方、すなわち、インビトロ試験で示された最適バイオアベイラビリティおよび効力は、本発明化合物の幾つかのインビボにおける高活性を明白にする。すなわち、例えば、Ｍakovecらが記載した方法［Ｊ．Ｍed．Ｃhem．３５（１９９２）、３６３３−３６４０］に従って予め感作したモルモットにおいて、オボアルブミン（食塩水中、０．５％ｗ／ｖ）をエーロゾル投与して行なう攻撃の３０分前に化合物１７を０．３ｍｇ／Ｋｇの用量で投与すると、気管支収縮の微候が完全に阻害され、該微候を腹収縮の第１出現として記録した。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITTO2000A000127 | 2000-02-09 | ||
| IT2000A000127 | 2000-02-09 | ||
| IT2000TO000127A IT1320162B1 (it) | 2000-02-09 | 2000-02-09 | Derivati della tirosina ad attivita' anti leucotrienica, procedimentoper la loro preparazione e loro uso farmaceutico. |
| PCT/EP2001/001315 WO2001058892A1 (en) | 2000-02-09 | 2001-02-07 | Tyrosine derivatives with anti-leukotriene activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003522768A JP2003522768A (ja) | 2003-07-29 |
| JP2003522768A5 true JP2003522768A5 (ja) | 2011-09-08 |
| JP4817577B2 JP4817577B2 (ja) | 2011-11-16 |
Family
ID=11457397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001558442A Expired - Fee Related JP4817577B2 (ja) | 2000-02-09 | 2001-02-07 | 抗ロイコトリエン活性を持つチロシン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6605722B2 (ja) |
| EP (1) | EP1255749B1 (ja) |
| JP (1) | JP4817577B2 (ja) |
| AT (1) | ATE354571T1 (ja) |
| AU (1) | AU776214B2 (ja) |
| CA (1) | CA2399451C (ja) |
| DE (1) | DE60126745T2 (ja) |
| ES (1) | ES2282234T3 (ja) |
| IT (1) | IT1320162B1 (ja) |
| PT (1) | PT1255749E (ja) |
| WO (1) | WO2001058892A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001261654A (ja) * | 2000-03-21 | 2001-09-26 | Mitsui Chemicals Inc | キノリン誘導体およびそれを有効成分として含有する核内レセプター作動薬 |
| AU2003284001A1 (en) * | 2002-10-07 | 2004-05-04 | Bristol-Myers Squibb Company | Triazolone and triazolethione derivatives |
| PL1644336T3 (pl) | 2003-06-06 | 2011-07-29 | Fibrogen Inc | Związki heteroarylowe zawierające azot i ich zastosowanie w zwiększaniu poziomu endogennej erytropoetyny |
| MX2008009581A (es) | 2006-01-27 | 2009-01-07 | Fibrogen Inc | Compuestos de cianoisoquinolina que estabilizan el factor inducible hipoxia (fih). |
| MX2008012734A (es) | 2006-04-04 | 2009-01-29 | Fibrogen Inc | Compuestos pirrolo- y tiazolo-piridina como moduladores del factor inducible de hipoxia (hif). |
| US7687705B2 (en) * | 2006-04-10 | 2010-03-30 | Alabama A&M University Institute | Efficient thermoelectric device |
| US8927591B2 (en) | 2008-11-14 | 2015-01-06 | Fibrogen, Inc. | Thiochromene derivatives as HIF hydroxylase inhibitors |
| US9409892B2 (en) | 2012-03-09 | 2016-08-09 | Fibrogen, Inc. | 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors |
| ES2631655T3 (es) | 2012-07-16 | 2017-09-01 | Fibrogen, Inc. | Procedimiento para fabricar compuestos de isoquinolina |
| SI3470397T1 (sl) | 2012-07-16 | 2022-07-29 | Fibrogen, Inc. | Kristalinične oblike zaviralca prolil hidroksilaze |
| US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
| KR102233081B1 (ko) | 2013-01-24 | 2021-03-29 | 피브로겐, 인크. | 〔[1-시아노-5-(4-클로로페녹시)-4-하이드록시-아이소퀴놀린-3-카보닐]-아미노〕-아세트산의 결정 형태 |
| EP3509590A4 (en) | 2016-09-07 | 2020-12-02 | Pliant Therapeutics, Inc. | N-ACYL AMINO ACID COMPOUNDS AND METHOD OF USING |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1261835A (en) | 1984-08-20 | 1989-09-26 | Masaaki Toda | (fused) benz(thio)amides |
| GB8607294D0 (en) | 1985-04-17 | 1986-04-30 | Ici America Inc | Heterocyclic amide derivatives |
| FI94342C (fi) | 1988-03-29 | 1995-08-25 | Ciba Geigy Ag | Menetelmä uusien alkanofenonien valmistamiseksi |
| EP0480717B1 (en) | 1990-10-12 | 1998-04-15 | Merck Frosst Canada Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
| US5508408A (en) | 1993-09-10 | 1996-04-16 | Ciba-Geigy Corporation | Quinoline compound |
| ES2103180B1 (es) * | 1994-08-01 | 1998-04-01 | Menarini Lab | Fenilacetamidas con accion antagonista de los leucotrienos. |
| JPH11506425A (ja) | 1995-04-21 | 1999-06-08 | 第一製薬株式会社 | エチニルチアゾール誘導体 |
| DE19823722A1 (de) * | 1998-05-27 | 1999-12-02 | Merckle Gmbh | Chinolinylmethoxyaryl-Verbindungen als duale Inhibitoren der Cyclooxygenase und 5-Lipoxygenase |
-
2000
- 2000-02-09 IT IT2000TO000127A patent/IT1320162B1/it active
-
2001
- 2001-02-07 AU AU33742/01A patent/AU776214B2/en not_active Ceased
- 2001-02-07 US US10/203,424 patent/US6605722B2/en not_active Expired - Fee Related
- 2001-02-07 ES ES01905744T patent/ES2282234T3/es not_active Expired - Lifetime
- 2001-02-07 EP EP01905744A patent/EP1255749B1/en not_active Expired - Lifetime
- 2001-02-07 CA CA002399451A patent/CA2399451C/en not_active Expired - Fee Related
- 2001-02-07 JP JP2001558442A patent/JP4817577B2/ja not_active Expired - Fee Related
- 2001-02-07 WO PCT/EP2001/001315 patent/WO2001058892A1/en active IP Right Grant
- 2001-02-07 PT PT01905744T patent/PT1255749E/pt unknown
- 2001-02-07 DE DE60126745T patent/DE60126745T2/de not_active Expired - Lifetime
- 2001-02-07 AT AT01905744T patent/ATE354571T1/de not_active IP Right Cessation
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