JP2003514903A5 - - Google Patents

Download PDF

Info

Publication number
JP2003514903A5
JP2003514903A5 JP2001540081A JP2001540081A JP2003514903A5 JP 2003514903 A5 JP2003514903 A5 JP 2003514903A5 JP 2001540081 A JP2001540081 A JP 2001540081A JP 2001540081 A JP2001540081 A JP 2001540081A JP 2003514903 A5 JP2003514903 A5 JP 2003514903A5
Authority
JP
Japan
Prior art keywords
carbon atoms
branched
straight
same
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001540081A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003514903A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2000/030149 external-priority patent/WO2001038318A1/fr
Publication of JP2003514903A publication Critical patent/JP2003514903A/ja
Publication of JP2003514903A5 publication Critical patent/JP2003514903A5/ja
Pending legal-status Critical Current

Links

JP2001540081A 1999-11-24 2000-11-21 タキサンを含有する細胞傷害薬とその治療への利用 Pending JP2003514903A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16722899P 1999-11-24 1999-11-24
US60/167,228 1999-11-24
PCT/US2000/030149 WO2001038318A1 (fr) 1999-11-24 2000-11-21 Agents cytotoxiques comprenant des taxanes et leur utilisation therapeutique

Publications (2)

Publication Number Publication Date
JP2003514903A JP2003514903A (ja) 2003-04-22
JP2003514903A5 true JP2003514903A5 (fr) 2007-10-04

Family

ID=22606479

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001540081A Pending JP2003514903A (ja) 1999-11-24 2000-11-21 タキサンを含有する細胞傷害薬とその治療への利用

Country Status (13)

Country Link
US (11) US6340701B1 (fr)
EP (1) EP1242401B1 (fr)
JP (1) JP2003514903A (fr)
AT (1) ATE349438T1 (fr)
AU (1) AU765588C (fr)
CA (1) CA2388063C (fr)
DE (1) DE60032633T2 (fr)
DK (1) DK1242401T3 (fr)
ES (1) ES2276708T3 (fr)
HK (1) HK1049997B (fr)
NZ (1) NZ517772A (fr)
PT (1) PT1242401E (fr)
WO (1) WO2001038318A1 (fr)

Families Citing this family (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
JP4808846B2 (ja) * 1999-02-24 2011-11-02 ザ ユーエイビー リサーチ ファンデイション 癌の標的付けられた治療のためのタキサン誘導体
EP2289549A3 (fr) 1999-10-01 2011-06-15 Immunogen, Inc. Des immunoconjugués pour le traitement des cancers.
DE60032633T2 (de) * 1999-11-24 2007-10-04 Immunogen Inc., Cambridge Zytotoxische mittel, die taxane enthalten und ihre therapeutische anwendung
US7097840B2 (en) * 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
HUP0302599A3 (en) * 2000-09-22 2005-05-30 Bristol Myers Squibb Co Method for reducing toxicity of combined chemotherapic compositions
EP1343531A2 (fr) * 2000-12-21 2003-09-17 McGILL UNIVERSITY Conjugues d'anticorps et de medicaments anti-cancereux
WO2002076394A2 (fr) * 2001-03-22 2002-10-03 The Ohio State University Research Foundation Compositions anticancereuses a base d'enzymes et techniques
EP1392359B2 (fr) 2001-05-11 2013-03-13 Ludwig Institute for Cancer Research Ltd. Proteines de liaison specifiques et utilisations associees
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
US7514078B2 (en) * 2001-06-01 2009-04-07 Cornell Research Foundation, Inc. Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
US7666414B2 (en) * 2001-06-01 2010-02-23 Cornell Research Foundation, Inc. Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen
WO2002098897A2 (fr) * 2001-06-01 2002-12-12 Cornell Research Foundation, Inc. Anticorps modifies diriges contre l'antigene prostatique specifique membranaire et utilisations associees
US6596757B1 (en) * 2002-05-14 2003-07-22 Immunogen Inc. Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use
EP1552002A4 (fr) * 2002-06-18 2006-02-08 Archemix Corp Molecules toxine-aptamere et procedes d'utilisation correspondants
JP2006502110A (ja) * 2002-07-03 2006-01-19 イミュノジェン・インコーポレーテッド 非放出Muc1およびMuc16に対する抗体、およびその使用
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
KR20050032110A (ko) * 2002-08-02 2005-04-06 이뮤노젠 아이엔씨 신규의 효능을 갖는 탁산을 포함하는 세포독성제 및 그치료용도
US6913748B2 (en) * 2002-08-16 2005-07-05 Immunogen, Inc. Cross-linkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs
US8853376B2 (en) 2002-11-21 2014-10-07 Archemix Llc Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
EA009285B1 (ru) 2003-05-14 2007-12-28 Иммуноджен, Инк. Композиция конъюгированного лекарственного средства
US7834155B2 (en) * 2003-07-21 2010-11-16 Immunogen Inc. CA6 antigen-specific cytotoxic conjugate and methods of using the same
JP2007503202A (ja) * 2003-07-21 2007-02-22 イミュノジェン・インコーポレーテッド Ca6抗原特異的な細胞毒性コンジュゲートおよびその使用方法
US7282590B2 (en) * 2004-02-12 2007-10-16 The Research Foundation Of State University Of New York Drug conjugates
EP1610818A4 (fr) * 2004-03-03 2007-09-19 Millennium Pharm Inc Anticorps modifies diriges contre un antigene membranaire specifique de la prostate
US7541330B2 (en) * 2004-06-15 2009-06-02 Kosan Biosciences Incorporated Conjugates with reduced adverse systemic effects
US8288557B2 (en) 2004-07-23 2012-10-16 Endocyte, Inc. Bivalent linkers and conjugates thereof
US20060045877A1 (en) * 2004-08-30 2006-03-02 Goldmakher Viktor S Immunoconjugates targeting syndecan-1 expressing cells and use thereof
EP1669358A1 (fr) * 2004-12-07 2006-06-14 Aventis Pharma S.A. Agents cytotoxiques comprenant des nouveau taxanes
EP1688415A1 (fr) * 2004-12-07 2006-08-09 Aventis Pharma S.A. Agents cytotoxiques comprenant des taxanes modifiés en position C2
AU2006213662B2 (en) 2005-02-11 2010-08-05 Immunogen, Inc. Process for preparing stable drug conjugates
US20110166319A1 (en) * 2005-02-11 2011-07-07 Immunogen, Inc. Process for preparing purified drug conjugates
EP1868647A4 (fr) 2005-03-24 2009-04-01 Millennium Pharm Inc Anticorps se liant à ov064 et leurs méthodes d'utilisation
AU2006278573A1 (en) 2005-08-03 2007-02-15 Immunogen, Inc. Immunoconjugate formulations
KR101364912B1 (ko) * 2005-08-19 2014-02-21 엔도사이트, 인코포레이티드 복수-약제 리간드 공액체
BRPI0615049B1 (pt) 2005-08-24 2023-04-25 Immunogen, Inc Processo para a preparação de um conjugado de anticorpo- maitansinóide
EP1806365A1 (fr) 2006-01-05 2007-07-11 Boehringer Ingelheim International GmbH Anticorps spécifiques pour la protéine alpha d'activation de fibroblastes et leurs immunoconjugués
EP1813614B1 (fr) 2006-01-25 2011-10-05 Sanofi Agents cytotoxiques comprenant de nouveaux dérivés de Tomaymycine
MY157757A (en) * 2006-07-18 2016-07-15 Sanofi Aventis Antagonist antibody against epha2 for the treatment of cancer
EP1914242A1 (fr) * 2006-10-19 2008-04-23 Sanofi-Aventis Nouveau anticorps Anti-CD38 pour le traitement du cancer
EP2727936B1 (fr) 2006-11-22 2016-09-07 Bristol-Myers Squibb Company Agents thérapeutiques ciblés sur la base des protéines modifiées de récepteurs de tyrosine kinases, dont le IGF-IR
US9090693B2 (en) * 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
WO2008097497A2 (fr) 2007-02-02 2008-08-14 Adnexus, A Bristol-Myers Squibb R & D Company Blocage de voie de vegf
US20080184892A1 (en) 2007-02-06 2008-08-07 Ctp Hydrogen Corporation Architectures for electrochemical systems
US20100104626A1 (en) * 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
NZ580132A (en) 2007-03-14 2012-11-30 Endocyte Inc Binding ligand linked drug delivery conjugates of tubulysins to vitamins
US9023356B2 (en) * 2007-03-15 2015-05-05 Ludwig Institute For Cancer Research Ltd Treatment method using EGFR antibodies and SRC inhibitors and related formulations
US20080233135A1 (en) * 2007-03-19 2008-09-25 Gebhard John R Cobalamin taxane bioconjugates
AU2008268432B2 (en) 2007-06-25 2015-01-15 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
ES2435779T3 (es) * 2007-07-19 2013-12-23 Sanofi Agentes citotóxicos que comprenden nuevos derivados de tomaimicina y su uso terapéutico
PE20090499A1 (es) 2007-08-09 2009-05-18 Boehringer Ingelheim Int Anticuerpos anti-cd37
ES2609915T3 (es) 2007-08-14 2017-04-25 Ludwig Institute For Cancer Research Ltd. Anticuerpo monoclonal 175 direccionado al receptor de EGF y derivados y usos del mismo
EP2209498A2 (fr) * 2007-10-03 2010-07-28 Cornell University Traitement de troubles de prolifération à l'aide d'anticorps du psma
EP2238169A1 (fr) * 2007-12-26 2010-10-13 Biotest AG Procédé permettant de réduire les effets secondaires cytotoxiques et d'améliorer l'efficacité des immunoconjugués
PL2242772T3 (pl) * 2007-12-26 2015-05-29 Biotest Ag Immunokonjugaty nakierowane na CD138 i ich zastosowanie
CN101945892B (zh) * 2007-12-26 2017-11-24 生物测试股份公司 用于改进对表达cd138的肿瘤细胞的靶向的方法和试剂
ES2475201T3 (es) * 2007-12-26 2014-07-10 Biotest Ag Agentes dirigidos contra CD138 y usos de los mismos
US8586625B2 (en) 2008-01-16 2013-11-19 Anwar Rayan Derivatives of taxol and closely related compounds
UA127472C2 (uk) 2008-03-18 2023-09-06 Дженентек, Інк. Комбінація кон'югата анти-her2-антитіло-лікарський засіб і хіміотерапевтичного засобу і спосіб застосування
SI2281006T1 (sl) 2008-04-30 2017-12-29 Immunogen, Inc. Premreževalci in njihova uporaba
PE20091931A1 (es) 2008-05-22 2009-12-31 Bristol Myers Squibb Co Proteinas de dominio de armazon basadas en fibronectina multivalentes
EP3100745B1 (fr) 2009-02-05 2018-04-18 Immunogen, Inc. Nouveaux dérivés de benzodiazépine
ES2712732T3 (es) * 2009-02-17 2019-05-14 Cornell Res Foundation Inc Métodos y kits para el diagnóstico de cáncer y la predicción de valor terapéutico
CA2939492C (fr) 2009-05-13 2019-03-19 Genzyme Corporation Immunoglobulines anti-cd52 humain
DK2437790T3 (da) 2009-06-03 2019-05-20 Immunogen Inc Konjugeringsfremgangsmåder
US20110076232A1 (en) * 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
TW201116297A (en) 2009-10-02 2011-05-16 Sanofi Aventis Antibodies that specifically bind to the EphA2 receptor
EP2486023A4 (fr) 2009-10-06 2014-05-07 Immunogen Inc Conjugués puissants et séquences de liaison hydrophiles
US8785600B2 (en) 2009-10-23 2014-07-22 Millennium Pharmaceuticals, Inc. Anti-GCC antibody molecules and related compositions and methods
EP2533810B1 (fr) 2010-02-10 2016-10-12 ImmunoGen, Inc. Anticorps anti-cd20 et utilisations de ceux-ci
NZ602161A (en) 2010-03-04 2014-12-24 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
ES2621874T3 (es) 2010-03-26 2017-07-05 Memorial Sloan-Kettering Cancer Center Anticuerpos para MUC16 y métodos de uso de los mismos
WO2011133555A2 (fr) 2010-04-20 2011-10-27 The Research Foundation Of State University Of New York Compositions et méthodes d'inhibition de la migration cellulaire médiée par une métalloprotéinase matricielle (mmp)
CN105399831A (zh) 2010-10-29 2016-03-16 伊缪诺金公司 非拮抗性egfr结合分子及其免疫偶联物
MX2013004761A (es) 2010-10-29 2013-08-27 Immunogen Inc Nuevas moleculas de union al receptor del factor de crecimiento epidermico (egfr) e inmunoconjugados de estas.
US20120148559A1 (en) 2010-12-01 2012-06-14 Board Of Regents The University Of Texas System Compositions and method for deimmunization of proteins
ES2702926T3 (es) 2010-12-09 2019-03-06 Immunogen Inc Métodos para la preparación de agentes de reticulación cargados
WO2012106368A2 (fr) 2011-01-31 2012-08-09 The Regents Of The University Of California Procédés d'inhibition du cancer de la prostate
MY183977A (en) 2011-02-15 2021-03-17 Immunogen Inc Cytotoxic benzodiazepine derivatives
US8795673B2 (en) 2011-03-29 2014-08-05 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
WO2012135517A2 (fr) 2011-03-29 2012-10-04 Immunogen, Inc. Préparation de conjugués de maytansinoïde anticorps par procédé en une étape
KR20190105112A (ko) 2011-05-21 2019-09-11 마크로제닉스, 인크. 사람 및 비-사람 cd3에 결합할 수 있는 cd3-결합 분자
KR101972303B1 (ko) 2011-06-10 2019-04-25 메르사나 테라퓨틱스, 인코포레이티드 단백질-중합체-약물 접합체
SG195172A1 (en) 2011-06-21 2013-12-30 Immunogen Inc Novel maytansinoid derivatives with peptide linker and conjugates thereof
JO3625B1 (ar) 2011-09-22 2020-08-27 Amgen Inc بروتينات رابطة للأنتيجين cd27l
EP2794010A4 (fr) 2011-11-21 2015-10-21 Immunogen Inc Méthode de traitement de tumeurs résistantes aux thérapies egfr par un conjugué anticorps egfr-agent cytotoxique
MX358680B (es) 2011-12-08 2018-08-31 Biotest Ag Usos de inmunoconjugados dirigidos a cd138.
WO2013126797A1 (fr) 2012-02-24 2013-08-29 Purdue Research Foundation Ciblage du récepteur de la cholécystokinine de type b pour imagerie et thérapie
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
WO2013160396A1 (fr) 2012-04-26 2013-10-31 Boehringer Ingelheim International Gmbh Combinaison d'anticorps cd37 avec la bendamustine
JP2015517512A (ja) 2012-05-16 2015-06-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cd37抗体の更なる薬剤との併用
EP2849784A1 (fr) 2012-05-16 2015-03-25 Boehringer Ingelheim International GmbH Combinaison d'anticorps anti-cd37 avec ice (ifosmamide, carboplatine, etoposide)
JO3623B1 (ar) 2012-05-18 2020-08-27 Amgen Inc البروتينات المرتبطة بمولد المستضاد st2
EP2855520B1 (fr) 2012-06-04 2018-09-26 Novartis AG Méthodes de marquage spécifiques à un site et molécules ainsi produites
CN105209592A (zh) 2012-10-04 2015-12-30 伊缪诺金公司 使用pvdf膜纯化细胞结合剂细胞毒性剂缀合物
CA2887727A1 (fr) 2012-10-16 2014-04-24 Endocyte, Inc. Conjugues d'administration de medicament contenant des acides amines artificiels et procedes d'utilisation
