JP2003514795A5 - - Google Patents
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- Publication number
- JP2003514795A5 JP2003514795A5 JP2001538870A JP2001538870A JP2003514795A5 JP 2003514795 A5 JP2003514795 A5 JP 2003514795A5 JP 2001538870 A JP2001538870 A JP 2001538870A JP 2001538870 A JP2001538870 A JP 2001538870A JP 2003514795 A5 JP2003514795 A5 JP 2003514795A5
- Authority
- JP
- Japan
- Prior art keywords
- twenty
- solvent
- cis
- formula
- sertraline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 4
- 229960002073 sertraline Drugs 0.000 description 4
- VOZKAJLKRJDJLL-UHFFFAOYSA-N 2,4-diaminotoluene Chemical compound CC1=CC=C(N)C=C1N VOZKAJLKRJDJLL-UHFFFAOYSA-N 0.000 description 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 239000003849 aromatic solvent Substances 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 150000003462 sulfoxides Chemical class 0.000 description 2
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
- JGMBHJNMQVKDMW-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-3,4-dihydro-2h-naphthalen-1-one Chemical compound C1=C(Cl)C(Cl)=CC=C1C1C2=CC=CC=C2C(=O)CC1 JGMBHJNMQVKDMW-UHFFFAOYSA-N 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
- 239000003377 acid catalyst Substances 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003586 protic polar solvent Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99811054 | 1999-11-16 | ||
| EP99811054.8 | 1999-11-16 | ||
| PCT/EP2000/010971 WO2001036378A1 (en) | 1999-11-16 | 2000-11-07 | Process for the preparation of ketimines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003514795A JP2003514795A (ja) | 2003-04-22 |
| JP2003514795A5 true JP2003514795A5 (enExample) | 2007-12-27 |
Family
ID=8243145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001538870A Pending JP2003514795A (ja) | 1999-11-16 | 2000-11-07 | ケトイミンの調製方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6806386B1 (enExample) |
| EP (1) | EP1230211B1 (enExample) |
| JP (1) | JP2003514795A (enExample) |
| CN (1) | CN1246298C (enExample) |
| AT (1) | ATE299862T1 (enExample) |
| AU (1) | AU1998701A (enExample) |
| CA (1) | CA2388816A1 (enExample) |
| DE (1) | DE60021410T2 (enExample) |
| ES (1) | ES2245652T3 (enExample) |
| HU (1) | HUP0203384A3 (enExample) |
| IL (2) | IL149526A0 (enExample) |
| MX (1) | MXPA02004854A (enExample) |
| PT (1) | PT1230211E (enExample) |
| WO (1) | WO2001036378A1 (enExample) |
| ZA (1) | ZA200204628B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002096860A1 (en) * | 2001-05-31 | 2002-12-05 | Orion Corporation Fermion | Process for preparing sertraline intermediates |
| US6723878B2 (en) | 2001-06-15 | 2004-04-20 | Orion Corporation Fermion | Method for preparing sertraline |
| AU2003254475A1 (en) * | 2002-07-29 | 2004-02-16 | Cipla Limited | Sertraline |
| EP1660432A2 (en) * | 2003-09-05 | 2006-05-31 | Teva Pharmaceutical Industries Limited | A recycling process for preparing sertraline |
| FR3102480B1 (fr) * | 2019-10-29 | 2022-02-04 | Commissariat Energie Atomique | Matériaux spécifiques utilisables pour la détection d’au moins un élément alcalin |
| CN115260066B (zh) * | 2022-08-08 | 2023-07-25 | 四川沃肯精细化工有限公司 | 一种超临界二氧化碳制备肟酯类化合物的方法 |
| CN116120539B (zh) * | 2023-03-02 | 2025-07-18 | 中国科学院长春应用化学研究所 | 一种含酮亚胺结构的聚芳醚类聚合物及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4536518A (en) * | 1979-11-01 | 1985-08-20 | Pfizer Inc. | Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
| US4855500A (en) * | 1988-05-04 | 1989-08-08 | Pfizer Inc. | Process for preparing a ketimine |
| JP3185312B2 (ja) * | 1992-02-07 | 2001-07-09 | 住友化学工業株式会社 | イミン誘導体およびその製造法 |
| JPH09239275A (ja) * | 1996-03-10 | 1997-09-16 | Daicel Chem Ind Ltd | イミン化合物合成用触媒、及びこれを用いたイミン化合物の製造法 |
| IN191358B (enExample) * | 1998-01-16 | 2003-11-29 | Pfizer Prod Inc | |
| AR018164A1 (es) | 1998-03-18 | 2001-10-31 | Ciba Sc Holding Ag | Proceso para la preparacion de cis-ciclohexilidenaminas |
| ES2226501T3 (es) | 1998-10-30 | 2005-03-16 | Ciba Specialty Chemicals Holding Inc. | Procedimiento para la obtrencion de cetiminas. |
-
2000
- 2000-11-07 WO PCT/EP2000/010971 patent/WO2001036378A1/en not_active Ceased
- 2000-11-07 EP EP00983112A patent/EP1230211B1/en not_active Expired - Lifetime
- 2000-11-07 CN CN00815760.XA patent/CN1246298C/zh not_active Expired - Fee Related
- 2000-11-07 CA CA002388816A patent/CA2388816A1/en not_active Abandoned
- 2000-11-07 HU HU0203384A patent/HUP0203384A3/hu unknown
- 2000-11-07 PT PT00983112T patent/PT1230211E/pt unknown
- 2000-11-07 IL IL14952600A patent/IL149526A0/xx unknown
- 2000-11-07 DE DE60021410T patent/DE60021410T2/de not_active Expired - Lifetime
- 2000-11-07 MX MXPA02004854A patent/MXPA02004854A/es active IP Right Grant
- 2000-11-07 AT AT00983112T patent/ATE299862T1/de not_active IP Right Cessation
- 2000-11-07 US US10/130,198 patent/US6806386B1/en not_active Expired - Fee Related
- 2000-11-07 JP JP2001538870A patent/JP2003514795A/ja active Pending
- 2000-11-07 AU AU19987/01A patent/AU1998701A/en not_active Abandoned
- 2000-11-07 ES ES00983112T patent/ES2245652T3/es not_active Expired - Lifetime
-
2002
- 2002-05-08 IL IL149526A patent/IL149526A/en not_active IP Right Cessation
- 2002-06-10 ZA ZA200204628A patent/ZA200204628B/en unknown
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