JP2003514523A5 - - Google Patents

Download PDF

Info

Publication number
JP2003514523A5
JP2003514523A5 JP2001538480A JP2001538480A JP2003514523A5 JP 2003514523 A5 JP2003514523 A5 JP 2003514523A5 JP 2001538480 A JP2001538480 A JP 2001538480A JP 2001538480 A JP2001538480 A JP 2001538480A JP 2003514523 A5 JP2003514523 A5 JP 2003514523A5
Authority
JP
Japan
Prior art keywords
particles
hcv
cell culture
beads
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2001538480A
Other languages
English (en)
Japanese (ja)
Other versions
JP4675017B2 (ja
JP2003514523A (ja
Filing date
Publication date
Priority claimed from GBGB9927320.3A external-priority patent/GB9927320D0/en
Application filed filed Critical
Publication of JP2003514523A publication Critical patent/JP2003514523A/ja
Publication of JP2003514523A5 publication Critical patent/JP2003514523A5/ja
Application granted granted Critical
Publication of JP4675017B2 publication Critical patent/JP4675017B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2001538480A 1999-11-18 2000-11-20 エキソソーム分離によって精製hcvrnaを調製するための方法 Expired - Fee Related JP4675017B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9927320.3 1999-11-18
GBGB9927320.3A GB9927320D0 (en) 1999-11-18 1999-11-18 Exosome separation
PCT/IB2000/001801 WO2001036601A1 (en) 1999-11-18 2000-11-20 Method for the preparation of purified hcv rna by exosome separation

Publications (3)

Publication Number Publication Date
JP2003514523A JP2003514523A (ja) 2003-04-22
JP2003514523A5 true JP2003514523A5 (OSRAM) 2007-11-22
JP4675017B2 JP4675017B2 (ja) 2011-04-20

Family

ID=10864765

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001538480A Expired - Fee Related JP4675017B2 (ja) 1999-11-18 2000-11-20 エキソソーム分離によって精製hcvrnaを調製するための方法

Country Status (13)

Country Link
US (2) US7198923B1 (OSRAM)
EP (1) EP1230347B1 (OSRAM)
JP (1) JP4675017B2 (OSRAM)
AT (1) ATE373084T1 (OSRAM)
AU (1) AU1721801A (OSRAM)
CA (1) CA2392075C (OSRAM)
CY (1) CY1107521T1 (OSRAM)
DE (1) DE60036403T2 (OSRAM)
DK (1) DK1230347T3 (OSRAM)
ES (1) ES2292489T3 (OSRAM)
GB (1) GB9927320D0 (OSRAM)
PT (1) PT1230347E (OSRAM)
WO (1) WO2001036601A1 (OSRAM)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9927320D0 (en) * 1999-11-18 2000-01-12 Chiron Spa Exosome separation
US8021847B2 (en) 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
US20080268429A1 (en) * 2004-06-02 2008-10-30 Sourcepharm, Inc. Rna - Containing Microvesicles and Methods Therefor
CA3061952C (en) * 2006-03-09 2022-07-19 Aethlon Medical, Inc. Extracorporeal removal of microvesicular particles
US9085778B2 (en) 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
US8617806B2 (en) * 2008-01-25 2013-12-31 Hansabiomed Ou Method to measure and characterize microvesicles in the human body fluids
ES2936256T3 (es) * 2008-02-01 2023-03-15 Massachusetts Gen Hospital Uso de microvesículas en el diagnóstico, y pronóstico de enfermedades y afecciones médicas
WO2014057128A2 (en) 2012-10-11 2014-04-17 Vin-De-Bona Trading Company Pte Ltd Method of painting microvesicles
US11266736B2 (en) 2008-04-17 2022-03-08 Vin De Bona Trading Company Pte Ltd Method of painting micro vesicles
AU2009259893A1 (en) * 2008-06-20 2009-12-23 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
US9487837B2 (en) 2008-10-06 2016-11-08 Morehouse School Of Medicine Exosome-mediated diagnosis of hepatitis virus infections and diseases
US10545149B2 (en) * 2008-10-06 2020-01-28 Morehouse School Of Medicine Detection of HIV-related proteins in urine
CN102308004A (zh) 2008-10-30 2012-01-04 卡里斯生命科学卢森堡控股有限责任公司 评价rna图案的方法
CA2743211A1 (en) 2008-11-12 2010-05-20 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods and systems of using exosomes for determining phenotypes
EP2419144B1 (en) 2009-04-17 2019-08-07 Oxford University Innovation Limited Composition for delivery of genetic material
BRPI0900815A2 (pt) * 2009-04-23 2010-12-28 Sociedade Benef Israelita Bras Hospital Albert Einstein método para isolamento de exossomos a partir de soluções biológicas utilizando nanopartìculas de óxido de ferro
IN2012DN00866A (OSRAM) 2009-07-16 2015-07-10 Gen Hospital Corp
WO2011031892A1 (en) 2009-09-09 2011-03-17 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
WO2011031877A1 (en) 2009-09-09 2011-03-17 The General Hospital Corporation Use of microvesicles in analyzing nucleic acid profiles
WO2011049059A1 (ja) * 2009-10-22 2011-04-28 国立大学法人岐阜大学 Rna内包キャリア組成物
US20130203061A1 (en) 2009-11-30 2013-08-08 Michael KLASS Methods and systems for isolating, storing, and analyzing vesicles
US9128101B2 (en) 2010-03-01 2015-09-08 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
WO2011156734A2 (en) * 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Method of characterizing vascular diseases
WO2011156763A1 (en) 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Methods for characterizing kidney function
EP2591359B1 (en) 2010-07-07 2017-03-01 Aethlon Medical Inc Methods for quantifying exosomes
WO2012031008A2 (en) 2010-08-31 2012-03-08 The General Hospital Corporation Cancer-related biological materials in microvesicles
EP2638057B1 (en) 2010-11-10 2019-03-06 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
ES2744589T3 (es) 2011-05-11 2020-02-25 Exosome Diagnostics Inc Extracción de ácido nucleico de materiales biológicos heterogéneos
JP5823031B2 (ja) 2011-06-10 2015-11-25 日立化成株式会社 小胞捕捉デバイスおよびそれを用いるための方法
EP2723865B1 (en) 2011-06-21 2019-03-27 Alnylam Pharmaceuticals, Inc. METHODS FOR DETERMINING ACTIVITY OF RNAi IN A SUBJECT
WO2013028788A1 (en) 2011-08-22 2013-02-28 Exosome Diagnostics, Inc. Urine biomarkers
HK1199754A1 (en) * 2011-09-22 2015-07-17 Universidad De Los Andes Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage
US10174361B2 (en) 2011-11-10 2019-01-08 Exosome Diagnostics, Inc. Cerebrospinal fluid assay
GB201121070D0 (en) 2011-12-07 2012-01-18 Isis Innovation composition for delivery of biotherapeutics
EP2875348B1 (en) * 2012-07-19 2018-09-26 Atlantic Cancer Research Institute Method for the isolation of microvesicles
EP2890783A4 (en) 2012-08-30 2016-03-02 Exosome Diagnostics Inc WITNESSES FOR NUCLEIC ACID ASSAYS
CN105025878A (zh) 2012-10-03 2015-11-04 外来体诊断公司 微泡在医学疾病和病况的诊断、预后和治疗中的用途
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
US20150353920A1 (en) 2013-01-03 2015-12-10 Exosome Diagnostics, Inc. Methods for isolating microvesicles
US12558316B2 (en) 2013-03-13 2026-02-24 University Of Miami Methods and compositions for the treatment of epidermolysis bullosa
CA2906502A1 (en) 2013-03-13 2014-10-02 University Of Miami Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids
JP6297676B2 (ja) 2013-05-06 2018-03-20 日立化成株式会社 標的分子を捕捉するためのデバイス及び方法
US10301681B2 (en) 2013-08-06 2019-05-28 Exosome Diagnostics, Inc. Methods of treating a subject with a high gleason score prostate cancer
WO2015031694A2 (en) 2013-08-28 2015-03-05 Caris Science, Inc. Oligonucleotide probes and uses thereof
TWI788704B (zh) * 2013-10-24 2023-01-01 美商納諾索米克斯公司 分析個體樣品之方法
WO2015112382A1 (en) * 2014-01-21 2015-07-30 Morehouse School Of Medicine Exosome-mediated detection of infections and diseases
US10844436B2 (en) 2014-04-01 2020-11-24 Cornell University Use of double-stranded DNA in exosomes: a novel biomarker in cancer detection
US11268085B2 (en) 2014-05-27 2022-03-08 Exosome Diagnostics, Inc. Methods for isolating microvesicles and extracting nucleic acids from biological samples
US10465183B2 (en) 2014-07-09 2019-11-05 Exosome Diagnostics, Inc. Methods for isolating microvesicles and extracting nucleic acids from biological samples
EP3808756A1 (en) 2014-07-17 2021-04-21 The Trustees of The University of Pennsylvania Methods for using exosomes to monitor transplanted organ status
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
US10370719B2 (en) 2014-11-12 2019-08-06 Hitachi Chemical Co., Ltd. Method and device for diagnosing organ injury
EP3112474A1 (en) 2015-06-29 2017-01-04 Evonik Degussa GmbH Method of detecting avian necrotic enteritis
AU2016229076B2 (en) 2015-03-09 2022-01-20 Caris Science, Inc. Oligonucleotide probes and uses thereof
IL256175B2 (en) 2015-06-10 2024-10-01 Univ Texas Using exosomes to treat the disease
IL318703A (en) 2015-06-29 2025-03-01 Caris Science Inc Therapeutic oligonucleotides
EP3328873B1 (en) 2015-07-28 2025-09-17 Caris Science, Inc. Targeted oligonucleotides
JP6624704B2 (ja) 2015-08-31 2019-12-25 日立化成株式会社 尿路上皮疾患の評価のための分子法
EP3165926A1 (en) 2015-11-06 2017-05-10 Humanitas Mirasole S.p.A. Method for characterization of cell specific microvesicles
WO2017181161A1 (en) 2016-04-15 2017-10-19 Predicine, Inc. Systems and methods for detecting genetic alterations
US20190093172A1 (en) 2016-04-15 2019-03-28 Exosome Diagnostics, Inc. Plasma-based detection of anaplastic lymphoma kinase (alk) nucleic acids and alk fusion transcripts and uses thereof in diagnosis and treatment of cancer
EP4299803A3 (en) 2016-05-02 2024-03-27 Encodia, Inc. Macromolecule analysis employing nucleic acid encoding
EP3452613B1 (en) 2016-05-05 2021-12-29 Exosome Diagnostics, Inc. Profiling microvesicle nucleic acids and uses thereof as signatures in diagnosis of renal transplant rejection
CN109642229A (zh) 2016-05-13 2019-04-16 外来体诊断公司 从生物液体分离细胞外囊泡和共分离无细胞dna的自动和手动方法
IL247368A0 (en) 2016-08-18 2016-11-30 Yeda Res & Dev Diagnostic and therapeutic uses of exosomes
US11174503B2 (en) 2016-09-21 2021-11-16 Predicine, Inc. Systems and methods for combined detection of genetic alterations
WO2018055080A1 (en) 2016-09-22 2018-03-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for reprograming immune environment in a subject in need thereof
US11396676B2 (en) 2016-10-21 2022-07-26 Exosome Diagnostics, Inc. Sequencing and analysis of exosome associated nucleic acids
EP3548635B1 (en) 2016-11-30 2021-04-28 Exosome Diagnostics, Inc. Methods to detect mutations in plasma using exosomal rna and cell free dna from non-small cell lung cancer patients
GB2559319B (en) 2016-12-23 2019-01-16 Cs Genetics Ltd Reagents and methods for the analysis of linked nucleic acids
US20200149036A1 (en) 2017-01-02 2020-05-14 Exosome Diagnostics, Inc. Methods to distinguish rna and dna in a combined preparation
BR112019023772A2 (pt) 2017-05-12 2020-06-09 Evonik Operations Gmbh método para detectar doenças induzidas por c. perfringens em animais e kit de diagnóstico
JP7225121B2 (ja) 2017-05-17 2023-02-20 エクソサム ダイアグノスティクス,インコーポレイティド 微小胞核酸および/またはタンパク質、並びに腎移植拒絶反応マーカーとしてのその使用
EP3652315A4 (en) * 2017-07-12 2021-09-01 Exosome Diagnostics, Inc. METHODS FOR ISOLATION AND ENRICHMENT OF EXTRACELLULAR VESICLE POPULATIONS DERIVED FROM BIOFLUIDS, AND ASSOCIATED METHODS OF USE
EP3655531B1 (en) 2017-07-18 2024-09-04 Exosome Diagnostics, Inc. Sequencing of nucleic acids associated with exosomal isolation from patients with glioblastoma multiforme
AU2018358057B2 (en) 2017-10-31 2023-03-02 Encodia, Inc. Kits for analysis using nucleic acid encoding and/or label
US20200339987A1 (en) 2017-11-09 2020-10-29 Alnylam Pharmaceuticals, Inc. Assays and methods for determining expression of the lect2 gene
CN110123838B (zh) * 2018-02-02 2022-04-01 上海睿泰生物科技股份有限公司 负载白藜芦醇的人多能干细胞外泌体及其制备方法与用途
CN110123841A (zh) * 2018-02-09 2019-08-16 上海市第六人民医院 负载白藜芦醇的人多能干细胞外泌体在制备治疗生殖系统疾病药物的用途
US20210011027A1 (en) 2018-03-02 2021-01-14 Evonik Operations Gmbh In vitro method for detecting intestinal barrier failure in animals by determining ovotransferrin
CN112739832B (zh) 2018-06-06 2024-06-04 外来体诊断公司 用于开发尿液生物标志物和用于检测膀胱癌的方法
WO2020106853A1 (en) 2018-11-20 2020-05-28 Exosome Diagnostics, Inc. Compositions and methods for internal controls of microvesicle isolations
MX2021006917A (es) 2018-12-14 2021-07-07 Evonik Operations Gmbh Procedimiento in vitro para la deteccion de disbiosis intestinal aviar.
CN114072499B (zh) 2019-04-30 2024-08-06 Encodia公司 用于制备分析物的方法和相关试剂盒
EP4031865A2 (en) * 2019-09-18 2022-07-27 Exosome Diagnostics, Inc. Compositions, methods, and kits for the isolation of extracellular vesicles
CN115666619A (zh) 2020-04-13 2023-01-31 埃索普罗瑟医疗有限公司 用于抗病毒治疗的包含野生型p53蛋白的细胞衍生囊泡
US20210322483A1 (en) 2020-04-16 2021-10-21 Ichilov Tech Ltd. Cell-derived particles presenting heterologous cd24 and use thereof in therapy
IL277743A (en) 2020-10-01 2022-04-01 Yeda Res & Dev A method for diagnosing breast cancer
TW202214851A (zh) * 2020-10-07 2022-04-16 國立中央大學 外泌體核酸萃取方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU225068B1 (en) * 1989-03-17 2006-05-29 Chiron Corp Process for producing diagnostics and vaccine of nanbh
US5372928A (en) * 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
AU7672991A (en) * 1990-04-03 1991-10-30 Southwest Foundation For Biomedical Research Purified hcv and hcv proteins and peptides
GB9416671D0 (en) 1994-08-17 1994-10-12 Biocine Spa Assay
CA2225553A1 (en) * 1995-08-03 1997-02-20 Rijksuniversiteit Te Leiden Cell derived antigen presenting vesicles
GB9517926D0 (en) 1995-09-01 1995-11-01 Biocine Spa Binding protein
FR2766205B1 (fr) 1997-07-16 2002-08-30 Inst Nat Sante Rech Med Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede
ATE449847T1 (de) 1997-10-06 2009-12-15 Novartis Vaccines & Diagnostic Hepatitis c rezeptorprotein cd81
AU756303B2 (en) 1997-11-06 2003-01-09 Innogenetics N.V. Host derived proteins binding HCV: medical, diagnostic and purification use
GB9927320D0 (en) * 1999-11-18 2000-01-12 Chiron Spa Exosome separation

