JP2003506447A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003506447A5 JP2003506447A5 JP2001515668A JP2001515668A JP2003506447A5 JP 2003506447 A5 JP2003506447 A5 JP 2003506447A5 JP 2001515668 A JP2001515668 A JP 2001515668A JP 2001515668 A JP2001515668 A JP 2001515668A JP 2003506447 A5 JP2003506447 A5 JP 2003506447A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- substituted
- alkyl
- alkylamino
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 67
- 125000001072 heteroaryl group Chemical group 0.000 claims description 33
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 33
- 125000000623 heterocyclic group Chemical group 0.000 claims description 24
- 125000001424 substituent group Chemical group 0.000 claims description 24
- 125000003107 substituted aryl group Chemical group 0.000 claims description 20
- 125000005114 heteroarylalkoxy group Chemical group 0.000 claims description 19
- 125000005553 heteroaryloxy group Chemical group 0.000 claims description 19
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 16
- -1 alkylsulfonyl halides Chemical class 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 58
- 125000004429 atom Chemical group 0.000 claims 43
- 229910052717 sulfur Inorganic materials 0.000 claims 30
- 229910052760 oxygen Inorganic materials 0.000 claims 28
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 25
- 125000004093 cyano group Chemical group *C#N 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 19
- 125000004414 alkyl thio group Chemical group 0.000 claims 19
- 229910052757 nitrogen Inorganic materials 0.000 claims 19
- 125000004430 oxygen atom Chemical group O* 0.000 claims 18
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 18
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 229910052799 carbon Inorganic materials 0.000 claims 14
- 125000004432 carbon atom Chemical group C* 0.000 claims 14
- 125000005236 alkanoylamino group Chemical group 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 10
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 229940002612 prodrug Drugs 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 6
- 125000006413 ring segment Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000004423 acyloxy group Chemical group 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 3
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 3
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 3
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 3
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 3
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37132299A | 1999-08-10 | 1999-08-10 | |
| US09/371,322 | 1999-08-10 | ||
| PCT/US2000/021579 WO2001010859A1 (en) | 1999-08-10 | 2000-08-08 | Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003506447A JP2003506447A (ja) | 2003-02-18 |
| JP2003506447A5 true JP2003506447A5 (https=) | 2005-06-02 |
Family
ID=23463486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001515668A Pending JP2003506447A (ja) | 1999-08-10 | 2000-08-08 | 血管形成阻害活性をもつ置換ピリダジン類および縮合ピリダジン類 |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1208096B1 (https=) |
| JP (1) | JP2003506447A (https=) |
| KR (1) | KR20020019969A (https=) |
| CN (1) | CN1378543A (https=) |
| AR (1) | AR025068A1 (https=) |
| AT (1) | ATE265448T1 (https=) |
| AU (1) | AU775237B2 (https=) |
| BR (1) | BR0013113A (https=) |
| CA (1) | CA2381621A1 (https=) |
| CO (1) | CO5180637A1 (https=) |
| DE (1) | DE60010280T2 (https=) |
| ES (1) | ES2219382T3 (https=) |
| IL (1) | IL147885A0 (https=) |
| MX (1) | MXPA02001324A (https=) |
| NO (1) | NO20020569L (https=) |
| NZ (1) | NZ517087A (https=) |
| PE (1) | PE20010494A1 (https=) |
| WO (1) | WO2001010859A1 (https=) |
| ZA (1) | ZA200200691B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6689883B1 (en) | 1999-09-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
| DOP2000000070A (es) * | 1999-09-28 | 2002-02-28 | Bayer Healthcare Llc | Piridinas y piridacinas sustituidas con actividad de inhibición de angiogénesis |
| US7977333B2 (en) | 2000-04-20 | 2011-07-12 | Bayer Healthcare Llc | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
| GB0111078D0 (en) | 2001-05-04 | 2001-06-27 | Novartis Ag | Organic compounds |
| EP1712234B1 (en) * | 2001-09-12 | 2009-01-28 | Novartis AG | Use of 4-Pyridylmethylphthalazines for Renal Cancer Treatment |
| WO2003059354A2 (en) * | 2001-12-21 | 2003-07-24 | Bayer Pharmaceuticals Corporation | Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives |
| AU2003249369A1 (en) * | 2002-06-21 | 2004-01-06 | Cellular Genomics, Inc. | Certain amino-substituted monocycles as kinase modulators |
| CN100372535C (zh) * | 2002-09-24 | 2008-03-05 | 诺瓦提斯公司 | 4-吡啶基甲基-酞嗪衍生物在制备治疗骨髓增生异常综合征的药物中的用途 |
| JP2006507319A (ja) * | 2002-11-12 | 2006-03-02 | ノバルティス アクチエンゲゼルシャフト | 中皮腫の処置 |
| GB0612721D0 (en) | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
| US7776857B2 (en) | 2007-04-05 | 2010-08-17 | Amgen Inc. | Aurora kinase modulators and method of use |
| ES2395877T3 (es) | 2007-06-19 | 2013-02-15 | Rynel, Inc. | Materiales que comprenden partículas poliméricas solubles en agua y métodos para prepararlos y usarlos |
| CA2716856C (en) | 2008-03-20 | 2013-02-19 | Amgen Inc. | Aurora kinase modulators and method of use |
| WO2010017240A2 (en) * | 2008-08-04 | 2010-02-11 | Amgen Inc. | Aurora kinase modulators and methods of use |
| US9126935B2 (en) | 2008-08-14 | 2015-09-08 | Amgen Inc. | Aurora kinase modulators and methods of use |
| JP2024505256A (ja) * | 2021-01-28 | 2024-02-05 | ユニバーシティ オブ フロリダ リサーチファウンデーション インコーポレイティッド | 神経変性、変性及び代謝性障害の処置のための化合物並びにその使用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| JPH03106875A (ja) * | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | １―（３―ピリジルメチル）フタラジン誘導体 |
| JPH0673022A (ja) * | 1992-08-27 | 1994-03-15 | Kumiai Chem Ind Co Ltd | ピリミジンまたはトリアジン誘導体及び除草剤 |
| DE69533057T2 (de) * | 1994-08-09 | 2005-06-16 | Eisai Co., Ltd. | Kondensierte pyridazinverbindungen |
| JP3919835B2 (ja) * | 1994-08-09 | 2007-05-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 縮合ピリダジン系化合物 |
| CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| CN1660840A (zh) * | 1999-03-30 | 2005-08-31 | 诺瓦提斯公司 | 治疗炎性疾病的酞嗪衍生物 |
-
2000
- 2000-08-07 AR ARP000104073A patent/AR025068A1/es unknown
- 2000-08-08 AU AU68954/00A patent/AU775237B2/en not_active Ceased
- 2000-08-08 DE DE60010280T patent/DE60010280T2/de not_active Expired - Lifetime
- 2000-08-08 CA CA002381621A patent/CA2381621A1/en not_active Abandoned
- 2000-08-08 CO CO00059237A patent/CO5180637A1/es unknown
- 2000-08-08 JP JP2001515668A patent/JP2003506447A/ja active Pending
- 2000-08-08 ES ES00957317T patent/ES2219382T3/es not_active Expired - Lifetime
- 2000-08-08 PE PE2000000799A patent/PE20010494A1/es not_active Application Discontinuation
- 2000-08-08 IL IL14788500A patent/IL147885A0/xx unknown
- 2000-08-08 CN CN00814059A patent/CN1378543A/zh active Pending
- 2000-08-08 MX MXPA02001324A patent/MXPA02001324A/es active IP Right Grant
- 2000-08-08 EP EP00957317A patent/EP1208096B1/en not_active Expired - Lifetime
- 2000-08-08 NZ NZ517087A patent/NZ517087A/en unknown
- 2000-08-08 AT AT00957317T patent/ATE265448T1/de not_active IP Right Cessation
- 2000-08-08 BR BR0013113-0A patent/BR0013113A/pt not_active IP Right Cessation
- 2000-08-08 KR KR1020027001797A patent/KR20020019969A/ko not_active Ceased
- 2000-08-08 WO PCT/US2000/021579 patent/WO2001010859A1/en not_active Ceased
-
2002
- 2002-01-25 ZA ZA200200691A patent/ZA200200691B/en unknown
- 2002-02-05 NO NO20020569A patent/NO20020569L/no not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003506447A5 (https=) | ||
| RU2002111414A (ru) | Замещенные пиридины и пиридазины, обладающие способностью ингибировать ангиогенез | |
| RU2221798C2 (ru) | Имидазонафтиридины, фармацевтическая композиция на их основе, способ стимуляции биосинтеза цитокина и промежуточные вещества | |
| CO5200835A1 (es) | Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis | |
| JP2002518384A5 (https=) | ||
| JP2005532287A5 (https=) | ||
| JP2007517044A5 (https=) | ||
| JP2004501940A5 (https=) | ||
| JPH11162650A5 (https=) | ||
| JP2001526218A5 (https=) | ||
| JP2008525416A5 (https=) | ||
| JP2004525888A5 (https=) | ||
| JP2002502874A5 (https=) | ||
| JP2006507235A5 (https=) | ||
| JP2022534702A5 (https=) | ||
| WO2001087845A3 (en) | N-containing heterocyclic compounds and their use as 5-ht antagonists | |
| JP2007505138A5 (https=) | ||
| JP2004530641A5 (https=) | ||
| JPH1180090A5 (https=) | ||
| JP2003206485A5 (https=) | ||
| JP2009530424A5 (https=) | ||
| JP2005505565A5 (https=) | ||
| JP2011520775A5 (https=) | ||
| JP2002532505A5 (https=) | ||
| JP2005535594A5 (https=) |