ES2322688T5 - Composiciones tópicas antimicrobianas - Google Patents
Composiciones tópicas antimicrobianas Download PDFInfo
- Publication number
- ES2322688T5 ES2322688T5 ES00944806.9T ES00944806T ES2322688T5 ES 2322688 T5 ES2322688 T5 ES 2322688T5 ES 00944806 T ES00944806 T ES 00944806T ES 2322688 T5 ES2322688 T5 ES 2322688T5
- Authority
- ES
- Spain
- Prior art keywords
- zinc
- composition
- antimicrobial
- hair
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 324
- 230000000699 topical effect Effects 0.000 title claims abstract description 33
- 230000000845 anti-microbial effect Effects 0.000 title claims description 150
- 150000003839 salts Chemical class 0.000 claims abstract description 49
- 229910052751 metal Inorganic materials 0.000 claims abstract description 37
- 239000002184 metal Substances 0.000 claims abstract description 37
- 238000000034 method Methods 0.000 claims abstract description 37
- FGVVTMRZYROCTH-UHFFFAOYSA-N pyridine-2-thiol N-oxide Chemical compound [O-][N+]1=CC=CC=C1S FGVVTMRZYROCTH-UHFFFAOYSA-N 0.000 claims abstract description 37
- 229960002026 pyrithione Drugs 0.000 claims abstract description 35
- 229910021645 metal ion Inorganic materials 0.000 claims abstract description 32
- 210000004761 scalp Anatomy 0.000 claims abstract description 14
- 208000015181 infectious disease Diseases 0.000 claims abstract description 6
- 230000000813 microbial effect Effects 0.000 claims abstract description 5
- 238000011282 treatment Methods 0.000 claims abstract description 5
- -1 pyrithione ion Chemical class 0.000 claims description 157
- 239000004094 surface-active agent Substances 0.000 claims description 54
- 239000002453 shampoo Substances 0.000 claims description 51
- 239000013543 active substance Substances 0.000 claims description 42
- 208000001840 Dandruff Diseases 0.000 claims description 35
- 239000004599 antimicrobial Substances 0.000 claims description 23
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 claims description 23
- 229940043810 zinc pyrithione Drugs 0.000 claims description 21
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 16
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 16
- 230000012010 growth Effects 0.000 claims description 13
- 229910052725 zinc Inorganic materials 0.000 claims description 13
- 239000011701 zinc Substances 0.000 claims description 13
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 12
- 229960001763 zinc sulfate Drugs 0.000 claims description 12
- 239000002738 chelating agent Substances 0.000 claims description 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 9
- VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 claims description 9
- 229960005265 selenium sulfide Drugs 0.000 claims description 9
- 150000003751 zinc Chemical class 0.000 claims description 9
- 150000001879 copper Chemical class 0.000 claims description 8
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 8
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims description 6
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 6
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims description 5
- 150000004985 diamines Chemical class 0.000 claims description 5
- 229960004125 ketoconazole Drugs 0.000 claims description 5
- 229920000768 polyamine Polymers 0.000 claims description 5
- 150000003378 silver Chemical class 0.000 claims description 5
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 4
- BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 claims description 4
- UAYWVJHJZHQCIE-UHFFFAOYSA-L zinc iodide Chemical compound I[Zn]I UAYWVJHJZHQCIE-UHFFFAOYSA-L 0.000 claims description 4
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims description 3
- JJLJMEJHUUYSSY-UHFFFAOYSA-L Copper hydroxide Chemical compound [OH-].[OH-].[Cu+2] JJLJMEJHUUYSSY-UHFFFAOYSA-L 0.000 claims description 3
- 239000005752 Copper oxychloride Substances 0.000 claims description 3
- HKMOPYJWSFRURD-UHFFFAOYSA-N chloro hypochlorite;copper Chemical compound [Cu].ClOCl HKMOPYJWSFRURD-UHFFFAOYSA-N 0.000 claims description 3
- 229960004130 itraconazole Drugs 0.000 claims description 3
- 239000011592 zinc chloride Substances 0.000 claims description 3
- 235000005074 zinc chloride Nutrition 0.000 claims description 3
- XDWXRAYGALQIFG-UHFFFAOYSA-L zinc;propanoate Chemical compound [Zn+2].CCC([O-])=O.CCC([O-])=O XDWXRAYGALQIFG-UHFFFAOYSA-L 0.000 claims description 3
- HSXKMKJYFOZAIV-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;copper Chemical compound [Cu].OCCN(CCO)CCO HSXKMKJYFOZAIV-UHFFFAOYSA-N 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 2
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 2
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 2
- 239000004110 Zinc silicate Substances 0.000 claims description 2
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 2
- 150000001661 cadmium Chemical class 0.000 claims description 2
- 239000011280 coal tar Substances 0.000 claims description 2
- BERDEBHAJNAUOM-UHFFFAOYSA-N copper(I) oxide Inorganic materials [Cu]O[Cu] BERDEBHAJNAUOM-UHFFFAOYSA-N 0.000 claims description 2
- GEZOTWYUIKXWOA-UHFFFAOYSA-L copper;carbonate Chemical compound [Cu+2].[O-]C([O-])=O GEZOTWYUIKXWOA-UHFFFAOYSA-L 0.000 claims description 2
- TZZBZCDKSFGCPV-UHFFFAOYSA-K copper;disodium;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Na+].[Na+].[Cu+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O TZZBZCDKSFGCPV-UHFFFAOYSA-K 0.000 claims description 2
- BQVVSSAWECGTRN-UHFFFAOYSA-L copper;dithiocyanate Chemical compound [Cu+2].[S-]C#N.[S-]C#N BQVVSSAWECGTRN-UHFFFAOYSA-L 0.000 claims description 2
- AQEDFGUKQJUMBV-UHFFFAOYSA-N copper;ethane-1,2-diamine Chemical compound [Cu].NCCN AQEDFGUKQJUMBV-UHFFFAOYSA-N 0.000 claims description 2
- 229960003280 cupric chloride Drugs 0.000 claims description 2
- KRFJLUBVMFXRPN-UHFFFAOYSA-N cuprous oxide Chemical compound [O-2].[Cu+].[Cu+] KRFJLUBVMFXRPN-UHFFFAOYSA-N 0.000 claims description 2
- 229940112669 cuprous oxide Drugs 0.000 claims description 2
- 150000002730 mercury Chemical class 0.000 claims description 2
- 150000002815 nickel Chemical class 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 2
- 239000004246 zinc acetate Substances 0.000 claims description 2
- 239000011667 zinc carbonate Substances 0.000 claims description 2
- 235000004416 zinc carbonate Nutrition 0.000 claims description 2
- 229910000010 zinc carbonate Inorganic materials 0.000 claims description 2
- 229940043825 zinc carbonate Drugs 0.000 claims description 2
- 239000011746 zinc citrate Substances 0.000 claims description 2
- 235000006076 zinc citrate Nutrition 0.000 claims description 2
- 229940068475 zinc citrate Drugs 0.000 claims description 2
- 239000011670 zinc gluconate Substances 0.000 claims description 2
- 235000011478 zinc gluconate Nutrition 0.000 claims description 2
- 229960000306 zinc gluconate Drugs 0.000 claims description 2
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 claims description 2
- 229910021511 zinc hydroxide Inorganic materials 0.000 claims description 2
- 229940007718 zinc hydroxide Drugs 0.000 claims description 2
- 239000011576 zinc lactate Substances 0.000 claims description 2
- 235000000193 zinc lactate Nutrition 0.000 claims description 2
- 229940050168 zinc lactate Drugs 0.000 claims description 2
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 claims description 2
- XSMMCTCMFDWXIX-UHFFFAOYSA-N zinc silicate Chemical compound [Zn+2].[O-][Si]([O-])=O XSMMCTCMFDWXIX-UHFFFAOYSA-N 0.000 claims description 2
- 235000019352 zinc silicate Nutrition 0.000 claims description 2
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 2
- 229940006174 zinc valerate Drugs 0.000 claims description 2
- VRGNUPCISFMPEM-ZVGUSBNCSA-L zinc;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VRGNUPCISFMPEM-ZVGUSBNCSA-L 0.000 claims description 2
- LPEBYPDZMWMCLZ-CVBJKYQLSA-L zinc;(z)-octadec-9-enoate Chemical compound [Zn+2].CCCCCCCC\C=C/CCCCCCCC([O-])=O.CCCCCCCC\C=C/CCCCCCCC([O-])=O LPEBYPDZMWMCLZ-CVBJKYQLSA-L 0.000 claims description 2
- ZPEJZWGMHAKWNL-UHFFFAOYSA-L zinc;oxalate Chemical compound [Zn+2].[O-]C(=O)C([O-])=O ZPEJZWGMHAKWNL-UHFFFAOYSA-L 0.000 claims description 2
- BUDAIZWUWHWZPQ-UHFFFAOYSA-L zinc;pentanoate Chemical compound [Zn+2].CCCCC([O-])=O.CCCCC([O-])=O BUDAIZWUWHWZPQ-UHFFFAOYSA-L 0.000 claims description 2
- GQLBMRKEAODAKR-UHFFFAOYSA-L zinc;selenate Chemical compound [Zn+2].[O-][Se]([O-])(=O)=O GQLBMRKEAODAKR-UHFFFAOYSA-L 0.000 claims description 2
- OBOMINCSAYZPGH-UHFFFAOYSA-L zinc;undecanoate Chemical compound [Zn+2].CCCCCCCCCCC([O-])=O.CCCCCCCCCCC([O-])=O OBOMINCSAYZPGH-UHFFFAOYSA-L 0.000 claims description 2
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 239000005083 Zinc sulfide Substances 0.000 claims 1
- WNMPGCKOSIFMAE-UHFFFAOYSA-L copper;chloro hypochlorite;sulfate Chemical compound [Cu+2].ClOCl.[O-]S([O-])(=O)=O WNMPGCKOSIFMAE-UHFFFAOYSA-L 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 229960001939 zinc chloride Drugs 0.000 claims 1
- 229910000165 zinc phosphate Inorganic materials 0.000 claims 1
- PZXFWBWBWODQCS-UHFFFAOYSA-L zinc;2-carboxyphenolate Chemical compound [Zn+2].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O PZXFWBWBWODQCS-UHFFFAOYSA-L 0.000 claims 1
- DRDVZXDWVBGGMH-UHFFFAOYSA-N zinc;sulfide Chemical compound [S-2].[Zn+2] DRDVZXDWVBGGMH-UHFFFAOYSA-N 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 description 122
- 229920000642 polymer Polymers 0.000 description 97
- 239000000178 monomer Substances 0.000 description 89
- 125000000217 alkyl group Chemical group 0.000 description 54
- 125000004432 carbon atom Chemical group C* 0.000 description 49
- 230000003750 conditioning effect Effects 0.000 description 43
- 239000003795 chemical substances by application Substances 0.000 description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 42
- 239000012530 fluid Substances 0.000 description 39
- 239000003981 vehicle Substances 0.000 description 39
- 238000007493 shaping process Methods 0.000 description 36
- 125000002091 cationic group Chemical group 0.000 description 35
- 239000000463 material Substances 0.000 description 31
- 229920006317 cationic polymer Polymers 0.000 description 27
- 229920001577 copolymer Polymers 0.000 description 27
- 150000002430 hydrocarbons Chemical class 0.000 description 26
- 125000003118 aryl group Chemical group 0.000 description 25
- 239000000047 product Substances 0.000 description 25
- 229930195733 hydrocarbon Natural products 0.000 description 24
- 239000000375 suspending agent Substances 0.000 description 24
- 150000002148 esters Chemical class 0.000 description 23
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 22
- 125000000129 anionic group Chemical group 0.000 description 21
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 20
- 235000014113 dietary fatty acids Nutrition 0.000 description 20
- SQEDZTDNVYVPQL-UHFFFAOYSA-N dodecylbenzene;sodium Chemical compound [Na].CCCCCCCCCCCCC1=CC=CC=C1 SQEDZTDNVYVPQL-UHFFFAOYSA-N 0.000 description 20
- 239000000194 fatty acid Substances 0.000 description 20
- 229930195729 fatty acid Natural products 0.000 description 20
- 239000003921 oil Substances 0.000 description 20
- 235000019198 oils Nutrition 0.000 description 20
- NLXFONFHPKEHOZ-UHFFFAOYSA-N diethylazanium;hydron;sulfate Chemical compound CCNCC.OS(O)(=O)=O NLXFONFHPKEHOZ-UHFFFAOYSA-N 0.000 description 19
- 241000555688 Malassezia furfur Species 0.000 description 18
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 18
- 125000001931 aliphatic group Chemical group 0.000 description 17
- 150000001875 compounds Chemical class 0.000 description 17
- 239000004205 dimethyl polysiloxane Substances 0.000 description 17
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- 150000001412 amines Chemical class 0.000 description 16
- 229910052739 hydrogen Inorganic materials 0.000 description 15
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 14
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 13
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 125000002252 acyl group Chemical group 0.000 description 7