Similar Documents

Publication Publication Date Title
CA2392075A1 (en) Method for the preparation of purified hcv rna by exosome separation
Takahashi et al. p26 protein and 33-nm particle associated with nucleocapsid of hepatitis C virus recovered from the circulation of infected hosts
Reiser et al. Serum interleukin 4 and interleukin 10 levels in patients with chronic hepatitis C virus infection
Fattovich et al. Serum levels of soluble CD30 in chronic hepatitis B virus infection
JP2002541204A (ja) B型肝炎、c型肝炎及びその他の肝臓の関連ウイルス感染の治療に有用な医薬製剤及びその調製方法
WO1993001210A3 (de) Hcv peptidantigene und verfahren zur bestimmung von hcv
Wight Atlas of liver pathology
CA2453100C (fr) Nouvelles lignees d'hepatomes humains, leurs obtentions et leurs applications
CN110590942B (zh) 一种中和肠道病毒71型的全人源单克隆抗体及其用途
Li et al. Identification of hepatitis C virus by immunoelectron microscopy
Ledinko Production of noninfectious complement-fixing poliovirus particles in HeLa cells treated with proflavine
WO2002004484A3 (en) Hcv mosaic antigen composition
CN113234147A (zh) 一种高亲和力抗丙型肝炎病毒的全人源单克隆抗体及其用途
Ray Hepatitis B virus antigens in tissues
Rizzetto et al. Hepatitis delta virus infection of the liver: progress in virology, pathobiology, and diagnosis
Colombo The role of hepatitis C virus in hepatocellular carcinoma
WO2001049821A3 (fr) Lignees des lymphocytes t cd4 specifiques de type th1 et procede pour leur induction ex vivo
CN104046591B (zh) 一种体外分离记忆性b细胞的制备方法
Barstow et al. Formation of gamma particles during zoosporogenesis in Blastocladiella emersonii
Ducos et al. Hepatitis B virus (HBV)-specific in vitro antibody production by peripheral blood mononuclear cells (PBMC) after vaccination by recombinant hepatitis B surface antigen (rHBsAg)
Sylvan et al. Characterization of cell mediated immune responses to the hepatitis B core protein in man
CN103977425A (zh) 一种检测和评价分子和药物生物学功能的方法及其用途
GB2099700A (en) Method for preparation of hepatitis b surface antigen from human plasma
Drzeniek et al. The possible role of lipid containing RNA viruses for the etiology of autoimmune diseases
Fabiyi et al. Strain Specific Complement-Fixation Differentiation of Influenza B Viruses Isolated in Tissue Culture.