JP2003511423A5 - - Google Patents

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Publication number
JP2003511423A5
JP2003511423A5 JP2001529754A JP2001529754A JP2003511423A5 JP 2003511423 A5 JP2003511423 A5 JP 2003511423A5 JP 2001529754 A JP2001529754 A JP 2001529754A JP 2001529754 A JP2001529754 A JP 2001529754A JP 2003511423 A5 JP2003511423 A5 JP 2003511423A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001529754A
Other languages
Japanese (ja)
Other versions
JP2003511423A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2000/028109 external-priority patent/WO2001026693A2/en
Publication of JP2003511423A publication Critical patent/JP2003511423A/ja
Publication of JP2003511423A5 publication Critical patent/JP2003511423A5/ja
Pending legal-status Critical Current

Links

JP2001529754A 1999-10-12 2000-10-12 ポリグルタメート−治療薬コンジュゲートの製造 Pending JP2003511423A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15913599P 1999-10-12 1999-10-12
US60/159,135 1999-10-12
PCT/US2000/028109 WO2001026693A2 (en) 1999-10-12 2000-10-12 Manufacture of polyglutamate-therapeutic agent conjugates

Publications (2)

Publication Number Publication Date
JP2003511423A JP2003511423A (ja) 2003-03-25
JP2003511423A5 true JP2003511423A5 (enExample) 2005-12-08

Family

ID=22571222

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001529754A Pending JP2003511423A (ja) 1999-10-12 2000-10-12 ポリグルタメート−治療薬コンジュゲートの製造

Country Status (16)

Country Link
US (2) US20020077279A1 (enExample)
EP (2) EP1225917A2 (enExample)
JP (1) JP2003511423A (enExample)
KR (1) KR100821437B1 (enExample)
CN (2) CN101507820A (enExample)
AU (1) AU781735B2 (enExample)
BR (1) BRPI0014652B1 (enExample)
CA (1) CA2387611C (enExample)
HU (1) HUP0203123A3 (enExample)
MX (1) MXPA02003719A (enExample)
NO (1) NO20021701L (enExample)
NZ (1) NZ529789A (enExample)
PL (1) PL354623A1 (enExample)
SG (1) SG147286A1 (enExample)
WO (1) WO2001026693A2 (enExample)
ZA (1) ZA200202695B (enExample)

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Publication number Priority date Publication date Assignee Title
US8323669B2 (en) 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane

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US8709998B2 (en) 2003-04-22 2014-04-29 Ipsen Pharma S.A.S. Peptide vectors
FR2855521B1 (fr) * 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
US7259156B2 (en) 2004-05-20 2007-08-21 Kosan Biosciences Incorporated Geldanamycin compounds and method of use
US8614228B2 (en) 2004-08-11 2013-12-24 Arqule, Inc. Quinone prodrug compositions and methods of use
WO2006020719A2 (en) 2004-08-11 2006-02-23 Arqule, Inc. Aminoacid conjugates of beta - lapachone for tumor targeting
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JP5237821B2 (ja) 2005-12-05 2013-07-17 日東電工株式会社 ポリグルタミン酸−アミノ酸結合体および方法
KR20080074202A (ko) * 2005-12-06 2008-08-12 셀 쎄러퓨틱스 인코포레이티드 에스트로겐 암 요법
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
CA2652656A1 (en) 2006-05-18 2007-11-29 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of podophyllotoxins
EP2080779B1 (en) 2006-11-06 2016-05-18 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
EP2090607B1 (en) 2006-11-08 2015-05-20 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
CN101209350B (zh) * 2006-12-30 2011-09-07 中国人民解放军军事医学科学院毒物药物研究所 以氨基酸为连接子的多聚谷氨酸-药物偶合物
MX2009008549A (es) * 2007-02-09 2009-08-18 Enzon Pharmaceuticals Inc Tratamiento de canceres resistentes o refractarios con conjugados polimericos de brazos multiples de 7-etil-10-hidroxicamptotecina.
EP2144631A2 (en) * 2007-04-10 2010-01-20 Nitto Denko Corporation Multi-functional polyglutamate drug carriers
BRPI0810717A2 (pt) 2007-04-30 2016-05-24 Arqule Inc sulfonato hidroxi de composto de quinona e seus usos
JP2010528122A (ja) * 2007-05-09 2010-08-19 日東電工株式会社 白金薬剤と結合されたポリマー
EP2155253A2 (en) * 2007-05-09 2010-02-24 Nitto Denko Corporation Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
DK2155255T3 (da) * 2007-05-09 2013-09-02 Nitto Denko Corp Sammensætninger der omfatter en hydrofob forbindelse og et polyaminosyrekonjugat
US8703878B2 (en) 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
KR20100122510A (ko) * 2008-03-06 2010-11-22 닛토덴코 가부시키가이샤 중합체 파클리탁셀 접합체 및 암 치료 방법
KR101589582B1 (ko) 2008-03-18 2016-01-28 니폰 가야꾸 가부시끼가이샤 생리활성물질의 고분자량 결합체
JP5366940B2 (ja) 2008-05-08 2013-12-11 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
TW201010732A (en) * 2008-08-29 2010-03-16 Enzon Pharmaceuticals Inc Method of treating RAS associated cancer
WO2010042638A2 (en) * 2008-10-07 2010-04-15 Young Bok Lee Hpma - docetaxel or gemcitabine conjugates and uses therefore
WO2010045370A2 (en) * 2008-10-15 2010-04-22 Nitto Denko Corporation Method of preparing polyglutamate conjugates
US20100098654A1 (en) * 2008-10-21 2010-04-22 Fabio Pastorino Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
DE102008060549A1 (de) * 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
JP5544357B2 (ja) 2009-05-15 2014-07-09 日本化薬株式会社 水酸基を有する生理活性物質の高分子結合体
CN104587484A (zh) 2009-10-13 2015-05-06 瑞沙恩医药公司 用于抗癌剂递送的聚合物系统
AU2011224374A1 (en) * 2010-03-11 2012-09-27 Nitto Denko Corporation Carbohydrate-polyamino acid-drug conjugates
EP4450523A3 (en) 2010-04-02 2025-03-12 Amunix Pharmaceuticals, Inc. Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same
JP5856069B2 (ja) 2010-11-17 2016-02-09 日本化薬株式会社 新規なシチジン系代謝拮抗剤の高分子誘導体
CN102649810A (zh) * 2011-05-19 2012-08-29 东北林业大学 喜树碱衍生物、其制备方法和用途
WO2013006173A1 (en) 2011-07-07 2013-01-10 Empire Technology Development Llc Fluorinated block co-polymers
JP5711378B2 (ja) 2011-09-11 2015-04-30 日本化薬株式会社 ブロック共重合体の製造方法
US8383093B1 (en) 2011-11-01 2013-02-26 Serina Therapeutics, Inc. Subcutaneous delivery of poly(oxazoline) conjugates
WO2013151537A1 (en) 2012-04-03 2013-10-10 Empire Technology Development Llc Biocompatible adhesive polymers
CN105143244A (zh) 2013-04-26 2015-12-09 日东电工株式会社 降低多聚阴离子聚合物偶联物中的内毒素
KR101507119B1 (ko) * 2013-05-31 2015-03-30 주식회사 바이오리더스 점막 점착성 폴리감마글루탐산 나노마이셀 및 이를 이용한 약물 전달체
CN106267227A (zh) * 2016-08-12 2017-01-04 北京蓝贝望生物医药科技股份有限公司 抗肿瘤药物
CN106750272B (zh) * 2016-12-05 2019-05-28 福建卫生职业技术学院 一种水溶性蛇葡萄素聚合物
CN110123748A (zh) * 2019-04-22 2019-08-16 南京师范大学 一种叶酸介导的靶向双载药聚合物胶束及其制备方法和应用
CN113773282A (zh) * 2021-09-22 2021-12-10 无锡紫杉药业有限公司 一种10-乙酰紫杉醇的制备方法

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US6441025B2 (en) * 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
PL189698B1 (pl) * 1996-03-12 2005-09-30 Pg Txl Co Kompozycja farmaceutyczna zawierająca lek przeciwnowotworowy i jej zastosowania
KR20020082888A (ko) * 2000-03-17 2002-10-31 쎌세러퓨틱스,인코포레이티드 폴리글루탐산-캄프토테신 컨주게이트 및 제조 방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8323669B2 (en) 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane

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