CN1186340C - 用作抗肿瘤剂的c10碳酸酯取代的紫杉烷 - Google Patents

用作抗肿瘤剂的c10碳酸酯取代的紫杉烷 Download PDF

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Publication number
CN1186340C
CN1186340C CNB018001483A CN01800148A CN1186340C CN 1186340 C CN1186340 C CN 1186340C CN B018001483 A CNB018001483 A CN B018001483A CN 01800148 A CN01800148 A CN 01800148A CN 1186340 C CN1186340 C CN 1186340C
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CN
China
Prior art keywords
pyridyl
taxane
group
thienyl
furyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018001483A
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English (en)
Chinese (zh)
Other versions
CN1429225A (zh
Inventor
R·A·赫尔顿
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Florida State University Research Foundation Inc
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Florida State University Research Foundation Inc
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Publication of CN1429225A publication Critical patent/CN1429225A/zh
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Publication of CN1186340C publication Critical patent/CN1186340C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
CNB018001483A 2000-02-02 2001-02-02 用作抗肿瘤剂的c10碳酸酯取代的紫杉烷 Expired - Fee Related CN1186340C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17968400P 2000-02-02 2000-02-02
US60/179,684 2000-02-02

Publications (2)

Publication Number Publication Date
CN1429225A CN1429225A (zh) 2003-07-09
CN1186340C true CN1186340C (zh) 2005-01-26

Family

ID=22657547

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018001483A Expired - Fee Related CN1186340C (zh) 2000-02-02 2001-02-02 用作抗肿瘤剂的c10碳酸酯取代的紫杉烷

Country Status (24)

Country Link
US (3) US6660866B2 (enExample)
EP (1) EP1165550A1 (enExample)
JP (1) JP2003522171A (enExample)
KR (1) KR20010111582A (enExample)
CN (1) CN1186340C (enExample)
AU (1) AU782028B2 (enExample)
BG (1) BG65298B1 (enExample)
BR (1) BR0104779A (enExample)
CA (1) CA2368151A1 (enExample)
CZ (1) CZ20013405A3 (enExample)
GE (1) GEP20043239B (enExample)
HU (1) HUP0200759A3 (enExample)
IL (1) IL145636A0 (enExample)
MX (1) MXPA01009902A (enExample)
NO (1) NO20014753L (enExample)
NZ (1) NZ514074A (enExample)
PL (1) PL350028A1 (enExample)
RO (1) RO121269B1 (enExample)
RU (1) RU2264400C2 (enExample)
SK (1) SK13632001A3 (enExample)
TR (1) TR200102855T1 (enExample)
UA (1) UA75038C2 (enExample)
WO (1) WO2001057031A1 (enExample)
ZA (2) ZA200108054B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638973B2 (en) * 2000-02-02 2003-10-28 Fsu Research Foundation, Inc. Taxane formulations
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
HUP0200759A3 (en) 2000-02-02 2002-10-28 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them and their use
JP2003522170A (ja) * 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ７カーボネート置換タキサン
CA2354478A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C10 carbonate substituted taxanes
US20030082229A1 (en) * 2001-11-01 2003-05-01 Board Of Regents, The University Of Texas Systems Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use
SV2006002010A (es) * 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
CA2597682A1 (en) * 2005-02-14 2006-08-24 Florida State University Research Foundation, Inc. C10 cyclopropyl ester substituted taxane compositions
RU2352340C1 (ru) * 2007-06-27 2009-04-20 Федеральное Государственное Учреждение Ростовский научно-исследовательский онкологический институт Росмедтехнологий Способ химиотерапии при раке мочевого пузыря
RU2370261C2 (ru) * 2007-08-03 2009-10-20 Закрытое Акционерное Общество "Биокад" Стабильная эмульсия для парентерального введения плохо растворимых в воде соединений, обладающих противоопухолевой активностью, и способ ее получения
EP2276755A4 (en) * 2008-03-31 2011-05-04 Univ Florida State Res Found C (10) -ETHYESTER- AND C (10) -CYCLOPROPYLESTER-SUBSTITUTED TAXANES

Family Cites Families (50)

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FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
SG46582A1 (en) 1991-09-23 1998-02-20 Univ Florida State 10-Desacetoxytaxol derivatives
CA2087359A1 (en) 1992-01-15 1993-07-16 Ramesh N. Patel Enzymatic processes for resolution of enantiomeric mixtures of compoundsuseful as intermediates in the preparation of taxanes
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5698712A (en) 1992-03-06 1997-12-16 Indena S.P.A. Baccatine III derivatives
US5939561A (en) 1992-03-10 1999-08-17 Rhone-Poulence Rorer S.A. Process for the preparation of β-phenylisoserine and β-lactam and their analogues
FR2691460B1 (fr) 1992-05-21 1994-07-22 Rhone Poulenc Rorer Sa Nouveaux derives du taxane, leur preparation et les compositions qui les contiennent.
US5254580A (en) 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
CA2100808A1 (en) 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
DE4241664C2 (de) 1992-12-04 1995-04-06 Borus Spezialverfahren Elektronisches Lebensdetektionssystem
CA2109861C (en) 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2111527C (en) 1992-12-24 2000-07-18 Jerzy Golik Phosphonooxymethyl ethers of taxane derivatives
FR2702212B1 (fr) 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
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IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
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CA2129288C (en) 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
IL127599A (en) * 1994-01-28 2004-06-01 Upjohn Co Process for preparing isotaxol analogs
FR2721024B1 (fr) * 1994-06-09 1996-07-12 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US6100411A (en) * 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
JPH10508022A (ja) * 1994-10-28 1998-08-04 ザ リサーチ ファウンデーション オブ ステート ユニバーシティ オブ ニューヨーク タキソイド誘導体、それらの製造、およびそれらの抗腫瘍薬としての使用
CA2162759A1 (en) 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
FR2732342B1 (fr) 1995-04-03 1997-04-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2732968B1 (fr) 1995-04-14 1997-05-16 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5801191A (en) * 1995-06-01 1998-09-01 Biophysica Foundation Taxoids
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
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FR2742751B1 (fr) 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2745814B1 (fr) 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
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JP2003026673A (ja) * 1999-03-05 2003-01-29 Asahi Kasei Corp 骨形成促進剤
HUP0200759A3 (en) * 2000-02-02 2002-10-28 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them and their use
NZ514073A (en) 2000-02-02 2004-02-27 Univ Florida State Res Found Taxane formulations having improved solubility

Also Published As

Publication number Publication date
AU782028B2 (en) 2005-06-30
IL145636A0 (en) 2002-06-30
BG105964A (en) 2002-08-30
NO20014753L (no) 2001-11-29
US20030114493A1 (en) 2003-06-19
SK13632001A3 (sk) 2002-06-04
US6660866B2 (en) 2003-12-09
US7256213B2 (en) 2007-08-14
ZA200108058B (en) 2003-12-01
RO121269B1 (ro) 2007-02-28
BG65298B1 (bg) 2007-12-28
JP2003522171A (ja) 2003-07-22
NZ514074A (en) 2004-03-26
CN1429225A (zh) 2003-07-09
KR20010111582A (ko) 2001-12-19
UA75038C2 (en) 2006-03-15
EP1165550A1 (en) 2002-01-02
PL350028A1 (en) 2002-10-21
ZA200108054B (en) 2003-12-01
BR0104779A (pt) 2001-12-26
US20060111401A1 (en) 2006-05-25
US7056946B2 (en) 2006-06-06
CZ20013405A3 (cs) 2002-03-13
WO2001057031A1 (en) 2001-08-09
AU3330101A (en) 2001-08-14
HUP0200759A3 (en) 2002-10-28
TR200102855T1 (tr) 2002-06-21
HUP0200759A2 (hu) 2002-07-29
NO20014753D0 (no) 2001-10-01
HK1053472A1 (en) 2003-10-24
US20040122055A1 (en) 2004-06-24
RU2264400C2 (ru) 2005-11-20
CA2368151A1 (en) 2001-08-09
MXPA01009902A (es) 2003-07-28
GEP20043239B (en) 2004-05-25

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee