JP2003522171A - 抗腫瘍剤としてのｃ１０カーボネート置換タキサン - Google Patents

抗腫瘍剤としてのｃ１０カーボネート置換タキサン

Info

Publication number
JP2003522171A
JP2003522171A JP2001557863A JP2001557863A JP2003522171A JP 2003522171 A JP2003522171 A JP 2003522171A JP 2001557863 A JP2001557863 A JP 2001557863A JP 2001557863 A JP2001557863 A JP 2001557863A JP 2003522171 A JP2003522171 A JP 2003522171A
Authority
JP
Japan
Prior art keywords
pyridyl
taxane
thienyl
furyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2001557863A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003522171A5 (enExample
Inventor
ロバート・エイ・ホルトン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida State University Research Foundation Inc
Original Assignee
Florida State University Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florida State University Research Foundation Inc filed Critical Florida State University Research Foundation Inc
Publication of JP2003522171A publication Critical patent/JP2003522171A/ja
Publication of JP2003522171A5 publication Critical patent/JP2003522171A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
JP2001557863A 2000-02-02 2001-02-02 抗腫瘍剤としてのｃ１０カーボネート置換タキサン Withdrawn JP2003522171A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17968400P 2000-02-02 2000-02-02
US60/179,684 2000-02-02
PCT/US2001/003588 WO2001057031A1 (en) 2000-02-02 2001-02-02 C10 carbonate substituted taxanes as antitumor agents

Publications (2)

Publication Number Publication Date
JP2003522171A true JP2003522171A (ja) 2003-07-22
JP2003522171A5 JP2003522171A5 (enExample) 2006-12-21

Family

ID=22657547

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001557863A Withdrawn JP2003522171A (ja) 2000-02-02 2001-02-02 抗腫瘍剤としてのｃ１０カーボネート置換タキサン

Country Status (24)

Country Link
US (3) US6660866B2 (enExample)
EP (1) EP1165550A1 (enExample)
JP (1) JP2003522171A (enExample)
KR (1) KR20010111582A (enExample)
CN (1) CN1186340C (enExample)
AU (1) AU782028B2 (enExample)
BG (1) BG65298B1 (enExample)
BR (1) BR0104779A (enExample)
CA (1) CA2368151A1 (enExample)
CZ (1) CZ20013405A3 (enExample)
GE (1) GEP20043239B (enExample)
HU (1) HUP0200759A3 (enExample)
IL (1) IL145636A0 (enExample)
MX (1) MXPA01009902A (enExample)
NO (1) NO20014753L (enExample)
NZ (1) NZ514074A (enExample)
PL (1) PL350028A1 (enExample)
RO (1) RO121269B1 (enExample)
RU (1) RU2264400C2 (enExample)
SK (1) SK13632001A3 (enExample)
TR (1) TR200102855T1 (enExample)
UA (1) UA75038C2 (enExample)
WO (1) WO2001057031A1 (enExample)
ZA (2) ZA200108054B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL350075A1 (en) * 2000-02-02 2002-11-04 Univ Florida State Res Found Taxane formulations having improved solubility
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
PL350028A1 (en) 2000-02-02 2002-10-21 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents
HK1047934A1 (zh) * 2000-02-02 2003-03-14 佛罗里达州立大学研究基金有限公司 用作抗肿瘤剂的c7碳酸酯取代的紫杉烷
CA2354478A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C10 carbonate substituted taxanes
US20030082229A1 (en) * 2001-11-01 2003-05-01 Board Of Regents, The University Of Texas Systems Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use
SV2006002010A (es) * 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
MX2007009748A (es) * 2005-02-14 2007-09-26 Univ Florida State Res Found Composiciones de taxano sustituidas con esteres ciclopropilicos en c10.
RU2352340C1 (ru) * 2007-06-27 2009-04-20 Федеральное Государственное Учреждение Ростовский научно-исследовательский онкологический институт Росмедтехнологий Способ химиотерапии при раке мочевого пузыря
RU2370261C2 (ru) * 2007-08-03 2009-10-20 Закрытое Акционерное Общество "Биокад" Стабильная эмульсия для парентерального введения плохо растворимых в воде соединений, обладающих противоопухолевой активностью, и способ ее получения
EP2276755A4 (en) * 2008-03-31 2011-05-04 Univ Florida State Res Found C (10) -ETHYESTER- AND C (10) -CYCLOPROPYLESTER-SUBSTITUTED TAXANES

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5350866A (en) 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
ES2230790T3 (es) 1992-01-15 2005-05-01 E.R. SQUIBB & SONS, INC. Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermedios en la preparacion de taxanos.
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5698712A (en) 1992-03-06 1997-12-16 Indena S.P.A. Baccatine III derivatives
US5939561A (en) 1992-03-10 1999-08-17 Rhone-Poulence Rorer S.A. Process for the preparation of β-phenylisoserine and β-lactam and their analogues
FR2691460B1 (fr) 1992-05-21 1994-07-22 Rhone Poulenc Rorer Sa Nouveaux derives du taxane, leur preparation et les compositions qui les contiennent.
US5254580A (en) 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
CA2100808A1 (en) 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
DE4241664C2 (de) 1992-12-04 1995-04-06 Borus Spezialverfahren Elektronisches Lebensdetektionssystem
CA2109861C (en) 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
IL107950A (en) * 1992-12-15 2001-04-30 Upjohn Co 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
NO310238B1 (no) 1992-12-24 2001-06-11 Bristol Myers Squibb Co Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater
FR2702212B1 (fr) 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IT1261667B (it) 1993-05-20 1996-05-29 Tassano ad attivita' antitumorale.
DE69424166T2 (de) 1993-06-11 2000-10-05 Pharmacia & Upjohn Co., Kalamazoo Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
CA2129288C (en) 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
IL127598A (en) * 1994-01-28 2003-04-10 Upjohn Co Process for preparing isotaxol analogs
FR2721024B1 (fr) * 1994-06-09 1996-07-12 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
WO1996013495A1 (en) 1994-10-28 1996-05-09 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
US6100411A (en) * 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
CA2162759A1 (en) 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
FR2732342B1 (fr) 1995-04-03 1997-04-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2732968B1 (fr) 1995-04-14 1997-05-16 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5801191A (en) 1995-06-01 1998-09-01 Biophysica Foundation Taxoids
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
CA2231837A1 (en) 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
FR2742751B1 (fr) * 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2745814B1 (fr) 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
IL126856A0 (en) 1996-05-06 1999-09-22 Univ Florida State 1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
JPH1045583A (ja) 1996-05-14 1998-02-17 Tanabe Seiyaku Co Ltd 医薬組成物
BR9710366A (pt) 1996-07-15 1999-08-17 Yakult Honsha Kk Derivados de taxane e drogas que os contêm
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
JP2003026673A (ja) 1999-03-05 2003-01-29 Asahi Kasei Corp 骨形成促進剤
PL350028A1 (en) * 2000-02-02 2002-10-21 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents
EP1175414A1 (en) 2000-02-02 2002-01-30 Florida State University Research Foundation, Inc. Taxane formulations having improved solubility

Also Published As

Publication number Publication date
AU782028B2 (en) 2005-06-30
ZA200108058B (en) 2003-12-01
CN1186340C (zh) 2005-01-26
RO121269B1 (ro) 2007-02-28
US6660866B2 (en) 2003-12-09
MXPA01009902A (es) 2003-07-28
NZ514074A (en) 2004-03-26
GEP20043239B (en) 2004-05-25
CA2368151A1 (en) 2001-08-09
US20060111401A1 (en) 2006-05-25
US20030114493A1 (en) 2003-06-19
RU2264400C2 (ru) 2005-11-20
NO20014753L (no) 2001-11-29
NO20014753D0 (no) 2001-10-01
HUP0200759A3 (en) 2002-10-28
US7256213B2 (en) 2007-08-14
HK1053472A1 (en) 2003-10-24
IL145636A0 (en) 2002-06-30
UA75038C2 (en) 2006-03-15
HUP0200759A2 (hu) 2002-07-29
BG65298B1 (bg) 2007-12-28
US20040122055A1 (en) 2004-06-24
CZ20013405A3 (cs) 2002-03-13
PL350028A1 (en) 2002-10-21
KR20010111582A (ko) 2001-12-19
BR0104779A (pt) 2001-12-26
CN1429225A (zh) 2003-07-09
EP1165550A1 (en) 2002-01-02
SK13632001A3 (sk) 2002-06-04
BG105964A (en) 2002-08-30
WO2001057031A1 (en) 2001-08-09
US7056946B2 (en) 2006-06-06
TR200102855T1 (tr) 2002-06-21
AU3330101A (en) 2001-08-14
ZA200108054B (en) 2003-12-01

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