AU2012395148B2 (en) 2012-11-24 2016-10-27 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
TW201425336A (zh) 2012-12-07 2014-07-01 Amgen Inc Bcma抗原結合蛋白質
JP6334553B2 (ja) 2012-12-10 2018-05-30 メルサナ セラピューティクス,インコーポレイティド タンパク質−高分子−薬剤コンジュゲート
EP2928503B1 (fr) 2012-12-10 2019-02-20 Mersana Therapeutics, Inc. Conjugués de composés auristatine
US9872918B2 (en) 2012-12-12 2018-01-23 Mersana Therapeutics, Inc. Hydroxyl-polymer-drug-protein conjugates
EP2948478B1 (fr) 2013-01-25 2019-04-03 Amgen Inc. Anticorps ciblant cdh19 pour un mélanome
WO2014124258A2 (fr) 2013-02-08 2014-08-14 Irm Llc Sites spécifiques de modification d'anticorps pour fabriquer des immunoconjugués
DK2953976T3 (da) 2013-02-08 2021-06-21 Novartis Ag Specifikke modificeringssteder i antistoffer til fremstilling af immunkonjugater
US9498532B2 (en) 2013-03-13 2016-11-22 Novartis Ag Antibody drug conjugates
EP2968590B1 (fr) 2013-03-15 2018-09-05 Novartis AG Conjugués anticorps-médicament
AR095199A1 (es) 2013-03-15 2015-09-30 Genzyme Corp Anticuerpos anti-cd52
NZ753995A (en) 2013-05-30 2022-07-01 Kiniksa Pharmaceuticals Ltd Oncostatin m receptor antigen binding proteins
TW201605896A (zh) 2013-08-30 2016-02-16 安美基股份有限公司 Gitr抗原結合蛋白
MX367851B (es) 2013-10-11 2019-09-09 Mersana Therapeutics Inc Conjugados de proteína-polímero-fármaco.
ES2754397T3 (es) 2013-10-11 2020-04-17 Asana Biosciences Llc Conjugados de proteína-polímero-fármaco
US9943606B2 (en) 2014-01-15 2018-04-17 Rutgers, The State University Of New Jersey Dendritic polypeptide-based nanocarriers for the delivery of therapeutic agents
CN103804472B (zh) * 2014-01-23 2016-06-08 浙江大学 一种紫杉烷类药物前体
SG11201606714TA (en) 2014-02-14 2016-09-29 Andrew S Chi Improved methods for the treatment of vascularizing cancers
WO2015127685A1 (fr) 2014-02-28 2015-09-03 Hangzhou Dac Biotech Co., Ltd Lieurs chargés et leurs utilisations pour la conjugaison
CN106659800A (zh) 2014-03-12 2017-05-10 诺华股份有限公司 用于修饰抗体以制备免疫缀合物的特定位点
US10786578B2 (en) 2014-08-05 2020-09-29 Novartis Ag CKIT antibody drug conjugates
WO2016024195A1 (fr) 2014-08-12 2016-02-18 Novartis Ag Conjugués médicament-anticorps anti-cdh6
EA034138B1 (ru) 2014-09-03 2020-01-09 Иммуноджен, Инк. Цитотоксические бензодиазепиновые производные
TW201613930A (en) 2014-09-03 2016-04-16 Immunogen Inc Cytotoxic benzodiazepine derivatives
GB201416960D0 (en) 2014-09-25 2014-11-12 Antikor Biopharma Ltd Biological materials and uses thereof
UY36401A (es) 2014-11-14 2016-06-30 Novartis Ag Conjugados anticuerpos-fármacos
CN114656483A (zh) 2014-12-04 2022-06-24 细胞基因公司 生物分子共轭物
WO2016149485A1 (fr) 2015-03-17 2016-09-22 The Regents Of The University Of California Nouvelle chimio-immunothérapie pour cancer épithélial
CN107667120B (zh) 2015-03-17 2022-03-08 纪念斯隆-凯特林癌症中心 抗muc16抗体及其应用
EP3280454A1 (fr) 2015-04-07 2018-02-14 Memorial Sloan Kettering Cancer Center Immunoconjugués de nanoparticules
US20190194315A1 (en) 2015-06-17 2019-06-27 Novartis Ag Antibody drug conjugates
LT3313845T (lt) 2015-06-29 2020-12-10 Immunogen, Inc. Cisteino inžinerijos antikūnų konjugatai
CA2991973C (fr) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Lieurs de pontage pour la conjugaison d'une molecule de liaison cellulaire
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
CN108026103B (zh) 2015-07-21 2021-04-16 伊缪诺金公司 制备细胞毒性苯并二氮杂䓬衍生物的方法
WO2017025458A1 (fr) 2015-08-07 2017-02-16 Gamamabs Pharma Anticorps, conjugués anticorps-médicaments et procédés d'utilisation
WO2017058944A1 (fr) 2015-09-29 2017-04-06 Amgen Inc. Inhibiteurs de l'asgr pour réduire les taux de cholestérol
US20170189548A1 (en) 2015-11-25 2017-07-06 Immunogen, Inc. Pharmaceutical formulations and methods of use thereof
