JP2003511423A5 - - Google Patents

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Publication number
JP2003511423A5
JP2003511423A5 JP2001529754A JP2001529754A JP2003511423A5 JP 2003511423 A5 JP2003511423 A5 JP 2003511423A5 JP 2001529754 A JP2001529754 A JP 2001529754A JP 2001529754 A JP2001529754 A JP 2001529754A JP 2003511423 A5 JP2003511423 A5 JP 2003511423A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001529754A
Other languages
Japanese (ja)
Other versions
JP2003511423A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2000/028109 external-priority patent/WO2001026693A2/en
Publication of JP2003511423A publication Critical patent/JP2003511423A/ja
Publication of JP2003511423A5 publication Critical patent/JP2003511423A5/ja
Pending legal-status Critical Current

Links

JP2001529754A 1999-10-12 2000-10-12 ポリグルタメート−治療薬コンジュゲートの製造 Pending JP2003511423A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15913599P 1999-10-12 1999-10-12
US60/159,135 1999-10-12
PCT/US2000/028109 WO2001026693A2 (en) 1999-10-12 2000-10-12 Manufacture of polyglutamate-therapeutic agent conjugates

Publications (2)

Publication Number Publication Date
JP2003511423A JP2003511423A (ja) 2003-03-25
JP2003511423A5 true JP2003511423A5 (enExample) 2005-12-08

Family

ID=22571222

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001529754A Pending JP2003511423A (ja) 1999-10-12 2000-10-12 ポリグルタメート−治療薬コンジュゲートの製造

Country Status (16)

Country Link
US (2) US20020077279A1 (enExample)
EP (2) EP1466627A1 (enExample)
JP (1) JP2003511423A (enExample)
KR (1) KR100821437B1 (enExample)
CN (2) CN101507820A (enExample)
AU (1) AU781735B2 (enExample)
BR (1) BRPI0014652B1 (enExample)
CA (1) CA2387611C (enExample)
HU (1) HUP0203123A3 (enExample)
MX (1) MXPA02003719A (enExample)
NO (1) NO20021701L (enExample)
NZ (1) NZ529789A (enExample)
PL (1) PL354623A1 (enExample)
SG (1) SG147286A1 (enExample)
WO (1) WO2001026693A2 (enExample)
ZA (1) ZA200202695B (enExample)

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US8323669B2 (en) 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane

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US7259156B2 (en) 2004-05-20 2007-08-21 Kosan Biosciences Incorporated Geldanamycin compounds and method of use
WO2006020722A2 (en) 2004-08-11 2006-02-23 Arqule, Inc. Polymer conjugates of beta-lapachone and beta-lapachone analogs for tumor targeting
US8614228B2 (en) 2004-08-11 2013-12-24 Arqule, Inc. Quinone prodrug compositions and methods of use
PL1792927T3 (pl) 2004-09-22 2013-09-30 Nippon Kayaku Kk Nowy kopolimer blokowy, preparat micelarny i lek przeciwnowotworowy zawierający ten preparat micelarny jako składnik czynny
RU2472812C2 (ru) 2005-12-05 2013-01-20 НИТТО ДЕНКО КОРПОРЭЙШН (Джэпэн/Джэпэн) Конъюгаты полиглутамат-аминокислота и способы
KR20080074202A (ko) * 2005-12-06 2008-08-12 셀 쎄러퓨틱스 인코포레이티드 에스트로겐 암 요법
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
KR20090009241A (ko) 2006-05-18 2009-01-22 니폰 가야꾸 가부시끼가이샤 포도필로톡신류의 고분자 결합체
EP2080779B1 (en) 2006-11-06 2016-05-18 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
WO2008056654A1 (fr) 2006-11-08 2008-05-15 Nippon Kayaku Kabushiki Kaisha Dérivé polymère d'un antagoniste métabolique d'acide nucléique
CN101209350B (zh) * 2006-12-30 2011-09-07 中国人民解放军军事医学科学院毒物药物研究所 以氨基酸为连接子的多聚谷氨酸-药物偶合物
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CN101674852A (zh) * 2007-04-10 2010-03-17 日东电工株式会社 多功能聚谷氨酸盐药物载体
US7790765B2 (en) 2007-04-30 2010-09-07 Arqule, Inc. Hydroxy sulfonate of quinone compounds and their uses
DK2155254T3 (da) * 2007-05-09 2013-03-04 Nitto Denko Corp Med platinlægemidler konjugerede polymere
JP5341879B2 (ja) * 2007-05-09 2013-11-13 日東電工株式会社 疎水性化合物及びポリアミノ酸複合体を含む組成物
JP2010526917A (ja) * 2007-05-09 2010-08-05 日東電工株式会社 複数種の薬物を有するポリグルタミン酸塩複合体及びポリグルタミン酸塩−アミノ酸複合体
USRE46190E1 (en) 2007-09-28 2016-11-01 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
EP2262537A1 (en) * 2008-03-06 2010-12-22 Nitto Denko Corporation Polymer paclitaxel conjugates and methods for treating cancer
JP5687899B2 (ja) 2008-03-18 2015-03-25 日本化薬株式会社 生理活性物質の高分子結合体
US9149540B2 (en) 2008-05-08 2015-10-06 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
TW201010732A (en) * 2008-08-29 2010-03-16 Enzon Pharmaceuticals Inc Method of treating RAS associated cancer
KR101705077B1 (ko) * 2008-10-07 2017-02-09 렉산 파마슈티컬스, 인코포레이티드 Hpma-도세탁셀 또는 젬시타빈 컨쥬게이트 및 이의 용도
US20100093935A1 (en) * 2008-10-15 2010-04-15 Nitto Denko Corporation Method of preparing polyglutamate conjugates
KR20110075029A (ko) * 2008-10-21 2011-07-05 엔즌 파마슈티칼스, 인코포레이티드 7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료
DE102008060549A1 (de) * 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
EP2431403B1 (en) 2009-05-15 2016-09-28 Nipponkayaku Kabushikikaisha Polymer conjugate of bioactive substance having hydroxy group
EP2488207A4 (en) 2009-10-13 2015-06-10 Rexahn Pharmaceuticals Inc POLYMERIC ANTIBODY RELEASE SYSTEMS
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TW201304805A (zh) 2010-11-17 2013-02-01 Nippon Kayaku Kk 新穎之胞核苷系代謝拮抗劑之高分子衍生物
CN102649810A (zh) * 2011-05-19 2012-08-29 东北林业大学 喜树碱衍生物、其制备方法和用途
US8691284B2 (en) 2011-07-07 2014-04-08 Empire Technology Development Llc Fluorinated block co-polymers
ES2635117T3 (es) 2011-09-11 2017-10-02 Nippon Kayaku Kabushiki Kaisha Método para la fabricación de un copolímero de bloques
US8383093B1 (en) 2011-11-01 2013-02-26 Serina Therapeutics, Inc. Subcutaneous delivery of poly(oxazoline) conjugates
US8907045B2 (en) 2012-04-03 2014-12-09 Empire Technology Development Llc Biocompatible adhesive polymers
US9839694B2 (en) 2013-04-26 2017-12-12 Nitto Denko Corporation Reduction of endotoxins from polyanionic polymer conjugates
KR101507119B1 (ko) * 2013-05-31 2015-03-30 주식회사 바이오리더스 점막 점착성 폴리감마글루탐산 나노마이셀 및 이를 이용한 약물 전달체
CN106267227A (zh) * 2016-08-12 2017-01-04 北京蓝贝望生物医药科技股份有限公司 抗肿瘤药物
CN106750272B (zh) * 2016-12-05 2019-05-28 福建卫生职业技术学院 一种水溶性蛇葡萄素聚合物
CN110123748A (zh) * 2019-04-22 2019-08-16 南京师范大学 一种叶酸介导的靶向双载药聚合物胶束及其制备方法和应用
CN113773282A (zh) * 2021-09-22 2021-12-10 无锡紫杉药业有限公司 一种10-乙酰紫杉醇的制备方法

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US4356166A (en) * 1978-12-08 1982-10-26 University Of Utah Time-release chemical delivery system
US5629433A (en) * 1994-07-18 1997-05-13 Hauser, Inc. Selective process for the deacylation and deacetylation of taxol and taxanes
CA2192725C (en) * 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8323669B2 (en) 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane

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