JP2003506447A5 - - Google Patents
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- Publication number
- JP2003506447A5 JP2003506447A5 JP2001515668A JP2001515668A JP2003506447A5 JP 2003506447 A5 JP2003506447 A5 JP 2003506447A5 JP 2001515668 A JP2001515668 A JP 2001515668A JP 2001515668 A JP2001515668 A JP 2001515668A JP 2003506447 A5 JP2003506447 A5 JP 2003506447A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- substituted
- alkyl
- alkylamino
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 67
- 125000001072 heteroaryl group Chemical group 0.000 claims description 33
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 33
- 125000000623 heterocyclic group Chemical group 0.000 claims description 24
- 125000001424 substituent group Chemical group 0.000 claims description 24
- 125000003107 substituted aryl group Chemical group 0.000 claims description 20
- 125000005114 heteroarylalkoxy group Chemical group 0.000 claims description 19
- 125000005553 heteroaryloxy group Chemical group 0.000 claims description 19
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 16
- -1 alkylsulfonyl halides Chemical class 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 58
- 125000004429 atom Chemical group 0.000 claims 43
- 229910052717 sulfur Inorganic materials 0.000 claims 30
- 229910052760 oxygen Inorganic materials 0.000 claims 28
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 25
- 125000004093 cyano group Chemical group *C#N 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 19
- 125000004414 alkyl thio group Chemical group 0.000 claims 19
- 229910052757 nitrogen Inorganic materials 0.000 claims 19
- 125000004430 oxygen atom Chemical group O* 0.000 claims 18
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 18
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 229910052799 carbon Inorganic materials 0.000 claims 14
- 125000004432 carbon atom Chemical group C* 0.000 claims 14
- 125000005236 alkanoylamino group Chemical group 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 10
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 229940002612 prodrug Drugs 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 6
- 125000006413 ring segment Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000004423 acyloxy group Chemical group 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 3
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 3
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 3
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 3
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 3
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37132299A | 1999-08-10 | 1999-08-10 | |
| US09/371,322 | 1999-08-10 | ||
| PCT/US2000/021579 WO2001010859A1 (en) | 1999-08-10 | 2000-08-08 | Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003506447A JP2003506447A (ja) | 2003-02-18 |
| JP2003506447A5 true JP2003506447A5 (https=) | 2005-06-02 |
Family
ID=23463486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001515668A Pending JP2003506447A (ja) | 1999-08-10 | 2000-08-08 | 血管形成阻害活性をもつ置換ピリダジン類および縮合ピリダジン類 |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1208096B1 (https=) |
| JP (1) | JP2003506447A (https=) |
| KR (1) | KR20020019969A (https=) |
| CN (1) | CN1378543A (https=) |
| AR (1) | AR025068A1 (https=) |
| AT (1) | ATE265448T1 (https=) |
| AU (1) | AU775237B2 (https=) |
| BR (1) | BR0013113A (https=) |
| CA (1) | CA2381621A1 (https=) |
| CO (1) | CO5180637A1 (https=) |
| DE (1) | DE60010280T2 (https=) |
| ES (1) | ES2219382T3 (https=) |
| IL (1) | IL147885A0 (https=) |
| MX (1) | MXPA02001324A (https=) |
| NO (1) | NO20020569L (https=) |
| NZ (1) | NZ517087A (https=) |
| PE (1) | PE20010494A1 (https=) |
| WO (1) | WO2001010859A1 (https=) |
| ZA (1) | ZA200200691B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6689883B1 (en) | 1999-09-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
| GT200000158A (es) * | 1999-09-28 | 2002-03-16 | Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis. | |
| US7977333B2 (en) | 2000-04-20 | 2011-07-12 | Bayer Healthcare Llc | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
| GB0111078D0 (en) * | 2001-05-04 | 2001-06-27 | Novartis Ag | Organic compounds |
| EP1712234B1 (en) * | 2001-09-12 | 2009-01-28 | Novartis AG | Use of 4-Pyridylmethylphthalazines for Renal Cancer Treatment |
| MXPA04005561A (es) * | 2001-12-21 | 2004-12-06 | Bayer Pharmaceuticals Corp | Terapias de combinacion anti-angiogenesis que comprenden derivados de piridazina o piridina. |
| US7015227B2 (en) | 2002-06-21 | 2006-03-21 | Cgi Pharmaceuticals, Inc. | Certain amino-substituted monocycles as kinase modulators |
| HRP20050281A2 (en) * | 2002-09-24 | 2006-07-31 | Novartis Ag | Use of 4-pyridylmethyl-phthalazine derivatives for the manufacture of a medicament for the treatment of myelodysplastic syndromes |
| US20060058313A1 (en) * | 2002-11-12 | 2006-03-16 | Hohneker John A | Treatment of mesothelioma |
| GB0612721D0 (en) | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
| US7776857B2 (en) | 2007-04-05 | 2010-08-17 | Amgen Inc. | Aurora kinase modulators and method of use |
| EP2167549B1 (en) | 2007-06-19 | 2012-09-26 | Rynel, Inc. | Materials comprising water-soluble polymer particles and methods of making and using them |
| ES2413806T3 (es) | 2008-03-20 | 2013-07-17 | Amgen Inc. | Moduladores de la aurora cinasa y método de uso |
| AU2009279760B2 (en) * | 2008-08-04 | 2012-07-12 | Amgen Inc. | Aurora kinase modulators and methods of use |
| US9126935B2 (en) | 2008-08-14 | 2015-09-08 | Amgen Inc. | Aurora kinase modulators and methods of use |
| CA3206794A1 (en) * | 2021-01-28 | 2022-08-04 | Thomas D. Bannister | Compounds and use thereof for treatment of neurodegenerative, degenerative and metabolic disorders |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| JPH03106875A (ja) * | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | １―（３―ピリジルメチル）フタラジン誘導体 |
| JPH0673022A (ja) * | 1992-08-27 | 1994-03-15 | Kumiai Chem Ind Co Ltd | ピリミジンまたはトリアジン誘導体及び除草剤 |
| WO1996005176A1 (en) * | 1994-08-09 | 1996-02-22 | Eisai Co., Ltd. | Fused pyridazine compound |
| JP3919835B2 (ja) * | 1994-08-09 | 2007-05-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 縮合ピリダジン系化合物 |
| CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| WO2000059509A1 (en) * | 1999-03-30 | 2000-10-12 | Novartis Ag | Phthalazine derivatives for treating inflammatory diseases |
-
2000
- 2000-08-07 AR ARP000104073A patent/AR025068A1/es unknown
- 2000-08-08 DE DE60010280T patent/DE60010280T2/de not_active Expired - Lifetime
- 2000-08-08 MX MXPA02001324A patent/MXPA02001324A/es active IP Right Grant
- 2000-08-08 AU AU68954/00A patent/AU775237B2/en not_active Ceased
- 2000-08-08 NZ NZ517087A patent/NZ517087A/en unknown
- 2000-08-08 JP JP2001515668A patent/JP2003506447A/ja active Pending
- 2000-08-08 KR KR1020027001797A patent/KR20020019969A/ko not_active Ceased
- 2000-08-08 CA CA002381621A patent/CA2381621A1/en not_active Abandoned
- 2000-08-08 WO PCT/US2000/021579 patent/WO2001010859A1/en not_active Ceased
- 2000-08-08 CN CN00814059A patent/CN1378543A/zh active Pending
- 2000-08-08 EP EP00957317A patent/EP1208096B1/en not_active Expired - Lifetime
- 2000-08-08 AT AT00957317T patent/ATE265448T1/de not_active IP Right Cessation
- 2000-08-08 IL IL14788500A patent/IL147885A0/xx unknown
- 2000-08-08 BR BR0013113-0A patent/BR0013113A/pt not_active IP Right Cessation
- 2000-08-08 PE PE2000000799A patent/PE20010494A1/es not_active Application Discontinuation
- 2000-08-08 CO CO00059237A patent/CO5180637A1/es unknown
- 2000-08-08 ES ES00957317T patent/ES2219382T3/es not_active Expired - Lifetime
-
2002
- 2002-01-25 ZA ZA200200691A patent/ZA200200691B/en unknown
- 2002-02-05 NO NO20020569A patent/NO20020569L/no not_active Application Discontinuation
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