RO121269B1 - Taxani substituiţi cu carbonat la c10, folosiţica agenţi antitumorali - Google Patents
Taxani substituiţi cu carbonat la c10, folosiţica agenţi antitumorali Download PDFInfo
- Publication number
- RO121269B1 RO121269B1 ROA200101082A RO200101082A RO121269B1 RO 121269 B1 RO121269 B1 RO 121269B1 RO A200101082 A ROA200101082 A RO A200101082A RO 200101082 A RO200101082 A RO 200101082A RO 121269 B1 RO121269 B1 RO 121269B1
- Authority
- RO
- Romania
- Prior art keywords
- pyridyl
- thienyl
- furyl
- coox
- cox
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17968400P | 2000-02-02 | 2000-02-02 | |
| PCT/US2001/003588 WO2001057031A1 (en) | 2000-02-02 | 2001-02-02 | C10 carbonate substituted taxanes as antitumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO121269B1 true RO121269B1 (ro) | 2007-02-28 |
Family
ID=22657547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ROA200101082A RO121269B1 (ro) | 2000-02-02 | 2001-02-02 | Taxani substituiţi cu carbonat la c10, folosiţica agenţi antitumorali |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US6660866B2 (enExample) |
| EP (1) | EP1165550A1 (enExample) |
| JP (1) | JP2003522171A (enExample) |
| KR (1) | KR20010111582A (enExample) |
| CN (1) | CN1186340C (enExample) |
| AU (1) | AU782028B2 (enExample) |
| BG (1) | BG65298B1 (enExample) |
| BR (1) | BR0104779A (enExample) |
| CA (1) | CA2368151A1 (enExample) |
| CZ (1) | CZ20013405A3 (enExample) |
| GE (1) | GEP20043239B (enExample) |
| HU (1) | HUP0200759A3 (enExample) |
| IL (1) | IL145636A0 (enExample) |
| MX (1) | MXPA01009902A (enExample) |
| NO (1) | NO20014753L (enExample) |
| NZ (1) | NZ514074A (enExample) |
| PL (1) | PL350028A1 (enExample) |
| RO (1) | RO121269B1 (enExample) |
| RU (1) | RU2264400C2 (enExample) |
| SK (1) | SK13632001A3 (enExample) |
| TR (1) | TR200102855T1 (enExample) |
| UA (1) | UA75038C2 (enExample) |
| WO (1) | WO2001057031A1 (enExample) |
| ZA (2) | ZA200108058B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL350028A1 (en) * | 2000-02-02 | 2002-10-21 | Univ Florida State Res Found | C10 carbonate substituted taxanes as antitumor agents |
| US6649632B2 (en) * | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
| CA2367661A1 (en) * | 2000-02-02 | 2001-08-09 | Robert A. Holton | Taxane formulations having improved solubility |
| CZ20013429A3 (cs) * | 2000-02-02 | 2002-04-17 | Florida State University Research Foundation, Inc. | Taxany substituované v poloze C7 karbonátem jako protinádorová činidla |
| CA2354478A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C10 carbonate substituted taxanes |
| US20030082229A1 (en) * | 2001-11-01 | 2003-05-01 | Board Of Regents, The University Of Texas Systems | Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use |
| PE20050693A1 (es) * | 2004-02-13 | 2005-09-27 | Univ Florida State Res Found | Taxanos sustituidos con esteres de ciclopentilo en c10 |
| TW200640447A (en) * | 2005-02-14 | 2006-12-01 | Univ Florida State Res Found | C10 cyclopropyl ester substituted taxane compositions |
| RU2352340C1 (ru) * | 2007-06-27 | 2009-04-20 | Федеральное Государственное Учреждение Ростовский научно-исследовательский онкологический институт Росмедтехнологий | Способ химиотерапии при раке мочевого пузыря |
| RU2370261C2 (ru) * | 2007-08-03 | 2009-10-20 | Закрытое Акционерное Общество "Биокад" | Стабильная эмульсия для парентерального введения плохо растворимых в воде соединений, обладающих противоопухолевой активностью, и способ ее получения |
| US8242166B2 (en) * | 2008-03-31 | 2012-08-14 | Florida State University Research Foundation, Inc. | C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5350866A (en) | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| EP0552041B1 (en) | 1992-01-15 | 2000-08-30 | E.R. Squibb & Sons, Inc. | Enzymatic processes for resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US5698712A (en) | 1992-03-06 | 1997-12-16 | Indena S.P.A. | Baccatine III derivatives |
| US5939561A (en) | 1992-03-10 | 1999-08-17 | Rhone-Poulence Rorer S.A. | Process for the preparation of β-phenylisoserine and β-lactam and their analogues |
| FR2691460B1 (fr) | 1992-05-21 | 1994-07-22 | Rhone Poulenc Rorer Sa | Nouveaux derives du taxane, leur preparation et les compositions qui les contiennent. |
| US5254580A (en) | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
| CA2100808A1 (en) | 1992-10-01 | 1994-04-02 | Vittorio Farina | Deoxy paclitaxels |
| FR2697752B1 (fr) | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| DE4241664C2 (de) | 1992-12-04 | 1995-04-06 | Borus Spezialverfahren | Elektronisches Lebensdetektionssystem |
| CA2109861C (en) | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
| IL107950A (en) * | 1992-12-15 | 2001-04-30 | Upjohn Co | 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| CA2111527C (en) | 1992-12-24 | 2000-07-18 | Jerzy Golik | Phosphonooxymethyl ethers of taxane derivatives |
| FR2702212B1 (fr) | 1993-03-02 | 1995-04-07 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| US5703247A (en) | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
| US5475011A (en) | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
| IT1261667B (it) | 1993-05-20 | 1996-05-29 | Tassano ad attivita' antitumorale. | |
| DE69433146T2 (de) | 1993-06-11 | 2004-06-09 | Pharmacia & Upjohn Co., Kalamazoo | Delta 6,7-Taxol Derivate antineoplastische Verbindungen und diese enthaltende pharmazeutische Zusammenstellungen |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| CA2129288C (en) | 1993-08-17 | 2000-05-16 | Jerzy Golik | Phosphonooxymethyl esters of taxane derivatives |
| IL127598A (en) * | 1994-01-28 | 2003-04-10 | Upjohn Co | Process for preparing isotaxol analogs |
| FR2721024B1 (fr) * | 1994-06-09 | 1996-07-12 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| US6100411A (en) * | 1994-10-28 | 2000-08-08 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| WO1996013495A1 (en) * | 1994-10-28 | 1996-05-09 | The Research Foundation Of State University Of New York | Taxoid derivatives, their preparation and their use as antitumor agents |
| CA2162759A1 (en) | 1994-11-17 | 1996-05-18 | Kenji Tsujihara | Baccatin derivatives and processes for preparing the same |
| FR2732342B1 (fr) | 1995-04-03 | 1997-04-30 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2732968B1 (fr) | 1995-04-14 | 1997-05-16 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5801191A (en) * | 1995-06-01 | 1998-09-01 | Biophysica Foundation | Taxoids |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| CA2231837A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| FR2742751B1 (fr) | 1995-12-22 | 1998-01-30 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2745814B1 (fr) | 1996-03-06 | 1998-04-03 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| WO1997042181A1 (en) | 1996-05-06 | 1997-11-13 | Florida State University | 1-deoxy baccatin iii, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
| JPH1045583A (ja) | 1996-05-14 | 1998-02-17 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| AU710156B2 (en) | 1996-07-15 | 1999-09-16 | Kabushiki Kaisha Yakult Honsha | Taxane derivatives and drugs containing the same |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| JP2003026673A (ja) | 1999-03-05 | 2003-01-29 | Asahi Kasei Corp | 骨形成促進剤 |
| BR0104358A (pt) | 2000-02-02 | 2002-01-02 | Univ Florida State Res Found | Formulações de taxana tendo solubilidade aperfeiçoada |
| PL350028A1 (en) | 2000-02-02 | 2002-10-21 | Univ Florida State Res Found | C10 carbonate substituted taxanes as antitumor agents |
-
2001
- 2001-02-02 PL PL01350028A patent/PL350028A1/xx not_active Application Discontinuation
- 2001-02-02 US US09/776,274 patent/US6660866B2/en not_active Expired - Fee Related
- 2001-02-02 RO ROA200101082A patent/RO121269B1/ro unknown
- 2001-02-02 TR TR2001/02855T patent/TR200102855T1/xx unknown
- 2001-02-02 NZ NZ514074A patent/NZ514074A/xx unknown
- 2001-02-02 CZ CZ20013405A patent/CZ20013405A3/cs unknown
- 2001-02-02 WO PCT/US2001/003588 patent/WO2001057031A1/en not_active Ceased
- 2001-02-02 MX MXPA01009902A patent/MXPA01009902A/es active IP Right Grant
- 2001-02-02 IL IL14563601A patent/IL145636A0/xx unknown
- 2001-02-02 BR BR0104779-5A patent/BR0104779A/pt not_active IP Right Cessation
- 2001-02-02 RU RU2001129533/04A patent/RU2264400C2/ru not_active IP Right Cessation
- 2001-02-02 CN CNB018001483A patent/CN1186340C/zh not_active Expired - Fee Related
- 2001-02-02 GE GEAP20016129A patent/GEP20043239B/en unknown
- 2001-02-02 EP EP01905420A patent/EP1165550A1/en not_active Withdrawn
- 2001-02-02 AU AU33301/01A patent/AU782028B2/en not_active Ceased
- 2001-02-02 JP JP2001557863A patent/JP2003522171A/ja not_active Withdrawn
- 2001-02-02 CA CA002368151A patent/CA2368151A1/en not_active Abandoned
- 2001-02-02 KR KR1020017012590A patent/KR20010111582A/ko not_active Ceased
- 2001-02-02 SK SK1363-2001A patent/SK13632001A3/sk unknown
- 2001-02-02 HU HU0200759A patent/HUP0200759A3/hu unknown
- 2001-02-02 UA UA2001106731A patent/UA75038C2/uk unknown
- 2001-10-01 ZA ZA200108058A patent/ZA200108058B/en unknown
- 2001-10-01 BG BG105964A patent/BG65298B1/bg unknown
- 2001-10-01 NO NO20014753A patent/NO20014753L/no not_active Application Discontinuation
- 2001-10-01 ZA ZA200108054A patent/ZA200108054B/xx unknown
-
2003
- 2003-11-24 US US10/720,615 patent/US7056946B2/en not_active Expired - Fee Related
-
2006
- 2006-01-12 US US11/330,770 patent/US7256213B2/en not_active Expired - Fee Related
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