JP2003506325A - Ｇｄｆ−８活性のダウン−レギュレート方法 - Google Patents
Ｇｄｆ−８活性のダウン−レギュレート方法Info
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- JP2003506325A JP2003506325A JP2001511477A JP2001511477A JP2003506325A JP 2003506325 A JP2003506325 A JP 2003506325A JP 2001511477 A JP2001511477 A JP 2001511477A JP 2001511477 A JP2001511477 A JP 2001511477A JP 2003506325 A JP2003506325 A JP 2003506325A
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- A—HUMAN NECESSITIES
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- A61K39/0005—Vertebrate antigens
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
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- A—HUMAN NECESSITIES
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Control Of Eletrric Generators (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK199901014 | 1999-07-20 | ||
| DKPA199901014 | 1999-07-20 | ||
| US14527599P | 1999-07-26 | 1999-07-26 | |
| US60/145,275 | 1999-07-26 | ||
| PCT/DK2000/000413 WO2001005820A2 (en) | 1999-07-20 | 2000-07-20 | Method for down-regulating gdf-8 activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003506325A true JP2003506325A (ja) | 2003-02-18 |
| JP2003506325A5 JP2003506325A5 (https=) | 2007-09-06 |
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| JP2001511477A Pending JP2003506325A (ja) | 1999-07-20 | 2000-07-20 | Ｇｄｆ−８活性のダウン−レギュレート方法 |
Country Status (21)
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| US (2) | US7070784B1 (https=) |
| EP (1) | EP1200119A2 (https=) |
| JP (1) | JP2003506325A (https=) |
| KR (1) | KR100750695B1 (https=) |
| CN (1) | CN1384757A (https=) |
| AU (1) | AU778470B2 (https=) |
| CA (1) | CA2379852A1 (https=) |
| EA (1) | EA005248B1 (https=) |
| EE (1) | EE200200025A (https=) |
| HK (1) | HK1048937A1 (https=) |
| HR (1) | HRP20010900A2 (https=) |
| HU (1) | HUP0201861A3 (https=) |
| IL (1) | IL146845A0 (https=) |
| MX (1) | MXPA01013232A (https=) |
| NO (1) | NO20016252L (https=) |
| NZ (1) | NZ517058A (https=) |
| PL (1) | PL353855A1 (https=) |
| SK (1) | SK722002A3 (https=) |
| TR (2) | TR200400621T2 (https=) |
| WO (1) | WO2001005820A2 (https=) |
| ZA (1) | ZA200109901B (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7393682B1 (en) * | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| US6369201B1 (en) | 1998-02-19 | 2002-04-09 | Metamorphix International, Inc. | Myostatin multimers |
| JP4544742B2 (ja) * | 1998-05-06 | 2010-09-15 | メタモーフイクス・インコーポレーテツド | Ｇｄｆ−８の阻害による糖尿病の処置法 |
| US7037501B2 (en) | 2001-01-04 | 2006-05-02 | Regents Of The University Of Minnesota | Myostatin immnoconjugate |
| TW200526779A (en) | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| WO2004019975A2 (en) * | 2002-08-30 | 2004-03-11 | Glaxo Group Limited | Il-14 vaccine for the treatment of asthma and atopic disorders |
| AR047392A1 (es) * | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
| BR0317538A (pt) * | 2002-12-20 | 2005-11-29 | Amgen Inc | Agente ligante, sequência de polinucleotìdeo, vetor de expressão, célula hospedeira, composição farmacêutica, e, métodos de inibir a atividade de miostatina, de aumentar a massa muscular magra e a razão de massa muscular magra para gordura, de tratar uma doença de emaciação muscular e um distúrbio metabólico relacionado com miostatina em um indivìduo, de detectar e medir miostatina em uma amostra, e, de diagnosticar um distúrbio relacionado com miostatina em um indivìduo |
