JP2003503333A - 局所用抗菌組成物 - Google Patents
局所用抗菌組成物Info
- Publication number
- JP2003503333A JP2003503333A JP2001505864A JP2001505864A JP2003503333A JP 2003503333 A JP2003503333 A JP 2003503333A JP 2001505864 A JP2001505864 A JP 2001505864A JP 2001505864 A JP2001505864 A JP 2001505864A JP 2003503333 A JP2003503333 A JP 2003503333A
- Authority
- JP
- Japan
- Prior art keywords
- zinc
- composition
- pyrithione
- copper
- antimicrobial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 334
- 230000000845 anti-microbial effect Effects 0.000 title claims description 127
- 230000000699 topical effect Effects 0.000 title claims description 31
- 150000003839 salts Chemical class 0.000 claims abstract description 46
- 238000000034 method Methods 0.000 claims abstract description 42
- 229910052751 metal Inorganic materials 0.000 claims abstract description 36
- 239000002184 metal Substances 0.000 claims abstract description 36
- 229960002026 pyrithione Drugs 0.000 claims abstract description 33
- 229910021645 metal ion Inorganic materials 0.000 claims abstract description 32
- FGVVTMRZYROCTH-UHFFFAOYSA-N pyridine-2-thiol N-oxide Chemical compound [O-][N+]1=CC=CC=C1S FGVVTMRZYROCTH-UHFFFAOYSA-N 0.000 claims abstract description 30
- 210000004761 scalp Anatomy 0.000 claims abstract description 13
- 230000000813 microbial effect Effects 0.000 claims abstract description 7
- 208000015181 infectious disease Diseases 0.000 claims abstract description 5
- -1 pyrithione ions Chemical class 0.000 claims description 161
- 239000002453 shampoo Substances 0.000 claims description 54
- 239000004094 surface-active agent Substances 0.000 claims description 54
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
- 229910001868 water Inorganic materials 0.000 claims description 32
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 claims description 25
- 230000000844 anti-bacterial effect Effects 0.000 claims description 24
- 125000000129 anionic group Chemical group 0.000 claims description 23
- 229940043810 zinc pyrithione Drugs 0.000 claims description 23
- 239000013543 active substance Substances 0.000 claims description 18
- 230000012010 growth Effects 0.000 claims description 14
- 208000001840 Dandruff Diseases 0.000 claims description 10
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 10
- 244000005700 microbiome Species 0.000 claims description 10
- 150000003751 zinc Chemical class 0.000 claims description 10
- 239000002738 chelating agent Substances 0.000 claims description 9
- 150000001879 copper Chemical class 0.000 claims description 8
- 239000010949 copper Substances 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 8
- 229910052802 copper Inorganic materials 0.000 claims description 7
- 229960005265 selenium sulfide Drugs 0.000 claims description 7
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 6
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 6
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 6
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 6
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 5
- 239000011787 zinc oxide Substances 0.000 claims description 5
- 229960001763 zinc sulfate Drugs 0.000 claims description 5
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 5
- JJLJMEJHUUYSSY-UHFFFAOYSA-L Copper hydroxide Chemical compound [OH-].[OH-].[Cu+2] JJLJMEJHUUYSSY-UHFFFAOYSA-L 0.000 claims description 4
- 150000003378 silver Chemical class 0.000 claims description 4
- BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 claims description 4
- UAYWVJHJZHQCIE-UHFFFAOYSA-L zinc iodide Chemical compound I[Zn]I UAYWVJHJZHQCIE-UHFFFAOYSA-L 0.000 claims description 4
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims description 3
- 150000001621 bismuth Chemical class 0.000 claims description 3
- 150000001661 cadmium Chemical class 0.000 claims description 3
- 239000011280 coal tar Substances 0.000 claims description 3
- BERDEBHAJNAUOM-UHFFFAOYSA-N copper(I) oxide Inorganic materials [Cu]O[Cu] BERDEBHAJNAUOM-UHFFFAOYSA-N 0.000 claims description 3
- 239000003581 cosmetic carrier Substances 0.000 claims description 3
- KRFJLUBVMFXRPN-UHFFFAOYSA-N cuprous oxide Chemical compound [O-2].[Cu+].[Cu+] KRFJLUBVMFXRPN-UHFFFAOYSA-N 0.000 claims description 3
- 229940112669 cuprous oxide Drugs 0.000 claims description 3
- 229960004130 itraconazole Drugs 0.000 claims description 3
- 150000002730 mercury Chemical class 0.000 claims description 3
- 150000002815 nickel Chemical class 0.000 claims description 3
- 239000011592 zinc chloride Substances 0.000 claims description 3
- 235000005074 zinc chloride Nutrition 0.000 claims description 3
- HSXKMKJYFOZAIV-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;copper Chemical compound [Cu].OCCN(CCO)CCO HSXKMKJYFOZAIV-UHFFFAOYSA-N 0.000 claims description 2
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims description 2
- 239000005752 Copper oxychloride Substances 0.000 claims description 2
- 206010013786 Dry skin Diseases 0.000 claims description 2
- 206010017533 Fungal infection Diseases 0.000 claims description 2
- 208000031888 Mycoses Diseases 0.000 claims description 2
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 2
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 2
- 239000004110 Zinc silicate Substances 0.000 claims description 2
- 239000005083 Zinc sulfide Substances 0.000 claims description 2
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 2
- 239000001099 ammonium carbonate Substances 0.000 claims description 2
- 235000012501 ammonium carbonate Nutrition 0.000 claims description 2
- HKMOPYJWSFRURD-UHFFFAOYSA-N chloro hypochlorite;copper Chemical compound [Cu].ClOCl HKMOPYJWSFRURD-UHFFFAOYSA-N 0.000 claims description 2
- 229940116318 copper carbonate Drugs 0.000 claims description 2
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 2
- GEZOTWYUIKXWOA-UHFFFAOYSA-L copper;carbonate Chemical compound [Cu+2].[O-]C([O-])=O GEZOTWYUIKXWOA-UHFFFAOYSA-L 0.000 claims description 2
- BQVVSSAWECGTRN-UHFFFAOYSA-L copper;dithiocyanate Chemical compound [Cu+2].[S-]C#N.[S-]C#N BQVVSSAWECGTRN-UHFFFAOYSA-L 0.000 claims description 2
- AQEDFGUKQJUMBV-UHFFFAOYSA-N copper;ethane-1,2-diamine Chemical compound [Cu].NCCN AQEDFGUKQJUMBV-UHFFFAOYSA-N 0.000 claims description 2
- 229960003280 cupric chloride Drugs 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- MFGZXPGKKJMZIY-UHFFFAOYSA-N ethyl 5-amino-1-(4-sulfamoylphenyl)pyrazole-4-carboxylate Chemical compound NC1=C(C(=O)OCC)C=NN1C1=CC=C(S(N)(=O)=O)C=C1 MFGZXPGKKJMZIY-UHFFFAOYSA-N 0.000 claims description 2
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000454 talc Substances 0.000 claims description 2
- 229910052623 talc Inorganic materials 0.000 claims description 2
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 claims description 2
- 201000004647 tinea pedis Diseases 0.000 claims description 2
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 2
- MJIBOYFUEIDNPI-HBNMXAOGSA-L zinc 5-[2,3-dihydroxy-5-[(2R,3R,4S,5R,6S)-4,5,6-tris[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]-2-[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxymethyl]oxan-3-yl]oxycarbonylphenoxy]carbonyl-3-hydroxybenzene-1,2-diolate Chemical compound [Zn++].Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c([O-])c([O-])c2)c1 MJIBOYFUEIDNPI-HBNMXAOGSA-L 0.000 claims description 2
- 239000004246 zinc acetate Substances 0.000 claims description 2
- 239000011667 zinc carbonate Substances 0.000 claims description 2
- 235000004416 zinc carbonate Nutrition 0.000 claims description 2
- 229910000010 zinc carbonate Inorganic materials 0.000 claims description 2
- 239000011746 zinc citrate Substances 0.000 claims description 2
- 235000006076 zinc citrate Nutrition 0.000 claims description 2
- 229940068475 zinc citrate Drugs 0.000 claims description 2
- 239000011576 zinc lactate Substances 0.000 claims description 2
- 235000000193 zinc lactate Nutrition 0.000 claims description 2
- 229940050168 zinc lactate Drugs 0.000 claims description 2
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 claims description 2
- 229910000165 zinc phosphate Inorganic materials 0.000 claims description 2
- XSMMCTCMFDWXIX-UHFFFAOYSA-N zinc silicate Chemical compound [Zn+2].[O-][Si]([O-])=O XSMMCTCMFDWXIX-UHFFFAOYSA-N 0.000 claims description 2
- 235000019352 zinc silicate Nutrition 0.000 claims description 2
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 2
- 229910052984 zinc sulfide Inorganic materials 0.000 claims description 2
- 229940006174 zinc valerate Drugs 0.000 claims description 2
- VRGNUPCISFMPEM-ZVGUSBNCSA-L zinc;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VRGNUPCISFMPEM-ZVGUSBNCSA-L 0.000 claims description 2
- LPEBYPDZMWMCLZ-CVBJKYQLSA-L zinc;(z)-octadec-9-enoate Chemical compound [Zn+2].CCCCCCCC\C=C/CCCCCCCC([O-])=O.CCCCCCCC\C=C/CCCCCCCC([O-])=O LPEBYPDZMWMCLZ-CVBJKYQLSA-L 0.000 claims description 2
- ZPEJZWGMHAKWNL-UHFFFAOYSA-L zinc;oxalate Chemical compound [Zn+2].[O-]C(=O)C([O-])=O ZPEJZWGMHAKWNL-UHFFFAOYSA-L 0.000 claims description 2
- BUDAIZWUWHWZPQ-UHFFFAOYSA-L zinc;pentanoate Chemical compound [Zn+2].CCCCC([O-])=O.CCCCC([O-])=O BUDAIZWUWHWZPQ-UHFFFAOYSA-L 0.000 claims description 2
- XDWXRAYGALQIFG-UHFFFAOYSA-L zinc;propanoate Chemical compound [Zn+2].CCC([O-])=O.CCC([O-])=O XDWXRAYGALQIFG-UHFFFAOYSA-L 0.000 claims description 2
- GQLBMRKEAODAKR-UHFFFAOYSA-L zinc;selenate Chemical compound [Zn+2].[O-][Se]([O-])(=O)=O GQLBMRKEAODAKR-UHFFFAOYSA-L 0.000 claims description 2
- DRDVZXDWVBGGMH-UHFFFAOYSA-N zinc;sulfide Chemical compound [S-2].[Zn+2] DRDVZXDWVBGGMH-UHFFFAOYSA-N 0.000 claims description 2
- OBOMINCSAYZPGH-UHFFFAOYSA-L zinc;undecanoate Chemical compound [Zn+2].CCCCCCCCCCC([O-])=O.CCCCCCCCCCC([O-])=O OBOMINCSAYZPGH-UHFFFAOYSA-L 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims 1
- TZZBZCDKSFGCPV-UHFFFAOYSA-K copper;disodium;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Na+].[Na+].[Cu+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O TZZBZCDKSFGCPV-UHFFFAOYSA-K 0.000 claims 1
- 230000003648 hair appearance Effects 0.000 claims 1
- VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 229960001939 zinc chloride Drugs 0.000 claims 1
- 239000011670 zinc gluconate Substances 0.000 claims 1
- 235000011478 zinc gluconate Nutrition 0.000 claims 1
- 229960000306 zinc gluconate Drugs 0.000 claims 1
- 229960001296 zinc oxide Drugs 0.000 claims 1
- 239000011686 zinc sulphate Substances 0.000 claims 1
- 235000009529 zinc sulphate Nutrition 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 description 120
- 229920000642 polymer Polymers 0.000 description 98
- 239000000178 monomer Substances 0.000 description 89
- 125000000217 alkyl group Chemical group 0.000 description 63
- 239000000126 substance Substances 0.000 description 56
- 125000004432 carbon atom Chemical group C* 0.000 description 50
- 239000003795 chemical substances by application Substances 0.000 description 47
- 230000003750 conditioning effect Effects 0.000 description 42
- 125000002091 cationic group Chemical group 0.000 description 30
- 235000014113 dietary fatty acids Nutrition 0.000 description 29
- 239000000194 fatty acid Substances 0.000 description 29
- 229930195729 fatty acid Natural products 0.000 description 29
- 229920006317 cationic polymer Polymers 0.000 description 28
- 229920001577 copolymer Polymers 0.000 description 28
- 239000012530 fluid Substances 0.000 description 26
- 229930195733 hydrocarbon Natural products 0.000 description 26
- 150000002430 hydrocarbons Chemical class 0.000 description 26
- 239000000047 product Substances 0.000 description 25
- 239000004615 ingredient Substances 0.000 description 24
- 239000007788 liquid Substances 0.000 description 23
- 125000003118 aryl group Chemical group 0.000 description 22
- 150000002148 esters Chemical class 0.000 description 22
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 20
- 239000003921 oil Substances 0.000 description 19
- 235000019198 oils Nutrition 0.000 description 19
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical class [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 18
- 125000001931 aliphatic group Chemical group 0.000 description 18
- 239000000463 material Substances 0.000 description 18
- 229920006395 saturated elastomer Polymers 0.000 description 18
- 239000004215 Carbon black (E152) Substances 0.000 description 17
- 150000001875 compounds Chemical class 0.000 description 17
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 17
- 125000003342 alkenyl group Chemical group 0.000 description 16
- 230000002209 hydrophobic effect Effects 0.000 description 16
- 229920002050 silicone resin Polymers 0.000 description 16
- 239000000375 suspending agent Substances 0.000 description 16
- 238000012360 testing method Methods 0.000 description 16
- 229910052739 hydrogen Inorganic materials 0.000 description 15
- 239000001257 hydrogen Substances 0.000 description 15
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 14
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 14
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 14
- 125000001453 quaternary ammonium group Chemical group 0.000 description 14
- 239000000243 solution Substances 0.000 description 14
- 125000001424 substituent group Chemical group 0.000 description 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 13
- 239000004599 antimicrobial Substances 0.000 description 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 13
- 229920001817 Agar Polymers 0.000 description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- 239000002253 acid Substances 0.000 description 12
- 239000008272 agar Substances 0.000 description 12
- 125000002877 alkyl aryl group Chemical group 0.000 description 12
- 150000001412 amines Chemical class 0.000 description 12
- 239000000969 carrier Substances 0.000 description 12
- 239000004205 dimethyl polysiloxane Substances 0.000 description 12
- 239000002245 particle Substances 0.000 description 12
- 229920005989 resin Polymers 0.000 description 12
- 239000011347 resin Substances 0.000 description 12
- 239000002904 solvent Substances 0.000 description 12
- 230000007480 spreading Effects 0.000 description 12
- 238000003892 spreading Methods 0.000 description 12
- 229920002554 vinyl polymer Polymers 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
- 125000001183 hydrocarbyl group Chemical group 0.000 description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 11
- 239000000843 powder Substances 0.000 description 11
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical class C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 11
- QLAJNZSPVITUCQ-UHFFFAOYSA-N 1,3,2-dioxathietane 2,2-dioxide Chemical compound O=S1(=O)OCO1 QLAJNZSPVITUCQ-UHFFFAOYSA-N 0.000 description 10
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 10
- 125000003545 alkoxy group Chemical group 0.000 description 10
- 150000004665 fatty acids Chemical class 0.000 description 10
- 230000000670 limiting effect Effects 0.000 description 10
- 229920001451 polypropylene glycol Polymers 0.000 description 10
- 239000011734 sodium Substances 0.000 description 10
- 239000000725 suspension Substances 0.000 description 10
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 10
- 229920000289 Polyquaternium Polymers 0.000 description 9
- 239000003242 anti bacterial agent Substances 0.000 description 9
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 9
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 9
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 8
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 8
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 8
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 8
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 8
- 150000001298 alcohols Chemical class 0.000 description 8
- 230000000843 anti-fungal effect Effects 0.000 description 8
- 229940121375 antifungal agent Drugs 0.000 description 8
- 230000008901 benefit Effects 0.000 description 8
- 239000001913 cellulose Substances 0.000 description 8
- 229920002678 cellulose Polymers 0.000 description 8
- 229920000578 graft copolymer Polymers 0.000 description 8
- 229920001519 homopolymer Polymers 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 8
- 229910052708 sodium Inorganic materials 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 239000003760 tallow Substances 0.000 description 8
- SJMYWORNLPSJQO-UHFFFAOYSA-N tert-butyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC(C)(C)C SJMYWORNLPSJQO-UHFFFAOYSA-N 0.000 description 8
- 239000011701 zinc Substances 0.000 description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 7
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 7
- 239000003945 anionic surfactant Substances 0.000 description 7
- 150000001735 carboxylic acids Chemical class 0.000 description 7
- 239000002537 cosmetic Substances 0.000 description 7
- 239000003599 detergent Substances 0.000 description 7
- 238000010790 dilution Methods 0.000 description 7
- 239000012895 dilution Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 229910052736 halogen Inorganic materials 0.000 description 7
- 150000002431 hydrogen Chemical group 0.000 description 7
- 230000002401 inhibitory effect Effects 0.000 description 7
- 229910052700 potassium Inorganic materials 0.000 description 7
- 239000003381 stabilizer Substances 0.000 description 7
- 239000002562 thickening agent Substances 0.000 description 7
- 239000004034 viscosity adjusting agent Substances 0.000 description 7
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K33/244—Lanthanides; Compounds thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14119599P | 1999-06-25 | 1999-06-25 | |
| US60/141,195 | 1999-06-25 | ||
| US09/599,624 US7026308B1 (en) | 1999-06-25 | 2000-06-22 | Topical anti-microbial compositions |
| US09/599,624 | 2000-06-22 | ||
| PCT/US2000/017273 WO2001000151A1 (en) | 1999-06-25 | 2000-06-23 | Topical anti-microbial compositions |
Related Child Applications (1)
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| JP2007207218A Division JP5450942B2 (ja) | 1999-06-25 | 2007-08-08 | 局所用抗菌組成物 |
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| JP2003503333A true JP2003503333A (ja) | 2003-01-28 |
| JP2003503333A5 JP2003503333A5 (enExample) | 2007-03-15 |
Family
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| JP2001505864A Pending JP2003503333A (ja) | 1999-06-25 | 2000-06-23 | 局所用抗菌組成物 |
| JP2007207218A Expired - Lifetime JP5450942B2 (ja) | 1999-06-25 | 2007-08-08 | 局所用抗菌組成物 |
Family Applications After (1)
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| JP2007207218A Expired - Lifetime JP5450942B2 (ja) | 1999-06-25 | 2007-08-08 | 局所用抗菌組成物 |
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| EP (2) | EP1189581B2 (enExample) |
| JP (2) | JP2003503333A (enExample) |
| KR (1) | KR100870257B1 (enExample) |
| CN (1) | CN100544704C (enExample) |
| AT (1) | ATE424181T1 (enExample) |
| AU (1) | AU5884600A (enExample) |
| BR (1) | BR0011852A (enExample) |
| CA (2) | CA2376803C (enExample) |
| DE (1) | DE60041699D1 (enExample) |
| ES (2) | ES2322688T5 (enExample) |
| HK (1) | HK1044489B (enExample) |
| MX (1) | MXPA02000295A (enExample) |
| WO (1) | WO2001000151A1 (enExample) |
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- 2000-06-23 CN CNB008117241A patent/CN100544704C/zh not_active Expired - Lifetime
- 2000-06-23 JP JP2001505864A patent/JP2003503333A/ja active Pending
- 2000-06-23 ES ES00944806.9T patent/ES2322688T5/es not_active Expired - Lifetime
- 2000-06-23 EP EP00944806.9A patent/EP1189581B2/en not_active Expired - Lifetime
- 2000-06-23 EP EP09153242.4A patent/EP2082723B1/en not_active Expired - Lifetime
- 2000-06-23 AT AT00944806T patent/ATE424181T1/de not_active IP Right Cessation
- 2000-06-23 DE DE60041699T patent/DE60041699D1/de not_active Expired - Lifetime