WO2017194568A1 (fr) 2016-05-11 2017-11-16 Sanofi Schéma de traitement utilisant un anticorps immunoconjugué anti-muc1 à base de maytansinoïde pour le traitement des tumeurs
KR102459469B1 (ko) 2016-11-14 2022-10-26 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
CN110392685B (zh) 2016-11-23 2023-07-04 伊缪诺金公司 苯并二氮卓衍生物的选择性磺化
US11135307B2 (en) 2016-11-23 2021-10-05 Mersana Therapeutics, Inc. Peptide-containing linkers for antibody-drug conjugates
JOP20190187A1 (ar) 2017-02-03 2019-08-01 Novartis Ag مترافقات عقار جسم مضاد لـ ccr7
WO2018160539A1 (fr) 2017-02-28 2018-09-07 Immunogen, Inc. Dérivés de maytansinoïdes comprenant des lieurs peptidiques auto-immolables et conjugués correspondants
WO2018185618A1 (fr) 2017-04-03 2018-10-11 Novartis Ag Conjugués de médicament-anticorps anti-cdh6 et combinaisons d'anticorps anti-gitr et méthodes de traitement
US20180346488A1 (en) 2017-04-20 2018-12-06 Immunogen, Inc. Cytotoxic benzodiazepine derivatives and conjugates thereof
WO2018201051A1 (fr) 2017-04-28 2018-11-01 Novartis Ag Agent ciblant le bcma et polythérapie incluant un inhibiteur de gamma-sécrétase
TW201905037A (zh) 2017-06-22 2019-02-01 美商梅爾莎納醫療公司 藥物攜帶聚合物支架及蛋白質聚合物藥物共軛物之製造方法
US11530413B2 (en) 2017-07-21 2022-12-20 Novartis Ag Compositions and methods to treat cancer
EP3732178A1 (fr) 2017-12-28 2020-11-04 ImmunoGen, Inc. Dérivés de benzodiazépine
US11401336B2 (en) 2018-02-21 2022-08-02 Celgene Corporation BCMA-binding antibodies and uses thereof
US20210330802A1 (en) 2018-10-10 2021-10-28 Takeda Pharmaceutical Company Limited Method for producing antibody-drug conjugate
CA3117050A1 (fr) 2018-10-29 2020-05-07 Mersana Therapeutics, Inc. Conjugues anticorps-medicament modifies par une cysteine avec des lieurs contenant des peptides
WO2020089811A1 (fr) 2018-10-31 2020-05-07 Novartis Ag Conjugué médicament-anticorps anti-dc-sign
CN113195541A (zh) 2018-12-21 2021-07-30 诺华股份有限公司 针对pmel17的抗体及其缀合物
CA3134055A1 (fr) 2019-03-20 2020-09-24 The Regents Of The University Of California Anticorps anti-claudine-6 et conjugues de medicaments
WO2020191344A1 (fr) 2019-03-20 2020-09-24 The Regents Of The University Of California Anticorps de claudin-6 bispécifiques
MA55520A (fr) 2019-03-29 2022-02-09 Immunogen Inc Dérivés de bis-benzodiazépine cytotoxiques et leurs conjugués avec des agents de liaison à une cellule pour inhiber la croissance cellulaire anormale ou pour traiter des maladies prolifératives
KR20220027828A (ko) 2019-04-26 2022-03-08 이뮤노젠 아이엔씨 캄프토테신 유도체
EP4087614A1 (fr) 2020-01-09 2022-11-16 Mersana Therapeutics, Inc. Conjugués anticorps-médicament spécifiques à un site avec des lieurs contenant des peptides
WO2021173773A1 (fr) 2020-02-25 2021-09-02 Mediboston, Inc. Dérivés de camptothécine et leurs utilisations
US20230181756A1 (en) 2020-04-30 2023-06-15 Novartis Ag Ccr7 antibody drug conjugates for treating cancer
WO2022010797A2 (fr) 2020-07-07 2022-01-13 Bionecure Therapeutics, Inc. Nouveaux maytansinoïdes en tant que charges utiles d'adc et leur utilisation pour le traitement du cancer
EP3970752A1 (fr) 2020-09-17 2022-03-23 Merck Patent GmbH Molécules ayant une étiquette de solubilité et procédés associés
AU2021388021A1 (en) 2020-11-24 2023-06-22 Novartis Ag Anti-cd48 antibodies, antibody drug conjugates, and uses thereof
US20220378929A1 (en) 2021-02-25 2022-12-01 MediBoston Limted Anti-her2 antibody-drug conjugates and uses thereof
BR112023021475A2 (pt) 2021-04-16 2023-12-19 Novartis Ag Conjugados anticorpo-fármaco e métodos para produzir os mesmos
WO2024023735A1 (fr) 2022-07-27 2024-02-01 Mediboston Limited Dérivés d'auristatine et conjugués de ceux-ci