| RU2322261C2 (ru) | 2003-06-02 | 2008-04-20 | Уайт | Применение ингибиторов миостатика (gdf8) в сочетании с кортикостероидами для лечения нервно-мышечных заболеваний |
| ITMI20071072A1 (it) | 2007-05-25 | 2008-11-26 | Lps Electronics S R L | Apparecchiatura per la rilevazione automatica dello stato di calore di una scrofa. |
| EP1699820A2 (en) * | 2003-12-31 | 2006-09-13 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
| JP4688483B2 (ja) | 2004-04-15 | 2011-05-25 | 株式会社テクノネットワーク四国 | フォリスタチン変異体ポリペプチド |
| EP1799709B1 (en) | 2004-09-30 | 2012-04-04 | ORICO Limited | Myostatin isoform |
| PL2407486T3 (pl) | 2005-08-19 | 2018-05-30 | Wyeth Llc | Przeciwciała antagonistyczne względem GDF-8 i zastosowania w leczeniu ALS i innych zaburzeń związanych z GDF-8 |
| CN100450545C (zh) * | 2006-08-03 | 2009-01-14 | 中国医学科学院基础医学研究所 | 肌肉生长抑制素在制备抗肿瘤药物中的应用 |
| CN101522707B (zh) | 2006-08-03 | 2013-08-28 | 莫约斯汀医疗有限公司 | 肌肉生长抑制素拮抗剂 |
| GB0715087D0 (en) | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
| CA2685540C (en) | 2007-08-03 | 2018-10-16 | Graham Michael Wynne | Drug combinations for the treatment of duchenne muscular dystrophy |
| KR100857861B1 (ko) * | 2007-10-15 | 2008-09-11 | 주식회사 바이오리더스 | Ｍｙｏ－２ 펩타이드 중합체와 마이오스타틴의 융합단백질표면발현용 벡터 및 상기 벡터로 형질전환된 미생물 |
| JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| CN103249835B (zh) * | 2011-07-06 | 2015-05-20 | 湖北省农业科学院畜牧兽医研究所 | 猪肌抑素基因座位及其应用 |
| DK2780368T3 (en) | 2011-11-14 | 2018-02-05 | Regeneron Pharma | COMPOSITIONS AND PROCEDURES FOR INCREASING MUSCLE MASS AND MUSCLE STRENGTH BY SPECIFIC ANTAGONIZATION OF GDF8 AND / OR ACTIVIN A |
| KR101704893B1 (ko) | 2012-06-15 | 2017-02-08 | 화이자 인코포레이티드 | Gdf-8에 대한 개선된 길항물질 항체 및 그의 용도 |
| US9873739B2 (en) | 2012-08-01 | 2018-01-23 | Ikaika Therapeutics, Llc | Mitigating tissue damage and fibrosis via latent transforming growth factor beta binding protein (LTBP4) |
| RS61778B1 (sr) | 2013-05-06 | 2021-06-30 | Scholar Rock Inc | Kompozicije i postupci za modulaciju faktora rasta |
| TW201920262A (zh) | 2013-07-30 | 2019-06-01 | 美商再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| EP2960653A1 (en) * | 2014-06-24 | 2015-12-30 | Stichting Kwaliteitsgarantie Vleeskalversector | Diagnostic kit and method for the identification of the manipulation of muscle mass in a domestic animal |
| KR20170135967A (ko) | 2015-04-15 | 2017-12-08 | 리제너론 파마슈티칼스 인코포레이티드 | Gdf8 억제제를 사용하여 강도 및 기능을 증가시키는 방법 |
| MX2020008991A (es) | 2018-03-01 | 2020-12-10 | Regeneron Pharma | Metodos para alterar la composicion corporal. |
| WO2020132647A1 (en) | 2018-12-21 | 2020-06-25 | Northwestern University | Use of annexins in preventing and treating muscle membrane injury |
| WO2020139977A1 (en) | 2018-12-26 | 2020-07-02 | Northwestern University | Use of glucocorticoid steroids in preventing and treating conditions of muscle wasting, aging and metabolic disorder |