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 description 7
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- 229910052700 potassium Inorganic materials 0.000 description 7
- SJMYWORNLPSJQO-UHFFFAOYSA-N tert-butyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC(C)(C)C SJMYWORNLPSJQO-UHFFFAOYSA-N 0.000 description 7
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- AEEZIRBYGITPDN-UHFFFAOYSA-M sodium;dodecanoyl sulfate Chemical compound [Na+].CCCCCCCCCCCC(=O)OS([O-])(=O)=O AEEZIRBYGITPDN-UHFFFAOYSA-M 0.000 description 1
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- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
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- 150000003628 tricarboxylic acids Chemical class 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
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- VQOXUMQBYILCKR-UHFFFAOYSA-N tridecaene Natural products CCCCCCCCCCCC=C VQOXUMQBYILCKR-UHFFFAOYSA-N 0.000 description 1
- IIYFAKIEWZDVMP-UHFFFAOYSA-N tridecane Chemical class CCCCCCCCCCCCC IIYFAKIEWZDVMP-UHFFFAOYSA-N 0.000 description 1
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- UUJLHYCIMQOUKC-UHFFFAOYSA-N trimethyl-[oxo(trimethylsilylperoxy)silyl]peroxysilane Chemical compound C[Si](C)(C)OO[Si](=O)OO[Si](C)(C)C UUJLHYCIMQOUKC-UHFFFAOYSA-N 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical group CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- PQDJYEQOELDLCP-UHFFFAOYSA-N trimethylsilane Chemical class C[SiH](C)C PQDJYEQOELDLCP-UHFFFAOYSA-N 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 229940117972 triolein Drugs 0.000 description 1
- QUTYHQJYVDNJJA-UHFFFAOYSA-K trisilver;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Ag+].[Ag+].[Ag+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QUTYHQJYVDNJJA-UHFFFAOYSA-K 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
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- 239000011782 vitamin Substances 0.000 description 1
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- 239000003878 whitfield ointment Substances 0.000 description 1
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- GPYYEEJOMCKTPR-UHFFFAOYSA-L zinc;dodecanoate Chemical compound [Zn+2].CCCCCCCCCCCC([O-])=O.CCCCCCCCCCCC([O-])=O GPYYEEJOMCKTPR-UHFFFAOYSA-L 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/244—Lanthanides; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2000/017273 WO2001000151A1 (en) | 1999-06-25 | 2000-06-23 | Topical anti-microbial compositions |
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| JPS6041979B2 (ja) * | 1976-01-30 | 1985-09-19 | 有限会社野々川商事 | 水性懸濁液の製造方法 |
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| US4529586A (en) | 1980-07-11 | 1985-07-16 | Clairol Incorporated | Hair conditioning composition and process |
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| US4364837A (en) | 1981-09-08 | 1982-12-21 | Lever Brothers Company | Shampoo compositions comprising saccharides |
| DE3263149D1 (en) * | 1981-10-21 | 1985-05-23 | Beecham Group Plc | Topical antimicrobial compositions |
| CA1261276A (en) | 1984-11-09 | 1989-09-26 | Mark B. Grote | Shampoo compositions |
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| JPH0621050B2 (ja) † | 1985-07-11 | 1994-03-23 | 尚子 浮田 | フケ取りシヤンプ− |
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| US4834767A (en) | 1987-06-10 | 1989-05-30 | Gaf Corporation | Compositions used in permanent alteration of hair color |
| US4835149A (en) † | 1986-11-13 | 1989-05-30 | Basf Corporation | Solubilization of salts of pyridine-2-thiol-1-oxide |
| US4885107A (en) | 1987-05-08 | 1989-12-05 | The Procter & Gamble Company | Shampoo compositions |
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| US5061481A (en) | 1989-03-20 | 1991-10-29 | Kobayashi Kose Co., Ltd. | Cosmetic composition having acryl-silicone graft copolymer |
| US5166276A (en) | 1989-07-12 | 1992-11-24 | Mitsubishi Petrochemical Company Ltd. | Polymer for hair-care products |
