JP2003518507A5 - - Google Patents
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- JP2003518507A5 JP2003518507A5 JP2001548135A JP2001548135A JP2003518507A5 JP 2003518507 A5 JP2003518507 A5 JP 2003518507A5 JP 2001548135 A JP2001548135 A JP 2001548135A JP 2001548135 A JP2001548135 A JP 2001548135A JP 2003518507 A5 JP2003518507 A5 JP 2003518507A5
- Authority
- JP
- Japan
- Prior art keywords
- vector
- inducer
- inhibitor
- description
- obstruction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013598 vector Substances 0.000 description 20
- 239000000411 inducer Substances 0.000 description 16
- 239000003795 chemical substances by application Substances 0.000 description 10
- 239000003112 inhibitor Substances 0.000 description 10
- 239000012634 fragment Substances 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 7
- 108010057466 NF-kappa B Proteins 0.000 description 5
- 102000003945 NF-kappa B Human genes 0.000 description 5
- 239000000427 antigen Substances 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 108020004707 nucleic acids Proteins 0.000 description 5
- 150000007523 nucleic acids Chemical class 0.000 description 5
- 229960005486 vaccine Drugs 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 239000002157 polynucleotide Substances 0.000 description 4
- 208000024827 Alzheimer disease Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- FAWLNURBQMTKEB-URDPEVQOSA-N 213546-53-3 Chemical compound N([C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N1[C@@H](CCC1)C(O)=O)C(C)C)C(C)C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(C)C FAWLNURBQMTKEB-URDPEVQOSA-N 0.000 description 2
- 102100021854 Inhibitor of nuclear factor kappa-B kinase subunit beta Human genes 0.000 description 2
- 101710205525 Inhibitor of nuclear factor kappa-B kinase subunit beta Proteins 0.000 description 2
- 230000000692 anti-sense effect Effects 0.000 description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000017128 negative regulation of NF-kappaB transcription factor activity Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 108091033319 polynucleotide Proteins 0.000 description 2
- 102000040430 polynucleotide Human genes 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102100024457 Cyclin-dependent kinase 9 Human genes 0.000 description 1
- 108010041986 DNA Vaccines Proteins 0.000 description 1
- 229940021995 DNA vaccine Drugs 0.000 description 1
- 206010011968 Decreased immune responsiveness Diseases 0.000 description 1
- 101000980930 Homo sapiens Cyclin-dependent kinase 9 Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 101710199015 Interleukin-1 receptor-associated kinase 1 Proteins 0.000 description 1
- 241000713666 Lentivirus Species 0.000 description 1
- 108010075654 MAP Kinase Kinase Kinase 1 Proteins 0.000 description 1
- 101150053046 MYD88 gene Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102100033115 Mitogen-activated protein kinase kinase kinase 1 Human genes 0.000 description 1
- 101710164353 Mitogen-activated protein kinase kinase kinase 8 Proteins 0.000 description 1
- 102100026907 Mitogen-activated protein kinase kinase kinase 8 Human genes 0.000 description 1
- 108010052419 NF-KappaB Inhibitor alpha Proteins 0.000 description 1
- 102100039337 NF-kappa-B inhibitor alpha Human genes 0.000 description 1
- 102000019148 NF-kappaB-inducing kinase activity proteins Human genes 0.000 description 1
- 108040008091 NF-kappaB-inducing kinase activity proteins Proteins 0.000 description 1
- 108700001237 Nucleic Acid-Based Vaccines Proteins 0.000 description 1
- -1 Or claim 18molecule Substances 0.000 description 1
- 102000004393 TNF receptor-associated factor 2 Human genes 0.000 description 1
- 108090000925 TNF receptor-associated factor 2 Proteins 0.000 description 1
- 102000003718 TNF receptor-associated factor 5 Human genes 0.000 description 1
- 108090000001 TNF receptor-associated factor 5 Proteins 0.000 description 1
- 102000003714 TNF receptor-associated factor 6 Human genes 0.000 description 1
- 108090000009 TNF receptor-associated factor 6 Proteins 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229940023146 nucleic acid vaccine Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9930616.9A GB9930616D0 (en) | 1999-12-24 | 1999-12-24 | Activation and inhibition of the immune system |
| GB9930616.9 | 1999-12-24 | ||
| PCT/GB2000/004925 WO2001047543A2 (en) | 1999-12-24 | 2000-12-22 | Activation and inhibition of the immune system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003518507A JP2003518507A (ja) | 2003-06-10 |
| JP2003518507A5 true JP2003518507A5 (https=) | 2008-02-28 |
Family
ID=10867023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001548135A Pending JP2003518507A (ja) | 1999-12-24 | 2000-12-22 | 免疫系の活性化および阻害 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7915009B2 (https=) |
| EP (2) | EP1852123A3 (https=) |
| JP (1) | JP2003518507A (https=) |
| CN (2) | CN1254272C (https=) |
| AT (1) | ATE390929T1 (https=) |
| AU (1) | AU781496B2 (https=) |
| CA (1) | CA2394880A1 (https=) |
| DE (1) | DE60038503T2 (https=) |
| ES (1) | ES2302707T3 (https=) |
| GB (1) | GB9930616D0 (https=) |
| NZ (1) | NZ519438A (https=) |
| WO (1) | WO2001047543A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9930616D0 (en) | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| US7651857B2 (en) * | 2000-12-22 | 2010-01-26 | The Mathilda And Terence Kennedy Institute Of Rheumatology Trust | Methods for enhancing antigen presentation |
| GB0116249D0 (en) * | 2001-07-05 | 2001-08-29 | Imp College Innovations Ltd | Methods |
| JP2003055202A (ja) * | 2001-08-15 | 2003-02-26 | Hiroyuki Hanai | 炎症性腸疾患の予防・治療剤 |
| EP1512415A4 (en) * | 2002-05-29 | 2005-11-09 | Anges Mg Inc | LURE COMPOSITION FOR TREATING AND PREVENTING INFLAMMATORY DISEASES |
| AU2002953094A0 (en) * | 2002-12-04 | 2002-12-19 | The University Of Queensland | Immunomodulating compositions, processes for their production and uses therefor |
| US20060257380A1 (en) * | 2002-09-19 | 2006-11-16 | Inst.Nat. De La Sante Et De La Recherche MED | Use of sirnas for gene silencing in antigen presenting cells |
| WO2004073641A2 (en) | 2003-02-18 | 2004-09-02 | Kevin Slawin | Induced activation in dendritic cells |
| WO2004101745A2 (en) * | 2003-05-08 | 2004-11-25 | Beth Israel Deaconess Medical Center, Inc. | NOVEL REGULATORY MECHANISMS OF NF-kappaB |
| AR051836A1 (es) | 2004-11-30 | 2007-02-14 | Centocor Inc | Antagonistas de receptor 3 simil toll metodos y usos |
| CN100418532C (zh) * | 2005-06-17 | 2008-09-17 | 吕志民 | 治疗多种疾病的NF-κB化合物抑制剂 |
| WO2007001487A2 (en) * | 2005-06-23 | 2007-01-04 | Baylor College Of Medicine | Modulation of negative immune regulators and applications for immunotherapy |
| WO2007033475A1 (en) * | 2005-09-20 | 2007-03-29 | London Health Sciences Centre Research Inc. | THE USE OF siRNAs IN ORGAN STORAGE/REPERFUSION SOLUTIONS |
| EP1945820B1 (en) | 2005-10-27 | 2013-08-28 | Janssen Biotech, Inc. | Toll like receptor 3 modulators, methods and uses |
| CN101240271B (zh) * | 2006-08-28 | 2012-08-29 | 长春华普生物技术有限公司 | Toll样受体调节性寡核苷酸及其用途 |
| AU2007306936B2 (en) | 2006-10-12 | 2014-02-06 | The University Of Queensland | Compositions and methods for modulating immune responses |
| CA3058450A1 (en) * | 2006-10-19 | 2008-04-24 | Baylor College Of Medicine | Generating an immune response by inducing cd40 and pattern recognition receptors |
| WO2008080195A1 (en) * | 2006-12-29 | 2008-07-10 | The University Of Queensland | Compositions and methods for treating or preventing unwanted immune responses |
| CA2738031C (en) * | 2008-09-22 | 2022-11-29 | Baylor College Of Medicine | Methods and compositions for generating an immune response by inducing cd40 and pattern recognition receptor adapters |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| AU2012284223B2 (en) * | 2011-07-18 | 2017-06-22 | University Of Kentucky Research Foundation | Protection of cells from Alu-RNA-induced degenereation and inhibitors for protecting cells |
| US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| CA2905352A1 (en) | 2013-03-14 | 2014-09-25 | Bellicum Pharmaceuticals, Inc. | Methods for controlling t cell proliferation |
| ES2791598T3 (es) | 2013-06-05 | 2020-11-05 | Bellicum Pharmaceuticals Inc | Métodos para inducir apoptosis parcial utilizando polipéptidos de caspasa |
| AU2014318520B2 (en) * | 2013-09-12 | 2020-09-03 | Icahn School Of Medicine At Mount Sinai | Methods of making transgenic animals with T cell receptors that are specific to a flourescent protein |
| US10934346B2 (en) | 2014-02-14 | 2021-03-02 | Bellicum Pharmaceuticals, Inc. | Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12 |
| WO2015187847A1 (en) * | 2014-06-03 | 2015-12-10 | Cure-It Lifesciences, Llc | Use of prostaglandin e1 (pge1) and misoprostol for treating chronic myelogenous/myeloid leukemia (cml) |
| AU2015312117A1 (en) | 2014-09-02 | 2017-03-02 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by Myd88 and CD40 polypeptides |
| JP6718444B2 (ja) | 2014-11-03 | 2020-07-08 | アカデミッシュ ザイケンホイス レイデン （エイチ．オー．ディー．エヌ． エルユーエムシー） | Ｂｏｂ１に対して指向されるＴ細胞レセプターおよびその使用 |
| CN116059378A (zh) | 2014-12-10 | 2023-05-05 | 明尼苏达大学董事会 | 用于治疗疾病的遗传修饰的细胞、组织和器官 |
| US10420836B2 (en) | 2015-10-08 | 2019-09-24 | Emory University | Methods of immunizing a subject and compositions related thereto |
| UA130430C2 (uk) | 2019-05-31 | 2026-02-18 | Янссен Фармацевтика Нв | НИЗЬКОМОЛЕКУЛЯРНІ ІНГІБІТОРИ КІНАЗИ, ЩО ІНДУКУЄ NF-kB |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6410516B1 (en) | 1986-01-09 | 2002-06-25 | President & Fellows Of Harvard College | Nuclear factors associated with transcriptional regulation |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5168053A (en) | 1989-03-24 | 1992-12-01 | Yale University | Cleavage of targeted RNA by RNAase P |
| US5149796A (en) | 1989-08-31 | 1992-09-22 | City Of Hope | Chimeric DNA-RNA catalytic sequences |
| ES2174822T3 (es) | 1989-11-03 | 2002-11-16 | Immulogic Pharma Corp | Una proteina felina reactiva con celulas t humanas (trfp) aislada de polvo domestico y usos para la misma. |
| US5180818A (en) | 1990-03-21 | 1993-01-19 | The University Of Colorado Foundation, Inc. | Site specific cleavage of single-stranded dna |
| ES2096750T3 (es) | 1990-10-31 | 1997-03-16 | Somatix Therapy Corp | Vectores retroviricos utiles para la terapia genica. |
| WO1994024281A1 (en) | 1993-04-14 | 1994-10-27 | Immulogic Pharmaceutical Corporation | T cell epitopes of the major allergens from dermatophagoides (house dust mite) |
| CA2105595A1 (en) * | 1992-09-23 | 1994-03-24 | Ramaswamy Narayanan | Antisense polynucleotides |
| US5951988A (en) | 1993-03-30 | 1999-09-14 | University Of Saskatchewan | Adjuvant formulation with enhanced immunogenic activity, and related compositions and methods |
| US5405941A (en) * | 1993-04-15 | 1995-04-11 | National Jewish Center For Immunology And Respiratory Medicine | MEKK protein, capable of phosphorylating MEK |
| ATE204300T1 (de) | 1994-05-13 | 2001-09-15 | Biovation Ltd | Zielzellen-bindende chimäre peptide |
| EP0769963A4 (en) | 1994-07-27 | 1999-07-28 | Commw Scient Ind Res Org | POLYEPITOPE VACCINES |
| US5597898A (en) * | 1995-02-15 | 1997-01-28 | Yale University | NF-κB activation regulatory protein, IκB-β |
| WO1997001340A1 (en) * | 1995-06-29 | 1997-01-16 | Mcneil-Ppc, Inc. | The combination of topical nasal antihistamines and topical nasal mast cell stabilizers |
| EP0779361A3 (en) * | 1995-12-15 | 1999-11-10 | F. Hoffmann-La Roche Ag | Truncated form of inhibitory kappa B protein (1kB), recombinant production and uses thereof |
| UA71889C2 (uk) | 1996-04-02 | 2005-01-17 | Йєда Рісерч Енд Дівелопмент Ко. Лтд. | Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування |
| JP2000516090A (ja) | 1996-07-26 | 2000-12-05 | スローン―ケッタリング インスティチュート フォー キャンサー リサーチ | 遺伝子的免疫化のための方法と試薬 |
| NZ334148A (en) | 1996-08-12 | 2001-12-21 | Celgene Corp | 3-Substituted phenyl-ethyl or ethenyl derivatives terminated with a nitrile, alkane, carboxyl or carbamoyl group useful to reduce cytokine levels |
| EP0920518A1 (en) * | 1996-08-26 | 1999-06-09 | Signal Pharmaceuticals, Inc. | Stimulus-inducible i (kappa)b kinase ikk] signalsome |
| US5891924A (en) * | 1996-09-26 | 1999-04-06 | Research Development Foundation | Curcumin (diferuloylmethane) inhibition of NFκB activation |
| DE69740107D1 (de) * | 1996-12-23 | 2011-03-10 | Immunex Corp | Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie |
| US6924308B1 (en) * | 1997-07-30 | 2005-08-02 | Howard L. Elford | Therapeutic process for inhibiting NF-κB |
| US5952483A (en) * | 1997-07-31 | 1999-09-14 | Smithkline Beecham Corporation | Human IκB-β |
| EP0897009A3 (en) * | 1997-08-04 | 1999-06-09 | Smithkline Beecham Plc | HKABY60 polypeptides |
| JPH1171278A (ja) * | 1997-09-01 | 1999-03-16 | Kanegafuchi Chem Ind Co Ltd | 転写因子ＮＦ−κＢ活性化阻害剤 |
| GB9719238D0 (en) | 1997-09-11 | 1997-11-12 | Mathilda & Terence Kennedy Ins | Viral infection of cells |
| US6503184B1 (en) * | 1997-10-21 | 2003-01-07 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
| US5965421A (en) * | 1997-11-26 | 1999-10-12 | Human Genome Sciences, Inc. | Human IRAK-2 |
| AU2294899A (en) * | 1998-02-19 | 1999-09-06 | Peter Bromley | Stress promoter control of therapeutic genes in gene therapy: compositions and methods |
| ES2251831T3 (es) * | 1998-05-06 | 2006-05-01 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Inhibidores de la activacion de nf-kb. |
| HUP0102782A3 (en) | 1998-06-19 | 2002-12-28 | Smithkline Beecham Corp | Salycilanilide as inhibitors of transcription factor nf-kb |
| GB9823897D0 (en) | 1998-11-02 | 1998-12-30 | Imp College Innovations Ltd | Immunotherapeutic methods and molecules |
| CA2367692A1 (en) * | 1999-03-15 | 2000-09-21 | Introgen Therapeutics, Inc. | Dendritic cells transduced with a wild-type self gene elicit potent antitumor immune responses |
| GB9930616D0 (en) | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| GB0005345D0 (en) | 2000-03-06 | 2000-04-26 | Mathilda & Terence Kennedy Ins | Methods of treating sepsis septic shock and inflammation |
| US7651857B2 (en) | 2000-12-22 | 2010-01-26 | The Mathilda And Terence Kennedy Institute Of Rheumatology Trust | Methods for enhancing antigen presentation |
| GB0116249D0 (en) | 2001-07-05 | 2001-08-29 | Imp College Innovations Ltd | Methods |
-
1999
- 1999-12-24 GB GBGB9930616.9A patent/GB9930616D0/en not_active Ceased
-
2000
- 2000-12-22 EP EP07014428A patent/EP1852123A3/en not_active Withdrawn
- 2000-12-22 CN CNB008191050A patent/CN1254272C/zh not_active Expired - Fee Related
- 2000-12-22 CA CA002394880A patent/CA2394880A1/en not_active Abandoned
- 2000-12-22 US US10/168,805 patent/US7915009B2/en not_active Expired - Fee Related
- 2000-12-22 AU AU22062/01A patent/AU781496B2/en not_active Ceased
- 2000-12-22 ES ES00985660T patent/ES2302707T3/es not_active Expired - Lifetime
- 2000-12-22 EP EP00985660A patent/EP1244466B1/en not_active Expired - Lifetime
- 2000-12-22 JP JP2001548135A patent/JP2003518507A/ja active Pending
- 2000-12-22 WO PCT/GB2000/004925 patent/WO2001047543A2/en not_active Ceased
- 2000-12-22 CN CNB200610051522XA patent/CN100563707C/zh not_active Expired - Fee Related
- 2000-12-22 DE DE60038503T patent/DE60038503T2/de not_active Expired - Lifetime
- 2000-12-22 AT AT00985660T patent/ATE390929T1/de not_active IP Right Cessation
- 2000-12-22 NZ NZ519438A patent/NZ519438A/en not_active IP Right Cessation
-
2007
- 2007-12-06 US US11/987,956 patent/US20080124322A1/en not_active Abandoned
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