| US20240366760A1 (en) * | 2023-01-17 | 2024-11-07 | Regen BioPharma, Inc. | Activation of survivin-specific immune responses using dendritic cell derived exosomes |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO1999002667A1 (en) * | 1997-07-14 | 1999-01-21 | University Of Liege | Mutations in the myostation gene cause double-muscling in mammals |
| WO1999031262A2 (en) * | 1997-12-16 | 1999-06-24 | Valentis, Inc. | Needle-free injection of formulated nucleic acid molecules |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6607884B1 (en) * | 1993-03-19 | 2003-08-19 | The Johns Hopkins University School Of Medicine | Methods of detecting growth differentiation factor-8 |
| DK96493D0 (da) * | 1993-08-26 | 1993-08-26 | Mouritsen Og Elsner Aps | Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden |
| DE69435171D1 (de) | 1993-09-14 | 2009-01-08 | Pharmexa Inc | Pan dr-bindeproteinen zur erhöhung der immunantwort |
| AUPO390396A0 (en) | 1996-11-29 | 1996-12-19 | Csl Limited | Novel promiscuous T helper cell epitopes |
| CN1178955C (zh) | 1997-04-15 | 2004-12-08 | 法默卡有限公司 | 经修饰的TNFα分子和编码该TNFα分子的DNA以及含有该TNFα分子和该DNA的疫苗 |
| GB2333706A (en) * | 1998-02-02 | 1999-08-04 | Merck & Co Inc | Method for increasing muscle mass in animals |
| US6369201B1 (en) * | 1998-02-19 | 2002-04-09 | Metamorphix International, Inc. | Myostatin multimers |
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2000
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- 2000-07-20 US US09/620,586 patent/US7056512B1/en not_active Expired - Fee Related
- 2000-07-20 HR HR20010900A patent/HRP20010900A2/hr not_active Application Discontinuation
- 2000-07-20 CA CA002379852A patent/CA2379852A1/en not_active Abandoned
- 2000-07-20 HU HU0201861A patent/HUP0201861A3/hu unknown
-
2001
- 2001-11-30 ZA ZA200109901A patent/ZA200109901B/xx unknown
- 2001-12-19 NO NO20016252A patent/NO20016252L/no not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999002667A1 (en) * | 1997-07-14 | 1999-01-21 | University Of Liege | Mutations in the myostation gene cause double-muscling in mammals |
| WO1999031262A2 (en) * | 1997-12-16 | 1999-06-24 | Valentis, Inc. | Needle-free injection of formulated nucleic acid molecules |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20020026544A (ko) | 2002-04-10 |
| TR200400621T2 (tr) | 2004-08-23 |
| ZA200109901B (en) | 2003-05-28 |
| KR100750695B1 (ko) | 2007-08-22 |
| TR200200133T2 (tr) | 2002-05-21 |
| WO2001005820A3 (en) | 2001-07-19 |
| EP1200119A2 (en) | 2002-05-02 |
| EE200200025A (et) | 2003-04-15 |
| MXPA01013232A (es) | 2005-05-24 |
| HK1048937A1 (zh) | 2003-04-25 |
| NO20016252D0 (no) | 2001-12-19 |
| IL146845A0 (en) | 2002-07-25 |
| EA200200182A1 (ru) | 2002-06-27 |
| NZ517058A (en) | 2004-04-30 |
| AU5967500A (en) | 2001-02-05 |
| WO2001005820A2 (en) | 2001-01-25 |
| CN1384757A (zh) | 2002-12-11 |
| PL353855A1 (en) | 2003-12-01 |
| HRP20010900A2 (en) | 2003-08-31 |
| HUP0201861A3 (en) | 2004-07-28 |
| US7056512B1 (en) | 2006-06-06 |
| US7070784B1 (en) | 2006-07-04 |
| EA005248B1 (ru) | 2004-12-30 |
| CA2379852A1 (en) | 2001-01-25 |
| AU778470B2 (en) | 2004-12-09 |
| SK722002A3 (en) | 2003-02-04 |
| NO20016252L (no) | 2002-03-15 |
| HUP0201861A2 (en) | 2002-09-28 |
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