HUP0203123A3 - Process for preparation of polyglutamate-therapeutic agent conjugates - Google Patents

Process for preparation of polyglutamate-therapeutic agent conjugates

Info

Publication number
HUP0203123A3
HUP0203123A3 HU0203123A HUP0203123A HUP0203123A3 HU P0203123 A3 HUP0203123 A3 HU P0203123A3 HU 0203123 A HU0203123 A HU 0203123A HU P0203123 A HUP0203123 A HU P0203123A HU P0203123 A3 HUP0203123 A3 HU P0203123A3
Authority
HU
Hungary
Prior art keywords
polyglutamate
preparation
therapeutic agent
agent conjugates
conjugates
Prior art date
Application number
HU0203123A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Cell Therapeutics Inc Seattle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Therapeutics Inc Seattle filed Critical Cell Therapeutics Inc Seattle
Publication of HUP0203123A2 publication Critical patent/HUP0203123A2/hu
Publication of HUP0203123A3 publication Critical patent/HUP0203123A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU0203123A 1999-10-12 2000-10-12 Process for preparation of polyglutamate-therapeutic agent conjugates HUP0203123A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15913599P 1999-10-12 1999-10-12
PCT/US2000/028109 WO2001026693A2 (en) 1999-10-12 2000-10-12 Manufacture of polyglutamate-therapeutic agent conjugates

Publications (2)

Publication Number Publication Date
HUP0203123A2 HUP0203123A2 (hu) 2003-01-28
HUP0203123A3 true HUP0203123A3 (en) 2004-12-28

Family

ID=22571222

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203123A HUP0203123A3 (en) 1999-10-12 2000-10-12 Process for preparation of polyglutamate-therapeutic agent conjugates

Country Status (16)

Country Link
US (2) US20020077279A1 (enExample)
EP (2) EP1225917A2 (enExample)
JP (1) JP2003511423A (enExample)
KR (1) KR100821437B1 (enExample)
CN (2) CN101507820A (enExample)
AU (1) AU781735B2 (enExample)
BR (1) BRPI0014652B1 (enExample)
CA (1) CA2387611C (enExample)
HU (1) HUP0203123A3 (enExample)
MX (1) MXPA02003719A (enExample)
NO (1) NO20021701L (enExample)
NZ (1) NZ529789A (enExample)
PL (1) PL354623A1 (enExample)
SG (1) SG147286A1 (enExample)
WO (1) WO2001026693A2 (enExample)
ZA (1) ZA200202695B (enExample)

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US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
WO2004093807A2 (en) 2003-04-22 2004-11-04 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatin vectors
FR2855521B1 (fr) * 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
US7259156B2 (en) 2004-05-20 2007-08-21 Kosan Biosciences Incorporated Geldanamycin compounds and method of use
WO2006020719A2 (en) 2004-08-11 2006-02-23 Arqule, Inc. Aminoacid conjugates of beta - lapachone for tumor targeting
US8614228B2 (en) 2004-08-11 2013-12-24 Arqule, Inc. Quinone prodrug compositions and methods of use
ES2410591T3 (es) 2004-09-22 2013-07-02 Nippon Kayaku Kabushiki Kaisha Nuevo copolímero en bloque, preparación micelar y agente antineoplásico que lo contiene como principio activo
WO2007067417A1 (en) 2005-12-05 2007-06-14 Nitto Denko Corporation Polyglutamate-amino acid conjugates and methods
EP1957065A1 (en) * 2005-12-06 2008-08-20 Cell Therapeutics, Inc. Estrogen cancer therapy
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
WO2007111211A1 (ja) 2006-03-28 2007-10-04 Nippon Kayaku Kabushiki Kaisha タキサン類の高分子結合体
JP5181347B2 (ja) 2006-05-18 2013-04-10 日本化薬株式会社 ポドフィロトキシン類の高分子結合体
JP5503872B2 (ja) 2006-11-06 2014-05-28 日本化薬株式会社 核酸系代謝拮抗剤の高分子誘導体
JP5548365B2 (ja) 2006-11-08 2014-07-16 日本化薬株式会社 核酸系代謝拮抗剤の高分子誘導体
CN101209350B (zh) * 2006-12-30 2011-09-07 中国人民解放军军事医学科学院毒物药物研究所 以氨基酸为连接子的多聚谷氨酸-药物偶合物
EP2109448B1 (en) * 2007-02-09 2013-09-11 Enzon Pharmaceuticals, Inc. Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
CN101674852A (zh) * 2007-04-10 2010-03-17 日东电工株式会社 多功能聚谷氨酸盐药物载体
AU2008246067B2 (en) 2007-04-30 2011-10-20 Arqule, Inc. Hydroxy sulfonate of quinone compounds and their uses
WO2008141110A2 (en) * 2007-05-09 2008-11-20 Nitto Denko Corporation Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
EP2155254B1 (en) * 2007-05-09 2012-11-28 Nitto Denko Corporation Polymers conjugated with platinum drugs
WO2008141107A2 (en) * 2007-05-09 2008-11-20 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
JP5349318B2 (ja) 2007-09-28 2013-11-20 日本化薬株式会社 ステロイド類の高分子結合体
JP2011513412A (ja) * 2008-03-06 2011-04-28 日東電工株式会社 ポリマーパクリタキセル結合体を含む癌を治療するための薬学組成物
US8920788B2 (en) 2008-03-18 2014-12-30 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of physiologically active substances
JP5366940B2 (ja) 2008-05-08 2013-12-11 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
TW201010732A (en) * 2008-08-29 2010-03-16 Enzon Pharmaceuticals Inc Method of treating RAS associated cancer
US9434610B2 (en) * 2008-10-07 2016-09-06 Rexahn Pharmaceuticals, Inc. HPMA—docetaxel conjugates and uses therefore
WO2010045370A2 (en) * 2008-10-15 2010-04-22 Nitto Denko Corporation Method of preparing polyglutamate conjugates
KR20110075029A (ko) * 2008-10-21 2011-07-05 엔즌 파마슈티칼스, 인코포레이티드 7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료
DE102008060549A1 (de) * 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
CN102421827B (zh) 2009-05-15 2014-07-30 日本化药株式会社 具有羟基的生理活性物质的高分子结合体
MX2012004416A (es) 2009-10-13 2012-05-08 Rexahn Pharmaceuticals Inc Sistemas polimericos para el suministro de agentes anticancer.
US20110224148A1 (en) * 2010-03-11 2011-09-15 Nitto Denko Corporation Carbohydrate-polyamino acid-drug conjugates
EP4450523A3 (en) 2010-04-02 2025-03-12 Amunix Pharmaceuticals, Inc. Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same
CA2816997A1 (en) 2010-11-17 2012-05-24 Nippon Kayaku Kabushiki Kaisha Novel polymer derivative of cytidine metabolic antagonist
CN102649810A (zh) * 2011-05-19 2012-08-29 东北林业大学 喜树碱衍生物、其制备方法和用途
US8691284B2 (en) 2011-07-07 2014-04-08 Empire Technology Development Llc Fluorinated block co-polymers
CA2847114C (en) 2011-09-11 2018-08-21 Nippon Kayaku Kabushiki Kaisha Method for manufacturing block copolymer
US8383093B1 (en) 2011-11-01 2013-02-26 Serina Therapeutics, Inc. Subcutaneous delivery of poly(oxazoline) conjugates
WO2013151537A1 (en) 2012-04-03 2013-10-10 Empire Technology Development Llc Biocompatible adhesive polymers
JP2016520687A (ja) 2013-04-26 2016-07-14 日東電工株式会社 ポリアニオン性ポリマー結合体からのエンドトキシンの減少
KR101507119B1 (ko) * 2013-05-31 2015-03-30 주식회사 바이오리더스 점막 점착성 폴리감마글루탐산 나노마이셀 및 이를 이용한 약물 전달체
CN106267227A (zh) * 2016-08-12 2017-01-04 北京蓝贝望生物医药科技股份有限公司 抗肿瘤药物
CN106750272B (zh) * 2016-12-05 2019-05-28 福建卫生职业技术学院 一种水溶性蛇葡萄素聚合物
CN110123748A (zh) * 2019-04-22 2019-08-16 南京师范大学 一种叶酸介导的靶向双载药聚合物胶束及其制备方法和应用
CN113773282A (zh) * 2021-09-22 2021-12-10 无锡紫杉药业有限公司 一种10-乙酰紫杉醇的制备方法

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US4356166A (en) * 1978-12-08 1982-10-26 University Of Utah Time-release chemical delivery system
US5629433A (en) * 1994-07-18 1997-05-13 Hauser, Inc. Selective process for the deacylation and deacetylation of taxol and taxanes
CA2192725C (en) * 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
ATE314843T1 (de) * 1996-03-12 2006-02-15 Pg Txl Co Lp Wasserlösliche paclitaxel-prodrogen
US6441025B2 (en) * 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
SK14822002A3 (sk) * 2000-03-17 2003-05-02 Cell Therapeutics, Inc. Konjugáty na báze polyglutámovej kyseliny a kamptotecínu a spôsoby ich prípravy

Also Published As

Publication number Publication date
PL354623A1 (en) 2004-02-09
JP2003511423A (ja) 2003-03-25
KR100821437B1 (ko) 2008-04-10
NO20021701D0 (no) 2002-04-11
EP1225917A2 (en) 2002-07-31
EP1466627A1 (en) 2004-10-13
SG147286A1 (en) 2008-11-28
US20030224971A1 (en) 2003-12-04
HUP0203123A2 (hu) 2003-01-28
US7399860B2 (en) 2008-07-15
US20020077279A1 (en) 2002-06-20
KR20020059616A (ko) 2002-07-13
CN1607962A (zh) 2005-04-20
ZA200202695B (en) 2004-02-25
WO2001026693A3 (en) 2001-12-27
NZ529789A (en) 2005-04-29
CA2387611A1 (en) 2001-04-19
MXPA02003719A (es) 2002-08-30
CA2387611C (en) 2011-03-29
NO20021701L (no) 2002-05-23
AU781735B2 (en) 2005-06-09
AU1079301A (en) 2001-04-23
WO2001026693A2 (en) 2001-04-19
BRPI0014652B1 (pt) 2016-08-09
BR0014652A (pt) 2003-06-10
CN101507820A (zh) 2009-08-19

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Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished