JP2003522749A5 - - Google Patents
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- Publication number
- JP2003522749A5 JP2003522749A5 JP2001558402A JP2001558402A JP2003522749A5 JP 2003522749 A5 JP2003522749 A5 JP 2003522749A5 JP 2001558402 A JP2001558402 A JP 2001558402A JP 2001558402 A JP2001558402 A JP 2001558402A JP 2003522749 A5 JP2003522749 A5 JP 2003522749A5
- Authority
- JP
- Japan
- Prior art keywords
- carnitine
- alkanoyl
- solution
- chloride
- inner salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 alkanoyl L-carnitine Chemical compound 0.000 description 7
- 239000000243 solution Substances 0.000 description 5
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- UFAHZIUFPNSHSL-MRVPVSSYSA-N O-propanoyl-L-carnitine Chemical compound CCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C UFAHZIUFPNSHSL-MRVPVSSYSA-N 0.000 description 1
- JATPLOXBFFRHDN-DDWIOCJRSA-N [(2r)-2-acetyloxy-3-carboxypropyl]-trimethylazanium;chloride Chemical compound [Cl-].CC(=O)O[C@H](CC(O)=O)C[N+](C)(C)C JATPLOXBFFRHDN-DDWIOCJRSA-N 0.000 description 1
- JXXCENBLGFBQJM-FYZOBXCZSA-N [(2r)-3-carboxy-2-hydroxypropyl]-trimethylazanium;chloride Chemical compound [Cl-].C[N+](C)(C)C[C@H](O)CC(O)=O JXXCENBLGFBQJM-FYZOBXCZSA-N 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 229960000678 carnitine chloride Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 229940035429 isobutyl alcohol Drugs 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000RM000060A IT1316988B1 (it) | 2000-02-10 | 2000-02-10 | Procedimento migliorato di preparazione industriale di mucati dellal-carnitina e di alcanoil l-carnitine. |
| ITRM2000A000060 | 2000-02-10 | ||
| IT2000A000060 | 2000-06-23 | ||
| PCT/IT2001/000056 WO2001058850A1 (en) | 2000-02-10 | 2001-02-09 | A process for the preparation of salts of l-carnitine and alkanoyl l-carnitine with mucic acid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003522749A JP2003522749A (ja) | 2003-07-29 |
| JP2003522749A5 true JP2003522749A5 (enExample) | 2008-03-27 |
| JP4708655B2 JP4708655B2 (ja) | 2011-06-22 |
Family
ID=11454414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001558402A Expired - Fee Related JP4708655B2 (ja) | 2000-02-10 | 2001-02-09 | ムチン酸とのｌ−カルニチンおよびアルカノイルｌ−カルニチンの塩の調製法 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6693215B2 (enExample) |
| EP (1) | EP1257524B1 (enExample) |
| JP (1) | JP4708655B2 (enExample) |
| KR (1) | KR100709629B1 (enExample) |
| CN (1) | CN1169781C (enExample) |
| AT (1) | ATE308509T1 (enExample) |
| AU (1) | AU2001234079A1 (enExample) |
| CA (1) | CA2399501C (enExample) |
| CZ (1) | CZ303031B6 (enExample) |
| DE (1) | DE60114572T2 (enExample) |
| DK (1) | DK1257524T3 (enExample) |
| ES (1) | ES2249411T3 (enExample) |
| HK (1) | HK1052682B (enExample) |
| HU (1) | HU226129B1 (enExample) |
| IT (1) | IT1316988B1 (enExample) |
| MX (1) | MXPA02007682A (enExample) |
| PL (1) | PL201605B1 (enExample) |
| SK (1) | SK287250B6 (enExample) |
| WO (1) | WO2001058850A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118638020B (zh) * | 2024-08-08 | 2024-11-19 | 杭州海尔希畜牧科技有限公司 | L-天门冬氨酸l(-)肉碱(1:1)的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1172394B (it) * | 1983-12-28 | 1987-06-18 | Sigma Tau Ind Farmaceuti | Sali della l-carnitina e di alcuni alcanoil derivati della l-carnitina e procedimento per la loro preparazione |
| AU718308B2 (en) | 1996-05-31 | 2000-04-13 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Stable, non-hygroscopic salts of L(-)carnitine and alkanoyl L(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts |
| IT1289974B1 (it) * | 1997-02-25 | 1998-10-19 | Aldo Fassi | Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine |
-
2000
- 2000-02-10 IT IT2000RM000060A patent/IT1316988B1/it active
-
2001
- 2001-02-09 DK DK01906116T patent/DK1257524T3/da active
- 2001-02-09 CN CNB018047637A patent/CN1169781C/zh not_active Expired - Fee Related
- 2001-02-09 SK SK1155-2002A patent/SK287250B6/sk not_active IP Right Cessation
- 2001-02-09 ES ES01906116T patent/ES2249411T3/es not_active Expired - Lifetime
- 2001-02-09 HU HU0204378A patent/HU226129B1/hu not_active IP Right Cessation
- 2001-02-09 CZ CZ20022533A patent/CZ303031B6/cs not_active IP Right Cessation
- 2001-02-09 PL PL358098A patent/PL201605B1/pl unknown
- 2001-02-09 EP EP01906116A patent/EP1257524B1/en not_active Expired - Lifetime
- 2001-02-09 HK HK03104608.3A patent/HK1052682B/zh not_active IP Right Cessation
- 2001-02-09 US US10/203,565 patent/US6693215B2/en not_active Expired - Lifetime
- 2001-02-09 DE DE60114572T patent/DE60114572T2/de not_active Expired - Lifetime
- 2001-02-09 WO PCT/IT2001/000056 patent/WO2001058850A1/en not_active Ceased
- 2001-02-09 JP JP2001558402A patent/JP4708655B2/ja not_active Expired - Fee Related
- 2001-02-09 MX MXPA02007682A patent/MXPA02007682A/es active IP Right Grant
- 2001-02-09 KR KR1020027010247A patent/KR100709629B1/ko not_active Expired - Fee Related
- 2001-02-09 AU AU2001234079A patent/AU2001234079A1/en not_active Abandoned
- 2001-02-09 CA CA2399501A patent/CA2399501C/en not_active Expired - Fee Related
- 2001-02-09 AT AT01906116T patent/ATE308509T1/de active
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