- 2000-06-23 AU AU58846/00A patent/AU5884600A/en not_active Abandoned
- 2000-06-23 MX MXPA02000295A patent/MXPA02000295A/es active IP Right Grant
- 2000-06-23 ES ES09153242.4T patent/ES2599027T3/es not_active Expired - Lifetime
- 2000-06-23 WO PCT/US2000/017273 patent/WO2001000151A1/en not_active Ceased
- 2000-06-23 CA CA002376803A patent/CA2376803C/en not_active Expired - Lifetime
- 2000-06-23 HK HK02106257.3A patent/HK1044489B/en not_active IP Right Cessation
- 2000-06-23 CA CA2632542A patent/CA2632542C/en not_active Expired - Lifetime
- 2000-06-23 BR BR0011852-4A patent/BR0011852A/pt not_active Application Discontinuation
- 2000-06-23 KR KR1020017016617A patent/KR100870257B1/ko not_active Expired - Fee Related
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- 2007-08-08 JP JP2007207218A patent/JP5450942B2/ja not_active Expired - Lifetime
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Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002338480A (ja) * | 2001-05-17 | 2002-11-27 | Sensho Go | 抗螺旋菌剤丸薬の製法 |
| JP2003201218A (ja) * | 2001-12-28 | 2003-07-18 | Kao Corp | 毛髪化粧料 |
| JP2004075546A (ja) * | 2002-08-09 | 2004-03-11 | Kao Corp | シャンプー組成物 |
| JP2006515330A (ja) * | 2003-03-18 | 2006-05-25 | ザ プロクター アンド ギャンブル カンパニー | 規定の結晶子径を有する粒子状亜鉛物質を含む組成物 |
| JP2005232014A (ja) * | 2004-02-17 | 2005-09-02 | Mandom Corp | 防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品 |
| JP2008531472A (ja) * | 2005-01-07 | 2008-08-14 | ザ トラスティース オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 亜鉛塩含有非刺激性組成物 |
| JP2008528591A (ja) * | 2005-01-28 | 2008-07-31 | ザ プロクター アンド ギャンブル カンパニー | 液体溶媒中に抗ふけ活性物質と共に存在する分散粒子としてのジヨードメチル−ｐ−トリルスルホン |
| JP2008528595A (ja) * | 2005-01-28 | 2008-07-31 | ザ プロクター アンド ギャンブル カンパニー | 液体溶媒中における分散粒子としてのジヨードメチル−ｐ−トリルスルホン |
| JP2007131594A (ja) * | 2005-11-11 | 2007-05-31 | Adeka Corp | 抗菌性組成物ならびにこれを含有する化粧料および洗浄剤 |
| JP2009154061A (ja) * | 2007-12-25 | 2009-07-16 | Asaka Riken:Kk | 抗菌性を向上させた光触媒溶液 |
| JP2013542944A (ja) * | 2010-10-28 | 2013-11-28 | ザ プロクター アンド ギャンブル カンパニー | ピリチオン及び鉄キレート化剤を含むパーソナルケア組成物 |
| JP2012131773A (ja) * | 2010-12-22 | 2012-07-12 | Dow Global Technologies Llc | グリホサート化合物とｚｐｔとの相乗的組み合わせ |
| JP2018515443A (ja) * | 2015-05-11 | 2018-06-14 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 身体洗浄組成物 |
| US10646414B2 (en) | 2015-05-11 | 2020-05-12 | Conopco, Inc. | Personal cleansing composition |
| JP2018150266A (ja) * | 2017-03-13 | 2018-09-27 | 日本メナード化粧品株式会社 | ニキビ予防及び／又は改善用皮膚外用剤 |
| JP2020511430A (ja) * | 2017-03-23 | 2020-04-16 | ユニリーバー・ナームローゼ・ベンノートシヤープ | ヘアケア組成物 |
| JP7159181B2 (ja) | 2017-03-23 | 2022-10-24 | ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ | ヘアケア組成物 |
| US11510854B2 (en) | 2017-03-23 | 2022-11-29 | Conopco, Inc. | Hair care composition |
| JP2020533307A (ja) * | 2017-09-11 | 2020-11-19 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 抗菌組成物 |
| JP7187544B2 (ja) | 2017-09-11 | 2022-12-12 | ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ | 抗菌組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02000295A (es) | 2004-05-21 |
| DE60041699D1 (de) | 2009-04-16 |
| EP1189581B1 (en) | 2009-03-04 |
| HK1044489A1 (en) | 2002-10-25 |
| BR0011852A (pt) | 2002-04-30 |
| CN1414846A (zh) | 2003-04-30 |
| CA2632542A1 (en) | 2001-01-04 |
| ES2322688T3 (es) | 2009-06-25 |
| EP1189581A1 (en) | 2002-03-27 |
| JP2007284459A (ja) | 2007-11-01 |
| KR100870257B1 (ko) | 2008-11-25 |
| CA2376803C (en) | 2008-08-19 |
| CN100544704C (zh) | 2009-09-30 |
| AU5884600A (en) | 2001-01-31 |
| EP2082723B1 (en) | 2016-07-20 |
| KR20020057808A (ko) | 2002-07-12 |
| JP5450942B2 (ja) | 2014-03-26 |
| CA2632542C (en) | 2012-03-27 |
| CA2376803A1 (en) | 2001-01-04 |
| EP1189581B2 (en) | 2017-09-27 |
| HK1044489B (en) | 2009-09-04 |
| WO2001000151A1 (en) | 2001-01-04 |
| ES2322688T5 (es) | 2018-02-12 |
| ATE424181T1 (de) | 2009-03-15 |
| ES2599027T3 (es) | 2017-01-31 |
| EP2082723A1 (en) | 2009-07-29 |
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