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68921982D1 (de) * 1988-06-14 1995-05-04 Cetus Oncology Corp Kupplungsmittel und sterisch gehinderte, mit disulfid gebundene konjugate daraus.
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5399726A (en) * 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
CA2076465C (fr) 1992-03-25 2002-11-26 Ravi V. J. Chari Conjugues agents de liaison cellulaire d'analogues et de derives de cc-1065
US5646176A (en) * 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
US5824701A (en) * 1993-10-20 1998-10-20 Enzon, Inc. Taxane-based prodrugs
US5663199A (en) * 1994-11-30 1997-09-02 Uniroyal Chemical Ltd./Ltee Anti-viral aromatic O-alkylated oximes, ethers and thioethers
DE69703294T2 (de) * 1996-05-22 2001-05-17 Protarga Inc Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthalten
WO1998019705A1 (fr) * 1996-11-05 1998-05-14 Bristol-Myers Squibb Company Sequences de liaison peptidiques ramifiees
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
JP2002502376A (ja) * 1997-05-21 2002-01-22 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ 生物学的膜を横切る輸送を増強するための組成物および方法
WO1999025729A1 (fr) * 1997-11-18 1999-05-27 Chugai Seiyaku Kabushiki Kaisha Composes possedant une activite antitumorale
JP4808846B2 (ja) 1999-02-24 2011-11-02 ザ ユーエイビー リサーチ ファンデイション 癌の標的付けられた治療のためのタキサン誘導体
DE60032633T2 (de) * 1999-11-24 2007-10-04 Immunogen Inc., Cambridge Zytotoxische mittel, die taxane enthalten und ihre therapeutische anwendung
US6175023B1 (en) * 2000-01-31 2001-01-16 Jian Liu Synthesis of water soluble 9-dihydro-paclitaxel derivatives from 9-dihydro-13-acetylbaccatin III

Similar Documents

Publication Publication Date Title
JP2003514903A5 (fr)
CA2388063A1 (fr) Agents cytotoxiques comprenant des taxanes et leur utilisation therapeutique
CA2485424A1 (fr) Agents cytotoxiques comprenant des taxanes contenant du polyethylene glycol et leur utilisation therapeutique
JP2009536660A5 (fr)
JP2005533026A5 (fr)
JP2003531821A5 (fr)
JP2004503564A5 (fr)
RU2000124100A (ru) Лиганды рецептора h3 гистамина
JP2002502874A5 (fr)
JP2007511504A5 (fr)
JP2003501474A5 (fr)
JP2002539156A5 (fr)
JP2001526218A5 (fr)
JP2007537147A5 (fr)
JP2002541233A5 (fr)
JP2006525944A5 (fr)
JP2005515978A5 (fr)
JP2002543114A5 (fr)
JP2002539181A5 (fr)
JP2004531478A5 (fr)
JPWO2020123827A5 (fr)
JPWO2019195124A5 (fr)
JP2002521334A5 (fr)
JP2003530433A5 (fr)
RU2002134754A (ru) Аналоги жирных кислот для лечения рака