JP2003518064A5 - - Google Patents

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Publication number
JP2003518064A5
JP2003518064A5 JP2001546648A JP2001546648A JP2003518064A5 JP 2003518064 A5 JP2003518064 A5 JP 2003518064A5 JP 2001546648 A JP2001546648 A JP 2001546648A JP 2001546648 A JP2001546648 A JP 2001546648A JP 2003518064 A5 JP2003518064 A5 JP 2003518064A5
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JP
Japan
Prior art keywords
compound
formula
substituted
chemical
independently
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2001546648A
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English (en)
Japanese (ja)
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JP2003518064A (ja
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Priority claimed from US09/476,927 external-priority patent/US6387897B1/en
Application filed filed Critical
Publication of JP2003518064A publication Critical patent/JP2003518064A/ja
Publication of JP2003518064A5 publication Critical patent/JP2003518064A5/ja
Pending legal-status Critical Current

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JP2001546648A 1999-12-20 2000-12-20 置換ピペラジンおよびピペリジンカルシウムチャネルブロッカー Pending JP2003518064A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17283199P 1999-12-20 1999-12-20
US60/172,831 1999-12-20
US09/476,927 1999-12-30
US09/476,927 US6387897B1 (en) 1998-06-30 1999-12-30 Preferentially substituted calcium channel blockers
PCT/CA2000/001557 WO2001045709A1 (en) 1999-12-20 2000-12-20 Substituted piperazine and piperidine calcium channel blockers

Publications (2)

Publication Number Publication Date
JP2003518064A JP2003518064A (ja) 2003-06-03
JP2003518064A5 true JP2003518064A5 (cg-RX-API-DMAC7.html) 2009-08-27

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ID=26868504

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001546648A Pending JP2003518064A (ja) 1999-12-20 2000-12-20 置換ピペラジンおよびピペリジンカルシウムチャネルブロッカー

Country Status (18)

Country Link
US (2) US6387897B1 (cg-RX-API-DMAC7.html)
EP (1) EP1244451B1 (cg-RX-API-DMAC7.html)
JP (1) JP2003518064A (cg-RX-API-DMAC7.html)
KR (1) KR100823889B1 (cg-RX-API-DMAC7.html)
CN (1) CN100477992C (cg-RX-API-DMAC7.html)
AT (1) ATE333878T1 (cg-RX-API-DMAC7.html)
AU (1) AU784206B2 (cg-RX-API-DMAC7.html)
BR (1) BR0016530A (cg-RX-API-DMAC7.html)
CA (1) CA2394327C (cg-RX-API-DMAC7.html)
DE (1) DE60029634T2 (cg-RX-API-DMAC7.html)
DK (1) DK1244451T3 (cg-RX-API-DMAC7.html)
ES (1) ES2269220T3 (cg-RX-API-DMAC7.html)
HK (1) HK1049969B (cg-RX-API-DMAC7.html)
IL (1) IL150117A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA02006138A (cg-RX-API-DMAC7.html)
NO (1) NO323724B1 (cg-RX-API-DMAC7.html)
PT (1) PT1244451E (cg-RX-API-DMAC7.html)
WO (1) WO2001045709A1 (cg-RX-API-DMAC7.html)