| US5104646A (en) | 1989-08-07 | 1992-04-14 | The Procter & Gamble Company | Vehicle systems for use in cosmetic compositions |
| US5106609A (en) | 1990-05-01 | 1992-04-21 | The Procter & Gamble Company | Vehicle systems for use in cosmetic compositions |
| US5100658A (en) | 1989-08-07 | 1992-03-31 | The Procter & Gamble Company | Vehicle systems for use in cosmetic compositions |
| US5120531A (en) | 1990-04-06 | 1992-06-09 | The Procter & Gamble Company | Hair styling conditioners |
| US5104642A (en) | 1990-04-06 | 1992-04-14 | The Procter & Gamble Company | Hair styling compositions containing particular hair styling polymers and non-aqueous solvents |
| US5120532A (en) | 1990-04-06 | 1992-06-09 | The Procter & Gamble Company | Hair styling shampoos |
| US5100657A (en) | 1990-05-01 | 1992-03-31 | The Procter & Gamble Company | Clean conditioning compositions for hair |
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| JPH11513685A (ja) | 1995-10-16 | 1999-11-24 | ザ、プロクター、エンド、ギャンブル、カンパニー | ポリアルキレングリコールを含むコンディショニングシャンプー |
| US5854319A (en) | 1995-11-30 | 1998-12-29 | Lambent Technologies Inc | Reactive silicone emulsions containing amino acids |
| US5750122A (en) | 1996-01-16 | 1998-05-12 | The Procter & Gamble Company | Compositions for treating hair or skin |
| US5674478A (en) | 1996-01-12 | 1997-10-07 | The Procter & Gamble Company | Hair conditioning compositions |
| US5672576A (en) | 1996-03-15 | 1997-09-30 | The Procter & Gamble Co. | High lather styling shampoos |
| US5886031A (en) † | 1997-01-27 | 1999-03-23 | Pacific Corporation | Hair-care cosmetic compositions having dandruff formation-suppressing effect |
-
2000
- 2000-06-23 CN CNB008117241A patent/CN100544704C/zh not_active Expired - Lifetime
- 2000-06-23 JP JP2001505864A patent/JP2003503333A/ja active Pending
- 2000-06-23 ES ES00944806.9T patent/ES2322688T5/es not_active Expired - Lifetime
- 2000-06-23 EP EP00944806.9A patent/EP1189581B2/en not_active Expired - Lifetime
- 2000-06-23 EP EP09153242.4A patent/EP2082723B1/en not_active Expired - Lifetime
- 2000-06-23 AT AT00944806T patent/ATE424181T1/de not_active IP Right Cessation
- 2000-06-23 DE DE60041699T patent/DE60041699D1/de not_active Expired - Lifetime
- 2000-06-23 AU AU58846/00A patent/AU5884600A/en not_active Abandoned
- 2000-06-23 MX MXPA02000295A patent/MXPA02000295A/es active IP Right Grant
- 2000-06-23 ES ES09153242.4T patent/ES2599027T3/es not_active Expired - Lifetime
- 2000-06-23 WO PCT/US2000/017273 patent/WO2001000151A1/en not_active Ceased
- 2000-06-23 CA CA002376803A patent/CA2376803C/en not_active Expired - Lifetime
- 2000-06-23 HK HK02106257.3A patent/HK1044489B/en not_active IP Right Cessation
- 2000-06-23 CA CA2632542A patent/CA2632542C/en not_active Expired - Lifetime
- 2000-06-23 BR BR0011852-4A patent/BR0011852A/pt not_active Application Discontinuation
- 2000-06-23 KR KR1020017016617A patent/KR100870257B1/ko not_active Expired - Fee Related
-
2007
- 2007-08-08 JP JP2007207218A patent/JP5450942B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02000295A (es) | 2004-05-21 |
| DE60041699D1 (de) | 2009-04-16 |
| EP1189581B1 (en) | 2009-03-04 |
| HK1044489A1 (en) | 2002-10-25 |
| BR0011852A (pt) | 2002-04-30 |
| CN1414846A (zh) | 2003-04-30 |
| JP2003503333A (ja) | 2003-01-28 |
| CA2632542A1 (en) | 2001-01-04 |
| ES2322688T3 (es) | 2009-06-25 |
| EP1189581A1 (en) | 2002-03-27 |
| JP2007284459A (ja) | 2007-11-01 |
| KR100870257B1 (ko) | 2008-11-25 |
| CA2376803C (en) | 2008-08-19 |
| CN100544704C (zh) | 2009-09-30 |
| AU5884600A (en) | 2001-01-31 |
| EP2082723B1 (en) | 2016-07-20 |
| KR20020057808A (ko) | 2002-07-12 |
| JP5450942B2 (ja) | 2014-03-26 |
| CA2632542C (en) | 2012-03-27 |
| CA2376803A1 (en) | 2001-01-04 |
| EP1189581B2 (en) | 2017-09-27 |
| HK1044489B (en) | 2009-09-04 |
| WO2001000151A1 (en) | 2001-01-04 |
| ATE424181T1 (de) | 2009-03-15 |
| ES2599027T3 (es) | 2017-01-31 |
| EP2082723A1 (en) | 2009-07-29 |
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