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US7186726B2 (en) * 1998-06-30 2007-03-06 Neuromed Pharmaceuticals Ltd. Preferentially substituted calcium channel blockers
US20060084660A1 (en) * 1998-06-30 2006-04-20 Neuromed Technologies Inc. Calcium channel blockers comprising two benzhydril moieties
US20040259866A1 (en) * 1998-06-30 2004-12-23 Snutch Terrance P. Calcium channel blockers comprising two benzhydril moieties
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US20050159403A1 (en) * 2003-04-22 2005-07-21 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of central nervous system damage
US20060135506A1 (en) * 2003-04-22 2006-06-22 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders
CA2527159A1 (en) * 2003-05-30 2004-12-09 Neuromed Technologies, Inc. 3-aminomethyl-pyrrolidines as n-type calcium channel blockers
WO2005015159A2 (en) * 2003-08-08 2005-02-17 The Regents Of The University Of California. Methods for modulating a drug-related effect or behavior
US7524846B2 (en) 2003-10-14 2009-04-28 Wyeth Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use
US7507760B2 (en) * 2004-01-22 2009-03-24 Neuromed Pharmaceuticals Ltd. N-type calcium channel blockers
US20050227999A1 (en) * 2004-04-09 2005-10-13 Neuromed Technologies Inc. Diarylamine derivatives as calcium channel blockers
JP2007532492A (ja) * 2004-04-09 2007-11-15 ニューロメッド ファーマシューティカルズ リミテッド カルシウムチャネルブロッカーとしてのジアリールアミン誘導体
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
US7378420B2 (en) 2004-08-30 2008-05-27 Neuromed Pharmaceuticals Ltd. Urea derivatives as calcium channel blockers
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
US7511077B2 (en) 2005-02-09 2009-03-31 Neuromed Pharmaceuticals Ltd. Diamine calcium channel blockers
EP1871372A4 (en) * 2005-04-08 2010-06-02 Neuromed Pharmaceuticals Ltd COMBINATION THERAPY WHICH INCLUDES AN AGENT BLOCKING CALCIUM CHANNELS OF TYPE N FOR THE RELIEF OF PAIN
CN101282953A (zh) * 2005-08-08 2008-10-08 阿斯利康(瑞典)有限公司 治疗剂
WO2007041360A2 (en) * 2005-09-30 2007-04-12 The Board Of Trustees Of The University Of Illinois Peptides and calcium regulation in mammalian cells
US8299211B2 (en) * 2005-09-30 2012-10-30 The Board Of Trustees Of The University Of Illinois Peptides and regulation of calcium channels
US8247442B2 (en) * 2006-03-29 2012-08-21 Purdue Pharma L.P. Benzenesulfonamide compounds and their use
US8791264B2 (en) * 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
TW200812963A (en) * 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
US8362021B2 (en) * 2006-05-11 2013-01-29 Zalicus Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
EP2061780A4 (en) * 2006-09-14 2010-12-22 Zalicus Pharmaceuticals Ltd DIARYLE PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS
US20100105682A1 (en) * 2006-10-13 2010-04-29 Hassan Pajouhesh Cyclopropyl-piperazine compounds as calcium channel blockers
UY30639A1 (es) * 2006-10-17 2008-05-31 Kudos Pharm Ltd Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
WO2008124118A1 (en) * 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
WO2009040659A2 (en) * 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
ES2428326T3 (es) * 2007-10-04 2013-11-07 Merck Sharp & Dohme Corp. Derivados de aril sulfona sustituida como bloqueadores de canales de calcio
US8183369B2 (en) * 2007-10-17 2012-05-22 Kudos Pharmaceuticals Limited 4- [3- (4-cyclopropanecarbonyl-piperazine-I-carbonyl) -4 -fluoro-benzyl] -2H-phthalaz in-1-one
WO2009132454A1 (en) * 2008-04-28 2009-11-05 Neuromed Pharmaceuticals Ltd. Di-t-butylphenyl piperazines as calcium channel blockers
WO2010036589A1 (en) * 2008-09-29 2010-04-01 Merck Sharp & Dohme Corp. Substituted aryl sulfone derivatives as calcium channel blockers
LT2346495T (lt) 2008-10-07 2016-10-10 Astrazeneca Uk Limited Farmacinė kompozicija 514
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WO2011026240A1 (en) 2009-09-04 2011-03-10 Zalicus Pharmaceuticals Ltd. Oxopiperazine derivatives for the treatment of pain and epilepsy
EP2618824A4 (en) 2010-09-20 2015-05-06 Kareus Therapeutics Sa METHOD AND COMPOSITIONS FOR TREATING DIABETES AND DYSLIPIDEMIA
KR20140011366A (ko) 2011-03-08 2014-01-28 잘리커스 파마슈티컬즈 리미티드 고체 분산체 제형 및 그의 이용방법
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
WO2014134306A1 (en) 2013-03-01 2014-09-04 Zalicus Pharmaceuticals, Ltd. Heterocyclic inhibitors of the sodium channel
US10168144B2 (en) 2016-03-25 2019-01-01 Sony Corporation Optical apparatus for 3D data collection

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US3997539A (en) 1974-05-31 1976-12-14 American Hoechst Corporation 3-(4-Acylaminopiperazin-1-yl alkyl)indoles, precursors and processes for the preparation thereof
US4188485A (en) 1978-06-16 1980-02-12 G. D. Searle & Co. 1-[(10,11-Dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)methyl]-4-substituted piperidines and related compounds
JPS61155358A (ja) 1984-12-21 1986-07-15 Suntory Ltd ジアリール酪酸誘導体
FR2584723B1 (fr) 1985-07-09 1988-02-12 Adir Nouveaux derives du dihydro-2,3 benzofuranne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
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US5703071A (en) 1990-08-29 1997-12-30 Pharmacia & Upjohn Company Tropolone derivatives and pharmaceutical composition thereof for preventing and treating ischemic diseases
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WO1994014786A1 (en) 1992-12-22 1994-07-07 Smithkline Beecham Plc Piperidine derivatives as calcium channel antagonists
DK0682664T3 (da) 1993-12-08 2001-07-16 Alcon Lab Inc Forbindelser med både potent calciumantagonist og antioxiderende aktivitet og anvendelse deraf som cytobeskyttende midler
US5623051A (en) 1994-11-10 1997-04-22 University Of Washington Methods and compositions for screening for presynaptic calcium channel blockers
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US6387897B1 (en) * 1998-06-30 2002-05-14 Neuromed Technologies, Inc. Preferentially substituted calcium channel blockers
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US6267945B1 (en) 1998-12-18 2001-07-31 Neuromed Technologies, Inc. Farnesol-related calcium channel blockers

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